T Wiedmer

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint Identification of three new members of the phospholipid scramblase gene family
    T Wiedmer
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1467:244-53. 2000
  2. ncbi request reprint c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1
    J Sun
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 276:28984-90. 2001
  3. ncbi request reprint Transcriptional control of the human plasma membrane phospholipid scramblase 1 gene is mediated by interferon-alpha
    Q Zhou
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Blood 95:2593-9. 2000
  4. ncbi request reprint Unraveling the mysteries of phospholipid scrambling
    P J Sims
    Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA
    Thromb Haemost 86:266-75. 2001
  5. pmc Mobilization of pro-inflammatory lipids in obese Plscr3-deficient mice
    David M Mutch
    The Scripps Research Institute, Department of Molecular and Experimental Medicine, La Jolla, CA 92037, USA
    Genome Biol 8:R38. 2007
  6. ncbi request reprint Phospholipid scramblase 1 binds to the promoter region of the inositol 1,4,5-triphosphate receptor type 1 gene to enhance its expression
    Quansheng Zhou
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 280:35062-8. 2005
  7. pmc Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3)
    Therese Wiedmer
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:13296-301. 2004
  8. pmc Phospholipid scramblase 1 potentiates the antiviral activity of interferon
    Beihua Dong
    Department of Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Virol 78:8983-93. 2004
  9. ncbi request reprint Protein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation
    Ke Wen Zhao
    Health Science Center, Shanghai Second Medical University, Shanghai Institutes for Biological Sciences and Graduate School of the Chinese Academy of Sciences, China
    Blood 104:3731-8. 2004
  10. ncbi request reprint Phospholipid scramblase 1 is imported into the nucleus by a receptor-mediated pathway and interacts with DNA
    Iris Ben-Efraim
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Biochemistry 43:3518-26. 2004

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Identification of three new members of the phospholipid scramblase gene family
    T Wiedmer
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1467:244-53. 2000
    ..Notable exceptions were HuPLSCR4, which was not detected in peripheral blood lymphocytes, and HuPLSCR1 and HuPLSCR3, which were not detected in brain...
  2. ncbi request reprint c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1
    J Sun
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 276:28984-90. 2001
    ..These findings indicate that c-Abl binds and phosphorylates PLSCR1, and raise the possibility that an interaction between c-Abl and plasma membrane PLSCR1 might contribute to the cellular response to genotoxic stress...
  3. ncbi request reprint Transcriptional control of the human plasma membrane phospholipid scramblase 1 gene is mediated by interferon-alpha
    Q Zhou
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Blood 95:2593-9. 2000
    ..Blood. 2000;95:2593-2599)..
  4. ncbi request reprint Unraveling the mysteries of phospholipid scrambling
    P J Sims
    Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA
    Thromb Haemost 86:266-75. 2001
    ..Evidence that PLSCR1 may serve functions other than its proposed activity as PL scramblase is also presented...
  5. pmc Mobilization of pro-inflammatory lipids in obese Plscr3-deficient mice
    David M Mutch
    The Scripps Research Institute, Department of Molecular and Experimental Medicine, La Jolla, CA 92037, USA
    Genome Biol 8:R38. 2007
    ..Using an untargeted comprehensive metabolite profiling approach coupled with targeted gene expression analyses, the perturbed biochemistry and functional redundancy of PLSCR proteins was assessed...
  6. ncbi request reprint Phospholipid scramblase 1 binds to the promoter region of the inositol 1,4,5-triphosphate receptor type 1 gene to enhance its expression
    Quansheng Zhou
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 280:35062-8. 2005
    ..These data suggest that in addition to its role at the plasma membrane, effects of PLSCR1 on cell proliferative and maturational responses may also relate to alterations in expression of cellular IP3 receptors...
  7. pmc Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3)
    Therese Wiedmer
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:13296-301. 2004
    ....
  8. pmc Phospholipid scramblase 1 potentiates the antiviral activity of interferon
    Beihua Dong
    Department of Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Virol 78:8983-93. 2004
    ..Our results suggest that PLSCR1, which is itself an ISG-encoded protein, provides a mechanism for amplifying and enhancing the IFN response through increased expression of a select subset of potent antiviral genes...
  9. ncbi request reprint Protein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation
    Ke Wen Zhao
    Health Science Center, Shanghai Second Medical University, Shanghai Institutes for Biological Sciences and Graduate School of the Chinese Academy of Sciences, China
    Blood 104:3731-8. 2004
    ..Taken together, these results suggest that as a protein induced upon PKCdelta activation, PLSCR1 is required for ATRA- and PMA-triggered leukemic cell differentiation...
  10. ncbi request reprint Phospholipid scramblase 1 is imported into the nucleus by a receptor-mediated pathway and interacts with DNA
    Iris Ben-Efraim
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Biochemistry 43:3518-26. 2004
    ..These data support a mechanism of receptor-mediated nuclear import of PLSCR1 and suggest a potential nuclear function for this plasma membrane protein...
  11. ncbi request reprint Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor
    Meera Nanjundan
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 278:37413-8. 2003
    ..We propose that PLSCR1, through its interaction with Shc, promotes Src kinase activation through the EGF receptor...
  12. ncbi request reprint Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane
    Therese Wiedmer
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Biochemistry 42:1227-33. 2003
    ..These data suggest that under the circumstance of rapid biosynthesis in response to gene induction by cytokines, PLSCR1 traffics into the nucleus, implying a potential nuclear function for this protein...
  13. ncbi request reprint Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1
    Quansheng Zhou
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 99:4030-8. 2002
    ..These data provide direct evidence that PLSCR1 functionally contributes to cytokine-regulated cell proliferation and differentiation and suggest it is required for normal myelopoiesis...
  14. ncbi request reprint Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor
    Jun Sun
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Biochemistry 41:6338-45. 2002
    ....
  15. ncbi request reprint Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1
    Robert H Silverman
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cancer Res 62:397-402. 2002
    ..These data suggest that the up-regulation of PLSCR1 expression in tumor cells exposed to IFN may contribute to the observed tumor-suppressive action of this cytokine...
  16. ncbi request reprint Expression of the phospholipid scramblase (PLSCR) gene family during the acute phase response
    Biao Lu
    Metabolism Section, Department of Veterans Affairs Medical Center, University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Biochim Biophys Acta 1771:1177-85. 2007
    ..These data provide evidence that PLSCR1 is a positive intracellular acute phase protein with a tissue-specific mechanism for up-regulation...