Peter S White

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. pmc A comprehensive view of human chromosome 1
    P S White
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 USA
    Genome Res 9:978-88. 1999
  2. ncbi request reprint Detailed molecular analysis of 1p36 in neuroblastoma
    P S White
    Division of Oncology, Children s Hospital of Philadelphia, Pennsylvania 19104 4318, USA
    Med Pediatr Oncol 36:37-41. 2001
  3. ncbi request reprint Definition and characterization of a region of 1p36.3 consistently deleted in neuroblastoma
    Peter S White
    Division of Oncology, The Children s Hospital of Philadelphia, 3516 Civic Center Blvd, Philadelphia, PA 19104, USA
    Oncogene 24:2684-94. 2005
  4. pmc High-resolution mapping and analysis of copy number variations in the human genome: a data resource for clinical and research applications
    Tamim H Shaikh
    Division of Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Genome Res 19:1682-90. 2009
  5. pmc Automated recognition of malignancy mentions in biomedical literature
    Yang Jin
    Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA
    BMC Bioinformatics 7:492. 2006
  6. pmc CHD5, a tumor suppressor gene deleted from 1p36.31 in neuroblastomas
    Tomoyuki Fujita
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Natl Cancer Inst 100:940-9. 2008
  7. pmc CNV Workshop: an integrated platform for high-throughput copy number variation discovery and clinical diagnostics
    Xiaowu Gai
    Center for Biomedical Informatics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    BMC Bioinformatics 11:74. 2010
  8. ncbi request reprint CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system
    Patricia M Thompson
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Oncogene 22:1002-11. 2003
  9. ncbi request reprint Homozygous deletion of CDKN2A (p16INK4a/p14ARF) but not within 1p36 or at other tumor suppressor loci in neuroblastoma
    P M Thompson
    Division of Oncology, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA
    Cancer Res 61:679-86. 2001
  10. ncbi request reprint Comprehensive analysis of chromosome 1p deletions in neuroblastoma
    J M Maris
    Division of Oncology, Children's Hospital of Philadelphia, Pennsylvania 19104-4138, USA
    Med Pediatr Oncol 36:32-6. 2001

Research Grants

  1. COMPREHENSIVE VIEWING OF THE HUMAN GENOME
    Peter White; Fiscal Year: 2002

Detail Information

Publications38

  1. pmc A comprehensive view of human chromosome 1
    P S White
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 USA
    Genome Res 9:978-88. 1999
    ..CompView creates comprehensive and fully integrated depictions of a chromosome's clinical, biological, and structural information...
  2. ncbi request reprint Detailed molecular analysis of 1p36 in neuroblastoma
    P S White
    Division of Oncology, Children s Hospital of Philadelphia, Pennsylvania 19104 4318, USA
    Med Pediatr Oncol 36:37-41. 2001
    ..Several lines of evidence es tablish that chromosome band 1p36 is frequently deleted in neuroblastoma primary tumors and cell lines, suggesting that a tumor suppressor gene within this region is involved in the development of this tumor...
  3. ncbi request reprint Definition and characterization of a region of 1p36.3 consistently deleted in neuroblastoma
    Peter S White
    Division of Oncology, The Children s Hospital of Philadelphia, 3516 Civic Center Blvd, Philadelphia, PA 19104, USA
    Oncogene 24:2684-94. 2005
    ..Together, these results suggest that one or more genes involved in neuroblastoma tumorigenesis or tumor progression are likely contained within this region...
  4. pmc High-resolution mapping and analysis of copy number variations in the human genome: a data resource for clinical and research applications
    Tamim H Shaikh
    Division of Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Genome Res 19:1682-90. 2009
    ..Together, this analysis and annotation provides a useful resource to assist with the assessment of CNVs in the contexts of human variation, disease susceptibility, and clinical molecular diagnostics...
  5. pmc Automated recognition of malignancy mentions in biomedical literature
    Yang Jin
    Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA
    BMC Bioinformatics 7:492. 2006
    ....
  6. pmc CHD5, a tumor suppressor gene deleted from 1p36.31 in neuroblastomas
    Tomoyuki Fujita
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Natl Cancer Inst 100:940-9. 2008
    ..31 that encodes 23 genes. Based on mutation analysis, expression pattern, and putative function, we identified CHD5 as the best tumor suppressor gene candidate...
  7. pmc CNV Workshop: an integrated platform for high-throughput copy number variation discovery and clinical diagnostics
    Xiaowu Gai
    Center for Biomedical Informatics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    BMC Bioinformatics 11:74. 2010
    ..However, few informatics tools for accurate and efficient CNV detection and assessment currently exist...
  8. ncbi request reprint CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system
    Patricia M Thompson
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Oncogene 22:1002-11. 2003
    ..These findings suggest that this gene may play a role in the development of the nervous system, and it may also play a role in the pathogenesis of neural tumors...
  9. ncbi request reprint Homozygous deletion of CDKN2A (p16INK4a/p14ARF) but not within 1p36 or at other tumor suppressor loci in neuroblastoma
    P M Thompson
    Division of Oncology, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA
    Cancer Res 61:679-86. 2001
    ..These results suggest that for neuroblastoma, large HDs do not occur within 1p36, most known TSGs are not homozygously deleted, and biallelic inactivation of CDKN2A may contribute to tumorigenicity in a subset of cases...
  10. ncbi request reprint Comprehensive analysis of chromosome 1p deletions in neuroblastoma
    J M Maris
    Division of Oncology, Children's Hospital of Philadelphia, Pennsylvania 19104-4138, USA
    Med Pediatr Oncol 36:32-6. 2001
    ..CONCLUSIONS: These data support the hypothesis that inactivation of a tumor suppressor gene within 1p36.3 is associated with an increased risk for disease relapse...
  11. doi request reprint Microdeletions and microduplications in patients with congenital heart disease and multiple congenital anomalies
    Elizabeth Goldmuntz
    Divisions of Cardiology Human Genetics Oncology Center for Applied Genomics Center for Biomedical Informatics, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Congenit Heart Dis 6:592-602. 2011
    ....
  12. ncbi request reprint Evidence for a hereditary neuroblastoma predisposition locus at chromosome 16p12-13
    John M Maris
    Department of Pediatrics, University of Pennsylvania School of Medicine and Children s Hospital of Philadelphia, Abramson Pediatric Research Center, Philadelphia, Pennsylvania 19104 4318, USA
    Cancer Res 62:6651-8. 2002
    ..Taken together, these data suggest that a hereditary neuroblastoma predisposition gene (HNB1) is located at 16p12-13 and that disruption of this gene may contribute to the pathogenesis of nonfamilial neuroblastomas...
  13. ncbi request reprint No evidence for the presence of an imprinted neuroblastoma suppressor gene within chromosome sub-band 1p36.3
    Michael D Hogarty
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    Cancer Res 62:6481-4. 2002
    ..58). These data strongly refute a parent-of-origin effect for 1p deletions in NB and exclude the existence of an imprinted NB suppressor locus in this region...
  14. pmc Region-specific detection of neuroblastoma loss of heterozygosity at multiple loci simultaneously using a SNP-based tag-array platform
    John M Maris
    Division of Oncology, The Children s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genome Res 15:1168-76. 2005
    ....
  15. ncbi request reprint An entity tagger for recognizing acquired genomic variations in cancer literature
    Ryan T McDonald
    Department of Computer and Information Science, University of Pennsylvania, 3330 Walnut Street, Philadelphia, PA 19104, USA
    Bioinformatics 20:3249-51. 2004
    ..VTag was tested with 345 training and 200 evaluation documents pertaining to cancer genetics. Our experiments resulted in 0.8541 precision, 0.7870 recall and 0.8192 F-measure on the evaluation set...
  16. ncbi request reprint Loss of heterozygosity for chromosome 14q in neuroblastoma
    P M Thompson
    Division of Oncology, Children's Hospital of Philadelphia, Pennsylvania 19104-4318, USA
    Med Pediatr Oncol 36:28-31. 2001
    ..These findings suggest that a tumor suppressor gene involved in the initiation or progression of neuroblastoma is located within distal 14q...
  17. ncbi request reprint Cloning, chromosomal localization, physical mapping, and genomic characterization of HKR3
    J M Maris
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, USA
    Genomics 35:289-98. 1996
    ..HKR3 is a novel zinc finger gene that maps to a region of the genome commonly rearranged or deleted in human cancers...
  18. ncbi request reprint Human Krüppel-related 3 (HKR3): a candidate for the 1p36 neuroblastoma tumour suppressor gene?
    J M Maris
    Division of Oncology, Children s Hospital of Philadelphia, Pennsylvania, USA
    Eur J Cancer 33:1991-6. 1997
    ..We conclude that HKR3 is a novel zinc finger gene that maps to a region of the genome commonly rearranged or deleted in neuroblastoma and other human cancers...
  19. ncbi request reprint An automated procedure to identify biomedical articles that contain cancer-associated gene variants
    Ryan McDonald
    Department of Computer and Information Science, University of Pennsylvania, Philadelphia, USA
    Hum Mutat 27:957-64. 2006
    ..This procedure can be readily adapted to any or all genes, organisms, or sets of documents...
  20. ncbi request reprint Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2
    P S White
    Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA USA
    Cytogenet Cell Genet 81:60-4. 1998
    ..This information should facilitate the mapping of tumor suppressor and genetic disease loci that have been localized to this region...
  21. ncbi request reprint Identification of a 1-megabase consensus region of deletion at 1p36.3 in primary neuroblastomas
    M D Hogarty
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    Med Pediatr Oncol 35:512-5. 2000
    ..In addition, neuroblastoma has been described in children with constitutional deletions within 1p36, supporting the existence of one or more neuroblastoma suppressor genes within this region...
  22. ncbi request reprint BIN1 inhibits colony formation and induces apoptosis in neuroblastoma cell lines with MYCN amplification
    M D Hogarty
    Department of Pediatrics, University of Pennsylvania School of Medicine and The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    Med Pediatr Oncol 35:559-62. 2000
    ..We hypothesized that BIN1, a MYC interacting protein capable of inducing apoptosis, may be an important regulator of MYCN in neuroblastoma...
  23. ncbi request reprint Expression and sequence analysis of candidates for the 1p36.31 tumor suppressor gene deleted in neuroblastomas
    E R Okawa
    Division of Oncology, The Children s Hospital of Philadelphia, Department of Pediatrics, The University of Pennsylvania, Philadelphia, PA 19104 4318, USA
    Oncogene 27:803-10. 2008
    ....
  24. ncbi request reprint Analysis of genomic imprinting at 1p35-36 in neuroblastoma
    M D Hogarty
    Division of Oncology, Children s Hospital of Philadelphia, Pennsylvania 19104 4318, USA
    Med Pediatr Oncol 36:52-5. 2001
    ..2-36.3. Indirect evidence suggests the presence of an imprinted neuroblastoma suppressor gene within this region, as well as an additional nonimprinted, proximal suppressor gene, inactivation of which correlates with MYCN amplification...
  25. ncbi request reprint Allelic deletion at chromosome bands 11q14-23 is common in neuroblastoma
    J M Maris
    Division of Oncology, Children s Hospital of Philadelphia, Pennsylvania 19104 4138, USA
    Med Pediatr Oncol 36:24-7. 2001
    ..Neuroblastoma tumorigenesis may involve the differential inactivation of multiple tumor suppressor genes. Recent data have suggested that a neuroblastoma suppressor gene may be located on the long arm of chromosome 11 (11q)...
  26. doi request reprint The Prevalence of 16p12.1 Microdeletion in Patients with Left-sided Cardiac Lesions
    Lisa C A D'Alessandro
    The Division of Cardiology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Congenit Heart Dis 9:83-6. 2014
    ..A large microdeletion at 16p12.1 is associated with childhood developmental delay, and initial studies describing this deletion identified left-sided lesions as an enriched phenotype compared with a control population...
  27. ncbi request reprint Genomic structure and organization of the high grade Myopia-2 locus (MYP2) critical region: mutation screening of 9 positional candidate genes
    Genaro S Scavello
    Division of Ophthalmology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Mol Vis 11:97-110. 2005
    ..31 using 7 families diagnosed with autosomal dominant high myopia and was designated the MYP2 locus. To characterize this region, we analyzed 9 known candidate genes localized to within the 2.2 cM interval by direct sequencing...
  28. ncbi request reprint me-PCR: a refined ultrafast algorithm for identifying sequence-defined genomic elements
    Kevin Murphy
    Division of Oncology, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia 19104 4318, USA
    Bioinformatics 20:588-90. 2004
    ..Thus, me-PCR provides increased annotation capabilities for complex genomes to non-expert laboratories...
  29. ncbi request reprint Genomic annotation of the meningioma tumor suppressor locus on chromosome 1p34
    Erik P Sulman
    The Fels Institute for Molecular Biology and Cancer Research, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Oncogene 23:1014-20. 2004
    ..This annotation of a putative tumor suppressor locus provides a resource for further analysis of meningioma candidate genes...
  30. ncbi request reprint Localization of a hereditary neuroblastoma predisposition gene to 16p12-p13
    M J Weiss
    Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    Med Pediatr Oncol 35:526-30. 2000
    ..Hereditary predisposition to develop neuroblastoma segregates as an autosomal dominant Mendelian trait...
  31. pmc A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3
    P S White
    Division of Oncology, Children s Hospital of Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 92:5520-4. 1995
    ..2-36.3, eliminating 33 centimorgans of proximal 1p36 from consideration. Furthermore, a consensus region of loss, which excludes the four leading candidate genes, was found in all tumors with 1p36 LOH...
  32. doi request reprint Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder
    Josephine Elia
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Nat Genet 44:78-84. 2012
    ..38 × 10(-10)) after correction for occurrence in the controls. We identified rare recurrent CNVs affecting glutamatergic neurotransmission genes that were overrepresented in multiple ADHD cohorts...
  33. ncbi request reprint Localization of the human Ror1 gene (NTRKR1) to chromosome 1p31-p32 by fluorescence in situ hybridization and somatic cell hybrid analysis
    U R Reddy
    Division of Neurology Research, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Genomics 41:283-5. 1997
    ..We have further localized the gene to chromosome 1p31-p32 by fluorescence in situ hybridization using a PAC clone that contains the Ror1 gene...
  34. ncbi request reprint Physical mapping and genomic structure of the human TNFR2 gene
    C P Beltinger
    Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104 4318, USA
    Genomics 35:94-100. 1996
    ....
  35. ncbi request reprint Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2)
    A Nakagawara
    Division of Oncology, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Genomics 25:538-46. 1995
    ..5-kb band encodes the full-length TRK-B mRNA and the 8.0-kb band encodes the truncated form of TRK-B mRNA. By fluorescence in situ hybridization and somatic cell hybrid mapping, the human TRK-B gene was localized to chromosome 9q22.1...
  36. pmc Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes
    J Elia
    Department of Child and Adolescent Psychiatry, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Mol Psychiatry 15:637-46. 2010
    ..Together, these results suggest that rare inherited structural variations play an important role in ADHD development and indicate a set of putative candidate genes for further study in the etiology of ADHD...
  37. pmc Systematic evaluation of map quality: human chromosome 22
    Tara C Matise
    Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA
    Am J Hum Genet 70:1398-410. 2002
    ....
  38. ncbi request reprint Fine mapping of the Schnyder's crystalline corneal dystrophy locus
    Veena Theendakara
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Hum Genet 114:594-600. 2004
    ..32 Mbp between markers D1S1160 and D1S1635. Within this interval, identity-by-state was present in all 13 families for two markers D1S244 and D1S3153, further refining the candidate region to 1.58 Mbp...

Research Grants1

  1. COMPREHENSIVE VIEWING OF THE HUMAN GENOME
    Peter White; Fiscal Year: 2002
    ..abstract_text> ..