Zachary M Weil

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi request reprint Theta reset produces optimal conditions for long-term potentiation
    Holly McCartney
    Department of Psychology, Ohio State University, Columbus, Ohio, USA
    Hippocampus 14:684-7. 2004
  2. doi request reprint Maternal pinealectomy increases depressive-like responses in Siberian hamster offspring
    Joanna L Workman
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Behav Brain Res 189:387-91. 2008
  3. pmc The injured nervous system: a Darwinian perspective
    Zachary M Weil
    Departments of Psychology and Neuroscience, Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH 43210, USA
    Prog Neurobiol 86:48-59. 2008
  4. pmc Photoperiod alters autonomic regulation of the heart
    Zachary M Weil
    Department of Psychology, and Institute for Behavioral Medicine Research, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 106:4525-30. 2009
  5. pmc Sleep deprivation attenuates inflammatory responses and ischemic cell death
    Zachary M Weil
    Department of Psychology, and Institute for Behavioral Medicine Research The Ohio State University, Columbus, OH 43210, USA
    Exp Neurol 218:129-36. 2009
  6. pmc Housing condition alters immunological and reproductive responses to day length in Siberian hamsters (Phodopus sungorus)
    Zachary M Weil
    Department of Psychology, Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH 43210, USA
    Horm Behav 52:261-6. 2007
  7. pmc Photoperiod alters affective responses in collared lemmings
    Zachary M Weil
    Department of Psychology and Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Behav Brain Res 179:305-9. 2007
  8. pmc Immune challenge retards seasonal reproductive regression in rodents: evidence for terminal investment
    Zachary M Weil
    Department of Neuroscience, Ohio State University, Columbus, OH 43210, USA
    Biol Lett 2:393-6. 2006
  9. ncbi request reprint Photoperiod differentially affects immune function and reproduction in collared lemmings (Dicrostonyx groenlandicus)
    Zachary M Weil
    Department of Psychology, Institute for Behavioral Medicine Research, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Rhythms 21:384-93. 2006
  10. ncbi request reprint Behavioural alterations in male mice lacking the gene for D-aspartate oxidase
    Zachary M Weil
    Department of Psychology, Institute for Behavioral Medicine Research, Ohio State University, Columbus, 43210, USA
    Behav Brain Res 171:295-302. 2006

Detail Information

Publications50

  1. ncbi request reprint Theta reset produces optimal conditions for long-term potentiation
    Holly McCartney
    Department of Psychology, Ohio State University, Columbus, Ohio, USA
    Hippocampus 14:684-7. 2004
    ..These results suggest that a memory-relevant stimulus produces a phase shift of ongoing theta rhythm that induces optimal conditions for the stimulus to undergo potentiation...
  2. doi request reprint Maternal pinealectomy increases depressive-like responses in Siberian hamster offspring
    Joanna L Workman
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Behav Brain Res 189:387-91. 2008
    ..Maternal pinealectomy increased rearing behaviour and postnatal pinealectomy increased locomotor behaviour in the open field test. These results suggest that prenatal melatonin organizes adult affective responses...
  3. pmc The injured nervous system: a Darwinian perspective
    Zachary M Weil
    Departments of Psychology and Neuroscience, Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH 43210, USA
    Prog Neurobiol 86:48-59. 2008
    ..Therefore, it remains important that researchers consider the role of the processes in the healthy or developing nervous system to understand how they become dysregulated following injury...
  4. pmc Photoperiod alters autonomic regulation of the heart
    Zachary M Weil
    Department of Psychology, and Institute for Behavioral Medicine Research, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 106:4525-30. 2009
    ..Finally, these effects were discovered to be independent of circulating androgens. These data indicate that the ANS of Siberian hamsters undergoes profound changes following prolonged exposure to short winter-like day lengths...
  5. pmc Sleep deprivation attenuates inflammatory responses and ischemic cell death
    Zachary M Weil
    Department of Psychology, and Institute for Behavioral Medicine Research The Ohio State University, Columbus, OH 43210, USA
    Exp Neurol 218:129-36. 2009
    ..Together, the ischemia and LPS data suggest that, ASD produces an anti-inflammatory bias that could be exploited to improve medical procedures that are compromised by inflammation...
  6. pmc Housing condition alters immunological and reproductive responses to day length in Siberian hamsters (Phodopus sungorus)
    Zachary M Weil
    Department of Psychology, Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH 43210, USA
    Horm Behav 52:261-6. 2007
    ..These data suggest that short day enhancement of immune function is independent of photoperiod-mediated changes in the reproductive system...
  7. pmc Photoperiod alters affective responses in collared lemmings
    Zachary M Weil
    Department of Psychology and Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Behav Brain Res 179:305-9. 2007
    ..Lemmings housed in long days reduced anxiety-like responses in the elevated plus maze. Depressive-like behaviours were decreased in the intermediate photoperiod relative to other photoperiod groups...
  8. pmc Immune challenge retards seasonal reproductive regression in rodents: evidence for terminal investment
    Zachary M Weil
    Department of Neuroscience, Ohio State University, Columbus, OH 43210, USA
    Biol Lett 2:393-6. 2006
    ..This delayed reproductive regression likely reflects a strategy to maintain reproductive function when survival prospects are compromised by infection...
  9. ncbi request reprint Photoperiod differentially affects immune function and reproduction in collared lemmings (Dicrostonyx groenlandicus)
    Zachary M Weil
    Department of Psychology, Institute for Behavioral Medicine Research, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Rhythms 21:384-93. 2006
    ..In conclusion, these data indicate that components of immune function among collared lemmings are responsive to changes in day length...
  10. ncbi request reprint Behavioural alterations in male mice lacking the gene for D-aspartate oxidase
    Zachary M Weil
    Department of Psychology, Institute for Behavioral Medicine Research, Ohio State University, Columbus, 43210, USA
    Behav Brain Res 171:295-302. 2006
    ....
  11. ncbi request reprint Maternal aggression persists following lipopolysaccharide-induced activation of the immune system
    Zachary M Weil
    Departments of Neuroscience and Psychology, and Institute of Behavioral Medicine Research, The Ohio State University, Columbus, OH 43210, USA
    Physiol Behav 87:694-9. 2006
    ..These findings suggest that maternal aggression is not suppressed by LPS-evoked immune activation at doses that attenuate other aspects of maternal and social behavior...
  12. ncbi request reprint Melatonin receptor (MT1) knockout mice display depression-like behaviors and deficits in sensorimotor gating
    Zachary M Weil
    Departments of Neuroscience and Institute for Behavioral Medicine Research, The Ohio State University, 09 Townshend Hall, Columbus, OH 43210, USA
    Brain Res Bull 68:425-9. 2006
    ..Taken together, MT1 receptor signaling may be important for normal brain and behavioral function...
  13. ncbi request reprint Perinatal photoperiod organizes adult immune responses in Siberian hamsters (Phodopus sungorus)
    Zachary M Weil
    Department of Neuroscience, and Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH 43210, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1714-9. 2006
    ....
  14. ncbi request reprint Social interactions alter proinflammatory cytokine gene expression and behavior following endotoxin administration
    Zachary M Weil
    Department of Neuroscience, Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH 43210, USA
    Brain Behav Immun 20:72-9. 2006
    ..These results suggest that social interactions can adjust behavioral responses to infection although the ultimate cause of this adjustment remains unspecified...
  15. doi request reprint Sleep deprivation attenuates endotoxin-induced cytokine gene expression independent of day length and circulating cortisol in male Siberian hamsters (Phodopus sungorus)
    Noah T Ashley
    Department of Neuroscience and Institute of Behavioral Medicine Research, Wexner Medical Center, The Ohio State University, Columbus, OH 43210 USA
    J Exp Biol 216:2581-6. 2013
    ..These results suggest that neither photoperiod nor glucocorticoids influence the suppressive effect of sleep deprivation upon LPS-induced inflammation. ..
  16. ncbi request reprint D-aspartate regulates melanocortin formation and function: behavioral alterations in D-aspartate oxidase-deficient mice
    Alex S Huang
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 26:2814-9. 2006
    ..Therefore, Ddo is the endogenous enzyme that degrades D-aspartate, and Ddo-enriched organs, low in D-aspartate, may represent areas of high turnover where D-aspartate may be physiologically important...
  17. ncbi request reprint Estrous phase alters social behavior in a polygynous but not a monogamous Peromyscus species
    Kate Karelina
    Department of Neuroscience, Ohio State University, Columbus, OH 43210, USA
    Horm Behav 58:193-9. 2010
    ..These results provide evidence for a rhythm in social behavior across the estrous cycle in polygynous, but not monogamous, Peromyscus species...
  18. doi request reprint Sex-specific effects of glucose deprivation on cell-mediated immunity and reproduction in Siberian hamsters (Phodopus sungorus)
    Lynn B Martin
    Department of Psychology, Neuroscience, and Evolution, The Ohio State University, Columbus, OH 43210, USA
    J Comp Physiol B 178:623-8. 2008
    ....
  19. pmc Dim light at night disrupts molecular circadian rhythms and increases body weight
    Laura K Fonken
    Department of Neuroscience and Institute for Behavioral Medicine Research, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA
    J Biol Rhythms 28:262-71. 2013
    ..Detailed analysis of temporal changes induced by nighttime light exposure may provide insight into the onset and progression of obesity and metabolic syndrome, as well as other disorders involving sleep and circadian rhythm disruption. ..
  20. pmc Light at night increases body mass by shifting the time of food intake
    Laura K Fonken
    Department of Neuroscience, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 107:18664-9. 2010
    ..These data are relevant to the coincidence between increasing use of light at night and obesity in humans...
  21. ncbi request reprint Influence of light at night on murine anxiety- and depressive-like responses
    Laura K Fonken
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Behav Brain Res 205:349-54. 2009
    ..Taken together, these data provide evidence that exposure to unnatural lighting can induce significant changes in affect, increasing depressive-like and decreasing anxiety-like responses...
  22. doi request reprint Dim light at night exaggerates weight gain and inflammation associated with a high-fat diet in male mice
    Laura K Fonken
    Department of Neuroscience, Wexner Medical Center, The Ohio State University, 636 Biomedical Research Tower, 460 West 12th Avenue, Columbus, Ohio 43210
    Endocrinology 154:3817-25. 2013
    ..Microglia activation is increased by dLAN, but only among chow-fed mice and dLAN does not affect inflammatory gene expression. These results suggest that dLAN exaggerates weight gain and peripheral inflammation associated with HFD. ..
  23. doi request reprint Photoperiod affects the diurnal rhythm of hippocampal neuronal morphology of Siberian hamsters
    Tomoko Ikeno
    Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA
    Chronobiol Int 30:1089-100. 2013
    ..However, there were no strong effects of day length on Bdnf. trkb, and Vegf gene expression, suggesting that these genes are not involved in the photoperiodic effects on hippocampal neurons. ..
  24. doi request reprint Nocturnal light exposure impairs affective responses in a wavelength-dependent manner
    Tracy A Bedrosian
    Department of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio 43210, USA
    J Neurosci 33:13081-7. 2013
    ..Modern sources of LAN that contain blue wavelengths may be particularly disruptive to the circadian system, potentially contributing to altered mood regulation. ..
  25. pmc Influence of photoperiod on hormones, behavior, and immune function
    James C Walton
    Department of Neuroscience, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Front Neuroendocrinol 32:303-19. 2011
    ..Thus, melatonin is the fulcrum mediating redistribution of energetic investment among physiological processes to maximize fitness and survival...
  26. pmc Time-of-day determines neuronal damage and mortality after cardiac arrest
    Zachary M Weil
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Neurobiol Dis 36:352-60. 2009
    ..Our results document that brain tissue displays endogenous fluctuations in susceptibility to ischemic damage and demonstrate that small differences in time of onset can significantly influence ischemic outcomes...
  27. ncbi request reprint Mice exposed to dim light at night exaggerate inflammatory responses to lipopolysaccharide
    Laura K Fonken
    Department of Neuroscience and Institute for Behavioral Medicine Research, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA Electronic address
    Brain Behav Immun 34:159-63. 2013
    ..These results may have important implications for humans and other urban dwelling species that commonly experience nighttime light exposure...
  28. doi request reprint Evidence for feedback control of pineal melatonin secretion
    Tracy A Bedrosian
    Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
    Neurosci Lett 542:123-5. 2013
    ..These results suggest the possibility of feedback control of melatonin release, occurring preferentially through the MT1 receptor subtype...
  29. pmc Dim light at night interacts with intermittent hypoxia to alter cognitive and affective responses
    Taryn G Aubrecht
    Department of Neuroscience and Institute of Behavioral Medicine Research, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA
    Am J Physiol Regul Integr Comp Physiol 305:R78-86. 2013
    ....
  30. ncbi request reprint Sexual experience and testosterone during adolescence alter adult neuronal morphology and behavior
    John S Morris
    Department of Neuroscience, The Ohio State University, Wexner Medical Center, Columbus, OH 43210, USA Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Horm Behav 64:454-60. 2013
    ..These data support the overall hypothesis that a sensitive period extends into adolescence and that salient social stimuli during this time can significantly and persistently alter adult phenotype. ..
  31. doi request reprint Dim light at night does not disrupt timing or quality of sleep in mice
    Jeremy C Borniger
    Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
    Chronobiol Int 30:1016-23. 2013
    ....
  32. doi request reprint Chronic citalopram treatment ameliorates depressive behavior associated with light at night
    Tracy A Bedrosian
    Department of Neuroscience, Wexner Medical Center at The Ohio State University, Columbus, OH 43210, USA
    Behav Neurosci 126:654-8. 2012
    ..These data also suggest standard SSRI therapy may be effective for individuals experiencing depression related to circadian disruption and LAN exposure, such as shift workers...
  33. pmc Photoperiod mediated changes in olfactory bulb neurogenesis and olfactory behavior in male white-footed mice (Peromyscus leucopus)
    James C Walton
    Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
    PLoS ONE 7:e42743. 2012
    ..Taken together, these data demonstrate that photoperiod, without altering olfactory bulb neuronal morphology, alters olfactory bulb neurogenesis and olfactory behavior in Peromyscus leucopus...
  34. doi request reprint Photoperiod alters duration and intensity of non-rapid eye movement sleep following immune challenge in Siberian hamsters (Phodopus sungorus)
    Noah T Ashley
    Department of Neuroscience and Institute of Behavioral Medicine Research, Wexner Medical Center at The Ohio State University, Columbus, USA
    Chronobiol Int 29:683-92. 2012
    ..Ultimately, the combination of increased sleep and reduced fever could represent a suite of physiological adaptations that increase the probability of surviving winter...
  35. doi request reprint Short photoperiods attenuate central responses to an inflammogen
    Laura K Fonken
    Department of Neuroscience and Institute for Behavioral Medicine Research, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Brain Behav Immun 26:617-22. 2012
    ..These results suggest that photoperiodic differences in response to infection are due in part to changes in central immune activation...
  36. ncbi request reprint Immunological memory is compromised by food restriction in deer mice Peromyscus maniculatus
    Lynn B Martin
    Department of Psychology, The Ohio State University, Columbus, OH 43210 1287, USA
    Am J Physiol Regul Integr Comp Physiol 292:R316-20. 2007
    ..Together, these data imply that secondary antibody responses and the benefits of immunological memory are energetically costly in this species...
  37. pmc Altered temporal patterns of anxiety in aged and amyloid precursor protein (APP) transgenic mice
    Tracy A Bedrosian
    Department of Neuroscience, Institute for Behavioral Medicine Research, Ohio State University Medical Center, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 108:11686-91. 2011
    ..These results may have useful applications to the study and treatment of age- and dementia-related circadian behavioral disturbances, namely, sundowning syndrome...
  38. doi request reprint Photoperiod modulates gut bacteria composition in male Siberian hamsters (Phodopus sungorus)
    Michael T Bailey
    Section of Oral Biology, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA
    Brain Behav Immun 24:577-84. 2010
    ..These data indicate that the intestinal microbiota are responsive to changes in photoperiod and suggest that these changes may in part influence photoperiodic changes in body and fat masses...
  39. doi request reprint Short photoperiods alter cannabinoid receptor expression in hypothalamic nuclei related to energy balance
    Zachary M Weil
    Department of Neuroscience, Ohio State University, Columbus, OH 43210, USA
    Neurosci Lett 491:99-103. 2011
    ..These data suggest a potential role for reduced cannabinoid drive in mediating short day-induced alterations in energy balance...
  40. pmc Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors
    Greg J Norman
    Department of Psychology, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 31:3446-52. 2011
    ..Furthermore, we provide evidence that pharmacological activation of α7 nicotinic acetylcholine receptors provide significant protection against ischemia-related cell death and inflammation within a clinically relevant time frame...
  41. ncbi request reprint Artificial light at night alters delayed-type hypersensitivity reaction in response to acute stress in Siberian hamsters
    Tracy A Bedrosian
    Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH, United States Electronic address
    Brain Behav Immun 34:39-42. 2013
    ..These results suggest that light pollution may significantly alter physiological responses in Siberian hamsters, particularly in response to a salient environmental challenge such as stress. ..
  42. ncbi request reprint Immune defense and reproductive pace of life in Peromyscus mice
    Lynn B Martin
    Department of Psychology, Ohio State University, Columbus, Ohio 43210, USA
    Ecology 88:2516-28. 2007
    ..Importantly, our study indicates that species may not be differentially immunocompetent; rather, they use unique defense strategies to prevent infection...
  43. ncbi request reprint Low temperatures during early development influence subsequent maternal and reproductive function in adult female mice
    Zeynep Benderlioglu
    Departments of Psychology and Neuroscience, Institute for Behavioral Medicine Research, 09 Townshend Hall, Ohio State University, Columbus, OH 43210, USA
    Physiol Behav 87:416-23. 2006
    ..Our findings also suggest that chronic low temperatures experienced only after birth may have less deleterious effects than exposure to a combination of pre- and postnatal or prenatal treatments alone...
  44. pmc Seasonal changes in vertebrate immune activity: mediation by physiological trade-offs
    Lynn B Martin
    Departments of Psychology and Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Philos Trans R Soc Lond B Biol Sci 363:321-39. 2008
    ..Although other factors besides trade-offs undoubtedly influence seasonal variation in immune defence in animals, a growing literature supports a role for physiological trade-offs and the fitness consequences they sometimes produce...
  45. doi request reprint Exercise attenuates the metabolic effects of dim light at night
    Laura K Fonken
    Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA Institute for Behavioral Medicine Research, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA Electronic address
    Physiol Behav 124:33-6. 2014
    ..These results indicate that voluntary exercise can prevent weight gain induced by dLAN without rescuing circadian rhythm disruptions. ..
  46. pmc Neuronal nitric oxide synthase and NADPH oxidase interact to affect cognitive, affective, and social behaviors in mice
    James C Walton
    Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA Electronic address
    Behav Brain Res 256:320-7. 2013
    ..The current findings provide evidence that the NOX and nNOS redox signaling cascades interact in the brain to affect both cognitive function and social behavior. ..
  47. pmc Melatonin treatment during early life interacts with restraint to alter neuronal morphology and provoke depressive-like responses
    Taryn G Aubrecht
    Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA Electronic address
    Behav Brain Res 263:90-7. 2014
    ..These results suggest that the photoperiodic conditions coincident with birth and early life stressors are important in the development of adult affective responses...
  48. doi request reprint Early sexual experience alters voluntary alcohol intake in adulthood
    John S Morris
    Departments of Psychology and Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA Electronic address
    Neurosci Lett 563:129-33. 2014
    ..The results of this study suggest that an isolated, though highly relevant, social experience during adolescence can significantly alter depressive-like behavior and alcohol self-administration in adulthood. ..
  49. doi request reprint Dim light at night disrupts the short-day response in Siberian hamsters
    Tomoko Ikeno
    Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA Electronic address
    Gen Comp Endocrinol 197:56-64. 2014
    ..These results suggest that dLAN disturbs the circadian clock function and affects the molecular mechanisms of the photoperiodic response. ..
  50. doi request reprint Ischemia-induced hyperglycemia: consequences, neuroendocrine regulation, and a role for RAGE
    Zachary M Weil
    Department of Neuroscience, Ohio State University Medical Center, Columbus, OH 43210, USA
    Horm Behav 62:280-5. 2012
    ..The possibility that the advanced glycation end product (AGE) and receptor for AGE (RAGE) axis mediates the deleterious effects of hyperglycemia on inflammation and neuronal damage is discussed...