Stephanie S Watowich

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc The erythropoietin receptor: molecular structure and hematopoietic signaling pathways
    Stephanie S Watowich
    Department of Immunology and Center for Inflammation and Cancer, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    J Investig Med 59:1067-72. 2011
  2. pmc Mechanisms regulating dendritic cell specification and development
    Stephanie S Watowich
    Department of Immunology and Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunol Rev 238:76-92. 2010
  3. pmc Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    Roza I Nurieva
    Department of Immunology, University of Texas MD Anderson Cancer Center and Graduate School of Biomedical Sciences, Houston, TX 77030, USA
    Immunity 29:138-49. 2008
  4. pmc Critical regulation of early Th17 cell differentiation by interleukin-1 signaling
    Yeonseok Chung
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 30:576-87. 2009
  5. pmc Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    Xuexian O Yang
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 29:44-56. 2008
  6. pmc CCR6 regulates the migration of inflammatory and regulatory T cells
    Tomohide Yamazaki
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 181:8391-401. 2008
  7. pmc STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction
    Hoainam Nguyen-Jackson
    Department of Immunology and Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Blood 115:3354-63. 2010
  8. pmc T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma
    Xuexian O Yang
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 28:29-39. 2008
  9. pmc STAT3 controls myeloid progenitor growth during emergency granulopoiesis
    Huiyuan Zhang
    Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 1903, USA
    Blood 116:2462-71. 2010
  10. ncbi request reprint Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
    Roza Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nature 448:480-3. 2007

Collaborators

Detail Information

Publications25

  1. pmc The erythropoietin receptor: molecular structure and hematopoietic signaling pathways
    Stephanie S Watowich
    Department of Immunology and Center for Inflammation and Cancer, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    J Investig Med 59:1067-72. 2011
    ..This review highlights the basic concepts of Epo signal transduction within the hematopoietic system, the major site of Epo action in vivo...
  2. pmc Mechanisms regulating dendritic cell specification and development
    Stephanie S Watowich
    Department of Immunology and Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunol Rev 238:76-92. 2010
    ..A critical question centers on how cytokines and lineage-restricted transcription factors operate molecularly to direct DC diversification. Here, we review recent findings that provide new insight into the DC developmental process...
  3. pmc Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    Roza I Nurieva
    Department of Immunology, University of Texas MD Anderson Cancer Center and Graduate School of Biomedical Sciences, Houston, TX 77030, USA
    Immunity 29:138-49. 2008
    ..This study thus demonstrates that Tfh is a distinct Th cell lineage...
  4. pmc Critical regulation of early Th17 cell differentiation by interleukin-1 signaling
    Yeonseok Chung
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 30:576-87. 2009
    ..Our data thus indicate a critical role of IL-1 in Th17 cell differentiation and this pathway may serve as a unique target for Th17 cell-mediated immunopathology...
  5. pmc Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    Xuexian O Yang
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 29:44-56. 2008
    ..STAT3 regulated Foxp3 downregulation, whereas STAT3, RORgamma, and ROR* were required for IL-17 expression in Treg cells. Our data demonstrate molecular antagonism and plasticity of Treg and Th17 cell programs...
  6. pmc CCR6 regulates the migration of inflammatory and regulatory T cells
    Tomohide Yamazaki
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 181:8391-401. 2008
    ..Similarly, CCR6 on Treg cells is also important for their recruitment into inflammatory tissues. Our data indicate an important role of CCR6 in Treg and Th17 cell migration...
  7. pmc STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction
    Hoainam Nguyen-Jackson
    Department of Immunology and Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Blood 115:3354-63. 2010
    ..Taken together, our study demonstrates that STAT3 regulates multiple aspects of chemokine and chemokine receptor expression and function within the bone marrow, indicating a central role in the neutrophil mobilization response...
  8. pmc T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma
    Xuexian O Yang
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 28:29-39. 2008
    ..Therefore, Th17 differentiation is directed by two lineage-specific nuclear receptors, ROR alpha and ROR gamma...
  9. pmc STAT3 controls myeloid progenitor growth during emergency granulopoiesis
    Huiyuan Zhang
    Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 1903, USA
    Blood 116:2462-71. 2010
    ..These results place STAT3 as an essential mediator of emergency granulopoiesis by its regulation of transcription factors that direct G-CSF-responsive myeloid progenitor expansion...
  10. ncbi request reprint Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
    Roza Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nature 448:480-3. 2007
    ..IL-21 is therefore an autocrine cytokine that is sufficient and necessary for T(H)17 differentiation, and serves as a target for treating inflammatory diseases...
  11. pmc Cell-intrinsic role for IFN-α-STAT1 signals in regulating murine Peyer patch plasmacytoid dendritic cells and conditioning an inflammatory response
    Haiyan S Li
    Department of Immunology and Center for Inflammation and Cancer, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Blood 118:3879-89. 2011
    ....
  12. pmc The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development
    Haiyan S Li
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Blood 120:4363-73. 2012
    ..Consistently, STAT3 stimulates Flt3L-responsive expression of the pDC regulator Tcf4 (E2-2). These data suggest that STATs contribute to DC development by controlling transcription factors involved in lineage differentiation...
  13. pmc Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and 'emergency' hematopoiesis
    Athanasia D Panopoulos
    Department of Immunology and Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, PO Box 301402, Unit 902, Houston, TX 77030, USA
    Cytokine 42:277-88. 2008
    ..Understanding the molecular control of granulopoiesis will aid in the development of new approaches designed to treat disorders of neutrophil production and function...
  14. doi request reprint The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation
    Xuexian O Yang
    Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 14:732-40. 2013
    ..STAT5 and STAT6 regulated IL-9 expression by directly binding to the Il9 promoter. Our data thus demonstrate a critical role for CIS in controlling the proallergic generation of helper T cells...
  15. pmc G-CSF-activated STAT3 enhances production of the chemokine MIP-2 in bone marrow neutrophils
    Hoainam T Nguyen-Jackson
    Department of Immunology and Center for Inflammation and Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    J Leukoc Biol 92:1215-25. 2012
    ..These results suggest that the G-CSF-STAT3 pathway directly regulates transcriptional events that induce neutrophil mobilization...
  16. pmc The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8
    Eiji Esashi
    Department of Immunology and Center for Cancer Immunology Research, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 28:509-20. 2008
    ..Our results therefore show that GM-CSF controls the production of pDCs by employing STAT5 to suppress IRF8 and the pDC transcriptional network in lin- Flt3+ progenitors...
  17. pmc A STATus report on DC development
    Haiyan S Li
    Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Leukoc Biol 92:445-59. 2012
    ....
  18. pmc miR-22 controls Irf8 mRNA abundance and murine dendritic cell development
    Haiyan S Li
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    PLoS ONE 7:e52341. 2012
    ..Collectively, these results suggest that miR-22 targets Irf8 mRNA for posttranscriptional repression and controls DC subset differentiation...
  19. pmc Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia
    Benjamin T Kile
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Blood 110:2371-80. 2007
    ..These studies establish an essential requirement for Wdr1 in megakaryocytes and neutrophils, indicating that cofilin-mediated actin dynamics are critically important to the development and function of both cell types...
  20. pmc STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function
    Roza I Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 287:11234-9. 2012
    ..Taken together, this study demonstrates that STAT5 controls Tfh differentiation...
  21. ncbi request reprint STAT3 regulates cytokine-mediated generation of inflammatory helper T cells
    Xuexian O Yang
    Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 282:9358-63. 2007
    ..Our data thus demonstrate a pathway whereby cytokines regulate THi differentiation through a selective STAT transcription factor that functions to regulate lineage-specific gene expression...
  22. pmc IL-6 signaling via the STAT3/SOCS3 pathway: functional analysis of the conserved STAT3 N-domain
    Ling Zhang
    Department of Immunology, The University of Texas MD Anderson Cancer Center, P O Box 301402, Unit 902, Houston, Texas, 77030 1903, USA
    Mol Cell Biochem 288:179-89. 2006
    ..We propose that the Socs3 gene in its chromosomal context is activated by the IL-6/STAT3 pathway independent of STAT3 N-domain sequences...
  23. doi request reprint BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice
    Chengwen Liu
    Departments of Melanoma Medical Oncology and Immunology, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 19:393-403. 2013
    ..In this study, we test the hypothesis that BRAF inhibition in combination with adoptive T-cell transfer (ACT) will be more effective at inducing long-term clinical regressions of BRAF-mutant tumors...
  24. pmc STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils
    Athanasia D Panopoulos
    Department of Immunology, The University of Texas M D Anderson Cancer Center, PO Box 301402, Unit 902, Houston, TX 77030 1903, USA
    Blood 108:3682-90. 2006
    ..Our results demonstrate the existence of distinct STAT3 target pathways in neutrophils required for granulopoiesis and innate immunity...
  25. pmc Control of myeloid-specific integrin alpha Mbeta 2 (CD11b/CD18) expression by cytokines is regulated by Stat3-dependent activation of PU.1
    Athanasia D Panopoulos
    Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 277:19001-7. 2002
    ..These data also demonstrate a link between Stat3 and PU.1, suggesting that Stat3 may play an instructive role in hematopoiesis...