Q Wei

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi A functional variant at the miR-885-5p binding site of CASP3 confers risk of both index and second primary malignancies in patients with head and neck cancer
    Xiaoxiang Guan
    Department of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
    FASEB J 27:1404-12. 2013
  2. ncbi Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck
    Zhongqiu Wang
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer 11:17. 2012
  3. ncbi Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer
    Xiaoxiang Guan
    Department of Epidemiology, The University of Texas M, d, Anderson Cancer Center, Houston, Texas 77030, USA
    J Exp Clin Cancer Res 28:94. 2009
  4. ncbi Polymorphisms in the SULF1 gene are associated with early age of onset and survival of ovarian cancer
    Chan H Han
    Department of Epidemiology, The University of Texas M, d, Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Clin Cancer Res 30:5. 2011
  5. ncbi The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer
    Xiaoxiang Guan
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    BMC Gastroenterol 9:77. 2009
  6. ncbi TNFRSF1B +676 T>G polymorphism predicts survival of non-small cell lung cancer patients treated with chemoradiotherapy
    Xiaoxiang Guan
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas 77030, USA
    BMC Cancer 11:447. 2011
  7. ncbi Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck
    Hongxia Ma
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    BMC Cancer 11:258. 2011
  8. ncbi Genotypes and haplotypes of the VEGF gene and survival in locally advanced non-small cell lung cancer patients treated with chemoradiotherapy
    Xiaoxiang Guan
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas 77030, USA
    BMC Cancer 10:431. 2010
  9. ncbi Association between p21 Ser31Arg polymorphism and cancer risk: a meta-analysis
    Hongxia Ma
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Chin J Cancer 30:254-63. 2011
  10. ncbi Expression of nucleotide excision repair proteins in lymphocytes as a marker of susceptibility to squamous cell carcinomas of the head and neck
    Qingyi Wei
    Department of Epidemiology, Unit 189, and Li Mao, Department of Thoracic and Head and Neck Medical Oncology, Unit 432, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 14:1961-6. 2005

Research Grants

  1. Molecular Epidemiology of DNA Repair in Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2010
  2. Genetic Predictors for DNA Repair Phenotype in CMM
    Qingyi Wei; Fiscal Year: 2007
  3. Molecular Epidemiology of Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2005
  4. Genotypes and Phenotypes of Apoptosis and Risk of Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2010

Collaborators

Detail Information

Publications112 found, 100 shown here

  1. ncbi A functional variant at the miR-885-5p binding site of CASP3 confers risk of both index and second primary malignancies in patients with head and neck cancer
    Xiaoxiang Guan
    Department of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
    FASEB J 27:1404-12. 2013
    ..Taken together, our data suggest that the miR-885-5p binding site rs1049253T>C SNP in the 3'-UTR of CASP3 modulates CASP3 expression at both mRNA and protein levels and thus contributes to SCCHN susceptibility...
  2. ncbi Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck
    Zhongqiu Wang
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer 11:17. 2012
    ....
  3. ncbi Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer
    Xiaoxiang Guan
    Department of Epidemiology, The University of Texas M, d, Anderson Cancer Center, Houston, Texas 77030, USA
    J Exp Clin Cancer Res 28:94. 2009
    ..Given that these genes are involved in tumor growth and progression including angiogenesis, dissemination, and invasiveness, we hypothesized that these polymorphisms would be associated with survival in patients with gastric cancer...
  4. ncbi Polymorphisms in the SULF1 gene are associated with early age of onset and survival of ovarian cancer
    Chan H Han
    Department of Epidemiology, The University of Texas M, d, Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Clin Cancer Res 30:5. 2011
    ..SULF1 expression has been reported to be decreased in various cancers, including ovarian cancer. We hypothesized that single nucleotide polymorphisms (SNPs) of SULF1 would impact clinicopathologic characteristics...
  5. ncbi The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer
    Xiaoxiang Guan
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    BMC Gastroenterol 9:77. 2009
    ..In this study, we investigated the association between potentially functional SNPs of these two genes and risk of gastric cancer in a US population...
  6. ncbi TNFRSF1B +676 T>G polymorphism predicts survival of non-small cell lung cancer patients treated with chemoradiotherapy
    Xiaoxiang Guan
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas 77030, USA
    BMC Cancer 11:447. 2011
    ..However, few reported studies have investigated the association between potentially functional SNPs in both TNF-α and TNFRSF1B and prognosis of NSCLC patients treated with chemoradiotherapy...
  7. ncbi Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck
    Hongxia Ma
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    BMC Cancer 11:258. 2011
    ..Therefore, we investigated the association between potentially functional SNPs in PLCE1 and susceptibility to SCCHN...
  8. ncbi Genotypes and haplotypes of the VEGF gene and survival in locally advanced non-small cell lung cancer patients treated with chemoradiotherapy
    Xiaoxiang Guan
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas 77030, USA
    BMC Cancer 10:431. 2010
    ..We hypothesized that VEGF polymorphisms may affect survival outcomes among locally advanced non-small cell lung cancer (LA-NSCLC) patients...
  9. ncbi Association between p21 Ser31Arg polymorphism and cancer risk: a meta-analysis
    Hongxia Ma
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Chin J Cancer 30:254-63. 2011
    ..83, df = 7, P = 0.003). The results from this large-sample sized meta-analysis suggest that the p21 31Arg/Arg genotype may serve as a potential marker for increased cancer risk...
  10. ncbi Expression of nucleotide excision repair proteins in lymphocytes as a marker of susceptibility to squamous cell carcinomas of the head and neck
    Qingyi Wei
    Department of Epidemiology, Unit 189, and Li Mao, Department of Thoracic and Head and Neck Medical Oncology, Unit 432, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 14:1961-6. 2005
    ..5; 95% CI, 2.32-56.6). These results suggest that XPF may be a crucial rate-limiting factor in DNA repair and that the reverse-protein microarray assay may be a useful tool for measuring protein markers of susceptibility to cancer...
  11. ncbi Association between low dietary folate intake and suboptimal cellular DNA repair capacity
    Qingyi Wei
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 12:963-9. 2003
    ..Once replicated by other investigators, this finding has public health implications by reinforcing the need for folate supplementation or dietary modification for the at-risk population...
  12. ncbi Repair of UV light-induced DNA damage and risk of cutaneous malignant melanoma
    Qingyi Wei
    Department of Epidemiology, Unit 189, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Natl Cancer Inst 95:308-15. 2003
    ....
  13. ncbi Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: a molecular epidemiologic study
    Q Wei
    Department of Epidemiology, Division of Cancer Prevention, The University of Texas M D Anderson Cancer, Houston, Texas 77030, USA
    J Natl Cancer Inst 92:1764-72. 2000
    ..We investigated whether differences in DNA repair capacity (DRC) for repairing tobacco carcinogen-induced DNA damage are associated with differential susceptibility to lung cancer...
  14. ncbi Polymorphic hCHK2/hCds1 codon 84 allele and risk of squamous cell carcinoma of the head and neck--a case-control analysis
    Y Zheng
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 22:2005-8. 2001
    ..Larger studies are warranted to confirm this finding and further mechanistic studies are needed to understand biological relevance of this polymorphism...
  15. ncbi In vitro BPDE-induced DNA adducts in peripheral lymphocytes as a risk factor for squamous cell carcinoma of the head and neck
    D Li
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 93:436-40. 2001
    ....
  16. ncbi Gamma-radiation sensitivity and risk of glioma
    M L Bondy
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, USA
    J Natl Cancer Inst 93:1553-7. 2001
    ....
  17. ncbi Reduced expression of hMLH1 and hGTBP/hMSH6: a risk factor for head and neck cancer
    Q Wei
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Epidemiol Biomarkers Prev 7:309-14. 1998
    ..The results suggest that low hMLH1 and hGTBP/hMSH6 expression is associated with an increased risk of head and neck cancer. Additional studies with a larger number of subjects are warranted to confirm these findings...
  18. ncbi Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients
    M R Spitz
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 61:1354-7. 2001
    ..These results suggest that the two XPD polymorphisms have a modulating effect on DRC, especially in the cases...
  19. ncbi Reduced expression of mismatch repair genes measured by multiplex reverse transcription-polymerase chain reaction in human gliomas
    Q Wei
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 57:1673-7. 1997
    ..These data suggest that reduced expression of MMR genes is frequent in human gliomas and that aberrant expression of more than one MMR gene may be associated with increased risk of second primary malignancies in glioma patients...
  20. ncbi Reduced expression of hMSH2 and hMLH1 and risk of prostate cancer: a case-control study
    S S Strom
    Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
    Prostate 47:269-75. 2001
    ..However, it cannot be ruled out that the reduced expression we observed may be caused by the disease status. Our findings and the factors that may affect the expression of hMLH1 need further confirmation in larger prospective studies...
  21. ncbi Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck
    Chunying Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 110:867-75. 2007
    ....
  22. ncbi Alcohol dehydrogenase 3 genotype is not associated with risk of squamous cell carcinoma of the oral cavity and pharynx
    E M Sturgis
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Epidemiol Biomarkers Prev 10:273-5. 2001
    ..23; confidence interval, 0.78-1.93, respectively). Therefore, we found no evidence that supports a main effect of ADH3 genotype or a combined effect of alcohol and ADH3 genotype on risk of cancer of the oral cavity or pharynx...
  23. ncbi Modulation of repair of ultraviolet damage in the host-cell reactivation assay by polymorphic XPC and XPD/ERCC2 genotypes
    Yawei Qiao
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 1515 Holcombe Boulevard, TX 77030, USA
    Carcinogenesis 23:295-9. 2002
    ..We concluded that these NER polymorphisms may modulate DRC and may be useful biomarkers for identifying individuals at risk of developing cancer...
  24. ncbi Haplotype and genotypes of the VDR gene and cutaneous melanoma risk in non-Hispanic whites in Texas: a case-control study
    Chunying Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 122:2077-84. 2008
    ..013) in modifying risk. Together, these findings suggest that VDR polymorphisms may directly affect or modify the risk associated with known melanoma risk factors. Larger, population-based studies are needed to replicate our findings...
  25. ncbi Reduced DNA repair capacity in lung cancer patients
    Q Wei
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 56:4103-7. 1996
    ..1-15.7). Younger cases (< 65 years) and smokers were more likely than controls to have reduced DRC. These findings suggest that individuals with reduced DRC are at an increased risk of developing lung cancer...
  26. ncbi Expression of nucleotide excision repair genes and the risk for squamous cell carcinoma of the head and neck
    Lie Cheng
    Department of Epidemiology, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA
    Cancer 94:393-7. 2002
    ..42 [2.63-15.69], 2.86 [1.39-5.90], 3.69 [1.73-7.90], and 2.46 [1.19-5.09], respectively). CONCLUSIONS: Reduced expression of ERCC1, XPB/ERCC3, XPG/ERCC5, and CSB/ERCC6 is associated with a more than two-fold increased risk of SCCHN...
  27. ncbi Reduced DNA repair of benzo[a]pyrene diol epoxide-induced adducts and common XPD polymorphisms in breast cancer patients
    Qiuling Shi
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 25:1695-700. 2004
    ..These findings suggest that women with reduced DRC may be at an increased risk of developing breast cancer. Large studies are warranted to confirm these preliminary findings...
  28. ncbi In vitro benzo[a]pyrene diol epoxide-induced DNA damage and chromosomal aberrations in primary lymphocytes, smoking, and risk of squamous cell carcinoma of the head and neck
    Ping Xiong
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Cancer 121:2735-40. 2007
    ..Further validation studies are warranted...
  29. ncbi An intronic poly (AT) polymorphism of the DNA repair gene XPC and risk of squamous cell carcinoma of the head and neck: a case-control study
    H Shen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 61:3321-5. 2001
    ..333, 0.281, 0.296, and 0.353, respectively). The case-control findings support the hypothesis that the XPC-PAT+ allele may contribute to the risk of developing SCCHN...
  30. ncbi Benzo(a)pyrene diol epoxide-induced chromosomal aberrations and risk of lung cancer
    Q Wei
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 56:3975-9. 1996
    ..These findings warrant additional molecular epidemiological studies. The BPDE mutagen sensitivity assay will facilitate epidemiological studies of genetic susceptibility to smoking-related cancers...
  31. ncbi Cyclin D1 polymorphism and risk for squamous cell carcinoma of the head and neck: a case-control study
    Y Zheng
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holocombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 22:1195-9. 2001
    ..26-10.0), non-smokers (3.71, 1.37-10.1) and non-alcohol users (4.76, 1.61-14.0). These results suggest that the CCND1 polymorphism is associated with early onset of SCCHN and contributes to susceptibility to SCCHN in this population...
  32. ncbi XPD/ERCC2 EXON 8 Polymorphisms: rarity and lack of significance in risk of squamous cell carcinoma of the head and neck
    Erich M Sturgis
    Department of Head and Neck Surgery, Box 441, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston 77030 4009, USA
    Oral Oncol 38:475-7. 2002
    ..The objective was to assess whether two polymorphisms in the nucleotide excision repair gene XPD (ERCC2) are markers of SCCHN risk...
  33. ncbi Nucleotide excision repair as a marker for susceptibility to tobacco-related cancers: a review of molecular epidemiological studies
    Ana S Neumann
    Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mol Carcinog 42:65-92. 2005
    ....
  34. ncbi Association and interactions between DNA repair gene polymorphisms and adult glioma
    Yanhong Liu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 18:204-14. 2009
    ..95; 95% confidence intervals, 2.21-16.65). Taken together, these results suggest that polymorphisms in DNA repair genes may act individually or together to contribute to glioma risk...
  35. ncbi Polymorphisms in the DNA repair genes XPC, XPD, and XPG and risk of cutaneous melanoma: a case-control analysis
    Chunying Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 1365, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 15:2526-32. 2006
    ..We concluded that genetic variants of the XPD gene might serve as biomarkers for susceptibility to cutaneous melanoma...
  36. ncbi XPD/ERCC2 polymorphisms and risk of head and neck cancer: a case-control analysis
    E M Sturgis
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 21:2219-23. 2000
    ..These results suggest a gene-environment interaction, but this did not reach statistical significance. The findings are limited due to the relatively small numbers in the subgroups and need to be verified by further investigations...
  37. ncbi Combined effects of the p53 and p73 polymorphisms on lung cancer risk
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
    Cancer Epidemiol Biomarkers Prev 15:158-61. 2006
    ....
  38. ncbi In vitro sensitivity to ultraviolet B light and skin cancer risk: a case-control analysis
    Li-E Wang
    Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 97:1822-31. 2005
    ..CONCLUSIONS: UVB-induced mutagen sensitivity may play a role in susceptibility to NMSC but not to CMM...
  39. ncbi Genetic variants of the vitamin D receptor gene alter risk of cutaneous melanoma
    Chunying Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Invest Dermatol 127:276-80. 2007
    ..26; 95% CI, 1.00-1.59) genotypes, compared with the VDR-FokI FF genotype. In conclusion, genetic variants (i.e., TaqI t protective allele and FokI f risk allele) in VDR may alter risk of CM...
  40. ncbi The functional promoter polymorphism (-842G>C) in the PIN1 gene is associated with decreased risk of breast cancer in non-Hispanic white women 55 years and younger
    Chan H Han
    Department of Epidemiology, Unit 1365, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Breast Cancer Res Treat 122:243-9. 2010
    ..In conclusion, the PIN1 polymorphisms may contribute to the etiology of sporadic breast cancer in non-Hispanic white women 55 years and younger. Further validation in large population-based studies is needed...
  41. ncbi Polymorphisms of methionine synthase and methionine synthase reductase and risk of squamous cell carcinoma of the head and neck: a case-control analysis
    Zhengdong Zhang
    Department of Epidemiology, Unit 189, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 14:1188-93. 2005
    ..In conclusion, our data provide evidence that support the association between the MTR A2756G and MTRR G66A polymorphisms and SCCHN risk and that these two polymorphisms may have a joint effect on risk of SCCHN...
  42. ncbi A variant of the DNA repair gene XRCC3 and risk of squamous cell carcinoma of the head and neck: a case-control analysis
    Hongbing Shen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 99:869-72. 2002
    ..26; 95% CI, 1.02-4.99). These findings suggest that the variant XRCC3 18067TT genotype may not play a major role in the etiology of SCCHN but may contribute to a subset of SCCHN. Larger studies are needed to verify these findings...
  43. ncbi Haplotypes of two variants in p16 (CDKN2/MTS-1/INK4a) exon 3 and risk of squamous cell carcinoma of the head and neck: a case-control study
    Yuxin Zheng
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 11:640-5. 2002
    ..We conclude that these polymorphic p16 genotypes or haplotypes may not play a major role in the etiology of SCCHN, if any. However, our limited sample size and power call for larger studies for additional verification of our findings...
  44. ncbi Sensitivity to benzo(a)pyrene diol-epoxide associated with risk of breast cancer in young women and modulation by glutathione S-transferase polymorphisms: a case-control study
    P Xiong
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 61:8465-9. 2001
    ..Larger studies are needed to confirm our findings...
  45. ncbi Polymorphisms of methylene-tetrahydrofolate reductase and risk of lung cancer: a case-control study
    H Shen
    Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 10:397-401. 2001
    ..0 (0.8-1.3) for 1298AC versus 1298AA wild type and 1.1 (0.7-1.8) for 1298CC versus 1298AA. These results suggest that the MTHFR C677T and A1298C polymorphisms by themselves do not play an important role in the etiology of lung cancer...
  46. ncbi Genotypes and haplotypes of ERCC1 and ERCC2/XPD genes predict levels of benzo[a]pyrene diol epoxide-induced DNA adducts in cultured primary lymphocytes from healthy individuals: a genotype-phenotype correlation analysis
    Hui Zhao
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 29:1560-6. 2008
    ..Our findings suggest that the genotypes and haplotypes of ERCC1 and ERCC2/XPD may have an effect on in vitro BPDE-induced DNA adduct levels...
  47. ncbi DNA repair gene XRCC3 241Met variant is not associated with risk of cutaneous malignant melanoma
    Zhigang Duan
    Departments of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 11:1142-3. 2002
  48. ncbi A novel functional variant (-842G>C) in the PIN1 promoter contributes to decreased risk of squamous cell carcinoma of the head and neck by diminishing the promoter activity
    Jiachun Lu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 30:1717-21. 2009
    ..Large prospective studies of diverse ethnic groups and diverse cancer sites are warranted to validate our findings...
  49. ncbi Thymidylate synthase 5'- and 3'-untranslated region polymorphisms associated with risk and progression of squamous cell carcinoma of the head and neck
    Zhengdong Zhang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 10:7903-10. 2004
    ..We hypothesized that polymorphisms of the thymidylate synthase (TYMS) gene, which regulates a key enzyme in folate metabolism required for DNA synthesis and repair, are associated with SCCHN risk...
  50. ncbi Association of a p73 exon 2 G4C14-to-A4T14 polymorphism with risk of squamous cell carcinoma of the head and neck
    Guojun Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 25:1911-6. 2004
    ..70; 95% CI, 1.19-2.43), women (1.61; 1.09-2.37), current smokers (1.77; 1.25-2.51) and patients with oral cancer (1.54; 1.15-2.07). Our results suggest that this p73 polymorphism may be a risk marker for genetic susceptibility to SCCHN...
  51. ncbi Expression in normal human tissues of five nucleotide excision repair genes measured simultaneously by multiplex reverse transcription-polymerase chain reaction
    L Cheng
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Epidemiol Biomarkers Prev 8:801-7. 1999
    ..This new multiplex RT-PCR assay may help detect aberrant expression of these NER genes in both normal and tumor tissues...
  52. ncbi Potentially functional single nucleotide polymorphisms in the core nucleotide excision repair genes and risk of squamous cell carcinoma of the head and neck
    Jiaze An
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 1365, 1155 Pressler, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:1633-8. 2007
    ..These findings suggest that these potentially functional SNPs may collectively contribute to susceptibility to SCCHN. These findings need to be validated in larger, independent studies...
  53. ncbi No Association between hOGG1 Ser326Cys polymorphism and risk of squamous cell carcinoma of the head and neck
    Zhengdong Zhang
    Department of Epidemiology, University of Texas M.D. Anderson Cancer Center, Houston, 77030, USA
    Cancer Epidemiol Biomarkers Prev 13:1081-3. 2004
  54. ncbi Single-nucleotide polymorphisms at the TP53-binding or responsive promoter regions of BAX and BCL2 genes and risk of squamous cell carcinoma of the head and neck
    Kexin Chen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 28:2008-12. 2007
    ..Our data suggest that the risk of SCCHN may be associated with these two SNPs of BAX and BCL2 promoter regions, particularly among TP53 heterozygotes. Larger studies are needed to validate these findings...
  55. ncbi Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck
    Zhensheng Liu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 31:1977-81. 2010
    ..Although we added additional evidence for the association of the two SNPs with cancer risk as reported in GWAS, additional studies are needed to replicate our findings...
  56. ncbi Gamma radiation sensitivity and risk of malignant and benign salivary gland tumors: a pilot case-control analysis
    Rong Zheng
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030-4009, USA
    Cancer 100:561-7. 2004
    ..However, larger studies are needed to verify these findings...
  57. ncbi Association between the V109G polymorphism of the p27 gene and the risk and progression of oral squamous cell carcinoma
    Guojun Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 10:3996-4002. 2004
    ..We hypothesized that this p27 T109G polymorphism is associated with squamous cell carcinoma of the head and neck (SCCHN) risk...
  58. ncbi Genetic variants of p21 and p27 and pancreatic cancer risk in non-Hispanic Whites: a case-control study
    Jinyun Chen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Pancreas 39:1-4. 2010
    ..We hypothesized that genetic variants in p21 and p27 may modify individual susceptibility to pancreatic cancer...
  59. ncbi Polymorphisms of the FAS and FAS ligand genes associated with risk of cutaneous malignant melanoma
    Chunying Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Pharmacogenet Genomics 16:253-63. 2006
    ..In conclusion, genetic variants in the FAS and FASLG genes may contribute to the etiology of CMM in the general population, particularly in those with a low risk of sunlight-induced CMM...
  60. ncbi Genetic polymorphisms of p21 are associated with risk of squamous cell carcinoma of the head and neck
    Guojun Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 26:1596-602. 2005
    ..001). Our results suggest that the presence of these two p21 polymorphisms may be a marker of genetic susceptibility to SCCHN...
  61. ncbi Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: a case-control analysis
    Ana S Neumann
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 115:131-6. 2005
    ..Future studies should incorporate detailed data on alcohol consumption, dietary folate intake and related serologic measurements...
  62. ncbi Polymorphisms of vitamin D receptor gene protect against the risk of head and neck cancer
    Zhensheng Liu
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Pharmacogenet Genomics 15:159-65. 2005
    ..001). These data suggest that the VDR f and t alleles and their genotypes may protect against SCCHN. However, further studies are warranted to confirm these findings...
  63. ncbi Polymorphism of DNA ligase I and risk of lung cancer--a case-control analysis
    Hongbing Shen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Lung Cancer 36:243-7. 2002
    ..64-1.36 for AA versus CC) neither in all cases nor in different histopathologic types. The results of this large case-control study suggest that this LIG1 polymorphism may not play an important role in susceptibility to lung cancer...
  64. ncbi Evidence that Gsta4 modifies susceptibility to skin tumor development in mice and humans
    Erika L Abel
    Department of Carcinogenesis, Science Park Research Division, The University of Texas M D Anderson Cancer Center, Smithville, TX, USA
    J Natl Cancer Inst 102:1663-75. 2010
    ..Here, we used the mouse two-stage skin carcinogenesis model to identify the gene(s) responsible for the effects of Psl1...
  65. ncbi Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma
    Chunying Li
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Hum Mutat 29:1443-51. 2008
    ..Therefore, these CASP8 and CASP10 polymorphisms may be biomarkers for susceptibility to CM...
  66. ncbi Polymorphisms of DNA repair genes and risk of glioma
    Li E Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 64:5560-3. 2004
    ..13-2.93). These results suggest that the T allele may be a risk allele, and this XRCC7 polymorphism may be a marker for the susceptibility to glioma. Larger studies are needed to confirm our findings and unravel the underlying mechanisms...
  67. ncbi Fas single nucleotide polymorphisms and risk of thyroid and salivary gland carcinomas: a case-control analysis
    Tang Ho
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Head Neck 30:297-305. 2008
    ..The purpose of this study was to examine the association between 4 Fas single nucleotide polymorphisms (SNPs) and risk of differentiated thyroid carcinoma (DTC) and salivary gland carcinoma (SGC)...
  68. ncbi p53 codon 72 polymorphism associated with risk of human papillomavirus-associated squamous cell carcinoma of the oropharynx in never-smokers
    Xuemei Ji
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 29:875-9. 2008
    ..5; 95% CI, 4.8-106.2). These findings suggest that p53 codon 72 variant genotypes modify the risk of HPV16-associated SCCOP and may be markers of genetic susceptibility to HPV16-associated SCCOP, especially among never-smokers...
  69. ncbi Dietary folate intake and lung cancer risk in former smokers: a case-control analysis
    Hongbing Shen
    Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 12:980-6. 2003
    ..Our data suggest that there is a possible protective role of dietary folate in lung carcinogenesis, a finding which may have implications in public health and cancer prevention...
  70. ncbi DNA repair phenotype and cancer susceptibility--a mini review
    Chunying Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 124:999-1007. 2009
    ..This finding needs additional validation by other investigators, and we also discussed issues in conducting this kind of research in the future...
  71. ncbi Overexpression of hMTH in peripheral lymphocytes and risk of prostate cancer: a case-control analysis
    Zhensheng Liu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Carcinog 36:123-9. 2003
    ..In addition, a correlation between the expression level of hMTH and the level of oxidative DNA damage in the target tissues needs to be established as well...
  72. ncbi Polymorphisms and haplotypes of the NBS1 gene are associated with risk of sporadic breast cancer in non-Hispanic white women <or=55 years
    Jiachun Lu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center Houston, TX 77030, USA
    Carcinogenesis 27:2209-16. 2006
    ..006). These findings suggest that NBS1 polymorphisms and haplotypes may contribute to the etiology of sporadic breast cancer in young non-Hispanic white women. Large studies are warranted to confirm these findings...
  73. ncbi Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck
    Zhensheng Liu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 116:4753-60. 2010
    ..The authors hypothesized that common polymorphisms in pre-miRNAs are associated individually and (more likely) collectively with the risk of squamous cell carcinoma of the head and neck (SCCHN)...
  74. ncbi p73 G4C14-to-A4T14 polymorphism and risk of second primary malignancy after index squamous cell carcinoma of head and neck
    Fanglin Li
    Department of Head and Neck Surgery, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 125:2660-5. 2009
    ..g., older patients, men, minorities, ever smokers, and ever drinkers). Our results support that this p73 polymorphism may be a marker for risk of SPM among patients with an incident SCCHN...
  75. ncbi p73 G4C14-to-A4T14 polymorphism and risk of lung cancer
    Guojun Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 64:6863-6. 2004
    ..61, 95% CI, 1.26-2.06), light smokers (OR = 1.58, 95% CI, 1.17-2.14), and squamous cell lung carcinoma (OR = 1.79, 95% CI, 1.32-2.42). These results suggest that this p73 polymorphism may be a marker for susceptibility to lung cancer...
  76. ncbi Expression of five selected human mismatch repair genes simultaneously detected in normal and cancer cell lines by a nonradioactive multiplex reverse transcription-polymerase chain reaction
    Q Wei
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Pathobiology 65:293-300. 1997
    ....
  77. ncbi Polymorphisms of the DNA repair gene MGMT and risk and progression of head and neck cancer
    Zhengdong Zhang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    DNA Repair (Amst) 9:558-66. 2010
    ....
  78. ncbi Smoking, DNA repair capacity and risk of nonsmall cell lung cancer
    Hongbing Shen
    Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 107:84-8. 2003
    ..The results suggest that suboptimal DRC is associated with increased risk of NSCLC and DRC may modulate the risk of lung cancer associated with smoking but the latter needs to be verified in larger studies...
  79. ncbi A novel polymorphism in human cytosine DNA-methyltransferase-3B promoter is associated with an increased risk of lung cancer
    Hongbing Shen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 62:4992-5. 2002
    ..Additional studies on the underlying molecular mechanism of this polymorphism are warranted...
  80. ncbi p73 G4C14-to-A4T14 polymorphism and risk of human papillomavirus-associated squamous cell carcinoma of the oropharynx in never smokers and never drinkers
    Xingming Chen
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 113:3307-14. 2008
    ....
  81. ncbi Rapid assessment of repair of ultraviolet DNA damage with a modified host-cell reactivation assay using a luciferase reporter gene and correlation with polymorphisms of DNA repair genes in normal human lymphocytes
    Yawei Qiao
    Department of Epidemiology, Box 189, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mutat Res 509:165-74. 2002
    ..These features make the LUC-based HCR assay suitable for molecular epidemiological studies...
  82. ncbi Association of XRCC1 polymorphisms and risk of differentiated thyroid carcinoma: a case-control analysis
    Tang Ho
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Thyroid 19:129-35. 2009
    ..These SNPs have been increasingly studied in the epidemiology of various cancer types. In this study we evaluated the risk association between six common SNPs of the XRCC1 gene and differentiated thyroid carcinoma (DTC)...
  83. ncbi A modified host-cell reactivation assay to measure repair of alkylating DNA damage for assessing risk of lung adenocarcinoma
    Luo Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 28:1430-6. 2007
    ..We conclude that variability in DRC is a risk factor for lung cancer and our results provide proof of principle for a new assay that can assess DRC for NNK-induced DNA damage...
  84. ncbi 172G>T variant in the 5' untranslated region of DNA repair gene RAD51 reduces risk of squamous cell carcinoma of the head and neck and interacts with a P53 codon 72 variant
    Jiachun Lu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 28:988-94. 2007
    ..The finding that the functional RAD51 172G>T SNP, particularly in the presence of the P53 Arg72Arg genotype, may be a marker of susceptibility to SCCHN needs to be validated by larger studies of different ethnic populations...
  85. ncbi 4-Nitroquinoline-1-oxide-induced mutagen sensitivity and risk of nonmelanoma skin cancer: a case-control analysis
    Li E Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Invest Dermatol 127:196-205. 2007
    ..However, there is a lack of correlation between UVB-induced b/c and 4-NQO-induced b/c in this study population. Therefore, these findings need to be verified by additional studies...
  86. ncbi Genetic variants in the H2AFX promoter region are associated with risk of sporadic breast cancer in non-Hispanic white women aged <or=55 years
    Jiachun Lu
    Department of Epidemiology, Unit 1365, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA
    Breast Cancer Res Treat 110:357-66. 2008
    ..Larger association studies and related functional studies are warranted to confirm these findings...
  87. ncbi DNMT3b polymorphism and hereditary nonpolyposis colorectal cancer age of onset
    J Shawn Jones
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 189, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 15:886-91. 2006
    ....
  88. ncbi Repair capacity for UV light induced DNA damage associated with risk of nonmelanoma skin cancer and tumor progression
    Li E Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:6532-9. 2007
    ..To examine the role of suboptimal DNA repair capacity (DRC) for UV light-induced DNA damage in the development of nonmelanoma skin cancer (NMSC) and tumor progression...
  89. ncbi Genetic variants of the ADPRT, XRCC1 and APE1 genes and risk of cutaneous melanoma
    Chunying Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 27:1894-901. 2006
    ..Larger studies with more SNPs in the BER genes are needed to verify these findings...
  90. ncbi Cryopreserving whole blood for functional assays using viable lymphocytes in molecular epidemiology studies
    L Cheng
    Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Lett 166:155-63. 2001
    ..61, P < 0.001). These data suggest that within the limits of the parameters investigated here, cryopreserved whole blood is a good source of viable lymphocytes for biomarker assays in molecular epidemiological studies...
  91. ncbi Risk assessment for developing gliomas: a comparison of two cytogenetic approaches
    R El-Zein
    Department of Epidemiology, The University of Texas, M.D. Anderson Cancer Center, Box 189, Houston, TX 77030, USA
    Mutat Res 490:35-44. 2001
    ..The results indicate that using the multicolor FISH assay for detection of CIN in peripheral blood lymphocytes in glioma patients is a more useful marker for risk assessment...
  92. ncbi Simultaneous amplification of four DNA repair genes and beta-actin in human lymphocytes by multiplex reverse transcriptase-PCR
    Q Wei
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 55:5025-9. 1995
    ..This approach should facilitate molecular epidemiological studies that incorporate screening for germline alterations that may affect gene expression and for changes in the levels of gene expression...
  93. ncbi DNA repair capacity in peripheral lymphocytes predicts survival of patients with non-small-cell lung cancer treated with first-line platinum-based chemotherapy
    Li E Wang
    The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Oncol 29:4121-8. 2011
    ..In this larger independent study of 591 patients with NSCLC, we further evaluated whether DRC in peripheral lymphocytes predicts survival of patients with NSCLC who receive platinum-based chemotherapy...
  94. ncbi Joint effects of single nucleotide polymorphisms in P53BP1 and p53 on breast cancer risk in a Chinese population
    Hongxia Ma
    Laboratory of Reproductive Medicine, Department of Epidemiology and Biostatistics, Nanjing Medical University, and Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, China
    Carcinogenesis 27:766-71. 2006
    ..Further functional studies are needed to confirm our findings...
  95. ncbi Polymorphisms in hMLH1 and risk of early-onset lung cancer in a southeast Chinese population
    Yu An
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Handan Road, Shanghai 200433, China
    Lung Cancer 59:164-70. 2008
    ..Larger association studies are warranted to validate our findings and mechanistic studies are needed to elucidate the underlying molecular mechanisms of the association...
  96. ncbi XRCC1 polymorphisms and cancer risk: a meta-analysis of 38 case-control studies
    Zhibin Hu
    Department of Epidemiology and Biostatistics, Nanjing Medical University School of Public Health, 140 Hanzhong Road, 210029 Nanjing, China
    Cancer Epidemiol Biomarkers Prev 14:1810-8. 2005
    ....
  97. ncbi A promoter polymorphism (-77T>C) of DNA repair gene XRCC1 is associated with risk of lung cancer in relation to tobacco smoking
    Zhibin Hu
    Department of Epidemiology and Biostatistics, Nanjing Medical University School of Public Health, Nanjing, China
    Pharmacogenet Genomics 15:457-63. 2005
    ..1560). These findings indicate that the new XRCC1 -77T>C polymorphism may contribute to the aetiology of lung cancer. Further functional studies are warranted to elucidate the underlying molecular mechanisms of the association...
  98. ncbi Polymorphisms of TP53 Arg72Pro, but not p73 G4C14>A4TA4 and p21 Ser31Arg, contribute to risk of cutaneous melanoma
    Chunying Li
    J Invest Dermatol 128:1585-8. 2008
  99. ncbi Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk
    Kyoung Mu Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, Chongno Gu, Seoul, Korea
    Clin Cancer Res 11:4620-6. 2005
    ..To evaluate the role of genetic polymorphisms of DNA repair genes in breast cancer, we conducted a hospital-based case-control study of Korean women...
  100. ncbi Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer
    Xuemei Zhang
    Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100 021, China
    Cancer Res 65:722-6. 2005
    ..In conclusion, the ADPRT Val762Ala polymorphism plays an important role in smoking-related lung cancer and the XRCC1 Arg399Gln polymorphism may serve as a risk modifier...
  101. ncbi Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma
    Bingtao Hao
    Laboratory of Systems Biology, Beijing Institute of Radiation Medicine, Beijing, People s Republic of China
    Cancer Res 64:4378-84. 2004
    ..The results suggest that the polymorphisms in five BER genes may be associated with the susceptibility to ESCC in a Chinese population...

Research Grants15

  1. Molecular Epidemiology of DNA Repair in Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2010
    ..The long-term goal of this study is to identify effective biomarkers that can be used to identify at-risk individuals who will be targeted for primary prevention of SCCHN in the general population. ..
  2. Genetic Predictors for DNA Repair Phenotype in CMM
    Qingyi Wei; Fiscal Year: 2007
    ..When the combined NER genotype representing genetic susceptibility to CMM is identified and is confirmed in the general population, it may have a significant impact on primary prevention of CMM. ..
  3. Molecular Epidemiology of Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2005
    ....
  4. Genotypes and Phenotypes of Apoptosis and Risk of Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2010
    ..The long-term goal of this study is to identify effective biomarkers that can be used to identify at-risk individuals in the general population who will be targeted for primary prevention and early detection of SCCHN. ..