F Weiss

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint Neurobiology of craving, conditioned reward and relapse
    Friedbert Weiss
    The Scripps Research Institute, Department of Neuropharmacology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Pharmacol 5:9-19. 2005
  2. ncbi request reprint Behavioral neurobiology of alcohol addiction: recent advances and challenges
    Friedbert Weiss
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 22:3332-7. 2002
  3. ncbi request reprint Enduring resistance to extinction of cocaine-seeking behavior induced by drug-related cues
    F Weiss
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 25:361-72. 2001
  4. ncbi request reprint Compulsive drug-seeking behavior and relapse. Neuroadaptation, stress, and conditioning factors
    F Weiss
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Ann N Y Acad Sci 937:1-26. 2001
  5. pmc Control of cocaine-seeking behavior by drug-associated stimuli in rats: effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens
    F Weiss
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 97:4321-6. 2000
  6. ncbi request reprint Opposite effects of stress on dopamine release in the limbic system of drug-naive and chronically amphetamine-treated rats
    F Weiss
    The Scripps Research Institute, Department of Neuropharmacology, La Jolla, CA 92037, USA
    Eur J Pharmacol 337:219-22. 1997
  7. ncbi request reprint Activation of group II metabotropic glutamate receptors attenuates both stress and cue-induced ethanol-seeking and modulates c-fos expression in the hippocampus and amygdala
    Yu Zhao
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 26:9967-74. 2006
  8. ncbi request reprint Additive effect of stress and drug cues on reinstatement of ethanol seeking: exacerbation by history of dependence and role of concurrent activation of corticotropin-releasing factor and opioid mechanisms
    Xiu Liu
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 22:7856-61. 2002
  9. ncbi request reprint Extracellular serotonin is decreased in the nucleus accumbens during withdrawal from cocaine self-administration
    L H Parsons
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037, USA
    Behav Brain Res 73:225-8. 1996
  10. ncbi request reprint Effect of selective blockade of mu(1) or delta opioid receptors on reinstatement of alcohol-seeking behavior by drug-associated stimuli in rats
    Roberto Ciccocioppo
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 27:391-9. 2002

Research Grants

  1. Neurochemical Basis of Ethanol-Seeking Behavior
    Friedbert Weiss; Fiscal Year: 2007
  2. NOVEL METHODS TO EXPLORE MECHANISMS OF COCAINE ABUSE
    Friedbert Weiss; Fiscal Year: 2004
  3. NOVEL METHODS TO EXPLORE MECHANISMS OF COCAINE ABUSE
    Friedbert Weiss; Fiscal Year: 2009
  4. The Nociceptin ORL1 System: Treatment Target for Relapse
    Friedbert Weiss; Fiscal Year: 2010
  5. The Nociceptin ORL1 System: Treatment Target for Relapse
    Friedbert Weiss; Fiscal Year: 2007
  6. NOVEL TREATMENTS FOR COCAINE DEPENDENCE
    Friedbert Weiss; Fiscal Year: 2007
  7. Dysregulation of Brain Stress Systems and of Relapse
    Friedbert Weiss; Fiscal Year: 2007
  8. Neural Substrates of Compulsive Ethanol-Seeking Behavior
    Friedbert Weiss; Fiscal Year: 2010
  9. NOVEL METHODS TO EXPLORE MECHANISMS OF COCAINE ABUSE
    Friedbert Weiss; Fiscal Year: 2010
  10. Neurochemical Basis of Ethanol-Seeking Behavior
    Friedbert Weiss; Fiscal Year: 2009

Detail Information

Publications50

  1. ncbi request reprint Neurobiology of craving, conditioned reward and relapse
    Friedbert Weiss
    The Scripps Research Institute, Department of Neuropharmacology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Pharmacol 5:9-19. 2005
    ..Recent research has substantially advanced our understanding of the neurobiological factors responsible for drug craving and relapse, with promising therapeutic implications...
  2. ncbi request reprint Behavioral neurobiology of alcohol addiction: recent advances and challenges
    Friedbert Weiss
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 22:3332-7. 2002
    ..More recently, increasing attention has been directed toward the understanding of neurobiological and environmental factors in susceptibility to relapse...
  3. ncbi request reprint Enduring resistance to extinction of cocaine-seeking behavior induced by drug-related cues
    F Weiss
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 25:361-72. 2001
    ..Finally, the results support a role of DA neurotransmission in cue-induced cocaine-seeking behavior...
  4. ncbi request reprint Compulsive drug-seeking behavior and relapse. Neuroadaptation, stress, and conditioning factors
    F Weiss
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Ann N Y Acad Sci 937:1-26. 2001
    ..This finding emphasizes that it will be important to consider the simultaneous effects of multiple environmental triggers for relapse in the development of treatment and medication strategies...
  5. pmc Control of cocaine-seeking behavior by drug-associated stimuli in rats: effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens
    F Weiss
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 97:4321-6. 2000
    ..The results demonstrate that cocaine-predictive stimuli elicit robust and persistent cocaine-seeking behavior, and that this effect may involve activation of dopamine transmission in the NAcc and amygdala...
  6. ncbi request reprint Opposite effects of stress on dopamine release in the limbic system of drug-naive and chronically amphetamine-treated rats
    F Weiss
    The Scripps Research Institute, Department of Neuropharmacology, La Jolla, CA 92037, USA
    Eur J Pharmacol 337:219-22. 1997
    ..The results suggest that chronic amphetamine impairs the dopaminergic response to stress and that this dopaminergic deficit may play a role in stress-induced drug-seeking behavior and relapse...
  7. ncbi request reprint Activation of group II metabotropic glutamate receptors attenuates both stress and cue-induced ethanol-seeking and modulates c-fos expression in the hippocampus and amygdala
    Yu Zhao
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 26:9967-74. 2006
    ..The results implicate group II mGluRs as a shared neuropharmacological substrate for ethanol-seeking elicited by both drug cues and stress and identify group II mGluRs as promising treatment targets for relapse prevention...
  8. ncbi request reprint Additive effect of stress and drug cues on reinstatement of ethanol seeking: exacerbation by history of dependence and role of concurrent activation of corticotropin-releasing factor and opioid mechanisms
    Xiu Liu
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 22:7856-61. 2002
    ..The results document that stress and drug-related environmental stimuli interact to augment the resumption of drug seeking after extinction and suggest that this effect results from concurrent activation of opioid and CRF transmission...
  9. ncbi request reprint Extracellular serotonin is decreased in the nucleus accumbens during withdrawal from cocaine self-administration
    L H Parsons
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037, USA
    Behav Brain Res 73:225-8. 1996
    ..The severity of this decrease is contingent on the length of time cocaine is self-administered...
  10. ncbi request reprint Effect of selective blockade of mu(1) or delta opioid receptors on reinstatement of alcohol-seeking behavior by drug-associated stimuli in rats
    Roberto Ciccocioppo
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 27:391-9. 2002
    ..Moreover, the data suggest that drugs aimed at the delta opioid receptor may offer advantages in the treatment and prevention of relapse compared with agents that also block the mu(1) receptor...
  11. ncbi request reprint Changes in levels of regional CRF-like-immunoreactivity and plasma corticosterone during protracted drug withdrawal in dependent rats
    E P Zorrilla
    CVN7, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 158:374-81. 2001
    ..One proposed mechanism for these alterations is dysregulation of corticotropin-releasing factor (CRF) neurocircuitry...
  12. ncbi request reprint Behavioral and neurochemical effects of 3-OH-pip-BTCP, an active metabolite of BTCP in rats
    R Martin-Fardon
    The Scripps Research Institute, Department of Neuropharmacology CVN-15, 10550 North Torrey Pines Road, La Jolla CA 92037, USA
    Neuroreport 12:4165-9. 2001
    ....
  13. ncbi request reprint Ethanol-associated olfactory stimuli reinstate ethanol-seeking behavior after extinction and modify extracellular dopamine levels in the nucleus accumbens
    S N Katner
    The Scripps Research Institute, Department of Neuropharmacology, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 23:1751-60. 1999
    ..The present study employed an operant response-reinstatement model to examine the effects of ethanol-associated environmental stimuli on alcohol-seeking behavior and extracellular dopamine (DA) levels in the nucleus accumbens (NAcc)...
  14. pmc Dissociation of the effects of MTEP [3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine] on conditioned reinstatement and reinforcement: comparison between cocaine and a conventional reinforcer
    R Martin-Fardon
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, SP30 2120, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 329:1084-90. 2009
    ..These observations identify mGluR5 as potential treatment targets for cocaine relapse prevention, although the profile of action of mGluR5 antagonists remains to be more closely examined for potential anhedonic effects...
  15. pmc Cocaine-predictive stimulus induces drug-seeking behavior and neural activation in limbic brain regions after multiple months of abstinence: reversal by D(1) antagonists
    R Ciccocioppo
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:1976-81. 2001
    ..Moreover, the results implicate D(1)-dependent neural mechanisms within the medial prefrontal cortex and basolateral amygdala as substrates for cocaine-seeking behavior elicited by cocaine-predictive environmental stimuli...
  16. ncbi request reprint Chronic footshock, but not a physiological stressor, suppresses the alcohol deprivation effect in dependent rats
    C V Dayas
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Alcohol Alcohol 39:190-6. 2004
    ..Moreover, to our knowledge, the effects of different types of stress on the alcohol deprivation effect (ADE), the temporary increase in alcohol consumption seen after periods of abstinence, has not been previously examined...
  17. ncbi request reprint In vivo CRF release in rat amygdala is increased during cocaine withdrawal in self-administering rats
    R M Richter
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Synapse 32:254-61. 1999
    ..These results provide evidence that cocaine withdrawal activates CRF neurons in the amygdala, a site that has been implicated in emotional and anxiogenic effects of stress and drug withdrawal syndromes...
  18. ncbi request reprint Stimuli linked to ethanol availability activate hypothalamic CART and orexin neurons in a reinstatement model of relapse
    Christopher V Dayas
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
    Biol Psychiatry 63:152-7. 2008
    ..However, the potential role of other hypothalamic feeding peptides, such as cocaine- and amphetamine-regulated transcript (CART), in conditioned reinstatement has yet to be explored...
  19. ncbi request reprint Remission and resurgence of anxiety-like behavior across protracted withdrawal stages in ethanol-dependent rats
    Yu Zhao
    Molecular and Integrative Neurosciences Department, Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Alcohol Clin Exp Res 31:1505-15. 2007
    ..The purpose of the present experiment was to characterize susceptibility to stress and anxiogenic stimuli in rats over an extended time period following ethanol withdrawal...
  20. ncbi request reprint Long-lasting resistance to extinction of response reinstatement induced by ethanol-related stimuli: role of genetic ethanol preference
    R Ciccocioppo
    Scripps Research Institute, Department of Neuropharmacology, La Jolla, California, USA
    Alcohol Clin Exp Res 25:1414-9. 2001
    ....
  21. ncbi request reprint Neurochemical characteristics associated with ethanol preference in selected alcohol-preferring and -nonpreferring rats: a quantitative microdialysis study
    S N Katner
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
    Alcohol Clin Exp Res 25:198-205. 2001
    ....
  22. ncbi request reprint Stimulus conditioned to foot-shock stress reinstates alcohol-seeking behavior in an animal model of relapse
    Xiu Liu
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 168:184-91. 2003
    ....
  23. ncbi request reprint Reinstatement of ethanol-seeking behavior by drug cues following single versus multiple ethanol intoxication in the rat: effects of naltrexone
    Roberto Ciccocioppo
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, Calif, USA
    Psychopharmacology (Berl) 168:208-15. 2003
    ..An important possibility is that withdrawal reactions also influence the motivation to obtain and consume ethanol...
  24. ncbi request reprint CCK-8 injected into the nucleus accumbens attenuates the supersensitive locomotor response to apomorphine in 6-OHDA and chronic-neuroleptic treated rats
    F Weiss
    Research Institute of Scripps Clinic, Department of Molecular and Experimental Medicine, La Jolla, CA 92037
    Psychopharmacology (Berl) 99:409-15. 1989
    ..These results provide further evidence that CCK-8 modulates mesolimbic DA activity by functionally opposing the postsynaptic effects of DA in the region of the nucleus accumbens...
  25. ncbi request reprint Coloboma hyperactive mutant mice exhibit regional and transmitter-specific deficits in neurotransmission
    J Raber
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California, USA
    J Neurochem 68:176-86. 1997
    ..These results suggest that reduced SNAP-25 expression may contribute to a region-specific and neurotransmitter-specific deficiency in neurotransmitter release...
  26. ncbi request reprint Substance dependence as a compulsive behavior
    G F Koob
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Psychopharmacol 12:39-48. 1998
    ..Challenges for the future involve not only elucidation of the neurobiological substrates of the different behavioral components of addiction, but better animal models of these components with which to effect such studies...
  27. ncbi request reprint Subtype-selective corticotropin-releasing factor receptor agonists exert contrasting, but not opposite, effects on anxiety-related behavior in rats
    Y Zhao
    Committee on the Neurobiology of Addictive Disorders, and Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 323:846-54. 2007
    ..With increasing CRF1 activation, however, the behavioral expression of anxiety qualitatively changes from "coping" to "noncoping" and offensive, agonistic behaviors...
  28. pmc Distinct patterns of neural activation associated with ethanol seeking: effects of naltrexone
    Christopher V Dayas
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 61:979-89. 2007
    ....
  29. ncbi request reprint Differential effects of sigma1 receptor blockade on self-administration and conditioned reinstatement motivated by cocaine vs natural reward
    Remi Martin-Fardon
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropsychopharmacology 32:1967-73. 2007
    ..The findings support a role for sigma(1) receptors in regulating conditioned responses to cocaine-related contextual stimuli and identify this receptor as a potential treatment target for the prevention of craving and relapse...
  30. ncbi request reprint Rats with extended access to cocaine exhibit increased stress reactivity and sensitivity to the anxiolytic-like effects of the mGluR 2/3 agonist LY379268 during abstinence
    Harinder Aujla
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 33:1818-26. 2008
    ....
  31. ncbi request reprint The dorsal subiculum mediates the acquisition of conditioned reinstatement of cocaine-seeking
    Remi Martin-Fardon
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 33:1827-34. 2008
    ....
  32. pmc Operant behavior and alcohol levels in blood and brain of alcohol-dependent rats
    Nicholas W Gilpin
    Committee on Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Alcohol Clin Exp Res 33:2113-23. 2009
    ..The purpose of the present investigation was to more clearly define blood-alcohol parameters associated with alcohol dependence produced by alcohol vapor inhalation and alcohol-containing liquid diet...
  33. pmc Role of innate and drug-induced dysregulation of brain stress and arousal systems in addiction: Focus on corticotropin-releasing factor, nociceptin/orphanin FQ, and orexin/hypocretin
    Remi Martin-Fardon
    The Scripps Research Institute, Molecular and Integrative Neurosciences Department, SP30 2120, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Brain Res 1314:145-61. 2010
    ....
  34. pmc Effects of the mGlu2/3 agonist LY379268 and the mGlu5 antagonist MTEP on ethanol seeking and reinforcement are differentially altered in rats with a history of ethanol dependence
    Nimish Sidhpura
    The Scripps Research Institute, Molecular and Integrative Neurosciences Department, La Jolla, California 92037, USA
    Biol Psychiatry 67:804-11. 2010
    ....
  35. ncbi request reprint Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization
    Emanuela Izzo
    Department of Neuropharmacology, The Scripps Research Institute, 10550 N Torrey Pines Rd, CVN12, La Jolla, California 92103, USA
    Nat Neurosci 5:1263-4. 2002
    ..Our results show that PI3K is required for the expression, but not the induction, of behavioral sensitization to cocaine...
  36. ncbi request reprint Priming with BTCP, a dopamine reuptake blocker, reinstates cocaine-seeking and enhances cocaine cue-induced reinstatement
    Remi Martin-Fardon
    The Scripps Research Institute, Department of Neuropharmacology, CVN 15, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Pharmacol Biochem Behav 82:46-54. 2005
    ..The results suggest that, in cocaine abstinent rats, BTCP produces cocaine-like effects...
  37. ncbi request reprint Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology
    George F Koob
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Recent Dev Alcohol 16:263-81. 2003
    ....
  38. ncbi request reprint BTCP is a potent reinforcer in rats: comparison of behavior maintained on fixed- and progressive-ratio schedules
    Remi Martin-Fardon
    Department of Neuropharmacology, The Scripps Research Institute, CVN 15, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Pharmacol Biochem Behav 72:343-53. 2002
    ..The results demonstrate that rats readily acquire responding maintained by BTCP and suggest that BTCP may have greater reinforcing effects than cocaine at equimolar concentrations...
  39. ncbi request reprint 3-OH-pip-BTCP, a metabolite of the potent DA uptake blocker BTCP, exerts cocaine-like action in rats
    Remi Martin-Fardon
    Departmentof Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuroreport 14:2439-44. 2003
    ..Together, these results suggest that 3-OH-pip-BTCP shares similar reinforcing effects with cocaine and therefore may serve as a substitutive drug and possible agonist therapy for cocaine addiction...
  40. ncbi request reprint Reversal of ethanol-seeking behavior by D1 and D2 antagonists in an animal model of relapse: differences in antagonist potency in previously ethanol-dependent versus nondependent rats
    Xiu Liu
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Pharmacol Exp Ther 300:882-9. 2002
    ..The results also indicate that chronic ethanol exposure produces changes in D1 and D2 receptor function that lead to enhanced sensitivity to the behavioral effects of antagonists for these receptors...
  41. ncbi request reprint Preferential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: comparison between cocaine and a potent conventional reinforcer
    Marco A S Baptista
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 24:4723-7. 2004
    ..As such, the results identify group II mGluRs as a pharmacotherapeutic target for craving and relapse prevention associated with cocaine cue exposure...
  42. pmc Behavioral and functional evidence of metabotropic glutamate receptor 2/3 and metabotropic glutamate receptor 5 dysregulation in cocaine-escalated rats: factor in the transition to dependence
    Yue Hao
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California, USA
    Biol Psychiatry 68:240-8. 2010
    ..We examined here whether neuroadaptive dysregulation of metabotropic glutamate receptor function is a factor in escalating cocaine self-administration...
  43. ncbi request reprint Nitric oxide synthesis inhibition attenuates conditioned reinstatement of ethanol-seeking, but not the primary reinforcing effects of ethanol
    Xiu Liu
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
    Alcohol Clin Exp Res 28:1194-9. 2004
    ....
  44. pmc Attenuation of ethanol self-administration and of conditioned reinstatement of alcohol-seeking behaviour by the antiopioid peptide nociceptin/orphanin FQ in alcohol-preferring rats
    Roberto Ciccocioppo
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Via Scalzino 3, 62032 Camerino, Italy
    Psychopharmacology (Berl) 172:170-8. 2004
    ....
  45. ncbi request reprint Stimuli associated with a single cocaine experience elicit long-lasting cocaine-seeking
    Roberto Ciccocioppo
    Department of Pharmacological Science and Experimental Medicine, University of Camerino, 62032 Camerino MC, Italy
    Nat Neurosci 7:495-6. 2004
    ..In contrast, conditioned stimuli that were associated with a highly palatable non-drug reinforcer elicited modest behavioral responses that extinguished within 3 months...
  46. doi request reprint Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat
    Daina Economidou
    Department of Experimental Medicine and Public Health, University of Camerino, Camerino MC, Italy
    Biol Psychiatry 64:211-8. 2008
    ....
  47. ncbi request reprint Subchronic cannabinoid agonist (WIN 55,212-2) treatment during cocaine abstinence alters subsequent cocaine seeking behavior
    Gustavo González-Cuevas
    Laboratorio de Psicobiologia, Facultad de Psicologia, Universidad Complutense de Madrid, Campus de Somosaguas S N, E 28223, Pozuelo de Alarcon, Madrid, Spain
    Neuropsychopharmacology 32:2260-6. 2007
    ..However, further studies will be necessary to understand possible implications of these findings for a role of the cannabinoid system as a treatment target for human cocaine abuse...
  48. ncbi request reprint Alcohol withdrawal and conditioning
    Hilary J Little
    Department of Pharmacology, George s Hospital Medical School, Cranmer Terrace, London, SW17 ORE, UK
    Alcohol Clin Exp Res 29:453-64. 2005
    ..Finally, Dr. C. Cunningham provided a summary of the concepts involved in the presentations and discussed the conditioning processes that affect behavior during and after alcohol withdrawal...
  49. pmc Stress enhancement of craving during sobriety: a risk for relapse
    George R Breese
    Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 29:185-95. 2005
    ..Collectively, the presentations provided convincing support for an involvement of stress in the cause of relapse and continuing alcohol abuse and suggested novel pharmacological approaches for treating relapse induced by stress...
  50. pmc The bed nucleus is a neuroanatomical substrate for the anorectic effect of corticotropin-releasing factor and for its reversal by nociceptin/orphanin FQ
    Roberto Ciccocioppo
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, 62032 Camerino, Italy
    J Neurosci 23:9445-51. 2003
    ..These data demonstrate that the BNST is involved in the modulation of CRF-induced anorexia, which is prevented by activation of N/OFQ receptors...

Research Grants51

  1. Neurochemical Basis of Ethanol-Seeking Behavior
    Friedbert Weiss; Fiscal Year: 2007
    ..As well, the results will provide information directly relevant for evaluating the potential of Group II mGluRs to serve as treatment drug targets for relapse prevention. ..
  2. NOVEL METHODS TO EXPLORE MECHANISMS OF COCAINE ABUSE
    Friedbert Weiss; Fiscal Year: 2004
    ..abstract_text> ..
  3. NOVEL METHODS TO EXPLORE MECHANISMS OF COCAINE ABUSE
    Friedbert Weiss; Fiscal Year: 2009
    ..This includes information relevant for novel therapeutic approaches aimed at enhancing the incentive salience of natural rewards to more effectively compete with and substitute for drug-derived reward. ..
  4. The Nociceptin ORL1 System: Treatment Target for Relapse
    Friedbert Weiss; Fiscal Year: 2010
    ..This research is expected to advance understanding the biological basis of alcohol dependence, and to reveal novel treatment targets for alcohol abuse and alcoholism ..
  5. The Nociceptin ORL1 System: Treatment Target for Relapse
    Friedbert Weiss; Fiscal Year: 2007
    ..abstract_text> ..
  6. NOVEL TREATMENTS FOR COCAINE DEPENDENCE
    Friedbert Weiss; Fiscal Year: 2007
    ..This information will be directly relevant for the development of treatments targeting the mGluR system. ..
  7. Dysregulation of Brain Stress Systems and of Relapse
    Friedbert Weiss; Fiscal Year: 2007
    ....
  8. Neural Substrates of Compulsive Ethanol-Seeking Behavior
    Friedbert Weiss; Fiscal Year: 2010
    ..understanding the biological basis of alcohol dependence, (b) reveal novel treatment targets for alcohol abuse and alcoholism, and (c) advance basic science understanding of normal and pathological goal- directed behavior, in general ..
  9. NOVEL METHODS TO EXPLORE MECHANISMS OF COCAINE ABUSE
    Friedbert Weiss; Fiscal Year: 2010
    ..This includes information relevant for novel therapeutic approaches aimed at enhancing the incentive salience of natural rewards to more effectively compete with and substitute for drug-derived reward. ..
  10. Neurochemical Basis of Ethanol-Seeking Behavior
    Friedbert Weiss; Fiscal Year: 2009
    ..As well, the results will provide information directly relevant for evaluating the potential of Group II mGluRs to serve as treatment drug targets for relapse prevention. ..
  11. NEUROCHEMICAL BASES OF ETHANOL-SEEKING BEHAVIOR
    Friedbert Weiss; Fiscal Year: 2004
    ....
  12. NEUROCHEMICAL BASES OF ETHANOL SEEKING BEHAVIORS
    Friedbert Weiss; Fiscal Year: 1999
    ..More importantly, this information will have direct implications for the development of effective pharmacotherapies for the treatment and prevention of ethanol abuse. ..
  13. NOVEL TREATMENTS FOR COCAINE DEPENDENCE AN ANIMAL MODEL
    Friedbert Weiss; Fiscal Year: 1992
    ....
  14. NOVEL TREATMENTS FOR COCAINE DEPENDENCE
    Friedbert Weiss; Fiscal Year: 2001
    ..It is expected that the results of these studies will assist in the development of more effective pharmacotherapeutic treatment strategies for cocaine abuse, and advance the understanding of the neurobiology of relapse phenomena. ..