Research Topics
| William Bernard WeglickiSummaryAffiliation: The George Washington University Country: USA Publications
Research Grants
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Detail Information
Publications
Hypomagnesemia and inflammation: clinical and basic aspectsWilliam B Weglicki
Department of Biochemistry and Molecular Biology, Division of Experimental Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA
Annu Rev Nutr 32:55-71. 2012....
Neutral endopeptidase inhibition enhances substance P mediated inflammation due to hypomagnesemiaWilliam B Weglicki
The Department of Biochemistry and Molecular Biology, 439 Ross Hall, The George Washington University Medical Center, 2300 Eye St, N W, Washington, DC 20037, USA
Magnes Res 22:167S-173S. 2009..Thus, we submit that inhibition of NEP by pharmacological, genetic and dietary approaches (magnesium restriction), causes greater neurogenic inflammation that may result in increased intestinal and cardiac dysfunction...- Cardiovascular and intestinal responses to oxidative and nitrosative stress during prolonged magnesium deficiencyWilliam B Weglicki
Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, DC 20037, USA
Am J Med Sci 342:125-8. 2011..The neurogenic signal transduction pathways that we have identified in the pro-oxidant/pro-inflammatory processes found with prolonged hypomagnesemia are described in this report... - The role of magnesium deficiency in cardiovascular and intestinal inflammationWilliam B Weglicki
Division of Experimental Medicine, Department of Biochemistry and Molecular Biology, George Washington University Medical Center, Washington, DC 20037, USA
Magnes Res 23:S199-206. 2010.... - Mg-gluconate provides superior protection against postischemic dysfunction and oxidative injury compared to Mg-sulfateSarah B Murthi
Department of Surgery, Division of Cardiothoracic Surgery, The George Washington University Medical Center, Washington, D.C. 20037, USA
Mol Cell Biochem 245:141-8. 2003..MgGl2 treated hearts exhibited less postischemic dysfunction and oxidative injury compared to MgSO4, suggesting the contribution of Gl(1-) to cardioprotection... - The nerve-heart connection in the pro-oxidant response to Mg-deficiencyMaria Isabel Tejero-Taldo
Dept of Biochemistry and Molecular Biology, Div of Experimental Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
Heart Fail Rev 11:35-44. 2006.... - Cardiac pathologic effects of azidothymidine (AZT) in Mg-deficient miceI Tong Mak
Department of Biochemistry and Molecular Biology, Division of Experimental Medicine, The George Washington University Medical Center, Washington, DC, USA
Cardiovasc Toxicol 4:169-77. 2004.... - Pro-oxidant properties and cytotoxicity of AZT-monophosphate and AZTI Tong Mak
Division of Experimental Medicine, Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, 2300 Eye St NW, Ross Hall, Room 443, Washington, DC 20037, USA
Cardiovasc Toxicol 4:109-15. 2004..Because AZT-MP is a major phosphorylated metabolite, the data suggest that potential pro-oxidative activities may be associated with AZT use when catalytic iron is present... - Intestinal and cardiac inflammatory response shows enhanced endotoxin receptor (CD14) expression in magnesium deficiencyJoanna J Chmielinska
Division of Experimental Medicine, Department of Biochemistry and Molecular Biology, USA
Mol Cell Biochem 278:53-7. 2005..These CD14 positive cells may amplify the cardiomyopathic inflammatory process by stimulating TNF-alpha and other pro-inflammatory cytokines... - Neurogenic inflammation and cardiac dysfunction due to hypomagnesemiaJay H Kramer
Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington DC 20037, USA
Am J Med Sci 338:22-7. 2009..In view of the clinical prevalence of hypomagnesemia, new treatments, beyond magnesium repletion, may be needed to diminish deleterious neurogenic and prooxidative components described in this article... - Chronic dietary Mg2+ deficiency induces cardiac apoptosis in the rat heartM Isabel Tejero-Taldo
Division of Experimental Medicine, Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, 2300 IST, NW Washington, D C 20037, USA
Magnes Res 20:208-12. 2007..6-fold increase of cleaved PARP in Mg-deficient rat hearts (p < 0.002). In summary, our data indicate that chronic Mg2+ deficiency induces apoptosis of myocardium in vivo... - Intestinal inflammation caused by magnesium deficiency alters basal and oxidative stress-induced intestinal functionBradford J Scanlan
Department of Surgery, Walter Reed Army Medical Center, Washington, DC 20307, USA
Mol Cell Biochem 306:59-69. 2007.... - Iron uptake and release by macrophages is sensitive to propranololAndrei M Komarov
Division of Experimental Medicine, Departments of Biochemistry and Molecular Biology, The George Washington University Medical Center, 2300 Eye St, NW, Ross Hall, Rm 441A, Washington, DC 20037, USA
Mol Cell Biochem 288:213-7. 2006..We found that loading cells with Fe-D increased their response to latex, which was prevented by the lysosomotropic antioxidant agent D-Pro (10 microM)... - Antioxidant and lysosomotropic properties of acute D-propranolol underlies its cardioprotection of postischemic hearts from moderate iron-overloaded ratsJay H Kramer
Department of Biochemistry, Division of Experimental Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
Exp Biol Med (Maywood) 231:473-84. 2006.... - Dietary magnesium intake influences circulating pro-inflammatory neuropeptide levels and loss of myocardial tolerance to postischemic stressJay H Kramer
Department of Physiology, George Washington University Medical Center, Washington, DC 20037, USA
Exp Biol Med (Maywood) 228:665-73. 2003..Our data suggest that varying dietary Mg intake directly influences the magnitude of the neurogenic/oxidative responses in vivo and the resultant myocardial tolerance to I/R stress... - N-methyl-D-aspartate receptor blockade inhibits cardiac inflammation in the Mg2+-deficient ratM Isabel Tejero-Taldo
Division of Experimental Medicine, Department of Biochemistry and Molecular Biology, George Washington University Medical Center, 2300 I St, NW, Washington, DC 20037, USA
J Pharmacol Exp Ther 311:8-13. 2004..05). We conclude that NMDA receptor blockade with dizolcipine maleate prevented SP depletion and reduced perivascular inflammatory infiltrates, thus decreasing cardiac injury due to Mg(2+) deficiency... - Azidothymidine promotes free radical generation by activated macrophages and hydrogen peroxide-iron-mediated oxidation in a cell-free systemAndrei M Komarov
Department of Physiology and Experimental Medicine, The George Washington University Medical Center, 2300 Eye Street, NW, Ross Hall, Rm 451A, Washington, DC 20037, USA
Biochim Biophys Acta 1688:257-64. 2004..Under these conditions, AZT and AZT phosphates exhibit a prooxidant effect in concentrations as low as 100 microM. Furthermore, GAZT is a less effective prooxidant and AMT acts like an antioxidant. Thymidine did not show any effect... - Potent antioxidant properties of 4-hydroxyl-propranololI Tong Mak
Department of Physiology and Experimental Medicine, Antioxidant Pharmacology Laboratory, George Washington University Medical Center, Washington, DC 20037, USA
J Pharmacol Exp Ther 308:85-90. 2004..Being a major metabolite in human and with its plasma level approaching that of propranolol, 4-HO-propranolol may contribute, in part, to the cardiovascular therapeutic benefits of propranolol... - AZT-induced oxidative cardiovascular toxicity: attenuation by Mg-supplementationI Tong Mak
Department of Biochemistry and Molecular Biology, Division of Experimental Medicine, The George Washington University Medical Center, 2300 Eye Street, N W Ross Hall, Rm 443, Washington, DC 20037, USA
Cardiovasc Toxicol 9:78-85. 2009..05) the weight gain loss due to AZT intake. It is concluded that high dietary Mg may provide beneficial effects against AZT toxicity due to its systemic antioxidative/anti-inflammatory properties... - Antioxidant and lysosomotropic properties of acridine-propranolol: protection against oxidative endothelial cell injuryBenjamin F Dickens
Department of Immunology, George Washington University Medical Center, Washington, DC 20037, USA
J Mol Cell Cardiol 34:129-37. 2002..These properties may contribute to the enhanced endothelial cytoprotective effects against free radical-induced injury... - Suppression of neutrophil and endothelial activation by substance P receptor blockade in the Mg-deficient ratI Tong Mak
The George Washington University Medical Center, Department of Physiology and Experimental Medicine, Washington, DC 20037, USA
Magnes Res 16:91-7. 2003.... - Protective effects of dihydropyridine Ca-blockers against endothelial cell oxidative injury due to combined nitric oxide and superoxideI Tong Mak
Department of Physiology and Experimental Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
Pharmacol Res 45:27-33. 2002..The protective mechanism against the cytotoxicity is most likely through a lipophilic 'chain-breaking' antiperoxidative action against the 'OH-like species' released from peroxynitrite or SIN-1... - D-propranolol attenuates lysosomal iron accumulation and oxidative injury in endothelial cellsI Tong Mak
Department of Biochemistry and Molecular Biology, Division of Experimental Medicine, George Washington University Medical Center, 2300 Eye Street, N W Ross Hall, Rm 443, Washington DC 20037, USA
J Pharmacol Exp Ther 317:522-8. 2006....
Research Grants
- SUBSTANCE P-MEDIATED CARDIOVASCULAR INFLAMMATIONWilliam Weglicki; Fiscal Year: 2007..The hypotheses to be pursued in the Research Plan are outlined in Illustration 1. The potential relevance of clinical MgD to proinflammatory events in heart failure and other disease processes is addressed in the text. ..
- Cardiomyopathy: Pro-Oxidant Role of Zidovudine (AZT)William Weglicki; Fiscal Year: 2007..The proposed iron chelation and antibiotic intervention strategies may lead to adjunct therapies aimed at lessen AZT-related cardiovascular toxicity. ..
- OXIDATIVE STRESS AND ANTIOXIDANTS IN IRON OVERLOADWilliam Weglicki; Fiscal Year: 2007..The proposed studies may reveal potential benefits of using Ang II receptor blockade and lysosomotropic/antioxidant agents as adjunct therapy for iron-overloaded patients. ..
- OXIDATIVE STRESS AND ANTIOXIDANTS IN IRON OVERLOADWilliam Weglicki; Fiscal Year: 2009..The proposed studies may reveal potential benefits of using Ang II receptor blockade and lysosomotropic/antioxidant agents as adjunct therapy for iron-overloaded patients. ..
- OXIDATIVE STRESS AND ANTIOXIDANTS IN IRON OVERLOADWilliam Weglicki; Fiscal Year: 2004..We believe our proposed studies may lead to a reassessment of the potential use of beta-blockers for iron-overload therapy. ..
- SUBSTANCE P-MEDIATED CARDIOVASCULAR INFLAMMATIONWilliam Weglicki; Fiscal Year: 2003..These studies will provide insight concerning the role of neurogenic inflammation in the cardiovascular pathologic consequences of clinically- achievable Mg-deficiency. ..
- CARDIOMYOPATHY:PRO-OXIDANT ROLE OF AZT & MG-DEFICIENCYWilliam Weglicki; Fiscal Year: 2003..We anticipate that the information from these in vivo animal, tissue, and cellular studies may lead to potential diagnostic criteria and therapy for patients at risk of developing cardiomyopathy due to HIV disease. ..
- OXIDATIVE STRESS AND ANTIOXIDANTS IN IRON OVERLOADWilliam Bernard Weglicki; Fiscal Year: 2010..The proposed studies may reveal potential benefits of using Ang II receptor blockade and lysosomotropic/antioxidant agents as adjunct therapy for iron-overloaded patients. ..