Research Topics
Species | Sunmee WeeSummaryAffiliation: The Scripps Research Institute Country: USA Publications
| Collaborators
|
Detail Information
Publications
Self-vaccination by methamphetamine glycation products chemically links chronic drug abuse and cardiovascular diseaseJennifer Treweek
Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 104:11580-4. 2007....- Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effectsSunmee Wee
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
Neuropsychopharmacology 37:1083-91. 2012..These data strongly suggest that our dAd5GNE vector-based vaccine may be effective in treating cocaine abuse and addiction... - Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaineSunmee Wee
Committee on the Neurobiology of Addictive Disorders SP30 2400, The Scripps Research Institute, La Jolla, CA 92037, USA
Psychopharmacology (Berl) 205:565-75. 2009..In the present study, we tested the hypothesis that increased cocaine self-administration with extended access was associated with increased activity of the kappa opioid system in rats... - Alpha 1-noradrenergic system role in increased motivation for cocaine intake in rats with prolonged accessSunmee Wee
Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Eur Neuropsychopharmacol 18:303-11. 2008..The data suggest that activation of the alpha 1-noradrenergic system, perhaps in the BNST, is associated with increased motivation for cocaine in rats with extended access... - The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuseSunmee Wee
Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Psychopharmacology (Berl) 210:121-35. 2010.... - Effect of aripiprazole, a partial dopamine D2 receptor agonist, on increased rate of methamphetamine self-administration in rats with prolonged session durationSunmee Wee
Committee on Neurobiology of Addictive Disorder, The Scripps Research Institute, La Jolla, CA92037, USA
Neuropsychopharmacology 32:2238-47. 2007..However, mechanisms other than downregulation of D(2) DA receptors in the nucleus accumbens and the striatum may be responsible for the increased sensitivity of the dopaminergic function in LgA rats... - Effects of dose and session duration on cocaine self-administration in ratsSunmee Wee
Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
J Pharmacol Exp Ther 320:1134-43. 2007..Therefore, high doses or prolonged access to cocaine are more likely to result in a pattern of cocaine intake that reflects compulsive use... - Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administrationPatrick Recinto
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA
Neuropsychopharmacology 37:1275-87. 2012.... - Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairmentsOlivier George
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
Neuropsychopharmacology 33:2474-82. 2008.... - The dopamine D3 receptor partial agonist CJB090 and antagonist PG01037 decrease progressive ratio responding for methamphetamine in rats with extended-accessLaura Orio
The Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
Addict Biol 15:312-23. 2010.... - Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesisChitra D Mandyam
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
Biol Psychiatry 64:958-65. 2008..We examined how intravenous methamphetamine self-administration modulates active division, proliferation of late progenitors, differentiation, maturation, survival, and mature phenotype of hippocampal subgranular zone (SGZ) progenitors... - A combination of buprenorphine and naltrexone blocks compulsive cocaine intake in rodents without producing dependenceSunmee Wee
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
Sci Transl Med 4:146ra110. 2012.... - CRF(1) receptor antagonists attenuate escalated cocaine self-administration in ratsSheila E Specio
The Scripps Research Institute, La Jolla, CA 92037, USA
Psychopharmacology (Berl) 196:473-82. 2008..However, the involvement of activation of CRF(1) receptors in rats self-administering cocaine with extended access is unknown... 
Escalation of methamphetamine self-administration in rats: a dose-effect functionOsamu Kitamura
Molecular and Integrative Neurosciences Department, SP30-2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Psychopharmacology (Berl) 186:48-53. 2006..Results suggest that the rapidity of escalation is dependent on dose and has an upper limit of intake over a period of 21 days...- Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: alleviation by CRF₁ receptor antagonismScott Edwards
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA
Neuropharmacology 62:1142-51. 2012..This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'... - Extended access cocaine self-administration differentially activates dorsal raphe and amygdala corticotropin-releasing factor systems in ratsEric P Zorrilla
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
Addict Biol 17:300-8. 2012..Increased availability of cocaine promotes greater tissue CRF levels in these extrahypothalamic brain regions, changes associated here with a model of cocaine dependence... - Methamphetamine self-administration and voluntary exercise have opposing effects on medial prefrontal cortex gliogenesisChitra D Mandyam
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
J Neurosci 27:11442-50. 2007..The susceptibility of mPFC gliogenesis to even modest doses of methamphetamine could account for the pronounced pathology linked to psychostimulant abuse... - Extended access methamphetamine decreases immature neurons in the hippocampus which results from loss and altered development of neural progenitors without altered dynamics of the S-phase of the cell cycleClara J Yuan
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA
Pharmacol Biochem Behav 100:98-108. 2011..These data suggest that altered hippocampal plasticity by methamphetamine could partially contribute to methamphetamine-induced impairments in hippocampal function... - A reduced rate of in vivo dopamine transporter binding is associated with lower relative reinforcing efficacy of stimulantsSunmee Wee
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, 39216, USA
Neuropsychopharmacology 31:351-62. 2006..The data under both the PR and FR schedules, however, suggest that a slow onset at the DAT influence reinforcing effect only to a limited extent... - Role of the increased noradrenergic neurotransmission in drug self-administrationSunmee Wee
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 N. State Street, Jackson, 39216-4505, USA
Drug Alcohol Depend 82:151-7. 2006..These results support the conclusion that CNS NE is not involved in the reinforcing mechanism of psychostimulants... - Self-administration of mixtures of fenfluramine and amphetamine by rhesus monkeysSunmee Wee
Division of Neurobiology and Behavior Research, Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 N. State Street, Jackson, MS 39216, United States
Pharmacol Biochem Behav 84:337-43. 2006..However, the involvement of 5-HT2 receptors in the interaction between the serotonergic system and the reinforcing efficacy still remains equivocal... - Evaluation of the reinforcing effects of atomoxetine in monkeys: comparison to methylphenidate and desipramineSunmee Wee
Department of Psychiatry and Human Behavior, Division of Neurobiology and Behavior Research, University of Mississippi Medical Center, 2500 N. State Street, Jackson, MS 39216, USA
Drug Alcohol Depend 75:271-6. 2004..These results predict that atomoxetine, in contrast to methylphenidate but like desipramine, will lack reinforcing effects and abuse potential in humans... - Reinforcing effect of pseudoephedrine isomers and the mechanism of actionSunmee Wee
Department of Psychiatry and Pharmacology, University of Mississippi Medical Center, Jackson, MS 39216-4505, USA
Eur J Pharmacol 493:117-25. 2004..Therefore, pseudoephedrine isomers can function as reinforcers and the mechanism at dopamine transporters may underlie this effect. However, pseudoephedrine appears to be a weak reinforcer and may have relatively low abuse potential...