Beate Winner

Summary

Affiliation: The Salk Institute
Country: USA

Publications

  1. pmc Impaired adult olfactory bulb neurogenesis in the R6/2 mouse model of Huntington's disease
    Zacharias Kohl
    Division of Molecular Neurology, University Hospital Erlangen, Erlangen, Germany
    BMC Neurosci 11:114. 2010
  2. doi request reprint Dopamine receptor activation promotes adult neurogenesis in an acute Parkinson model
    Beate Winner
    Department of Neurology, University of Regensburg, Universitaetsstr 84, 93053 Regensburg, Germany
    Exp Neurol 219:543-52. 2009
  3. doi request reprint Dopaminergic lesion enhances growth factor-induced striatal neuroblast migration
    Beate Winner
    Department of Neurology, University of Regensburg, Regensburg, Germany
    J Neuropathol Exp Neurol 67:105-16. 2008
  4. ncbi request reprint Striatal deafferentation increases dopaminergic neurogenesis in the adult olfactory bulb
    Beate Winner
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Exp Neurol 197:113-21. 2006
  5. doi request reprint Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein
    Franz Marxreiter
    Department of Neurology, University of Regensburg, Universitatsstrasse 84, 93053 Regensburg, Germany
    Eur J Neurosci 29:879-90. 2009
  6. ncbi request reprint Physical activity fails to rescue hippocampal neurogenesis deficits in the R6/2 mouse model of Huntington's disease
    Zacharias Kohl
    Department of Neurology, University of Regensburg, Universitätsstr 84, Regensburg, Germany
    Brain Res 1155:24-33. 2007
  7. doi request reprint Adult neural precursor cells unaffected in animal models of DYT1 dystonia
    Martin Regensburger
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Neuroreport 20:1529-33. 2009
  8. ncbi request reprint Targeted transgene expression in neuronal precursors: watching young neurons in the old brain
    Sebastien Couillard-Despres
    Volkswagen Foundation Junior Group, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Eur J Neurosci 24:1535-45. 2006
  9. ncbi request reprint Transforming growth factor-beta1 is a negative modulator of adult neurogenesis
    Frank Peter Wachs
    Department of Neurology, University of Regensburg, Regensburg, Germany
    J Neuropathol Exp Neurol 65:358-70. 2006
  10. pmc Mutant alpha-synuclein exacerbates age-related decrease of neurogenesis
    Beate Winner
    Department of Neurology, University of Regensburg, Universitaetsstr 84, 93053 Regensburg, Germany
    Neurobiol Aging 29:913-25. 2008

Collaborators

Detail Information

Publications18

  1. pmc Impaired adult olfactory bulb neurogenesis in the R6/2 mouse model of Huntington's disease
    Zacharias Kohl
    Division of Molecular Neurology, University Hospital Erlangen, Erlangen, Germany
    BMC Neurosci 11:114. 2010
    ..Therefore, we hypothesized that mutant huntingtin also affects newly generated neurons derived from the subventricular zone of adult R6/2 HD mice...
  2. doi request reprint Dopamine receptor activation promotes adult neurogenesis in an acute Parkinson model
    Beate Winner
    Department of Neurology, University of Regensburg, Universitaetsstr 84, 93053 Regensburg, Germany
    Exp Neurol 219:543-52. 2009
    ..Analyzing the neurogenic fate decisions mediated by D2/D3 signaling pathways may lead to new avenues to induce neural repair in the adult brain...
  3. doi request reprint Dopaminergic lesion enhances growth factor-induced striatal neuroblast migration
    Beate Winner
    Department of Neurology, University of Regensburg, Regensburg, Germany
    J Neuropathol Exp Neurol 67:105-16. 2008
    ..Similar mechanisms may be involved in the increased numbers of dopaminergic neurons observed in the olfactory bulbs of PD patients and their functional olfactory deficits...
  4. ncbi request reprint Striatal deafferentation increases dopaminergic neurogenesis in the adult olfactory bulb
    Beate Winner
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Exp Neurol 197:113-21. 2006
    ..This study supports the accumulating evidence that neurotransmitters play a crucial role in determining survival and differentiation of newly generated neurons...
  5. doi request reprint Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein
    Franz Marxreiter
    Department of Neurology, University of Regensburg, Universitatsstrasse 84, 93053 Regensburg, Germany
    Eur J Neurosci 29:879-90. 2009
    ..This finding suggests that interfering with alpha-synuclein pathology can rescue newly generated neurons, possibly leading to new targets for therapeutic interventions in synucleinopathies...
  6. ncbi request reprint Physical activity fails to rescue hippocampal neurogenesis deficits in the R6/2 mouse model of Huntington's disease
    Zacharias Kohl
    Department of Neurology, University of Regensburg, Universitätsstr 84, Regensburg, Germany
    Brain Res 1155:24-33. 2007
    ..Future studies need to decipher the molecular pathways involved in repressing the generation of new neurons after physical activity in huntingtin transgenic rodents...
  7. doi request reprint Adult neural precursor cells unaffected in animal models of DYT1 dystonia
    Martin Regensburger
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Neuroreport 20:1529-33. 2009
    ..However, both hippocampal and olfactory neurogenesis levels were unchanged compared with control animals. We conclude that overexpression of human wild-type or mutant torsinA does not affect the survival of adult newborn neurons...
  8. ncbi request reprint Targeted transgene expression in neuronal precursors: watching young neurons in the old brain
    Sebastien Couillard-Despres
    Volkswagen Foundation Junior Group, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Eur J Neurosci 24:1535-45. 2006
    ..Therefore, maintenance of the fundamental properties of neuronal precursors even at advanced age suggests that stimulation of neurogenesis may constitute a valid strategy to counteract age-related neuronal loss and cognitive declines...
  9. ncbi request reprint Transforming growth factor-beta1 is a negative modulator of adult neurogenesis
    Frank Peter Wachs
    Department of Neurology, University of Regensburg, Regensburg, Germany
    J Neuropathol Exp Neurol 65:358-70. 2006
    ..This might have potential implications for neurogenesis in a variety of TGF-beta1-associated CNS diseases and pathologic conditions...
  10. pmc Mutant alpha-synuclein exacerbates age-related decrease of neurogenesis
    Beate Winner
    Department of Neurology, University of Regensburg, Universitaetsstr 84, 93053 Regensburg, Germany
    Neurobiol Aging 29:913-25. 2008
    ..The impaired neurogenesis in the olfactory bulb of different transgenic alpha-synuclein mice during aging highlights the need to further explore the interplay between olfactory dysfunction and neurogenesis in Parkinson disease...
  11. ncbi request reprint Human wild-type alpha-synuclein impairs neurogenesis
    Beate Winner
    Department of Neurology, University of Regensburg, Regensburg, Germany
    J Neuropathol Exp Neurol 63:1155-66. 2004
    ..We hypothesize that reduced adult neurogenesis in the olfactory bulb may contribute to olfactory deficits in neurodegenerative disorders associated with alpha-synuclein inclusions...
  12. ncbi request reprint In vivo optical imaging of neurogenesis: watching new neurons in the intact brain
    Sebastien Couillard-Despres
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Mol Imaging 7:28-34. 2008
    ..Hence, our DCX-promo-luciferase transgenic model constitutes an effective tool that answers the pressing need for rapid investigation of the impact on neurogenesis of a large number of candidate compounds waiting to be tested...
  13. ncbi request reprint Caspase inhibition decreases cell death in regions of adult neurogenesis
    Manfred Biebl
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Neuroreport 16:1147-50. 2005
    ..These data suggest that inhibiting the caspase activity in vivo decreases the rate of cell death, but has no influence on the generation of new neurons...
  14. ncbi request reprint Doublecortin expression levels in adult brain reflect neurogenesis
    Sebastien Couillard-Despres
    Volkswagen Foundation Junior Group, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Eur J Neurosci 21:1-14. 2005
    ....
  15. ncbi request reprint Long-term course and mutational spectrum of spatacsin-linked spastic paraplegia
    Ute Hehr
    Department of Human Genetics, University of Regensburg, Regensburg, Germany
    Ann Neurol 62:656-65. 2007
    ..We assessed the long-term course and the mutational spectrum of spatacsin-associated ARHSP with TCC...
  16. ncbi request reprint Long-term survival and cell death of newly generated neurons in the adult rat olfactory bulb
    Beate Winner
    Department of Neurology, University of Regensburg, Universitatsstrasse 84, D 93053 Regensburg, Germany
    Eur J Neurosci 16:1681-9. 2002
    ..Rather than replacing old neurons, this data suggests that adult olfactory bulb neurogenesis utilizes the overproduction and turnover of young neurons, which is reminiscent of the cellular dynamics observed during brain development...
  17. ncbi request reprint Thin corpus callosum and amyotrophy in spastic paraplegia--case report and review of literature
    Beate Winner
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Clin Neurol Neurosurg 108:692-8. 2006
    ..Thin CC and peripheral neuropathy often appear together in spastic paraplegia and might be indicative for combined degeneration mechanism of central and peripheral axons...
  18. pmc Cellular repair strategies in Parkinson's disease
    Beate Winner
    Department of Neurology, University of Regensburg, Regensburg, Germany and Salk Institute of Biological Studies, La Jolla, CA, USA
    Ther Adv Neurol Disord 2:51-60. 2009
    ....