G Wernovsky

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. doi request reprint Guidelines for the outpatient management of complex congenital heart disease
    Gil Wernovsky
    Division of Pediatric Cardiology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Congenit Heart Dis 1:10-26. 2006
  2. ncbi request reprint Outcomes regarding the central nervous system in children with complex congenital cardiac malformations
    Gil Wernovsky
    Division of Pediatric Cardiology, The Cardiac Center at The Children s Hospital of Philadelphia, Pennsylvania 19104, United States of America
    Cardiol Young 15:132-3. 2005
  3. ncbi request reprint Postoperative course in the cardiac intensive care unit following the first stage of Norwood reconstruction
    Gil Wernovsky
    Department of Pediatrics Division of Pediatric Cardiology, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cardiol Young 17:652-65. 2007
  4. doi request reprint Hypoplastic left heart syndrome: consensus and controversies in 2007
    Gil Wernovsky
    Division of Pediatric Cardiology, The Cardiac Centre at The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia 19104, United States of America
    Cardiol Young 17:75-86. 2007
  5. doi request reprint The paradigm shift toward surgical intervention for neonates with hypoplastic left heart syndrome
    Gil Wernovsky
    Divisions of Pediatric Cardiology and Critical Care Medicine, The Children s Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
    Arch Pediatr Adolesc Med 162:849-54. 2008
  6. ncbi request reprint Central nervous system outcomes in children with complex congenital heart disease
    Gil Wernovsky
    Division of Pediatric Cardiology, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Curr Opin Cardiol 20:94-9. 2005
  7. ncbi request reprint Cognitive development after the Fontan operation
    G Wernovsky
    Department of Cardiology, Children s Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 102:883-9. 2000
  8. ncbi request reprint Current insights regarding neurological and developmental abnormalities in children and young adults with complex congenital cardiac disease
    Gil Wernovsky
    Division of Pediatric Cardiology, The Cardiac Center at The Children s Hospital of Philadelphia, Philadelphia 19104, USA
    Cardiol Young 16:92-104. 2006
  9. ncbi request reprint Long-term follow-up after staged reconstruction or transplantation for patients with functionally univentricular heart
    Gil Wernovsky
    Division of Pediatric Cardiology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Cardiol Young 14:115-26. 2004
  10. ncbi request reprint Sinus node function after a systematically staged Fontan procedure
    M I Cohen
    Division of Cardiology, Children s Hospital of Philadelphia, PA 19104, USA
    Circulation 98:II352-8; discussion II358-9. 1998

Detail Information

Publications97

  1. doi request reprint Guidelines for the outpatient management of complex congenital heart disease
    Gil Wernovsky
    Division of Pediatric Cardiology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Congenit Heart Dis 1:10-26. 2006
    ..The purpose of this position article is to provide a framework for outpatient follow-up of complex congenital heart disease, based on a review of current literature and the experience of the authors...
  2. ncbi request reprint Outcomes regarding the central nervous system in children with complex congenital cardiac malformations
    Gil Wernovsky
    Division of Pediatric Cardiology, The Cardiac Center at The Children s Hospital of Philadelphia, Pennsylvania 19104, United States of America
    Cardiol Young 15:132-3. 2005
  3. ncbi request reprint Postoperative course in the cardiac intensive care unit following the first stage of Norwood reconstruction
    Gil Wernovsky
    Department of Pediatrics Division of Pediatric Cardiology, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cardiol Young 17:652-65. 2007
    ....
  4. doi request reprint Hypoplastic left heart syndrome: consensus and controversies in 2007
    Gil Wernovsky
    Division of Pediatric Cardiology, The Cardiac Centre at The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia 19104, United States of America
    Cardiol Young 17:75-86. 2007
    ....
  5. doi request reprint The paradigm shift toward surgical intervention for neonates with hypoplastic left heart syndrome
    Gil Wernovsky
    Divisions of Pediatric Cardiology and Critical Care Medicine, The Children s Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
    Arch Pediatr Adolesc Med 162:849-54. 2008
  6. ncbi request reprint Central nervous system outcomes in children with complex congenital heart disease
    Gil Wernovsky
    Division of Pediatric Cardiology, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Curr Opin Cardiol 20:94-9. 2005
    ....
  7. ncbi request reprint Cognitive development after the Fontan operation
    G Wernovsky
    Department of Cardiology, Children s Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 102:883-9. 2000
    ..Patients with a single ventricle have multiple risk factors for central nervous system injury, both before and after the Fontan procedure...
  8. ncbi request reprint Current insights regarding neurological and developmental abnormalities in children and young adults with complex congenital cardiac disease
    Gil Wernovsky
    Division of Pediatric Cardiology, The Cardiac Center at The Children s Hospital of Philadelphia, Philadelphia 19104, USA
    Cardiol Young 16:92-104. 2006
  9. ncbi request reprint Long-term follow-up after staged reconstruction or transplantation for patients with functionally univentricular heart
    Gil Wernovsky
    Division of Pediatric Cardiology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Cardiol Young 14:115-26. 2004
  10. ncbi request reprint Sinus node function after a systematically staged Fontan procedure
    M I Cohen
    Division of Cardiology, Children s Hospital of Philadelphia, PA 19104, USA
    Circulation 98:II352-8; discussion II358-9. 1998
    ..This study sought to determine the early and late incidences of sinus node dysfunction in patients systematically and uniformly staged to a Fontan operation after a prior hemi-Fontan...
  11. doi request reprint Morbidity and mortality after surgery for congenital cardiac disease in the infant born with low weight
    Anne M Ades
    Department of Pediatrics, Division of Neonatology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Cardiol Young 20:8-17. 2010
    ..Our goal was to report on the current incidences of morbidities and mortality in infants born with low weight and undergoing surgery for congenital cardiac disease...
  12. ncbi request reprint The effect of duration of deep hypothermic circulatory arrest in infant heart surgery on late neurodevelopment: the Boston Circulatory Arrest Trial
    David Wypij
    Department of Cardiology, Children s Hospital, Harvard Medical School, Boston, 02115, USA
    J Thorac Cardiovasc Surg 126:1397-403. 2003
    ..Our goal was to determine the functional form of the association between duration of circulatory arrest and risk of neurodevelopmental dysfunction...
  13. ncbi request reprint Modifications to the cavopulmonary anastomosis do not eliminate early sinus node dysfunction
    M I Cohen
    Divisions of Cardiology and Cardiothoracic Surgery and The Departments of Pediatrics and Surgery, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Thorac Cardiovasc Surg 120:891-900. 2000
    ....
  14. ncbi request reprint Neurodevelopmental status at eight years in children with dextro-transposition of the great arteries: the Boston Circulatory Arrest Trial
    David C Bellinger
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Thorac Cardiovasc Surg 126:1385-96. 2003
    ..Our goal was to determine which of the two major methods of vital organ support used in infant cardiac surgery, total circulatory arrest and low-flow cardiopulmonary bypass, results in better neurodevelopmental outcomes at school age...
  15. ncbi request reprint Improved early results with cavopulmonary connections
    A R Mott
    Department of Anesthesiology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Cardiol Young 11:3-11. 2001
    ..The long-term results of staged reconstruction for functionally single ventricle, nonetheless, await ongoing study...
  16. ncbi request reprint Cardiac surgery in the low-birth weight neonate. New approaches
    G Wernovsky
    Cardiac Intensive Care Unit, Children's Hospital of Philadelphia, Pennsylvania, USA
    Clin Perinatol 28:249-64. 2001
    ..The medical and surgical teams should collaborate to determine the optimal timing and type of surgery, with body weight being only of minor importance...
  17. ncbi request reprint Assessment of pulmonary/systemic blood flow ratio after first-stage palliation for hypoplastic left heart syndrome: development of a new index with the use of doppler echocardiography
    J Rychik
    Divisions of Cardiology and Cardiothoracic Surgery, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 120:81-7. 2000
    ....
  18. ncbi request reprint Length of stay after infant heart surgery is related to cognitive outcome at age 8 years
    Jane W Newburger
    Department of Cardiology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Pediatr 143:67-73. 2003
    ..To test the hypothesis that postoperative length of stay (LOS) after infant heart surgery might be an easily measured surrogate marker for various events that culminate in later adverse cognitive outcome...
  19. doi request reprint Predictors of impaired neurodevelopmental outcomes at one year of age after infant cardiac surgery
    Stephanie Fuller
    Division of Pediatric Cardiothoracic Surgery, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Eur J Cardiothorac Surg 36:40-7. 2009
    ..For most newborns, congenital heart defects (CHD) appear to be isolated anomalies and the brain is presumed to have normal developmental potential. Most studies of neurodevelopmental outcomes have focused on operative management strategies...
  20. ncbi request reprint Epicardial pacemaker implantation and follow-up in patients with a single ventricle after the Fontan operation
    M I Cohen
    Divisions of Cardiology and Cardiothoracic Surgery, The Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 121:804-11. 2001
    ..The purpose of this study was to compare the hospital course and follow-up of epicardial pacing lead implantation in patients with Fontan physiology and patients with 2-ventricle physiology...
  21. ncbi request reprint Effects of inspired hypoxic and hypercapnic gas mixtures on cerebral oxygen saturation in neonates with univentricular heart defects
    Chandra Ramamoorthy
    Department of Anesthesiology Critical Care Medicine, and Division of Cardiothoracic Surgery, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Anesthesiology 96:283-8. 2002
    ..This study examined the effect of these treatments on cerebral oxygen saturation and systemic hemodynamics...
  22. ncbi request reprint Periventricular leukomalacia is common after neonatal cardiac surgery
    Kristin K Galli
    Division of Cardiothoracic Anesthesiology, The Cardiac Center, Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 127:692-704. 2004
    ..The incidence of periventricular leukomalacia and the risk factors for development of periventricular leukomalacia after infant cardiac surgery are not known...
  23. ncbi request reprint Long-term developmental outcome of children with complex congenital heart disease
    W T Mahle
    Division of Cardiology, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, USA
    Clin Perinatol 28:235-47. 2001
    ..Continued efforts are underway to reduce cerebral injury before, during, and after congenital heart surgery...
  24. ncbi request reprint Surgical management of tricuspid atresia and anomalous left brachiocephalic vein
    T C Koutlas
    Division of Cardiothoracic Surgery, The Children s Hospital of Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 65:1770-2. 1998
    ..We describe a case of tricuspid atresia with such an anomalous left brachiocephalic vein. The presence of this unusual venous anomaly had a number of implications in the surgical management of the tricuspid atresia...
  25. ncbi request reprint Preoperative risk-of-death prediction model in heart surgery with deep hypothermic circulatory arrest in the neonate
    R R Clancy
    Division of Neurology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 119:347-57. 2000
    ..Our goal was to generate a preoperative risk-of-death prediction model in selected neonates with congenital heart disease undergoing surgery with deep hypothermic circulatory arrest...
  26. ncbi request reprint Outcome following single-stage repair of coarctation with ventricular septal defect
    J W Gaynor
    Divisions of Pediatric Cardiothoracic Surgery and Pediatric Cardiology, The Cardiac Center, The Children s Hospital of Philadelphia, 34th Street and Civic Center Blvd, Suite 8527, Philadelphia, PA 19104, USA
    Eur J Cardiothorac Surg 18:62-7. 2000
    ..The current study was undertaken to determine outcome and need for reintervention following single-stage repair of coarctation and VSD at our institution...
  27. ncbi request reprint Neurodevelopmental outcomes following congenital heart surgery
    Jean A Ballweg
    The Cardiac Center at The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatr Cardiol 28:126-33. 2007
    ..The purpose of this review is to examine these mechanisms as they relate to available outcome data...
  28. ncbi request reprint Risk factors for mortality in 137 pediatric cardiac intensive care unit patients managed with extracorporeal membrane oxygenation
    Marilyn C Morris
    Children s Hospital of Philadelphia, Department of Anesthesia and Critical Care Medicine, USA
    Crit Care Med 32:1061-9. 2004
    ..To identify factors associated with mortality in children with heart disease managed with extracorporeal membrane oxygenation (ECMO)...
  29. ncbi request reprint Functional state of patients with heterotaxy syndrome following the Fontan operation
    Andrew M Atz
    Department of Pediatrics, Division of Cardiology, Medical University of South Carolina, Children s Hospital, Charleston, South Carolina 29425, United States of America
    Cardiol Young 17:44-53. 2007
    ..Little is known, however, about the functional state of surviving patients with heterotaxy following a Fontan operation...
  30. ncbi request reprint Relation of seizures after cardiac surgery in early infancy to neurodevelopmental outcome. Boston Circulatory Arrest Study Group
    L A Rappaport
    Department of Medicine, Children s Hospital, Boston, MA 02115, USA
    Circulation 97:773-9. 1998
    ....
  31. pmc What factors are important to parents making decisions about neonatal research?
    K S Hoehn
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, PA 19104, USA
    Arch Dis Child Fetal Neonatal Ed 90:F267-9. 2005
    ..Although parents of neonates with congenital heart disease are often asked permission for their neonates to participate in research studies, little is known about the factors parents consider when making these decisions...
  32. ncbi request reprint Quantitative echocardiographic assessment of the performance of the functionally single right ventricle after the Fontan operation
    W T Mahle
    Division of Cardiology, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA
    Cardiol Young 11:399-406. 2001
    ..Use of the echocardiographic techniques provide insight into ventricular mechanics in patients with functionally single ventricles, and may be valuable tools for serial quantitative follow-up...
  33. pmc Preoperative brain injury in transposition of the great arteries is associated with oxygenation and time to surgery, not balloon atrial septostomy
    Christopher J Petit
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circulation 119:709-16. 2009
    ..We hypothesized that brain injury results from hypoxic injury, not from the BAS itself...
  34. ncbi request reprint Prophylactic intravenous use of milrinone after cardiac operation in pediatrics (PRIMACORP) study. Prophylactic Intravenous Use of Milrinone After Cardiac Operation in Pediatrics
    Timothy M Hoffman
    Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Am Heart J 143:15-21. 2002
    ....
  35. ncbi request reprint An MRI study of neurological injury before and after congenital heart surgery
    William T Mahle
    Department of Pediatrics, Division of Cardiology, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Penn, USA
    Circulation 106:I109-14. 2002
    ..To understand the impact of preoperative events and to characterize the evaluation of neurological injury, we performed serial magnetic resonance imaging (MRI) studies of the brain in a cohort of neonates undergoing open-heart surgery...
  36. ncbi request reprint Somatic growth failure after the Fontan operation
    M I Cohen
    Division of Cardiology, The Children Hospital of Philadelphia and The University of Pennsylvania School of Medicine, 19104, USA
    Cardiol Young 10:447-57. 2000
    ..In our experience, children with functionally univentricular hearts who have been palliated with a Fontan operation are significantly underweight and shorter than the general population and their siblings...
  37. ncbi request reprint Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest
    R R Clancy
    Division of Neurology, Pennsylvania, USA
    Pediatrics 108:61-70. 2001
    ....
  38. doi request reprint Accuracy of intraoperative transesophageal echocardiography in the prediction of future neo-aortic valve function after the Ross procedure in children and young adults
    Bradley S Marino
    Children s Hospital of Philadelphia, Pediatrics Divisions of Cardiology, Philadelphia, PA, USA
    Congenit Heart Dis 3:39-46. 2008
    ....
  39. ncbi request reprint Midterm outcomes and predictors of reintervention after the Ross procedure in infants, children, and young adults
    Sara K Pasquali
    Division of Cardiology in the Departments of Pediatrics, Surgery, and Anesthesia Critical Care Medicine at The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 133:893-9. 2007
    ..This study assessed the type, time course, and risk factors for right and left ventricular outflow tract reinterventions after the Ross procedure in a population of infants, children, and young adults...
  40. ncbi request reprint Is the Ross procedure as good as we thought it would be?
    Bradley S Marino
    Divisione of Cardiology, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Cardiol Young 16:125-30. 2006
  41. ncbi request reprint Is the arterial switch operation as good over the long term as we thought it would be?
    Meryl S Cohen
    Division of Cardiology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cardiol Young 16:117-24. 2006
  42. ncbi request reprint Risk factors for adverse outcomes after surgery on the systemic atrioventricular valve in 109 children
    Matthew J Gillespie
    Division of Cardiology, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Cardiol Young 16:35-42. 2006
  43. ncbi request reprint Aortic morphometry and microcephaly in hypoplastic left heart syndrome
    Amanda J Shillingford
    Division of Cardiology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Cardiol Young 17:189-95. 2007
    ..Microcephaly was associated with a small ascending aorta, but not a small transverse aortic arch. Impairment of somatic growth may be an additional factor in the development of microcephaly in these neonates...
  44. doi request reprint Rhythm and conduction disturbances at midterm follow-up after the ross procedure in infants, children, and young adults
    Sara K Pasquali
    Division of Cardiology, Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 85:2072-8. 2008
    ..To our knowledge, late electrophysiologic outcomes after the Ross procedure have not been described. The purpose of this study was to assess rhythm and conduction disturbances at midterm follow-up after the Ross procedure...
  45. ncbi request reprint Neo-aortic valvar function after the arterial switch
    Bradley S Marino
    Cardiac Center, Children s Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania School of Medicine, United States of America
    Cardiol Young 16:481-9. 2006
    ....
  46. ncbi request reprint The relationship between neo-aortic root dilation, insufficiency, and reintervention following the Ross procedure in infants, children, and young adults
    Sara K Pasquali
    Division of Cardiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 49:1806-12. 2007
    ..The purpose of this study was to describe the relationship between neo-aortic root size, neo-aortic insufficiency (AI), and reintervention at mid-term follow-up...
  47. pmc Patient characteristics are important determinants of neurodevelopmental outcome at one year of age after neonatal and infant cardiac surgery
    J William Gaynor
    Division of Cardiothoracic Surgery, The Cardiac Center at The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 133:1344-53, 1353.e1-3. 2007
    ..There is increasing evidence that patient-specific factors are more important determinants of outcome...
  48. doi request reprint Neurodevelopmental outcomes after staged palliation for hypoplastic left heart syndrome
    Sarah Tabbutt
    Department of Pediatrics, Division of Cardiology, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 121:476-83. 2008
    ..The goal was to determine the relative effects of underlying genetic factors and current management strategies on neurodevelopmental disabilities among one-year old survivors of palliation for hypoplastic left heart syndrome...
  49. doi request reprint Inattention, hyperactivity, and school performance in a population of school-age children with complex congenital heart disease
    Amanda J Shillingford
    Division of Cardiology, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatrics 121:e759-67. 2008
    ....
  50. ncbi request reprint Cause and prevention of central nervous system injury in neonates undergoing cardiac surgery
    Troy E Dominguez
    Division of Cardiothoracic Surgery, The Cardiac Center at The Childre s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Semin Thorac Cardiovasc Surg 19:269-77. 2007
    ..Unfortunately, modifiable perioperative factors may explain less of the variability in long-term outcomes than do patient-specific factors...
  51. pmc Impact of oral sildenafil on exercise performance in children and young adults after the fontan operation: a randomized, double-blind, placebo-controlled, crossover trial
    David J Goldberg
    Division of Cardiology, The Children s Hospital of Philadelphia, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA
    Circulation 123:1185-93. 2011
    ..A medication capable of decreasing pulmonary vascular resistance should allow improved cardiac filling and improved exercise capacity...
  52. ncbi request reprint Hyperglycemia after infant cardiac surgery does not adversely impact neurodevelopmental outcome
    Jean A Ballweg
    Division of Pediatric Cardiology, The Cardiac Center at The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 84:2052-8. 2007
    ..Hyperglycemia has been associated with worse outcome after traumatic brain injury and cardiac surgery in adults. It is not known whether postoperative hyperglycemia results in worse neurodevelopmental outcome after infant cardiac surgery...
  53. pmc J. Maxwell Chamberlain Memorial Paper for congenital heart surgery. Deep hypothermic circulatory arrest does not impair neurodevelopmental outcome in school-age children after infant cardiac surgery
    Stephanie Fuller
    Division of Cardiothoracic Surgery, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 90:1985-94; discussion 1994-5. 2010
    ..The purpose of this study was to assess deep hypothermic circulatory arrest (DHCA) as a modifier of neurodevelopmental (ND) outcomes in preschool children after cardiac surgery in infancy for repair of congenital heart defects (CHD)...
  54. ncbi request reprint A contemporary comparison of the effect of shunt type in hypoplastic left heart syndrome on the hemodynamics and outcome at stage 2 reconstruction
    Jean A Ballweg
    Department of Pediatrics, Division of Cardiology, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19119, USA
    J Thorac Cardiovasc Surg 134:297-303. 2007
    ..We compare the hemodynamics and perioperative course of shunt type in hypoplastic left heart syndrome at the time of stage 2 reconstruction and longer-term survival...
  55. ncbi request reprint Late cardiopulmonary and musculoskeletal exercise performance after repair for total anomalous pulmonary venous connection during infancy
    Michael G McBride
    Division of Cardiology, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 133:1533-9. 2007
    ..We evaluated cardiopulmonary function at rest and during exercise in children after surgical repair for total anomalous pulmonary venous connection...
  56. ncbi request reprint Surrogate markers for neurological outcome in children after deep hypothermic circulatory arrest
    Scott D Markowitz
    Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Semin Cardiothorac Vasc Anesth 11:59-65. 2007
    ..This article summarizes the state of the art and an admission about how far we have yet to travel as we strive to make the neurodevelopmental outcomes of patients with CHD comparable to their healthy peers...
  57. ncbi request reprint Early results of single-stage biventricular repair of severe aortic hypoplasia or atresia with ventricular septal defect and normal left ventricle
    Peter J Gruber
    Pediatric Cardiothoracic Surgery, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 132:260-3. 2006
    ..We considered whether primary biventricular repair was a safe alternative in all cases, even in the presence of interrupted aortic arch...
  58. ncbi request reprint Extracorporeal membrane oxygenation after stage I reconstruction for hypoplastic left heart syndrome
    Chitra Ravishankar
    Division of Cardiology, The Children s Hospital of Philadelphia, PA 19104 4399, USA
    Pediatr Crit Care Med 7:319-23. 2006
    ..Our objective is to describe the outcome of "nonelective" ECMO after stage I reconstruction...
  59. ncbi request reprint Neurodevelopmental outcome after early repair of a ventricular septal defect with or without aortic arch obstruction
    Jonathan R Kaltman
    Division of Cardiology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 131:792-8. 2006
    ..The purpose of this study was to evaluate the neurodevelopmental outcome at 1 year of age of children who had surgical repair in infancy of a ventricular septal defect or a ventricular septal defect with aortic arch obstruction...
  60. ncbi request reprint Haemodynamic changes during modified ultrafiltration immediately following the first stage of the Norwood reconstruction
    J William Gaynor
    Division of Cardiothoracic Surgery, The Cardiac Center at The Children s Hospital of Philadelphia, Philadelphia 19104, USA
    Cardiol Young 15:4-7. 2005
    ..There has been concern, however, about the safety and efficacy of modified ultrafiltration after the first stage of Norwood reconstruction for palliation of neonates with hypoplasia of the left heart and its variants...
  61. ncbi request reprint Parental decision-making in congenital heart disease
    K Sarah Hoehn
    Division of Critical Care Medicine, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cardiol Young 14:309-14. 2004
    ..To explore whether prenatal diagnosis of congenital heart disease is associated with lower levels of parental distress and greater satisfaction with decisions about cardiothoracic surgery when compared to postnatal diagnosis...
  62. ncbi request reprint Neo-aortic root dilation and valve regurgitation up to 21 years after staged reconstruction for hypoplastic left heart syndrome
    Meryl S Cohen
    Department of Pediatrics, University of Pennsylvania School of Medicine, Cardiac Center at Children s Hospital of Philadelphia, 19104, USA
    J Am Coll Cardiol 42:533-40. 2003
    ..We sought to assess the prevalence and progression of neo-aortic root dilation and valvar regurgitation after staged reconstruction for hypoplastic left heart syndrome (HLHS)...
  63. ncbi request reprint Preoperative cerebral blood flow is diminished in neonates with severe congenital heart defects
    Daniel J Licht
    Division of Neurology, Department of Pediatrics, The Children s Hospital of Philadelphia, Wood Building 6th Floor, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 128:841-9. 2004
    ..The hypothesis of this study is that preoperative cerebral blood flow is substantially diminished and might relate to preoperative neurologic conditions...
  64. ncbi request reprint Academic performance and behavioral difficulties after neonatal and infant heart surgery
    Amanda J Shillingford
    Division of Pediatric Cardiology, Department of Pediatrics, The Cardiac Center, The Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatr Clin North Am 51:1625-39, ix. 2004
    ....
  65. ncbi request reprint Brain versus lung: hierarchy of feedback loops in single-ventricle patients with superior cavopulmonary connection
    Mark A Fogel
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Circulation 110:II147-52. 2004
    ..When the brain and lungs are connected exclusively in series, which feedback loop predominates is unknown. The circulation of the superior cavopulmonary connection (SCPC) provides a unique physiology to answer this question...
  66. ncbi request reprint Outcomes after the stage I reconstruction comparing the right ventricular to pulmonary artery conduit with the modified Blalock Taussig shunt
    Sarah Tabbutt
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 80:1582-90; discussion 1590-1. 2005
    ..Recent reports advocate that a right ventricular to pulmonary artery (RV-PA) conduit improves outcome after the stage I reconstruction...
  67. pmc Perioperative stroke in infants undergoing open heart operations for congenital heart disease
    Jodi Chen
    Division of Pediatric Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 88:823-9. 2009
    ....
  68. ncbi request reprint Critical care in cardiovascular medicine
    Chitra Ravishankar
    Department of Pediatrics, Children s Hospital of Philadelphia, Pennsylvania, USA
    Curr Opin Pediatr 15:443-53. 2003
    ..The authors also briefly review the recent advances in the treatment of pulmonary hypertension, mechanical support, and neurologic surveillance after cardiac surgery...
  69. doi request reprint Assessment of parental decision-making in neonatal cardiac research: a pilot study
    Aruna T Nathan
    Department of Anesthesiology and Critical Care Medicine, University of Pennsylvania, Pennsylvania, USA
    J Med Ethics 36:106-10. 2010
    ..To assess parental permission for a neonate's research participation using the MacArthur competence assessment tool for clinical research (MacCAT-CR), specifically testing the components of understanding, appreciation, reasoning and choice...
  70. pmc Apolipoprotein E genotype modifies the risk of behavior problems after infant cardiac surgery
    J William Gaynor
    Division of Cardiothoracic Surgery, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 124:241-50. 2009
    ..The goal was to evaluate polymorphisms of the APOE gene as modifiers of neurobehavioral outcomes for preschool-aged children with congenital heart defects, after cardiac surgery...
  71. ncbi request reprint Population pharmacokinetics of milrinone in neonates with hypoplastic left heart syndrome undergoing stage I reconstruction
    Athena F Zuppa
    Division of Clinical Pharmacology and Therapeutics, Department of Pediatrics, Abramson Research Center, Philadelphia, Pennsylvania 19104 4318, USA
    Anesth Analg 102:1062-9. 2006
    ..6 mL x kg(-1) x min(-1)) by postoperative day 4. In the postoperative setting of markedly impaired renal function, an infusion rate of 0.2 microg x kg(-1) x min(-1) should be considered...
  72. ncbi request reprint Invited commentary
    J William Gaynor
    Division of Cardiothoracic Surgery, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Ann Thorac Surg 81:967. 2006
  73. pmc Neurological complications associated with the treatment of patients with congenital cardiac disease: consensus definitions from the Multi-Societal Database Committee for Pediatric and Congenital Heart Disease
    Geoffrey L Bird
    Division of Pediatric Cardiology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4399, USA
    Cardiol Young 18:234-9. 2008
    ..Clinicians caring for patients with congenital cardiac disease may be able to use this list for databases, initiatives to improve quality, reporting of complications, and comparing strategies of treatment...
  74. pmc The relationship of postoperative electrographic seizures to neurodevelopmental outcome at 1 year of age after neonatal and infant cardiac surgery
    J William Gaynor
    Division of Cardiothoracic Surgery, The Cardiac Center at The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 131:181-9. 2006
    ..The occurrence of a seizure after the arterial switch operation is associated with a worse long-term neurodevelopmental outcome. The significance of seizures after neonatal and infant repair of other congenital heart defects is not known...
  75. ncbi request reprint Electrographic neonatal seizures after infant heart surgery
    Robert R Clancy
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19105, USA
    Epilepsia 46:84-90. 2005
    ....
  76. pmc Increasing duration of deep hypothermic circulatory arrest is associated with an increased incidence of postoperative electroencephalographic seizures
    J William Gaynor
    Division of Cardiothoracic Surgery, The Cardiac Center at The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 130:1278-86. 2005
    ..The contemporary incidence of postoperative seizures after repair of cardiac defects such as hypoplastic left heart syndrome and other forms of single ventricle is not known...
  77. pmc Is cardiac diagnosis a predictor of neurodevelopmental outcome after cardiac surgery in infancy?
    J William Gaynor
    Division of Cardiothoracic Surgery, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 140:1230-7. 2010
    ..To determine whether a cardiac diagnosis is a predictor of neurodevelopmental outcomes after infant cardiac surgery...
  78. ncbi request reprint Apolipoprotein E genotype and neurodevelopmental sequelae of infant cardiac surgery
    J William Gaynor
    Division of Cardiothoracic Surgery, The Children s Hospital of Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 126:1736-45. 2003
    ..Polymorphisms of apolipoprotein E have been identified as a risk factor for worse neurologic recovery after central nervous system injury...
  79. pmc Brain maturation is delayed in infants with complex congenital heart defects
    Daniel J Licht
    Divison of Neurology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Thorac Cardiovasc Surg 137:529-36; discussion 536-7. 2009
    ..This study tests the hypothesis that congenital heart defects delay in utero structural brain development...
  80. ncbi request reprint Risk of seizures in survivors of newborn heart surgery using deep hypothermic circulatory arrest
    Robert R Clancy
    Division of Neurology and the Cardiac Center, Children s Hospital of Philadelphia, PA 19104, USA
    Pediatrics 111:592-601. 2003
    ....
  81. doi request reprint Neuropsychological status in children after repair of acyanotic congenital heart disease
    Michael D Quartermain
    Divisions of Cardiology, Department of Anesthesia, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatrics 126:e351-9. 2010
    ..We sought to limit confounding variables and isolate potential independent effects of CPB by describing neuropsychological function in school-aged children after repair of acyanotic CHD...
  82. ncbi request reprint Impact of inspired gas mixtures on preoperative infants with hypoplastic left heart syndrome during controlled ventilation
    S Tabbutt
    Department of Pediatrics, Division of Cardiology, The Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, USA
    Circulation 104:I159-64. 2001
    ..These data cannot differentiate cerebral from systemic oxygen delivery...
  83. ncbi request reprint The incidence of arrhythmias in a pediatric cardiac intensive care unit
    T M Hoffman
    Division of Cardiology, The Cardiac Center at The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4399, USA
    Pediatr Cardiol 23:598-604. 2002
    ..9% of admissions). Patients admitted to a pediatric CICU have a high incidence of arrhythmias, most likely associated with their underlying pathophysiology and to the breadth of medical and surgical interventions conducted...
  84. ncbi request reprint Diagnosis and management of the newborn with suspected congenital heart disease
    B S Marino
    Division of Cardiology, Cardiac Center, Children's Hospital of Philadelphia, Pennsylvania, USA
    Clin Perinatol 28:91-136. 2001
    ..Crucial to this process is continuous communication among medical, surgical, and nursing disciplines...
  85. ncbi request reprint Outcomes of neonates with congenital heart disease
    D B McElhinney
    Division of Pediatric Cardiology, Department of Pediatrics, Children's Hospital of Philadelphia, and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Curr Opin Pediatr 13:104-10. 2001
    ....
  86. ncbi request reprint A case of congenitally protected d-transposition of the great arteries in a very low-birth-weight infant
    K E Woodson
    Department of Cardiology, Children s National Medical Center, 111 Michigan Avenue, N W, Washington, DC 20010, USA
    Pediatr Cardiol 24:175-8. 2003
    ..This case also represents the smallest reported patient to undergo a successful balloon atrial septostomy...
  87. ncbi request reprint Postoperative junctional ectopic tachycardia in children: incidence, risk factors, and treatment
    Timothy M Hoffman
    Division of Cardiology, The Cardiac Center at The Children s Hospital of Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 74:1607-11. 2002
    ..The purpose of this study was to determine perioperative risk factors for the development of JET...
  88. ncbi request reprint Neurologic and developmental morbidity in children with complex congenital heart disease
    Gil Wernovsky
    J Pediatr 142:6-8. 2003
  89. ncbi request reprint Survival outcomes after extracorporeal cardiopulmonary resuscitation instituted during active chest compressions following refractory in-hospital pediatric cardiac arrest
    Marilyn C Morris
    Clinical Pediatrics, The Children s Hospital of New York, New York, NY, USA
    Pediatr Crit Care Med 5:440-6. 2004
    ..To report survival outcomes and to identify factors associated with survival following extracorporeal cardiopulmonary resuscitation for in-hospital pediatric cardiac arrest...
  90. ncbi request reprint Late neurodevelopmental outcome after repair of total anomalous pulmonary venous connection
    Paul M Kirshbom
    Division of Cardiovascular Surgery, Emory University, Emory Cklinic Building A, Atlanta, GA 30322, USA
    J Thorac Cardiovasc Surg 129:1091-7. 2005
    ..Evaluation of these children is indicated to identify those who are at risk for learning disabilities and who could benefit from early intervention...
  91. ncbi request reprint Challenges facing the child, adolescent, and young adult after the arterial switch operation
    Kathleen Mussatto
    The Herma Heart Center at The Children s Hospital of Wisconsin, United States of America
    Cardiol Young 15:111-21. 2005
  92. ncbi request reprint Intermediate outcomes after the Fontan procedure in the current era
    Michael E Mitchell
    Department of Surgery, Division of Cardiothoracic Surgery, University of Louisville, Louisville, KY 40202, USA
    J Thorac Cardiovasc Surg 131:172-80. 2006
    ..This study was undertaken to investigate the intermediate outcomes after the Fontan operation in the current era...
  93. ncbi request reprint Exercise performance in children and adolescents after the Ross procedure
    Bradley S Marino
    Division of Cardiology, at the Cardiac Center of The Children s Hospital of Philadelphia, and the Department of Pediatrics at the University of Pennsylvania School of Medicine 19104, USA
    Cardiol Young 16:40-7. 2006
    ..The Ross procedure is increasingly utilized in the treatment of aortic valvar disease in children and adolescents. Our purpose was to compare pre- and post-operative exercise state in this population...
  94. ncbi request reprint A population pharmacokinetic analysis of milrinone in pediatric patients after cardiac surgery
    James M Bailey
    Emory University School of Medicine, Atlanta, GA, USA
    J Pharmacokinet Pharmacodyn 31:43-59. 2004
    ..The volume of distribution was 482 ml kg(-1) and was independent of age. Clearance was a linear function of age given by Cl = 2.42 ml kg(-1) min(-1) [1 + 0.396*age]...
  95. ncbi request reprint Outcomes of the Fontan procedure using cardiopulmonary bypass with aortic cross-clamping
    David B Meyer
    Department of Cardiothoracic Surgery, New York University, New York, New York, USA
    Ann Thorac Surg 82:1611-8; discussion 1618-20. 2006
    ..Avoidance of cardiopulmonary bypass (CPB) and aortic cross-clamping during the Fontan procedure has been advocated to improve outcomes. We continue to use CPB with aortic cross-clamping for the Fontan procedure...
  96. doi request reprint Genetic factors are important determinants of neurodevelopmental outcome after repair of tetralogy of Fallot
    Ilana Zeltser
    Division of Cardiology, The Children s Medical Center at Dallas, Dallas, Tex 75235, USA
    J Thorac Cardiovasc Surg 135:91-7. 2008
    ..Tetralogy of Fallot is part of the clinical phenotype of many genetic syndromes. We evaluated the determinants of neurodevelopmental outcome in patients with tetralogy of Fallot...
  97. doi request reprint Improving neurologic and quality-of-life outcomes in children with congenital heart disease: past, present, and future
    Gil Wernovsky
    J Thorac Cardiovasc Surg 135:240-2, 242.e1-2. 2008