Clare M Waterman-Storer

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin
    Stephanie L Gupton
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 168:619-31. 2005
  2. pmc Regulation of leading edge microtubule and actin dynamics downstream of Rac1
    Torsten Wittmann
    Department of Cell Biology and Institute for Childhood and Neglected Diseases, La Jolla, CA 92037, USA
    J Cell Biol 161:845-51. 2003
  3. pmc Dual-wavelength fluorescent speckle microscopy reveals coupling of microtubule and actin movements in migrating cells
    Wendy C Salmon
    Department of Cell Biology and Institute for Childhood and Neglected Diseases, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 158:31-7. 2002
  4. ncbi request reprint New directions for fluorescent speckle microscopy
    Clare M Waterman-Storer
    Department of Cell Biology and Institute for Childhood and Neglected Diseases, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Biol 12:R633-40. 2002
  5. pmc Feedback interactions between cell-cell adherens junctions and cytoskeletal dynamics in newt lung epithelial cells
    C M Waterman-Storer
    Department of Cell Biology and Institute for Childhood and Neglected Diseases, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Biol Cell 11:2471-83. 2000
  6. ncbi request reprint Decreased polarity and increased random motility in PtK1 epithelial cells correlate with inhibition of endosomal recycling
    Natalie L Prigozhina
    The Burnham Institute, La Jolla, CA 92037, USA
    J Cell Sci 119:3571-82. 2006
  7. pmc Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells
    Torsten Wittmann
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 169:929-39. 2005
  8. ncbi request reprint A high-speed multispectral spinning-disk confocal microscope system for fluorescent speckle microscopy of living cells
    Michael C Adams
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA
    Methods 29:29-41. 2003
  9. ncbi request reprint Differential transmission of actin motion within focal adhesions
    Ke Hu
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Science 315:111-5. 2007
  10. ncbi request reprint Converging populations of f-actin promote breakage of associated microtubules to spatially regulate microtubule turnover in migrating cells
    Stephanie L Gupton
    Department of Cell Biology and Institute for Childhood and Neglected Diseases, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Biol 12:1891-9. 2002

Research Grants

  1. ASCB Summer Meeting: Coordinating the Events of Directed
    Clare Waterman Storer; Fiscal Year: 2005
  2. Quantitative Fluorescent Speckle Microscopy
    Clare Waterman; Fiscal Year: 2006
  3. MICROTUBULE/ACTIN INTERACTIONS IN CELL MOTILITY
    Clare Waterman; Fiscal Year: 2004
  4. Quantitative Fluorescent Speckle Microscopy
    Clare Waterman Storer; Fiscal Year: 2003
  5. MICROTUBULE/ACTIN INTERACTIONS IN CELL MOTILITY
    Sandra Schmid; Fiscal Year: 2007

Collaborators

Detail Information

Publications22

  1. pmc Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin
    Stephanie L Gupton
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 168:619-31. 2005
    ..Inhibition of endogenous long TM isoforms alters protrusion persistence. Thus, cells can migrate with inhibited lamellipodia, and we suggest that TM is a major regulator of F-actin functional specialization in migrating cells...
  2. pmc Regulation of leading edge microtubule and actin dynamics downstream of Rac1
    Torsten Wittmann
    Department of Cell Biology and Institute for Childhood and Neglected Diseases, La Jolla, CA 92037, USA
    J Cell Biol 161:845-51. 2003
    ..In addition, Rac1(Q61L) promoted lamellipodial actin polymerization and Pak-dependent retrograde flow. Together, these results indicate coordinated regulation of the two cytoskeletal systems in the leading edge of migrating cells...
  3. pmc Dual-wavelength fluorescent speckle microscopy reveals coupling of microtubule and actin movements in migrating cells
    Wendy C Salmon
    Department of Cell Biology and Institute for Childhood and Neglected Diseases, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 158:31-7. 2002
    ..These results show that the movement and organization of f-actin has a profound effect on the dynamic organization of MTs in migrating cells, and suggest that MTs and f-actin bind to one another in vivo...
  4. ncbi request reprint New directions for fluorescent speckle microscopy
    Clare M Waterman-Storer
    Department of Cell Biology and Institute for Childhood and Neglected Diseases, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Biol 12:R633-40. 2002
    ..Here, we review the most recent applications and developments and give a glimpse of future directions and potentials of FSM...
  5. pmc Feedback interactions between cell-cell adherens junctions and cytoskeletal dynamics in newt lung epithelial cells
    C M Waterman-Storer
    Department of Cell Biology and Institute for Childhood and Neglected Diseases, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Biol Cell 11:2471-83. 2000
    ..These results indicate that a MT plus end capping protein is regulated by cell-cell contact, and in turn, that MT growth regulates the maintenance of adherens junctions contacts in epithelia...
  6. ncbi request reprint Decreased polarity and increased random motility in PtK1 epithelial cells correlate with inhibition of endosomal recycling
    Natalie L Prigozhina
    The Burnham Institute, La Jolla, CA 92037, USA
    J Cell Sci 119:3571-82. 2006
    ..We have also tested the effects of other Rab proteins, implicated in endocytic recycling, and discovered a clear correlation between the degree of recycling inhibition and the increase in non-directional cell motility...
  7. pmc Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells
    Torsten Wittmann
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 169:929-39. 2005
    ....
  8. ncbi request reprint A high-speed multispectral spinning-disk confocal microscope system for fluorescent speckle microscopy of living cells
    Michael C Adams
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA
    Methods 29:29-41. 2003
    ..We present recent applications of this system for imaging the cytoskeleton in migrating tissue cells and neurons...
  9. ncbi request reprint Differential transmission of actin motion within focal adhesions
    Ke Hu
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Science 315:111-5. 2007
    ....
  10. ncbi request reprint Converging populations of f-actin promote breakage of associated microtubules to spatially regulate microtubule turnover in migrating cells
    Stephanie L Gupton
    Department of Cell Biology and Institute for Childhood and Neglected Diseases, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Biol 12:1891-9. 2002
    ..Here, we test the hypothesis that MT polymer loss occurs in central cell regions and is induced by the convergence of actin retrograde and anterograde flow, which buckles and breaks associated MTs and promotes minus-end depolymerization...
  11. ncbi request reprint Spatiotemporal feedback between actomyosin and focal-adhesion systems optimizes rapid cell migration
    Stephanie L Gupton
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 125:1361-74. 2006
    ..Thus, the interplay between actomyosin and FA dynamics results in a specific balance between adhesion and contraction, which induces maximal migration velocity...
  12. pmc A dynamic actin cytoskeleton functions at multiple stages of clathrin-mediated endocytosis
    Defne Yarar
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 16:964-75. 2005
    ..Our results demonstrate a key role for actin during clathrin-mediated endocytosis in mammalian cells...
  13. ncbi request reprint Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1
    Torsten Wittmann
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 279:6196-203. 2004
    ..However, in vivo, Pak1 activity alone is not sufficient to phosphorylate Op18, indicating that additional pathways downstream of Rac1 are required for Op18 regulation...
  14. pmc Modulation of Rac localization and function by dynamin
    Gunther Schlunck
    Division of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Biol Cell 15:256-67. 2004
    ..These data suggest an indispensable role of dynamin in Rac trafficking to allow for lamellipodia formation and cell spreading...
  15. ncbi request reprint SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis
    Defne Yarar
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Dev Cell 13:43-56. 2007
    ..These results suggest a mechanism for the spatial and temporal regulation of N-WASP-dependent actin assembly and implicate SNX9 in directly coupling actin dynamics to membrane remodeling during multiple modes of endocytosis...
  16. ncbi request reprint mDia2 regulates actin and focal adhesion dynamics and organization in the lamella for efficient epithelial cell migration
    Stephanie L Gupton
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Sci 120:3475-87. 2007
    ....
  17. pmc Integrin-dependent actomyosin contraction regulates epithelial cell scattering
    Johan de Rooij
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 171:153-64. 2005
    ..We conclude that integrin-dependent actomyosin traction force mediates the disruption of cell-cell adhesion during epithelial cell scattering...
  18. pmc Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1
    Katsuhiro Kita
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 17:2331-45. 2006
    ....
  19. ncbi request reprint Conserved microtubule-actin interactions in cell movement and morphogenesis
    Olga C Rodriguez
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Nat Cell Biol 5:599-609. 2003
    ..These interactions comprise at least three conserved 'mechanochemical activity modules' that perform similar roles in these diverse cell functions...
  20. ncbi request reprint Quantitative fluorescent speckle microscopy: where it came from and where it is going
    G Danuser
    BioMicroMetrics Group, Laboratory for Biomechanics, ETH Zurich, 8952 Schlieren, Switzerland
    J Microsc 211:191-207. 2003
    ..Biol., 12, R633-R640), in which we emphasized the use of FSM in cell biological applications. Here, we focus on the technical aspects of making FSM a quantitative method...
  21. ncbi request reprint Quantitative fluorescent speckle microscopy of cytoskeleton dynamics
    Gaudenz Danuser
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Annu Rev Biophys Biomol Struct 35:361-87. 2006
    ....
  22. ncbi request reprint Protein kinase D-mediated anterograde membrane trafficking is required for fibroblast motility
    Natalie L Prigozhina
    Department Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, CB163, La Jolla, CA 92037, USA
    Curr Biol 14:88-98. 2004
    ..However, the intracellular source of these PM components and whether their continuous retrograde flow is required for cell motility is unknown...

Research Grants14

  1. ASCB Summer Meeting: Coordinating the Events of Directed
    Clare Waterman Storer; Fiscal Year: 2005
    ..A more thorough understanding of the processes involved will impact on multiple health-related issues, such as cancer treatment, wound recovery, and anti-inflammatory therapy. ..
  2. Quantitative Fluorescent Speckle Microscopy
    Clare Waterman; Fiscal Year: 2006
    ..These advances will allow FSM to become a powerful tool for studying molecular dynamics in cell biology, neurobiology, biotechnology, and material science. ..
  3. MICROTUBULE/ACTIN INTERACTIONS IN CELL MOTILITY
    Clare Waterman; Fiscal Year: 2004
    ..The results of these studies will greatly enhance our understanding of the mechanisms and mechanics of cell locomotion and will provide new methods for analyzing protein dynamics in living cells. ..
  4. Quantitative Fluorescent Speckle Microscopy
    Clare Waterman Storer; Fiscal Year: 2003
    ..These advances will allow FSM to become a powerful tool for studying molecular dynamics in cell biology, neurobiology, biotechnology, and material science. ..
  5. MICROTUBULE/ACTIN INTERACTIONS IN CELL MOTILITY
    Sandra Schmid; Fiscal Year: 2007
    ..abstract_text> ..