E Wherry

Summary

Affiliation: The Wistar Institute
Country: USA

Publications

  1. pmc Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells
    Todd C Becker
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 195:1541-8. 2002
  2. pmc Low CD8 T-cell proliferative potential and high viral load limit the effectiveness of therapeutic vaccination
    E John Wherry
    Emory Vaccine Center, Emory University School of Medicine, 1510 Clifton Road, Room G211, Atlanta, GA 30322, USA
    J Virol 79:8960-8. 2005
  3. ncbi Molecular signature of CD8+ T cell exhaustion during chronic viral infection
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road Room G211, Atlanta, GA 30322, USA
    Immunity 27:670-84. 2007
  4. ncbi HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Virology 353:366-73. 2006
  5. ncbi Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    Susan M Kaech
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA
    Nat Immunol 4:1191-8. 2003
  6. pmc Antigen-independent memory CD8 T cells do not develop during chronic viral infection
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Room G211, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 101:16004-9. 2004
  7. ncbi Homeostatic proliferation but not the generation of virus specific memory CD8 T cells is impaired in the absence of IL-15 or IL-15Ralpha
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Adv Exp Med Biol 512:165-75. 2002
  8. pmc Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 77:4911-27. 2003
  9. ncbi Cutting edge: rapid in vivo killing by memory CD8 T cells
    Daniel L Barber
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA
    J Immunol 171:27-31. 2003
  10. ncbi Changing immunodominance patterns in antiviral CD8 T-cell responses after loss of epitope presentation or chronic antigenic stimulation
    Robbert G van der Most
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Virology 315:93-102. 2003

Collaborators

Detail Information

Publications53

  1. pmc Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells
    Todd C Becker
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 195:1541-8. 2002
    ..Taken together, these results show that IL-15 is not essential for the generation of memory CD8 T cells, but is required for homeostatic proliferation to maintain populations of memory cells over long periods of time...
  2. pmc Low CD8 T-cell proliferative potential and high viral load limit the effectiveness of therapeutic vaccination
    E John Wherry
    Emory Vaccine Center, Emory University School of Medicine, 1510 Clifton Road, Room G211, Atlanta, GA 30322, USA
    J Virol 79:8960-8. 2005
    ....
  3. ncbi Molecular signature of CD8+ T cell exhaustion during chronic viral infection
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road Room G211, Atlanta, GA 30322, USA
    Immunity 27:670-84. 2007
    ..Thus, functional exhaustion is probably due to both active suppression and passive defects in signaling and metabolism. These results provide a framework for designing rational immunotherapies during chronic infections...
  4. ncbi HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Virology 353:366-73. 2006
    ..These results indicate impaired HIV-specific memory CD8 T cell differentiation, regardless of level of control of viremia, epitopes targeted or restricting HLA alleles...
  5. ncbi Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    Susan M Kaech
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA
    Nat Immunol 4:1191-8. 2003
    ..Thus, selective expression of IL-7R identifies memory cell precursors, and this marker may be useful in predicting the number of memory T cells generated after infection or immunization...
  6. pmc Antigen-independent memory CD8 T cells do not develop during chronic viral infection
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Room G211, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 101:16004-9. 2004
    ..These findings raise concerns about using vaccines that may persist and also suggest that there may be limitations and challenges in designing effective immunological interventions for the treatment of chronic infections and tumors...
  7. ncbi Homeostatic proliferation but not the generation of virus specific memory CD8 T cells is impaired in the absence of IL-15 or IL-15Ralpha
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Adv Exp Med Biol 512:165-75. 2002
    ..Together these results suggest that IL-15 is not essential for the generation of memory CD8 T cells, but is required for homeostatic proliferation to maintain populations of memory cells over long periods of time...
  8. pmc Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 77:4911-27. 2003
    ..These results have implications for the study of human chronic infections, where similar T-cell deletion and functional dysregulation has been observed...
  9. ncbi Cutting edge: rapid in vivo killing by memory CD8 T cells
    Daniel L Barber
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA
    J Immunol 171:27-31. 2003
    ..These data indicate that virus specific memory CD8 T cells can rapidly acquire cytotoxic function upon re-exposure to Ag and are much more efficient killers in vivo than previously appreciated...
  10. ncbi Changing immunodominance patterns in antiviral CD8 T-cell responses after loss of epitope presentation or chronic antigenic stimulation
    Robbert G van der Most
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Virology 315:93-102. 2003
    ..A model in which recruitment time plays a role in the longevity of antiviral T-cell responses during persistent infection is discussed...
  11. pmc Memory CD8 T-cell differentiation during viral infection
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, G211 Rollins Research Building, 1510 Clifton Rd, Atlanta, GA 30322, USA
    J Virol 78:5535-45. 2004
  12. ncbi Differential sensitivity of naive and memory CD8+ T cells to apoptosis in vivo
    Jason M Grayson
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 169:3760-70. 2002
    ..These findings have implications for designing prime/boost vaccine strategies and also for optimizing immunotherapeutic regimens for treatment of chronic infections...
  13. ncbi TCR signal transduction in antigen-specific memory CD8 T cells
    Ellen N Kersh
    Department of Microbiology and Immunology, Emory Vaccine Center and Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 170:5455-63. 2003
    ..We propose that this regulatory mechanism might increase signal transduction in memory T cells, while limiting TCR cross-reactivity and autoimmunity...
  14. ncbi Bone marrow is a preferred site for homeostatic proliferation of memory CD8 T cells
    Todd C Becker
    Emory Vaccine Center, and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 174:1269-73. 2005
    ..These results show that the bone marrow is not only the source of stem cells for generating naive T cells but also provides the necessary signals for the self-renewal of memory T cells...
  15. ncbi Restoring function in exhausted CD8 T cells during chronic viral infection
    Daniel L Barber
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nature 439:682-7. 2006
    ..These studies identify a specific mechanism of T-cell exhaustion and define a potentially effective immunological strategy for the treatment of chronic viral infections...
  16. ncbi Strength of stimulus and clonal competition impact the rate of memory CD8 T cell differentiation
    Surojit Sarkar
    Department of Microbiology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 179:6704-14. 2007
    ..Thus, long-lasting, Ag-independent CD8 T cell memory results from progressive differentiation of memory CD8 T cells, and the rate of memory T cell differentiation is governed by events occurring early during T cell priming...
  17. pmc Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection
    Sang Jun Ha
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 205:543-55. 2008
    ..Such an approach may have broad applications in developing treatment strategies for chronic infections in general, and perhaps also for tumors...
  18. ncbi Cutting edge: gut microenvironment promotes differentiation of a unique memory CD8 T cell population
    David Masopust
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 176:2079-83. 2006
    ..Our data suggests that anatomic location directly impacts the memory T cell differentiation program...
  19. ncbi The role of programming in memory T-cell development
    David Masopust
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA
    Curr Opin Immunol 16:217-25. 2004
    ..Defining what memory qualities best protect the organism from re-infection, as well as how commitment to the memory lineage is specified following T-cell activation remains an important goal...
  20. ncbi Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo
    Joseph N Blattman
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA
    Nat Med 9:540-7. 2003
    ..Thus, timing of IL-2 administration and differentiation status of the T cell are critical parameters in designing IL-2 therapies...
  21. pmc Heterologous immunity provides a potent barrier to transplantation tolerance
    Andrew B Adams
    Emory Transplant Center and Department of Surgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Invest 111:1887-95. 2003
    ..These data offer a potential explanation for the difficulty encountered when inducing tolerance in nonhuman primates and human patients and provide insight into the signaling pathways essential for memory T cell activation and function...
  22. ncbi Diminished primary CD8 T cell response to viral infection during protein energy malnutrition in mice is due to changes in microenvironment and low numbers of viral-specific CD8 T cell precursors
    Janel Hart Chatraw
    Department of Rehabilitation Medicine, Division of Physical Therapy, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Nutr 138:806-12. 2008
    ..Furthermore, the diminished primary CD8 T cell response during PEM may in part have been due to low numbers of viral-specific CD8 T cells and an altered microenvironment...
  23. ncbi Generation and maintenance of immunological memory
    Tania S Gourley
    Department of Microbiology and Immunology, Emory Vaccine Center, Emory University, 1510 Clifton Road, Atlanta, GA 30033, USA
    Semin Immunol 16:323-33. 2004
    ..In this article we will review our current understanding of the generation and maintenance of B cell and T cell memory...
  24. pmc Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection
    Joseph N Blattman
    Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 83:4386-94. 2009
    ....
  25. ncbi Lineage relationship and protective immunity of memory CD8 T cell subsets
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Nat Immunol 4:225-34. 2003
    ..We propose that T(CM) and T(EM) do not necessarily represent distinct subsets, but are part of a continuum in a linear naive --> effector --> T(EM) --> T(CM) differentiation pathway...
  26. ncbi Effector and memory T-cell differentiation: implications for vaccine development
    Susan M Kaech
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nat Rev Immunol 2:251-62. 2002
    ..Models of the pathways of effector and memory T-cell differentiation are discussed, and we highlight the implications of this new understanding for the optimization of vaccine strategies...
  27. pmc Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression
    Henry Radziewicz
    Emory University School of Medicine, 954 Gatewood Road N E, Atlanta, GA 30329, USA
    J Virol 81:2545-53. 2007
    ....
  28. pmc Tissue-specific differences in PD-1 and PD-L1 expression during chronic viral infection: implications for CD8 T-cell exhaustion
    Shawn D Blackburn
    Department of Medical Oncology, Dana Farber Cancer Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 84:2078-89. 2010
    ..These observations have implications for human chronic infections and for therapeutic interventions based on blockade of the PD-1 pathway...
  29. pmc Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection
    Susan M Kaech
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06437, USA
    Immunity 27:393-405. 2007
    ..Here we discuss recent findings that might help redefine how heterogeneity in antiviral T cell populations gives rise to T cell subsets with short- and long-lived cell fates...
  30. doi Targeting of antigen to the herpesvirus entry mediator augments primary adaptive immune responses
    Marcio O Lasaro
    The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Nat Med 14:205-12. 2008
    ..The immunopotentiating effect required binding of the gD chimeric protein to HVEM. Overall, the studies demonstrate that targeting of antigen to the BTLA binding site of HVEM augments the immunogenicity of vaccines...
  31. pmc Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells
    W Nicholas Haining
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Immunol 181:1859-68. 2008
    ..Thus, our data suggest that in addition to lineage-specific differentiation programs, T and B lymphocytes use a common transcriptional program during memory development that is disrupted in chronic viral infection...
  32. pmc Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade
    Shawn D Blackburn
    Immunology Program, The Wistar Institute, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:15016-21. 2008
    ..These results have implications for predicting clinical responses to PD-1-based therapeutic interventions and for understanding T cell dynamics during persisting infections...
  33. doi Dynamic programmed death 1 expression by virus-specific CD8 T cells correlates with the outcome of acute hepatitis B
    Zheng Zhang
    Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, China
    Gastroenterology 134:1938-49, 1949.e1-3. 2008
    ....
  34. pmc MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection
    Adeeb H Rahman
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia PA 19104, USA
    J Immunol 181:3804-10. 2008
    ....
  35. pmc Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin
    Andrew M Intlekofer
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 321:408-11. 2008
    ..T-bet and Eomes, thus, ensure that CD8+ T cells adopt an appropriate course of intracellular rather than extracellular destruction...
  36. pmc Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells
    Andrew M Intlekofer
    Abramson Family Cancer Research Institute, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Exp Med 204:2015-21. 2007
    ..T-bet, thus, appears to function as a molecular switch between central- and effector-memory cell differentiation. Antagonism of T-bet may, therefore, represent a novel strategy to offset dysfunctional programming of memory CD8+ T cells...
  37. ncbi CD8 T cell dysfunction during chronic viral infection
    Haina Shin
    Immunology Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Curr Opin Immunol 19:408-15. 2007
    ..In this review, we will discuss recent work that highlights two main types of T cell dysfunction during chronic infection: exhaustion of effector functions and altered memory T cell development...
  38. ncbi Viral FLIP impairs survival of activated T cells and generation of CD8+ T cell memory
    Zhengqi Wu
    Immunoregulation Unit, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:6313-23. 2004
    ..Through this mechanism, vFLIP proteins expressed by T cell tropic viruses may impair the CD8(+) T cell immune responses directed against them...
  39. ncbi Hypogammaglobulinemia and exacerbated CD8 T-cell-mediated immunopathology in SAP-deficient mice with chronic LCMV infection mimics human XLP disease
    Shane Crotty
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Blood 108:3085-93. 2006
    ..These findings in a chronic viral infection mouse model recapitulate key features of human XLP and clarify SAP's critical role regulating both cellular and humoral immunity...
  40. ncbi Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
    Andrew M Intlekofer
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 6:1236-44. 2005
    ..Therefore, these key transcription factors link the long-term renewal of memory CD8(+) T cells to their characteristic effector potency...
  41. pmc Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization
    Nobuhiro Nakamoto
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Gastroenterology 134:1927-37, 1937.e1-2. 2008
    ..As hepatitis C virus (HCV) persists in the liver with immune-mediated disease pathogenesis, we examined the role of PD-1/PD-L pathway in antigen-specific CD8 T-cell dysfunction in the liver and blood of HCV-infected patients...
  42. ncbi PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
    Cheryl L Day
    HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban 4013, South Africa
    Nature 443:350-4. 2006
    ..Moreover, this pathway of reversible T-cell impairment provides a potential target for enhancing the function of exhausted T cells in chronic HIV infection...
  43. ncbi Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiation
    Naofumi Takemoto
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    J Immunol 177:7515-9. 2006
    ....
  44. pmc Adenoviral vectors persist in vivo and maintain activated CD8+ T cells: implications for their use as vaccines
    Nia Tatsis
    Wistar Institute, Philadelphia, PA 19104, USA
    Blood 110:1916-23. 2007
    ....
  45. pmc Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection
    Haina Shin
    Immunology Program, The Wistar Institute, Philadelphia, PA 19104, USA
    J Exp Med 204:941-9. 2007
    ..These results indicate that antigen-specific CD8 T cell responses during persisting infection are maintained by a mechanism distinct from that after acute infection...
  46. pmc Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade
    Gordon J Freeman
    Department of Medical Oncology, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 203:2223-7. 2006
    ..New studies now extend these observations to HIV infection and human disease...
  47. ncbi Generation of CD8(+) T cell memory in response to low, high, and excessive levels of epitope
    E John Wherry
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Immunol 168:4455-61. 2002
    ..Furthermore, when epitope is overexpressed, the quality of the response can be adversely affected. Therefore, epitope expression level is an important consideration when developing approaches to optimize CTL memory induction...
  48. ncbi Efficient and qualitatively distinct MHC class I-restricted presentation of antigen targeted to the endoplasmic reticulum
    Tatiana N Golovina
    Department of Microbiology and Immunology, Jefferson Medical College and Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Immunol 168:2667-75. 2002
    ..These results indicate that delivery of Ag to the ER need not preclude efficient presentation and that processing of cytosolic and ER-targeted Ag is qualitatively distinct...
  49. ncbi Inhibitory receptors: whose side are they on?
    Alison Crawford
    Nat Immunol 8:1201-3. 2007
  50. ncbi Cytosolic delivery of viral nucleoprotein by listeriolysin O-liposome induces enhanced specific cytotoxic T lymphocyte response and protective immunity
    Manas Mandal
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Pharm 1:2-8. 2004
    ..Our study demonstrates that LLO-liposomes can be used as an efficient vaccine delivery system carrying a viral antigenic protein to generate protective antiviral immunity...
  51. ncbi Re-evaluating the generation of a "proteasome-independent" MHC class I-restricted CD8 T cell epitope
    E John Wherry
    Department of Microbiology and Immunology, Jefferson Medical College and Kimmel Cancer Institute, Thomas Jefferson University, Bluemle Life Sciences Building, Philadelphia, PA 19107, USA
    J Immunol 176:2249-61. 2006
    ....
  52. ncbi The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
    Arlene H Sharpe
    Department of Pathology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nat Immunol 8:239-45. 2007
    ..Here we examine the functions of PD-1 and its ligands in regulating antimicrobial and self-reactive T cell responses and discuss the therapeutic potential of manipulating this pathway...
  53. ncbi A brief history of CD8 T cells
    David Masopust
    Department of Microbiology, University of Minnesota, Minneapolis, MN, USA
    Eur J Immunol 37:S103-10. 2007
    ..Herein, we recount the historical developments leading to the discovery of CD8 T cells, highlight a few of the important discoveries that have followed, and discuss some of the critical issues on the horizon...

Research Grants6

  1. Regulation of exhaustion and altered CD8 T cell memory during chronic Infection
    E Wherry; Fiscal Year: 2007
    ..Our studies may provide important information for the design of prophylactic vaccines and also may uncover opportunities to develop novel therapeutic interventions for chronic diseases. ..
  2. Memory CD8 T cell subset cooperation via chemokines in protective immunity to inf
    E Wherry; Fiscal Year: 2007
    ....
  3. Regulation of exhaustion and altered CD8 T cell memory during chronic Infection
    E Wherry; Fiscal Year: 2009
    ..Our studies may provide important information for the design of prophylactic vaccines and also may uncover opportunities to develop novel therapeutic interventions for chronic diseases. ..