Qi En Wang

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc Modulation of nucleotide excision repair by mammalian SWI/SNF chromatin-remodeling complex
    Qun Zhao
    Department of Radiology, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 284:30424-32. 2009
  2. pmc Ubiquitylation-independent degradation of Xeroderma pigmentosum group C protein is required for efficient nucleotide excision repair
    Qi En Wang
    Department of Radiology, The Ohio State University, 460 W 12th Ave, Columbus, OH 43210, USA
    Nucleic Acids Res 35:5338-50. 2007
  3. pmc Differential contributory roles of nucleotide excision and homologous recombination repair for enhancing cisplatin sensitivity in human ovarian cancer cells
    Qi En Wang
    Department of Radiology, The Ohio State University, Columbus, OH 43210, USA
    Mol Cancer 10:24. 2011
  4. pmc Stem cell protein Piwil2 modulates chromatin modifications upon cisplatin treatment
    Qi En Wang
    Department of Radiology, The Ohio State University, Columbus, OH 43210, USA
    Mutat Res 708:59-68. 2011
  5. pmc Human SNF5/INI1, a component of the human SWI/SNF chromatin remodeling complex, promotes nucleotide excision repair by influencing ATM recruitment and downstream H2AX phosphorylation
    Alo Ray
    Department of Radiology, The Ohio State University, Columbus, OH 43210, USA
    Mol Cell Biol 29:6206-19. 2009
  6. ncbi request reprint Cullin 4A-mediated proteolysis of DDB2 protein at DNA damage sites regulates in vivo lesion recognition by XPC
    Mohamed A El-Mahdy
    Department of Radiology, The Ohio State University, Columbus, Ohio 43210 1000, USA
    J Biol Chem 281:13404-11. 2006
  7. ncbi request reprint DNA damage binding protein component DDB1 participates in nucleotide excision repair through DDB2 DNA-binding and cullin 4A ubiquitin ligase activity
    Jinyou Li
    Department of Radiology, The Ohio State University, Columbus, Ohio 43240, USA
    Cancer Res 66:8590-7. 2006
  8. doi request reprint Overexpression of DDB2 enhances the sensitivity of human ovarian cancer cells to cisplatin by augmenting cellular apoptosis
    Bassant M Barakat
    Department of Radiology, The Ohio State University, Columbus, OH 43210, USA
    Int J Cancer 127:977-88. 2010
  9. ncbi request reprint Deubiquitination by proteasome is coordinated with substrate translocation for proteolysis in vivo
    Qianzheng Zhu
    Department of Radiology, The Ohio State University, Columbus, OH 43210, USA
    Exp Cell Res 307:436-51. 2005
  10. ncbi request reprint The ubiquitin-proteasome pathway is required for the function of the viral VP16 transcriptional activation domain
    Qianzheng Zhu
    Department of Radiology, The Ohio State University, Columbus, OH 43210, USA
    FEBS Lett 556:19-25. 2004

Collaborators

Detail Information

Publications25

  1. pmc Modulation of nucleotide excision repair by mammalian SWI/SNF chromatin-remodeling complex
    Qun Zhao
    Department of Radiology, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 284:30424-32. 2009
    ....
  2. pmc Ubiquitylation-independent degradation of Xeroderma pigmentosum group C protein is required for efficient nucleotide excision repair
    Qi En Wang
    Department of Radiology, The Ohio State University, 460 W 12th Ave, Columbus, OH 43210, USA
    Nucleic Acids Res 35:5338-50. 2007
    ..XPC degradation is necessary for recruiting XPG and efficient NER. The overall results provide crucial insights regarding the fate and role of XPC protein in the initiation of excision repair...
  3. pmc Differential contributory roles of nucleotide excision and homologous recombination repair for enhancing cisplatin sensitivity in human ovarian cancer cells
    Qi En Wang
    Department of Radiology, The Ohio State University, Columbus, OH 43210, USA
    Mol Cancer 10:24. 2011
    ....
  4. pmc Stem cell protein Piwil2 modulates chromatin modifications upon cisplatin treatment
    Qi En Wang
    Department of Radiology, The Ohio State University, Columbus, OH 43210, USA
    Mutat Res 708:59-68. 2011
    ..To conclude, the overexpression of Piwil2 in some cancers could lead to cellular cisplatin resistance, possibly due to enhanced chromatin condensation affecting normal DNA repair...
  5. pmc Human SNF5/INI1, a component of the human SWI/SNF chromatin remodeling complex, promotes nucleotide excision repair by influencing ATM recruitment and downstream H2AX phosphorylation
    Alo Ray
    Department of Radiology, The Ohio State University, Columbus, OH 43210, USA
    Mol Cell Biol 29:6206-19. 2009
    ..We propose that the SWI/SNF chromatin remodeling function is utilized to increase the DNA accessibility of NER machinery and checkpoint factors at the damage site, which influences NER and ensures genomic integrity...
  6. ncbi request reprint Cullin 4A-mediated proteolysis of DDB2 protein at DNA damage sites regulates in vivo lesion recognition by XPC
    Mohamed A El-Mahdy
    Department of Radiology, The Ohio State University, Columbus, Ohio 43210 1000, USA
    J Biol Chem 281:13404-11. 2006
    ..These results suggest that CUL-4A mediates the proteolytic degradation of DDB2 and that this degradation event, initiated at the lesion sites, regulates damage recognition by XPC during the early steps of NER...
  7. ncbi request reprint DNA damage binding protein component DDB1 participates in nucleotide excision repair through DDB2 DNA-binding and cullin 4A ubiquitin ligase activity
    Jinyou Li
    Department of Radiology, The Ohio State University, Columbus, Ohio 43240, USA
    Cancer Res 66:8590-7. 2006
    ....
  8. doi request reprint Overexpression of DDB2 enhances the sensitivity of human ovarian cancer cells to cisplatin by augmenting cellular apoptosis
    Bassant M Barakat
    Department of Radiology, The Ohio State University, Columbus, OH 43210, USA
    Int J Cancer 127:977-88. 2010
    ..These results suggest that ovarian cancer cells containing high level of DDB2 become susceptible to cisplatin by undergoing enhanced apoptosis...
  9. ncbi request reprint Deubiquitination by proteasome is coordinated with substrate translocation for proteolysis in vivo
    Qianzheng Zhu
    Department of Radiology, The Ohio State University, Columbus, OH 43210, USA
    Exp Cell Res 307:436-51. 2005
    ..Taken together, the results support a model in which deubiquitination process is a crucial event for proteolysis of ubiquitinated substrates and such an event is coordinated with substrate translocation...
  10. ncbi request reprint The ubiquitin-proteasome pathway is required for the function of the viral VP16 transcriptional activation domain
    Qianzheng Zhu
    Department of Radiology, The Ohio State University, Columbus, OH 43210, USA
    FEBS Lett 556:19-25. 2004
    ..These results support a model in which ubiquitin plays an accessory role, in recruiting the 19S regulatory subunit of the proteasome, for transcriptional activation...
  11. ncbi request reprint Tumor suppressor p53 dependent recruitment of nucleotide excision repair factors XPC and TFIIH to DNA damage
    Qi En Wang
    Department of Radiology, The Ohio State University, 103 Wiseman Hall, 400 W 12th Avenue, Columbus, OH 43210, USA
    DNA Repair (Amst) 2:483-99. 2003
    ..Most likely mechanism of this p53 action is through its downstream effector protein, DDB2...
  12. ncbi request reprint Role of Claspin in regulation of nucleotide excision repair factor DDB2
    Mette Praetorius-Ibba
    Department of Radiology, The Ohio State University, Columbus, OH 43240, United States
    DNA Repair (Amst) 6:578-87. 2007
    ..Taken together, these findings reveal physical and functional interplay between Claspin and NER-related proteins and demonstrate crosstalk between the DNA damage checkpoint control and DNA damage repair pathways...
  13. ncbi request reprint Cellular ubiquitination and proteasomal functions positively modulate mammalian nucleotide excision repair
    Qi En Wang
    Department of Radiology, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Carcinog 42:53-64. 2005
    ..Taken together, we conclude that the ubiquitin-proteasome pathway has a positive regulatory role for optimal NER capacity in mammalian cells and appears to act through facilitating the recruitment of repair factors to DNA damage sites...
  14. pmc p38 MAPK- and Akt-mediated p300 phosphorylation regulates its degradation to facilitate nucleotide excision repair
    Qi En Wang
    Department of Radiology, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA
    Nucleic Acids Res 41:1722-33. 2013
    ..Thereupon, p300 is promptly degraded to allow the sequential recruitment of downstream repair proteins for successful execution of NER...
  15. ncbi request reprint UV radiation-induced XPC translocation within chromatin is mediated by damaged-DNA binding protein, DDB2
    Qi En Wang
    Department of Radiology, The Ohio State University, Columbus, OH 43210, USA
    Carcinogenesis 25:1033-43. 2004
    ..These results indicate that DDB2 is a key downstream factor of p53 for regulating the movement of XPC to DNA damage in irradiated cells...
  16. pmc Naringenin protects HaCaT human keratinocytes against UVB-induced apoptosis and enhances the removal of cyclobutane pyrimidine dimers from the genome
    Mohamed A El-Mahdy
    Department of Radiology, The Ohio State University, Columbus, OH, USA
    Photochem Photobiol 84:307-16. 2008
    ..The study provides a molecular basis for the action of NG as a promising natural flavonoid in preventing skin aging and carcinogenesis...
  17. pmc Nucleotide excision repair factor XPC enhances DNA damage-induced apoptosis by downregulating the antiapoptotic short isoform of caspase-2
    Qi En Wang
    Department of Radiology, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 72:666-75. 2012
    ....
  18. pmc The p38 mitogen-activated protein kinase augments nucleotide excision repair by mediating DDB2 degradation and chromatin relaxation
    Qun Zhao
    Department of Radiology, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 283:32553-61. 2008
    ..We conclude that p38 MAPK regulates chromatin remodeling as well as DDB2 degradation for facilitating NER factor assembly...
  19. pmc Caspase-2 short isoform interacts with membrane-associated cytoskeleton proteins to inhibit apoptosis
    Chunhua Han
    Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
    PLoS ONE 8:e67033. 2013
    ..Taken together, our data suggests that casp-2S affects cellular apoptosis through its interaction with membrane-associated cytoskeletal Fodrin protein. ..
  20. pmc DNA repair factor XPC is modified by SUMO-1 and ubiquitin following UV irradiation
    Qi En Wang
    Department of Radiology, The Ohio State University 103 Wiseman Hall, 400 W 12th Avenue, Columbus, OH 43210, USA
    Nucleic Acids Res 33:4023-34. 2005
    ..Our results also suggest that at least one function of UV-induced XPC sumoylation is related to the stabilization of XPC protein...
  21. pmc Thymoquinone inhibits autophagy and induces cathepsin-mediated, caspase-independent cell death in glioblastoma cells
    Ira O Racoma
    Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
    PLoS ONE 8:e72882. 2013
    ..Inhibition of autophagy is an exciting and emerging strategy in cancer therapy. In this vein, our results describe a novel mechanism of action for TQ as an autophagy inhibitor selectively targeting glioblastoma cells. ..
  22. ncbi request reprint Efficient repair of bulky anti-BPDE DNA adducts from non-transcribed DNA strand requires functional p53 but not p21(waf1/cip1) and pRb
    Manzoor A Wani
    Department of Radiology, The Ohio State University, Columbus 43210, USA
    Mutat Res 505:13-25. 2002
    ....
  23. pmc DNA damage-binding complex recruits HDAC1 to repress Bcl-2 transcription in human ovarian cancer cells
    Ran Zhao
    Department of Radiology, The Ohio State University, Room 1014 BRT, 460 W 12th Avenue, Columbus, OH 43210
    Mol Cancer Res 12:370-80. 2014
    ..Implications: Increasing the expression of DDB complex may provide a molecular strategy for cancer therapy...
  24. ncbi request reprint Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells
    Mohamed A El-Mahdy
    Department of Radiology, Ohio State University, Columbus, OH 43210, USA
    Int J Cancer 117:409-17. 2005
    ..Activated caspase-8 initiates the release of cytochrome c during TQ-induced apoptosis. Overall, these results offer a potential mechanism for TQ-induced apoptosis in p53-null HL-60 cancer cells...
  25. pmc Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia
    Jianhua Yu
    Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 8:e55934. 2013
    ....