Andrew Ward

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Nucleotide dependent packing differences in helical crystals of the ABC transporter MsbA
    Andrew Ward
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, CB227, La Jolla, CA 92037, USA
    J Struct Biol 165:169-75. 2009
  2. ncbi request reprint Windex: a toolset for indexing helices
    Andrew Ward
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Struct Biol 144:172-83. 2003
  3. ncbi request reprint The structures of MsbA: Insight into ABC transporter-mediated multidrug efflux
    Christopher L Reyes
    Department of Molecular Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, CB105, La Jolla, CA 92137, USA
    FEBS Lett 580:1042-8. 2006
  4. pmc Flexibility in the ABC transporter MsbA: Alternating access with a twist
    Andrew Ward
    Departments of Cell Biology and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, CB 105, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:19005-10. 2007
  5. doi request reprint Insights into the trimeric HIV-1 envelope glycoprotein structure
    Andrew B Ward
    Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA International AIDS Vaccine Initiative Neutralizing Antibody Center and Center for HIV AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA Electronic address
    Trends Biochem Sci 40:101-7. 2015
  6. pmc Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits
    Anila Yasmeen
    Department of Microbiology and Immunology, Weill Cornell Medical College, Cornell University, New York, USA
    Retrovirology 11:41. 2014
  7. pmc Stable 293 T and CHO cell lines expressing cleaved, stable HIV-1 envelope glycoprotein trimers for structural and vaccine studies
    Nancy P Y Chung
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA
    Retrovirology 11:33. 2014
  8. pmc Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans
    Jean Philippe Julien
    Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA
    PLoS Pathog 9:e1003342. 2013
  9. pmc Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding
    Stephen G Aller
    Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, CB105, La Jolla, CA 92037, USA
    Science 323:1718-22. 2009
  10. pmc A helical processing pipeline for EM structure determination of membrane proteins
    Lauren S Fisher
    The National Resource for Automated Molecular Microscopy, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Methods 55:350-62. 2011

Collaborators

  • Qinghai Zhang
  • Veli Pekka Jaakola
  • Nigel Unwin
  • Anila Yasmeen
  • Rogier W Sanders
  • Ian A Wilson
  • John P Moore
  • Albert Cupo
  • Jean Philippe Julien
  • Nancy P Y Chung
  • Per Johan Klasse
  • Dennis R Burton
  • Andre J Marozsan
  • Lauren S Fisher
  • Stephen G Aller
  • Jodie Yu
  • Geoffrey Chang
  • Christopher L Reyes
  • Rajesh Ringe
  • Helen J Kim
  • Ronald Derking
  • Michael Golabek
  • Katie Matthews
  • Kevin de Los Reyes
  • Thomas J Ketas
  • Jacob Korzun
  • Alejandra Ramos
  • Robyn L Stanfield
  • Laura M Walker
  • Rafael S Depetris
  • Pascal Poignard
  • Katie J Doores
  • Reza Khayat
  • Jeong Hyun Lee
  • Devan C Diwanji
  • Umesh Katpally
  • Devin Sok
  • Robert Pejchal
  • Ryan McBride
  • James C Paulson
  • Clinton S Potter
  • Ronald A Milligan
  • Bridget Carragher
  • Ina L Urbatsch
  • Yue Weng
  • Srinivas Chittaboina
  • Yenphuong T Trinh
  • Patina M Harrell
  • Rupeng Zhuo

Detail Information

Publications11

  1. pmc Nucleotide dependent packing differences in helical crystals of the ABC transporter MsbA
    Andrew Ward
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, CB227, La Jolla, CA 92037, USA
    J Struct Biol 165:169-75. 2009
    ..This suggests that while there are likely structural differences between the nucleotide transition states, membrane embedded MsbA remains in an outward facing conformation while nucleotide is bound...
  2. ncbi request reprint Windex: a toolset for indexing helices
    Andrew Ward
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Struct Biol 144:172-83. 2003
    ..The new procedures have been tested using a number of helical specimens, including TMV, acto-myosin, decorated microtubules, and a variety of helical tubes of a bacterial membrane protein...
  3. ncbi request reprint The structures of MsbA: Insight into ABC transporter-mediated multidrug efflux
    Christopher L Reyes
    Department of Molecular Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, CB105, La Jolla, CA 92137, USA
    FEBS Lett 580:1042-8. 2006
    ..In this review, we examine recent structural and functional analysis of the ABC transporter MsbA and implications on the mechanism of multidrug efflux...
  4. pmc Flexibility in the ABC transporter MsbA: Alternating access with a twist
    Andrew Ward
    Departments of Cell Biology and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, CB 105, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:19005-10. 2007
    ..Altogether, the conformational changes between these structures suggest that large ranges of motion may be required for substrate transport...
  5. doi request reprint Insights into the trimeric HIV-1 envelope glycoprotein structure
    Andrew B Ward
    Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA International AIDS Vaccine Initiative Neutralizing Antibody Center and Center for HIV AIDS Vaccine Immunology and Immunogen Discovery, Scripps Research Institute, La Jolla, CA 92037, USA Electronic address
    Trends Biochem Sci 40:101-7. 2015
    ..We describe our current knowledge of the Env trimer structure in the context of exciting recent developments in the identification and characterization of HIV broadly neutralizing antibodies. ..
  6. pmc Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits
    Anila Yasmeen
    Department of Microbiology and Immunology, Weill Cornell Medical College, Cornell University, New York, USA
    Retrovirology 11:41. 2014
    ..By introducing stabilizing mutations (SOSIP), we constructed soluble, cleaved Env trimers derived from the HIV-1 subtype A isolate BG505 that resemble native Env spikes on virions both structurally and antigenically...
  7. pmc Stable 293 T and CHO cell lines expressing cleaved, stable HIV-1 envelope glycoprotein trimers for structural and vaccine studies
    Nancy P Y Chung
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA
    Retrovirology 11:33. 2014
    ..Making cell lines that produce BG505 SOSIP.664 trimers requires the co-expression of the Furin protease to ensure that the cleavage site between the gp120 and gp41 subunits is fully utilized...
  8. pmc Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans
    Jean Philippe Julien
    Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA
    PLoS Pathog 9:e1003342. 2013
    ....
  9. pmc Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding
    Stephen G Aller
    Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, CB105, La Jolla, CA 92037, USA
    Science 323:1718-22. 2009
    ..The inward-facing conformation represents an initial stage of the transport cycle that is competent for drug binding...
  10. pmc A helical processing pipeline for EM structure determination of membrane proteins
    Lauren S Fisher
    The National Resource for Automated Molecular Microscopy, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Methods 55:350-62. 2011
    ..We describe here the integration of standard Fourier-Bessel helical analysis techniques into Appion, an integrated, database-driven pipeline...
  11. ncbi request reprint Designing facial amphiphiles for the stabilization of integral membrane proteins
    Qinghai Zhang
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 46:7023-5. 2007