Research Topics
Species | Sa A WangSummaryAffiliation: The University of Texas Country: USA Publications
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Publications
Systemic mastocytosis with associated clonal hematological non-mast cell lineage disease: clinical significance and comparison of chomosomal abnormalities in SM and AHNMD componentsSa A Wang
Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Am J Hematol 88:219-24. 2013..The presentation, treatment, and outcome of patients with SM-AHNMD is often dictated by the type of AHNMD...- Diagnosis of myelodysplastic syndromes in cytopenic patientsSa A Wang
Department of Hematopathology, University of Texas, MD Anderson Cancer Center, Unit 72, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
Hematol Oncol Clin North Am 25:1085-110, vii. 2011.... - Erythroid proliferations in myeloid neoplasmsSa A Wang
Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Hum Pathol 43:153-64. 2012.... - Erythroid-predominant myelodysplastic syndromes: enumeration of blasts from nonerythroid rather than total marrow cells provides superior risk stratificationSa A Wang
Department of Pathology, UMass Memorial Medical Center, University of Massachusetts, Worcester, MA, USA
Mod Pathol 21:1394-402. 2008..We conclude that in erythroid-predominant myelodysplastic syndrome, blast calculation as a proportion of marrow nonerythroid rather than total nucleated cells can better stratify patients into prognostically relevant groups... 
Detection of paroxysmal nocturnal hemoglobinuria clones in patients with myelodysplastic syndromes and related bone marrow diseases, with emphasis on diagnostic pitfalls and caveatsSa A Wang
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
Haematologica 94:29-37. 2009..However, the status of paroxysmal nocturnal hemoglobinuria clones in various categories of myelodysplastic syndrome and in other bone marrow disorders is not well-studied...- Trisomy 11 in myelodysplastic syndromes defines a unique group of disease with aggressive clinicopathologic featuresS A Wang
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
Leukemia 24:740-7. 2010..97). We conclude that trisomy 11 in MDS correlates with clinical aggressiveness, may suggest an early/evolving AML with myelodysplasia-related changes and is best considered a high-risk cytogenetic abnormality in MDS prognostication... - Myelodysplastic syndromes with deletions of chromosome 11q lack cryptic MLL rearrangement and exhibit characteristic clinicopathologic featuresSa A Wang
Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
Leuk Res 35:351-7. 2011..These clinicopathological features are likely attributed to commonly deleted regions of 11q and their involved genes... - Immunophenotypic heterogeneity of normal plasma cells: comparison with minimal residual plasma cell myelomaDingsheng Liu
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
J Clin Pathol 65:823-9. 2012..With advances in multicolour flow cytometry and application of recently validated markers, PCM MRD may still be reliably distinguished from non-neoplastic plasma cells... - Precursor B-acute lymphoblastic leukemia occurring in patients with a history of prior malignancies: is it therapy-related?Guilin Tang
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Haematologica 97:919-25. 2012..Precursor B-acute lymphoblastic leukemia occurring in patients with a history of malignancies is uncommon, and this condition is not well understood... - Pure erythroid leukemia: a reassessment of the entity using the 2008 World Health Organization classificationWei Liu
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
Mod Pathol 24:375-83. 2011..These new assigned categories fail to capture the distinct features of PEL, where the phenotype of PEL correlates with a very complex karyotype and an extremely aggressive clinical course... - Multi-color CD34⁺ progenitor-focused flow cytometric assay in evaluation of myelodysplastic syndromes in patients with post cancer therapy cytopeniaGuilin Tang
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Leuk Res 36:974-81. 2012..With a median follow-up of 11 months, this assay demonstrated 89% sensitivity, 94% specificity, and 92% accuracy in establishing or excluding a diagnosis of MDS... - Flow cytometric detection of peripheral blood involvement by mycosis fungoides and Sézary syndrome using T-cell receptor Vbeta chain antibodies and its application in blood stagingBo Feng
Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
Mod Pathol 23:284-95. 2010.... - Therapy-related acute myeloid leukemia with t(8;21) (q22;q22) shares many features with de novo acute myeloid leukemia with t(8;21)(q22;q22) but does not have a favorable outcomeSteven A Gustafson
Department of Hematopathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Am J Clin Pathol 131:647-55. 2009..002). These findings suggest that t-AML-t(8;21) shares many features with de novo AML-t(8;21)(q22;q22), but affected patients have a worse outcome... - Chronic basophilic leukemia: a rare form of chronic myeloproliferative neoplasmGuilin Tang
Department of Pathology, University of Massachusetts Medical Center, Worcester, MA 01605, USA
Hum Pathol 40:1194-9. 2009..Conventional karyotyping revealed a t(5;12)(q31;p13). ETV6 but not PDGFRB rearrangement was detected by fluorescence in situ hybridization... 
Hypocellularity in myelodysplastic syndrome is an independent factor which predicts a favorable outcomeGang Yue
Department of Pathology, UMass Memorial Medical Center, 3 Biotech, 1 Innovation Drive, University of Massachusetts, Worcester, MA 01605, USA
Leuk Res 32:553-8. 2008..01). In conclusion, our study demonstrated that hypocellular MDS has characteristic clinicopathologic features, and bone marrow hypocellularity in MDS is an independent factor which predicts a favorable outcome...- Flow cytometric analysis of myelomonocytic cells by a pattern recognition approach is sensitive and specific in diagnosing myelodysplastic syndrome and related marrow diseases: emphasis on a global evaluation and recognition of diagnostic pitfallsDariusz Stachurski
Department of Pathology, UMass Memorial Medical Center, University of Massachusetts, Worcester, MA, USA
Leuk Res 32:215-24. 2008..Based on a global evaluation of myelomonocytic abnormalities, and recognition of diagnostic pitfalls and caveats, the pattern recognition approach of FCM is sensitive and reliable in diagnosing MDS and related myeloid diseases... - Anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma with a complex karyotype and cryptic 3' ALK gene insertion to chromosome 4 q22-24Dariusz Stachurski
Department of Pathology, University of Massachusetts Medical Center, Worcester, MA 01605, USA
Hum Pathol 38:940-5. 2007..This case indicates that ALK-positive DLBCL is more heterogeneous at the cytogenetic/molecular level than previously recognized... - Acute erythroid leukemia: a reassessment using criteria refined in the 2008 WHO classificationRobert P Hasserjian
Department of Pathology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
Blood 115:1985-92. 2010..Our findings suggest that AEL is in the continuum of MDS and AML with erythroid hyperplasia, where karyotype rather than an arbitrary blast cutoff represents the most important prognostic factor... - Usefulness of flow cytometric immunophenotyping for bone marrow staging in patients with mantle cell lymphoma after therapyWei Liu
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
Am J Clin Pathol 137:634-40. 2012..We conclude that FCI is more sensitive than morphologic examination of BM at the time of restaging in patients with MCL and that positivity by only FCI in BM often correlates with concurrent disease or subsequent relapse... - High-level CD34 expression on megakaryocytes independently predicts an adverse outcome in patients with myelodysplastic syndromesGuilin Tang
Department of Pathology, University of Massachusetts Medical Center, Worcester, MA 01605, USA
Leuk Res 35:766-70. 2011..Multivariate analysis indicated that the expression of CD34 on megakaryocytes could be a strong and an independent poor prognostic factor in MDS, with a hazard ratio of 2.53... - The utility of flow cytometric immunophenotyping in cytopenic patients with a non-diagnostic bone marrow: a prospective studyFrancoise Truong
Department of Pathology, UMass Memorial Medical Center, University of Massachusetts School of Medicine, Worcester, MA, USA
Leuk Res 33:1039-46. 2009.... - Usefulness of CD11a and CD18 in flow cytometric immunophenotypic analysis for diagnosis of acute promyelocytic leukemiaYi Zhou
Dept of Hematopathology, Unit 72, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Am J Clin Pathol 138:744-50. 2012..These data compare favorably with the combination of HLA-DR-, CD34-, and CD117+ for APL diagnosis, which had a sensitivity of 64% in this study... - Cytogenetic abnormalities in a series of 1,029 patients with primary myelodysplastic syndromes: a report from the US with a focus on some undefined single chromosomal abnormalitiesOlga Pozdnyakova
Department of Pathology, University of Massachusetts Memorial Medical Center, University of Massachusetts School of Medicine, Worcester, MA, USA
Cancer 113:3331-40. 2008..In addition, the emerging therapeutic agents may change the natural course of disease in patients with MDS and the cytogenetic impact on risk stratification... - The oncofetal protein IMP3: a novel molecular marker to predict aggressive meningiomaSuyang Hao
Department of Pathology, University of Massachusetts Medical Center, Worcester, USA
Arch Pathol Lab Med 135:1032-6. 2011..One of the major clinical challenges is to predict recurrence of meningioma. Recently, we have found that IMP3, an oncofetal RNA-binding protein, is a biomarker to predict aggressive tumors... - Chronic myelomonocytic leukemia evolving from preexisting myelodysplasia shares many features with de novo diseaseSa A Wang
Department of Medicine, University of Massachusetts Medical Center, Worcester, MA 01605, USA
Am J Clin Pathol 126:789-97. 2006..These findings indicate that in some cases of otherwise typical MDS, the progenitor cells may have some capacity for monocytic proliferation at diagnosis and manifest rapid disease progression once a monocytic proliferation supervenes... - Aberrant underexpression of CD81 in precursor B-cell acute lymphoblastic leukemia: utility in detection of minimal residual disease by flow cytometryTariq Muzzafar
Dept of Hematopathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Am J Clin Pathol 132:692-8. 2009..Decreased CD81 expression is a sensitive and specific marker for residual pre-B-ALL, even in a background of hematogones, making CD81 a useful addition to a panel for MRD detection by FC... - Acute myeloid leukemia (AML) with erythroid predominance exhibits clinical and molecular characteristics that differ from other types of AMLZhuang Zuo
Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
PLoS ONE 7:e41485. 2012.... - Transient/reversible ring sideroblasts in bone marrow of patients post cytotoxic therapies for primary malignanciesChi Young Ok
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Leuk Res 35:1605-10. 2011..Four patients with transient/reversible RS received α-interferon therapy which may contribute to RS formation in this setting... - Prognostic significance of immunophenotypic and karyotypic features of Philadelphia positive B-lymphoblastic leukemia in the era of tyrosine kinase inhibitorsJesse Jaso
Department of Pathology, The University of Texas Medical Center Health Sciences Center, Houston, Texas, USA
Cancer 117:4009-17. 2011..The prognostic significance of these parameters was assessed in the context of intensive tyrosine kinase inhibitor (TKI)-based chemotherapy... - Interphase FISH in plasma cell dyscrasia: increase in abnormality detection with plasma cell enrichmentOlga Pozdnyakova
Department of Pathology, UMass Memorial Medical Center, Worcester, MA 01605, USA
Cancer Genet Cytogenet 189:112-7. 2009..We conclude that the plasma cell enrichment step for iFISH should be incorporated into the routine cytogenetic work-up for all patients with plasma cell neoplasms... - A comparative analysis of lymphatic vessel density in ovarian serous tumors of low malignant potential (borderline tumors) with and without lymph node involvementOluwole Fadare
Department of Pathology, Wilford Hall Medical Center, Lackland AFB, San Antonio, Texas 78236, USA
Int J Gynecol Pathol 27:483-90. 2008..We discuss the possibility that nodal deposits may represent metastatic disease from secondary tumor implants... - Therapy-related myeloid neoplasms following fludarabine, cyclophosphamide, and rituximab (FCR) treatment in patients with chronic lymphocytic leukemia/small lymphocytic lymphomaYi Zhou
Department of Hematopathology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA
Mod Pathol 25:237-45. 2012..The fact that therapy-related myeloid neoplasms can directly emerge from 'prolonged myelosuppression' warrants a bone marrow examination to rule out therapy-related myeloid neoplasms in this clinical setting... - The expression of cytokeratin 5/6 in invasive lobular carcinoma of the breast: evidence of a basal-like subset?Oluwole Fadare
Department of Pathology, Wilford Hall Medical Center, Lackland AFB, TX 78236, USA
Hum Pathol 39:331-6. 2008..Future studies are required to define the prognostic significance of CK5/6 expression in ILCs... - Clinicopathological features of extramedullary recurrence/relapse of multiple myelomaJan Cerny
Division of Hematology Oncology, Department of Internal Medicine, UMass Memorial Medical Center, University of Massachusetts School of Medicine, Worcester, MA 01605, USA
Eur J Haematol 81:65-9. 2008..Our case series shows that extramedullary relapse of MM is characterized by high-grade histology, loss of CD56 expression, frequent resistance to current therapeutic regimens, aggressive biological behavior, and very short survival... - Eosinophilia with FIP1L1-PDGFRA fusion in a patient with chronic myelomonocytic leukemiaVictor Zota
Department of Pathology, University of Massachusetts Memorial Medical Center, University of Massachusetts, Worcester, MA, USA
J Clin Oncol 26:2040-1. 2008 - Mosaic tetraploidy and transient GFI1 mutation in a patient with severe chronic neutropeniaJessica C Hochberg
Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Pediatr Blood Cancer 50:630-2. 2008..We speculate that an underlying genetic defect, inherited in an autosomal dominant pattern, leads to both disordered mitosis and neutropenia in this kindred... - Donor-specific anti-HLA Abs and graft failure in matched unrelated donor hematopoietic stem cell transplantationStefan O Ciurea
Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Blood 118:5957-64. 2011..1%; P < .0001) and higher in women with 1 (P = .008) and 2 or more pregnancies (P = .0003) than in men. We conclude that the presence of anti-DPB1 DSAs is associated with graft failure in MUD hematopoietic stem cell transplantation... - High-grade B cell lymphoma, unclassifiable, with blastoid features: an unusual morphological subgroup associated frequently with BCL2 and/or MYC gene rearrangements and a poor prognosisRashmi Kanagal-Shamanna
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Histopathology 61:945-54. 2012..At a haematopathology workshop, experts had suggested the term 'high-grade B cell lymphoma, unclassifiable, with blastoid features', and recommended further studies... - Lymphovascular space invasion does not predict vaginal relapses in stage I endometrioid adenocarcinoma of the endometriumLaurephile Desrosiers
Department of Pathology, University of Massachusetts Medical Center, Worcester, MA 01605, USA
Ann Diagn Pathol 12:112-7. 2008..However, LVSI does not denote an increased likelihood of vaginal recurrences in S1EE. The presence of LVSI should not, in of itself, alter clinical staging, or trigger unnecessary therapeutic intervention... - Improved early outcomes using a T cell replete graft compared with T cell depleted haploidentical hematopoietic stem cell transplantationStefan O Ciurea
Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M D Anderson Cancer Center, Houston, Texas Electronic address
Biol Blood Marrow Transplant 18:1835-44. 2012..These results indicate that a TCR graft followed by effective control of GVHD posttransplantation may lower NRM and improve survival after haploidentical SCT... - Inotuzumab ozogamicin, an anti-CD22-calecheamicin conjugate, for refractory and relapsed acute lymphocytic leukaemia: a phase 2 studyHagop Kantarjian
Department of Leukemia, MD Anderson Cancer Center, Houston, TX 77030, USA
Lancet Oncol 13:403-11. 2012..CD22 is highly expressed in patients with ALL. Inotuzumab ozogamicin is a CD22 monoclonal antibody conjugated to the toxin calecheamicin. We did a phase 2 study to assess the efficacy of this antibody... - Splenic marginal zone lymphoma with micronodular T-cell rich B-cell lymphomaSa A Wang
Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Am J Surg Pathol 30:128-32. 2006..We describe a unique case of splenic marginal zone lymphoma associated with micronodular T cell/histiocyte-rich large B-cell lymphoma in the red pulp, a combination that has not previously reported in the literature... - Clinicopathologic features associated with cytohistologic noncorrelation in the diagnosis of cervical dysplasia: a study of concurrently obtained samplesOluwole Fadare
Department of Pathology, Wilford Hall Medical Center, Lackland AFB, TX 78236, USA
Int J Surg Pathol 17:31-7. 2009..03), consistent with smaller extent of disease. These findings further illustrate that lesional factors are important potential contributors to the false-negative rate of the Papanicolaou test... - Lobular intraepithelial neoplasia [lobular carcinoma in situ] with comedo-type necrosis: A clinicopathologic study of 18 casesOluwole Fadare
Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
Am J Surg Pathol 30:1445-53. 2006..However, because classic LIN with necrosis is apparently rare in its pure form, reexcision is recommended when this lesion is detected in isolation in a core biopsy... - Gastrointestinal endoscopic findings in men with unexplained anemia and low normal ferritin valuesSa A Wang
Department of Pathology, University of Massachusetts Medical Center, Worcester, Massachusetts, USA
Am J Hematol 81:324-7. 2006..7%). CONCLUSION: Our study supports GI endoscopy in anemic patients with ferritin between 40 and 100 ng/ml, even in the absence of GI symptoms or documented bleeding...