Wei Lien Wang

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. doi request reprint Expression of ERG, an Ets family transcription factor, identifies ERG-rearranged Ewing sarcoma
    Wei Lien Wang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 25:1378-83. 2012
  2. pmc Efficacy of first-line doxorubicin and ifosfamide in myxoid liposarcoma
    Daniela Katz
    Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Clin Sarcoma Res 2:2. 2012
  3. doi request reprint Sarcoma metastases to the skin: a clinicopathologic study of 65 patients
    Wei Lien Wang
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 118:2900-4. 2012
  4. doi request reprint MUC4 is a sensitive and extremely useful marker for sclerosing epithelioid fibrosarcoma: association with FUS gene rearrangement
    Leona A Doyle
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 36:1444-51. 2012
  5. doi request reprint Fluorescence in situ hybridization is a useful ancillary diagnostic tool for extraskeletal myxoid chondrosarcoma
    Wei Lien Wang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 21:1303-10. 2008
  6. pmc The role of chemotherapy in advanced solitary fibrous tumors: a retrospective analysis
    Min S Park
    Department of Sarcoma Medical Oncology Unit 0450, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Clin Sarcoma Res 3:7. 2013
  7. doi request reprint Dermatofibrosarcoma protuberans with unusual sarcomatous transformation: a series of 4 cases with molecular confirmation
    Michael G Swaby
    Department of Pathology, The University of Texas Medical School, Houston, TX, USA
    Am J Dermatopathol 33:354-60. 2011
  8. doi request reprint Ambiguous melanocytic tumors in a tertiary referral center: the contribution of fluorescence in situ hybridization (FISH) to conventional histopathologic and immunophenotypic analyses
    Michael T Tetzlaff
    Department of Pathology, Section of Dermatopathology Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
    Am J Surg Pathol 37:1783-96. 2013
  9. doi request reprint Treatment of tenosynovial giant cell tumor and pigmented villonodular synovitis
    Vinod Ravi
    Department of Sarcoma Medical Oncology, UT MD Anderson Cancer Center, Houston, Texas 77030, USA
    Curr Opin Oncol 23:361-6. 2011
  10. doi request reprint Pleomorphic fibroma and dermal atypical lipomatous tumor: are they related?
    Tariq Al-Zaid
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    J Cutan Pathol 40:379-84. 2013

Collaborators

Detail Information

Publications38

  1. doi request reprint Expression of ERG, an Ets family transcription factor, identifies ERG-rearranged Ewing sarcoma
    Wei Lien Wang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 25:1378-83. 2012
    ..In contrast, FLI1 was not specific to rearrangement type, likely because of cross reactivity with the highly homologous Ets DNA-binding domain present in the C-terminus of both ERG and FLI1...
  2. pmc Efficacy of first-line doxorubicin and ifosfamide in myxoid liposarcoma
    Daniela Katz
    Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Clin Sarcoma Res 2:2. 2012
    ..abstract:..
  3. doi request reprint Sarcoma metastases to the skin: a clinicopathologic study of 65 patients
    Wei Lien Wang
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 118:2900-4. 2012
    ..The authors of this report examined the distribution and clinical significance of cutaneous and superficial subcutaneous sarcoma metastases...
  4. doi request reprint MUC4 is a sensitive and extremely useful marker for sclerosing epithelioid fibrosarcoma: association with FUS gene rearrangement
    Leona A Doyle
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 36:1444-51. 2012
    ..SEF without MUC4 expression may represent a distinct group of tumors. MUC4 expression correlates with glandular epithelial differentiation in biphasic synovial sarcoma and is very limited in other epithelioid soft tissue tumors...
  5. doi request reprint Fluorescence in situ hybridization is a useful ancillary diagnostic tool for extraskeletal myxoid chondrosarcoma
    Wei Lien Wang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 21:1303-10. 2008
    ..Fluorescence in situ hybridization is useful to support the diagnosis of extraskeletal myxoid chondrosarcomas and may help to differentiate it from mimics such as other myxoid sarcomas, particularly in limited biopsies...
  6. pmc The role of chemotherapy in advanced solitary fibrous tumors: a retrospective analysis
    Min S Park
    Department of Sarcoma Medical Oncology Unit 0450, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Clin Sarcoma Res 3:7. 2013
    ..We thus sought to estimate the efficacy of conventional chemotherapy for SFTs by reviewing data on tumor response to therapy and progression-free survival from SFT patients who received this therapy...
  7. doi request reprint Dermatofibrosarcoma protuberans with unusual sarcomatous transformation: a series of 4 cases with molecular confirmation
    Michael G Swaby
    Department of Pathology, The University of Texas Medical School, Houston, TX, USA
    Am J Dermatopathol 33:354-60. 2011
    ..Ancillary diagnostic testing may be helpful to confirm the diagnosis, especially in small biopsies...
  8. doi request reprint Ambiguous melanocytic tumors in a tertiary referral center: the contribution of fluorescence in situ hybridization (FISH) to conventional histopathologic and immunophenotypic analyses
    Michael T Tetzlaff
    Department of Pathology, Section of Dermatopathology Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
    Am J Surg Pathol 37:1783-96. 2013
    ..In contrast, a positive FISH test should be carefully interrogated in the context of the complete histopathologic findings. ..
  9. doi request reprint Treatment of tenosynovial giant cell tumor and pigmented villonodular synovitis
    Vinod Ravi
    Department of Sarcoma Medical Oncology, UT MD Anderson Cancer Center, Houston, Texas 77030, USA
    Curr Opin Oncol 23:361-6. 2011
    ..To review recent developments in the molecular pathogenesis of tenosynovial giant cell tumor (TGCT) or pigmented villonodular synovitis (PVNS) and its therapeutic implications...
  10. doi request reprint Pleomorphic fibroma and dermal atypical lipomatous tumor: are they related?
    Tariq Al-Zaid
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    J Cutan Pathol 40:379-84. 2013
    ..Therefore, these two entities are best regarded as pathogenetically distinct. MDM2 immunohistochemistry or fluorescence in situ hybridization studies can be used to differentiate between the two if needed...
  11. doi request reprint Osseous myxochondroid sarcoma: a detailed study of 5 cases of extraskeletal myxoid chondrosarcoma of the bone
    Elizabeth G Demicco
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg Pathol 37:752-62. 2013
    ..We propose to classify tumors with the appropriate phenotype and molecularly confirmed NR4A3/EWSR1 rearrangements as myxochondroid sarcoma, either osseous or extraskeletal variants...
  12. doi request reprint Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model
    Elizabeth G Demicco
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 25:1298-306. 2012
    ....
  13. doi request reprint Validation of potential therapeutic targets in alveolar soft part sarcoma: an immunohistochemical study utilizing tissue microarray
    Alexander J Lazar
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Sarcoma Research Center, Houston, TX 77030 4009, USA
    Histopathology 55:750-5. 2009
    ..The aim of this study was to evaluate the expression of potential molecular therapeutic targets in a cohort of ASPS tumour samples...
  14. doi request reprint The expression of c-Met pathway components in unclassified pleomorphic sarcoma/malignant fibrous histiocytoma (UPS/MFH): a tissue microarray study
    Guy Lahat
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Histopathology 59:556-61. 2011
    ..The aim was to evaluate expression of c-Met pathway components in a large cohort of UPS/MFH samples...
  15. doi request reprint COL1A1:PDGFB chimeric transcripts are not present in indeterminate fibrohistiocytic lesions of the skin
    Wei Lien Wang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
    Am J Dermatopathol 32:149-53. 2010
    ..Although indeterminate fibrohistiocytic lesions share some features with DFSP, the lack of COL1A1-PDGFB chimeric transcripts suggests that they are distinct entities...
  16. doi request reprint Immunodetection of phosphohistone H3 as a surrogate of mitotic figure count and clinical outcome in cutaneous melanoma
    Michael T Tetzlaff
    Department of Pathology, Section of Dermatopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77005, USA
    Mod Pathol 26:1153-60. 2013
    ....
  17. pmc Extensive adipocytic maturation can be seen in myxoid liposarcomas treated with neoadjuvant doxorubicin and ifosfamide and pre-operative radiation therapy
    Wei Lien Wang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, Houston, TX, 77030, USA
    Clin Sarcoma Res 2:25. 2012
    ..We examined the histological changes, including adipocytic maturation, associated with this treatment in patients with myxoid liposarcoma and evaluated for prognostic significance...
  18. doi request reprint CTNNB1 genotyping and APC screening in pediatric desmoid tumors: a proposed algorithm
    Wei Lien Wang
    Department of Pathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 085, Houston, TX 77030, USA
    Pediatr Dev Pathol 15:361-7. 2012
    ..Given the implications, genetic counseling is recommended for children diagnosed with desmoid tumors lacking CTNNB1 mutations because this population is enriched for FAP patients...
  19. doi request reprint Trichilemmomas show loss of PTEN in Cowden syndrome but only rarely in sporadic tumors
    Tariq Al-Zaid
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Cutan Pathol 39:493-9. 2012
    ..31), a tumor suppressor gene. We sought to identify PTEN loss by immunohistochemistry (IHC) in sporadic and CS-associated TL to determine whether IHC is a useful tool to assess an individual for CS...
  20. doi request reprint Correlation between KIT expression and KIT mutation in melanoma: a study of 173 cases with emphasis on the acral-lentiginous/mucosal type
    Carlos A Torres-Cabala
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Mod Pathol 22:1446-56. 2009
    ....
  21. doi request reprint FUS rearrangements are rare in 'pure' sclerosing epithelioid fibrosarcoma
    Wei Lien Wang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 25:846-53. 2012
    ....
  22. doi request reprint Cutaneous and subcutaneous metastases of gastrointestinal stromal tumors: a series of 5 cases with molecular analysis
    Wei Lien Wang
    Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Am J Dermatopathol 31:297-300. 2009
    ..Cutaneous metastases seem to be a late complication of GIST, but their presence does not necessarily herald a rapid demise of the patient...
  23. doi request reprint Epithelioid inflammatory myofibroblastic sarcoma: An aggressive intra-abdominal variant of inflammatory myofibroblastic tumor with nuclear membrane or perinuclear ALK
    Adrian Mariño-Enríquez
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 35:135-44. 2011
    ..We propose the designation "epithelioid inflammatory myofibroblastic sarcoma" to convey both the malignant behavior of these tumors and their close relationship with IMT...
  24. doi request reprint Syringocystadenocarcinoma papilliferum with transition to areas of squamous differentiation: a case report and review of the literature
    Yu Helen Zhang
    Department of Pathology, Temple University Hospital, Philadelphia, PA, USA
    Am J Dermatopathol 34:428-33. 2012
    ..Tumor cells were reactive for both cytokeratins 5/6 and 7. This case represents SCACP arising from syringocystadenoma papilliferum in the upper arm, with distinct transition to areas of squamous differentiation...
  25. doi request reprint Cutaneous digital papillary adenocarcinoma: a clinicopathologic study of 31 cases of a rare neoplasm with new observations
    Ravi Suchak
    St John s Institute of Dermatology, St Thomas Hospital, London SE17EH, UK
    Am J Surg Pathol 36:1883-91. 2012
    ..Delayed occurrence of metastases and a protracted course despite metastatic disease, necessitates long-term follow-up. As the name implies a malignant neoplasm, the rubric "aggressive" is unnecessary...
  26. doi request reprint Detection of myxoid liposarcoma-associated FUS-DDIT3 rearrangement variants including a newly identified breakpoint using an optimized RT-PCR assay
    Martin P Powers
    Division of Molecular Pathology, Department of Pathology, Baylor College of Medicine and Texas Children s Hospital, Houston, TX 77030, USA
    Mod Pathol 23:1307-15. 2010
    ..In addition to the common fusions, our assay also identified a novel FUS-DDIT3 fusion between exon 9 of FUS and exon 3 of DDIT3 in one of the cases...
  27. doi request reprint Cutaneous epithelioid angiomatous nodule of the chest wall with expression of estrogen receptor: a mimic of carcinoma and a potential diagnostic pitfall
    Michael S McLemore
    Division of Pathology and Laboratory Medicine, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    J Cutan Pathol 38:818-22. 2011
    ..This is the most comprehensive immunohistochemical profile reported for CEAN to date and the first time that ER expression has been described...
  28. doi request reprint Mechanisms of resistance to imatinib and sunitinib in gastrointestinal stromal tumor
    Wei Lien Wang
    Departments of Pathology, The University of Texas, M D Anderson Cancer Center, Houston, TX, USA
    Cancer Chemother Pharmacol 67:S15-24. 2011
    ..In this review, we describe the biology of the genes and gene mutations responsible for GIST and discuss known and potential clinical implications...
  29. pmc Involvement of the PI3K/Akt pathway in myxoid/round cell liposarcoma
    Elizabeth G Demicco
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Mod Pathol 25:212-21. 2012
    ..The PI3K/Akt pathway may therefore provide a therapeutic target in round cell liposarcoma...
  30. doi request reprint Retroperitoneal undifferentiated pleomorphic sarcoma having microsatellite instability associated with Muir-Torre syndrome: case report and review of literature
    Nathan Lee
    Department of Pathology, Methodist Hospital, Houston, TX, USA
    J Cutan Pathol 40:730-3. 2013
    ..This is a rare case of a patient with Muir-Torre syndrome who developed a related high-grade undifferentiated pleomorphic sarcoma as the associated internal malignancy...
  31. ncbi request reprint Enchondroma with secondary aneurysmal bone cyst
    Justin E Bird
    The University of Texas Health Science Center, 6410 Fannin St, Suite 1535, Houston, TX 77030, USA
    Skeletal Radiol 41:1475-8. 2012
    ..The case illustrates a unique presentation of an enchondroma and reinforces the importance of considering the presence of secondary aneurysmal bone cysts in both benign and malignant lesions of bone...
  32. doi request reprint Detection and characterization of EWSR1/ATF1 and EWSR1/CREB1 chimeric transcripts in clear cell sarcoma (melanoma of soft parts)
    Wei Lien Wang
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 2313, USA
    Mod Pathol 22:1201-9. 2009
    ....
  33. pmc Liposarcoma in children and young adults: a multi-institutional experience
    Winston W Huh
    Division of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Pediatr Blood Cancer 57:1142-6. 2011
    ..There are limited data regarding the differences in clinical presentation and outcome of liposarcomas between adult and pediatric patients. The role of adjuvant radiotherapy in the treatment of childhood liposarcoma is unclear...
  34. doi request reprint Increased vascular endothelial growth factor-C expression is insufficient to induce lymphatic metastasis in human soft-tissue sarcomas
    Guy Lahat
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 15:2637-46. 2009
    ..Consequently, we examined expression and function of vascular endothelial growth factor (VEGF)-C and STS-associated lymphatic vessel density (LVD) components of this process...
  35. pmc Activity of temozolomide and bevacizumab in the treatment of locally advanced, recurrent, and metastatic hemangiopericytoma and malignant solitary fibrous tumor
    Min S Park
    Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77230 1402, USA
    Cancer 117:4939-47. 2011
    ..An optimal systemic treatment strategy for advanced HPC/SFT has not yet been identified...
  36. doi request reprint 'Difficult to diagnose' desmoid tumours: a potential role for CTNNB1 mutational analysis
    Chiara Colombo
    Department of Surgical Oncology, Sarcoma Research Center, The University of Texas MD Anderson Cancer Center, Houston, Texas77030 4009, USA
    Histopathology 59:336-40. 2011
    ..The utility of CTNNB1 (encoding β-catenin) genotyping for diagnosing sporadic desmoid tumours (DT) when traditional clinicopathological parameters were inconclusive was evaluated...
  37. doi request reprint Clinical, pathological, and molecular variables predictive of malignant peripheral nerve sheath tumor outcome
    Changye Zou
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Ann Surg 249:1014-22. 2009
    ..Consequently, we sought to identify clinical, pathologic, and molecular predictors of outcome in patients with/without neurofibromatosis type 1 (NF-1) associated MPNST...
  38. doi request reprint The surgical pathology of notochordal remnants in adult intervertebral disks: a report of 3 cases
    Wei Lien Wang
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Surg Pathol 32:1123-9. 2008
    ..Notochordal rests can be a source of diagnostic confusion and should be distinguished from notochordal neoplasms because they do not necessitate resection or other forms of therapy...