Sunmee Wee

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Self-vaccination by methamphetamine glycation products chemically links chronic drug abuse and cardiovascular disease
    Jennifer Treweek
    Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:11580-4. 2007
  2. pmc Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effects
    Sunmee Wee
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 37:1083-91. 2012
  3. pmc Effect of aripiprazole, a partial dopamine D2 receptor agonist, on increased rate of methamphetamine self-administration in rats with prolonged session duration
    Sunmee Wee
    Committee on Neurobiology of Addictive Disorder, The Scripps Research Institute, La Jolla, CA92037, USA
    Neuropsychopharmacology 32:2238-47. 2007
  4. pmc Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine
    Sunmee Wee
    Committee on the Neurobiology of Addictive Disorders SP30 2400, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 205:565-75. 2009
  5. pmc The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse
    Sunmee Wee
    Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 210:121-35. 2010
  6. pmc Alpha 1-noradrenergic system role in increased motivation for cocaine intake in rats with prolonged access
    Sunmee Wee
    Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Eur Neuropsychopharmacol 18:303-11. 2008
  7. pmc Effects of dose and session duration on cocaine self-administration in rats
    Sunmee Wee
    Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 320:1134-43. 2007
  8. pmc Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration
    Patrick Recinto
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA
    Neuropsychopharmacology 37:1275-87. 2012
  9. pmc Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 33:2474-82. 2008
  10. pmc The dopamine D3 receptor partial agonist CJB090 and antagonist PG01037 decrease progressive ratio responding for methamphetamine in rats with extended-access
    Laura Orio
    The Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Addict Biol 15:312-23. 2010

Collaborators

Detail Information

Publications24

  1. pmc Self-vaccination by methamphetamine glycation products chemically links chronic drug abuse and cardiovascular disease
    Jennifer Treweek
    Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:11580-4. 2007
    ....
  2. pmc Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effects
    Sunmee Wee
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 37:1083-91. 2012
    ..These data strongly suggest that our dAd5GNE vector-based vaccine may be effective in treating cocaine abuse and addiction...
  3. pmc Effect of aripiprazole, a partial dopamine D2 receptor agonist, on increased rate of methamphetamine self-administration in rats with prolonged session duration
    Sunmee Wee
    Committee on Neurobiology of Addictive Disorder, The Scripps Research Institute, La Jolla, CA92037, USA
    Neuropsychopharmacology 32:2238-47. 2007
    ..However, mechanisms other than downregulation of D(2) DA receptors in the nucleus accumbens and the striatum may be responsible for the increased sensitivity of the dopaminergic function in LgA rats...
  4. pmc Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine
    Sunmee Wee
    Committee on the Neurobiology of Addictive Disorders SP30 2400, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 205:565-75. 2009
    ..In the present study, we tested the hypothesis that increased cocaine self-administration with extended access was associated with increased activity of the kappa opioid system in rats...
  5. pmc The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse
    Sunmee Wee
    Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 210:121-35. 2010
    ....
  6. pmc Alpha 1-noradrenergic system role in increased motivation for cocaine intake in rats with prolonged access
    Sunmee Wee
    Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Eur Neuropsychopharmacol 18:303-11. 2008
    ..The data suggest that activation of the alpha 1-noradrenergic system, perhaps in the BNST, is associated with increased motivation for cocaine in rats with extended access...
  7. pmc Effects of dose and session duration on cocaine self-administration in rats
    Sunmee Wee
    Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 320:1134-43. 2007
    ..Therefore, high doses or prolonged access to cocaine are more likely to result in a pattern of cocaine intake that reflects compulsive use...
  8. pmc Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration
    Patrick Recinto
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA
    Neuropsychopharmacology 37:1275-87. 2012
    ....
  9. pmc Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 33:2474-82. 2008
    ....
  10. pmc The dopamine D3 receptor partial agonist CJB090 and antagonist PG01037 decrease progressive ratio responding for methamphetamine in rats with extended-access
    Laura Orio
    The Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Addict Biol 15:312-23. 2010
    ....
  11. pmc Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis
    Chitra D Mandyam
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Biol Psychiatry 64:958-65. 2008
    ..We examined how intravenous methamphetamine self-administration modulates active division, proliferation of late progenitors, differentiation, maturation, survival, and mature phenotype of hippocampal subgranular zone (SGZ) progenitors...
  12. pmc CRF(1) receptor antagonists attenuate escalated cocaine self-administration in rats
    Sheila E Specio
    The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 196:473-82. 2008
    ..However, the involvement of activation of CRF(1) receptors in rats self-administering cocaine with extended access is unknown...
  13. pmc A combination of buprenorphine and naltrexone blocks compulsive cocaine intake in rodents without producing dependence
    Sunmee Wee
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Sci Transl Med 4:146ra110. 2012
    ....
  14. ncbi request reprint Escalation of methamphetamine self-administration in rats: a dose-effect function
    Osamu Kitamura
    Molecular and Integrative Neurosciences Department, SP30 2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 186:48-53. 2006
    ..The transition from stable to escalated drug intake has been demonstrated in rats self-administrating cocaine and heroin using a single dose of drug...
  15. pmc Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction
    Marsida Kallupi
    School of Pharmacy, Pharmacology Unit, University of Camerino, Camerino, Italy Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California
    Biol Psychiatry 74:520-8. 2013
    ..Studies have demonstrated an enhanced dynorphin/kappa-opioid receptor (KOR) system following repeated cocaine exposure, but few reports have focused on neuroadaptations within the central amygdala (CeA)...
  16. pmc Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: alleviation by CRF₁ receptor antagonism
    Scott Edwards
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA
    Neuropharmacology 62:1142-51. 2012
    ..This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'...
  17. pmc Extended access cocaine self-administration differentially activates dorsal raphe and amygdala corticotropin-releasing factor systems in rats
    Eric P Zorrilla
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Addict Biol 17:300-8. 2012
    ..Increased availability of cocaine promotes greater tissue CRF levels in these extrahypothalamic brain regions, changes associated here with a model of cocaine dependence...
  18. pmc Methamphetamine self-administration and voluntary exercise have opposing effects on medial prefrontal cortex gliogenesis
    Chitra D Mandyam
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 27:11442-50. 2007
    ..The susceptibility of mPFC gliogenesis to even modest doses of methamphetamine could account for the pronounced pathology linked to psychostimulant abuse...
  19. pmc Extended access methamphetamine decreases immature neurons in the hippocampus which results from loss and altered development of neural progenitors without altered dynamics of the S-phase of the cell cycle
    Clara J Yuan
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA
    Pharmacol Biochem Behav 100:98-108. 2011
    ..These data suggest that altered hippocampal plasticity by methamphetamine could partially contribute to methamphetamine-induced impairments in hippocampal function...
  20. ncbi request reprint A reduced rate of in vivo dopamine transporter binding is associated with lower relative reinforcing efficacy of stimulants
    Sunmee Wee
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, 39216, USA
    Neuropsychopharmacology 31:351-62. 2006
    ..The data under both the PR and FR schedules, however, suggest that a slow onset at the DAT influence reinforcing effect only to a limited extent...
  21. ncbi request reprint Evaluation of the reinforcing effects of atomoxetine in monkeys: comparison to methylphenidate and desipramine
    Sunmee Wee
    Department of Psychiatry and Human Behavior, Division of Neurobiology and Behavior Research, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, USA
    Drug Alcohol Depend 75:271-6. 2004
    ..These results predict that atomoxetine, in contrast to methylphenidate but like desipramine, will lack reinforcing effects and abuse potential in humans...
  22. ncbi request reprint Role of the increased noradrenergic neurotransmission in drug self-administration
    Sunmee Wee
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 N State Street, Jackson, 39216 4505, USA
    Drug Alcohol Depend 82:151-7. 2006
    ..These results support the conclusion that CNS NE is not involved in the reinforcing mechanism of psychostimulants...
  23. ncbi request reprint Self-administration of mixtures of fenfluramine and amphetamine by rhesus monkeys
    Sunmee Wee
    Division of Neurobiology and Behavior Research, Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, United States
    Pharmacol Biochem Behav 84:337-43. 2006
    ..However, the involvement of 5-HT2 receptors in the interaction between the serotonergic system and the reinforcing efficacy still remains equivocal...
  24. ncbi request reprint Reinforcing effect of pseudoephedrine isomers and the mechanism of action
    Sunmee Wee
    Department of Psychiatry and Pharmacology, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Eur J Pharmacol 493:117-25. 2004
    ..Therefore, pseudoephedrine isomers can function as reinforcers and the mechanism at dopamine transporters may underlie this effect. However, pseudoephedrine appears to be a weak reinforcer and may have relatively low abuse potential...