Li Shu Wang

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc Modulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries: a phase I pilot study
    Li Shu Wang
    Department of Internal Medicine, Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, Ohio 43240, USA
    Clin Cancer Res 17:598-610. 2011
  2. ncbi request reprint Conjugated linoleic acid (CLA) up-regulates the estrogen-regulated cancer suppressor gene, protein tyrosine phosphatase gamma (PTPgama), in human breast cells
    Li Shu Wang
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 26:27-34. 2006
  3. ncbi request reprint Induction of apoptosis by (-)-gossypol-enriched cottonseed oil in human breast cancer cells
    Weiping Ye
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Int J Mol Med 26:113-9. 2010
  4. ncbi request reprint Effects of serum on (-)-gossypol-suppressed growth in human prostate cancer cells
    Yi Wen Huang
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 26:3613-20. 2006
  5. ncbi request reprint Keratinocyte growth factor (KGF) induces tamoxifen (Tam) resistance in human breast cancer MCF-7 cells
    Hsiang Lin Chang
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 26:1773-84. 2006
  6. doi request reprint Mechanistic basis for the chemopreventive effects of black raspberries at a late stage of rat esophageal carcinogenesis
    Li Shu Wang
    Ohio State University Comprehensive Cancer Center, Columbus, Ohio 43240, USA
    Mol Carcinog 50:291-300. 2011
  7. ncbi request reprint Modulation of multidrug resistance gene expression in human breast cancer cells by (-)-gossypol-enriched cottonseed oil
    Weiping Ye
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210 1092, USA
    Anticancer Res 27:107-16. 2007
  8. pmc Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both black raspberries and phenylethyl isothiocyanate
    Gary D Stoner
    Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, Ohio 43240, USA
    Cancer Res 68:6460-7. 2008
  9. pmc Black raspberry components inhibit proliferation, induce apoptosis, and modulate gene expression in rat esophageal epithelial cells
    Nancy N Zikri
    The Ohio State University, Columbus, Ohio 43240, USA
    Nutr Cancer 61:816-26. 2009
  10. pmc Drinking water with red beetroot food color antagonizes esophageal carcinogenesis in N-nitrosomethylbenzylamine-treated rats
    John F Lechner
    Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43240, USA
    J Med Food 13:733-9. 2010

Collaborators

Detail Information

Publications31

  1. pmc Modulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries: a phase I pilot study
    Li Shu Wang
    Department of Internal Medicine, Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, Ohio 43240, USA
    Clin Cancer Res 17:598-610. 2011
    ....
  2. ncbi request reprint Conjugated linoleic acid (CLA) up-regulates the estrogen-regulated cancer suppressor gene, protein tyrosine phosphatase gamma (PTPgama), in human breast cells
    Li Shu Wang
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 26:27-34. 2006
    ..Our previous results indicated that estradiol-17beta (E2)-induced suppression of PTPgamma may play a role in mammary tumorigenesis...
  3. ncbi request reprint Induction of apoptosis by (-)-gossypol-enriched cottonseed oil in human breast cancer cells
    Weiping Ye
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Int J Mol Med 26:113-9. 2010
    ..It might be possible for (-)-GPCSO to be developed as a novel chemotherapeutic agent for breast cancer patients...
  4. ncbi request reprint Effects of serum on (-)-gossypol-suppressed growth in human prostate cancer cells
    Yi Wen Huang
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 26:3613-20. 2006
    ..Here, the effect of bovine serum albumin (BSA) and dextran-coated charcoal-treated fetal bovine serum (DCC-FBS)-containing medium on the ability of (-)-gossypol to inhibit the growth of human prostate cancer cells was studied...
  5. ncbi request reprint Keratinocyte growth factor (KGF) induces tamoxifen (Tam) resistance in human breast cancer MCF-7 cells
    Hsiang Lin Chang
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 26:1773-84. 2006
    ..In the present study, ER-alpha, two estrogen-regulated genes, PR and PTPgamma, KGF and their relationship with endocrine resistance in human breast cancer cells were investigated...
  6. doi request reprint Mechanistic basis for the chemopreventive effects of black raspberries at a late stage of rat esophageal carcinogenesis
    Li Shu Wang
    Ohio State University Comprehensive Cancer Center, Columbus, Ohio 43240, USA
    Mol Carcinog 50:291-300. 2011
    ..This is the first report of the effects of berries on the expression of genes associated with the late stages of rat esophageal carcinogenesis...
  7. ncbi request reprint Modulation of multidrug resistance gene expression in human breast cancer cells by (-)-gossypol-enriched cottonseed oil
    Weiping Ye
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210 1092, USA
    Anticancer Res 27:107-16. 2007
    ....
  8. pmc Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both black raspberries and phenylethyl isothiocyanate
    Gary D Stoner
    Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, Ohio 43240, USA
    Cancer Res 68:6460-7. 2008
    ..Because both PEITC and BRB maintain near-normal levels of expression of these 53 genes, their dysregulation during the early phase of NMBA-induced esophageal cancer may be especially important in the genesis of the disease...
  9. pmc Black raspberry components inhibit proliferation, induce apoptosis, and modulate gene expression in rat esophageal epithelial cells
    Nancy N Zikri
    The Ohio State University, Columbus, Ohio 43240, USA
    Nutr Cancer 61:816-26. 2009
    ....
  10. pmc Drinking water with red beetroot food color antagonizes esophageal carcinogenesis in N-nitrosomethylbenzylamine-treated rats
    John F Lechner
    Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43240, USA
    J Med Food 13:733-9. 2010
    ..However, the sum of constituents of E162 has not been determined, and other components with other mechanisms may also be involved in antagonizing cancer development...
  11. ncbi request reprint Effects of human breast stromal cells on conjugated linoleic acid (CLA) modulated vascular endothelial growth factor-A (VEGF-A) expression in MCF-7 cells
    Li Shu Wang
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 25:4061-8. 2005
    ..Our previous results indicated that CLA induced suppression of VEGF-A in MCF-7 cells, which may be one of CLA's anticancer mechanisms...
  12. ncbi request reprint Function and regulatory mechanisms of the candidate tumor suppressor receptor protein tyrosine phosphatase gamma (PTPRG) in breast cancer cells
    Sherry T Shu
    Laboratory of Reproductive and Molecular Endocrinology, Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210 1093, USA
    Anticancer Res 30:1937-46. 2010
    ..To understand the tumor suppression characteristics of PTPRG, we studied its tumor suppressive function in an athymic mouse model and evaluated factors that can potentially regulate its expression in breast cancer cells...
  13. ncbi request reprint Molecular mechanisms of (-)-gossypol-induced apoptosis in human prostate cancer cells
    Yi Wen Huang
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine and The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 26:1925-33. 2006
    ..The (-)-gossypol enantiomer is a more potent inhibitor of cancer cell growth. Here, the molecular mechanisms of apoptosis induced by (-)-gossypol were studied in human prostate cancer cells...
  14. pmc Multiple berry types prevent N-nitrosomethylbenzylamine-induced esophageal cancer in rats
    Gary D Stoner
    Department of Internal Medicine and Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Pharm Res 27:1138-45. 2010
    ..We also determined if berries influence the levels of inflammatory cytokines in the serum of carcinogen-treated rats...
  15. pmc Berry ellagitannins may not be sufficient for prevention of tumors in the rodent esophagus
    Li Shu Wang
    The Ohio State University Comprehensive Cancer Center, Columbus, Ohio 43240, USA
    J Agric Food Chem 58:3992-5. 2010
    ..01-0.62 g/kg of diet). These results suggest that the ellagitannins may not be responsible for the chemopreventive effects of the alcohol/water-insoluble fraction of berries...
  16. pmc Cancer prevention with freeze-dried berries and berry components
    Gary D Stoner
    Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine, The Ohio State University, Innovation Centre, 2001 Polaris Parkway, Columbus, OH 43240, USA
    Semin Cancer Biol 17:403-10. 2007
    ..e., Barrett's esophagus, esophageal dysplasia and colonic polyps, to determine if berries will modulate various histological and molecular biomarkers of development of these diseases...
  17. ncbi request reprint Effect of keratinocyte growth factor on cell viability in primary cultured human prostate cancer stromal cells
    Yi Wen Huang
    Laboratory of Reproductive and Molecular Endocrinology, Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1900 Coffey Road, Columbus, OH 43210, USA
    J Steroid Biochem Mol Biol 100:24-33. 2006
    ..In summary, KGF has an autocrine effect and serves as a survival factor in primary cultured human prostate cancer stromal cells...
  18. ncbi request reprint Conjugated linoleic acid (CLA) modulates prostaglandin E2 (PGE2) signaling in canine mammary cells
    Li Shu Wang
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 26:889-98. 2006
    ..Moreover, a PGE2 receptor subtype, EP2, is highly expressed in mammary tumors. Thus, various studies have implicated the important role of PGE2 and EP2 in COX-2-regulated tumor development...
  19. ncbi request reprint Primary cultured human breast epithelial cells up-regulate protein disulfide isomerase in response to zeranol
    Michael Scott Updike
    Department of Animal Sciences, College of Food, Agricultural and Environmental Sciences, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 27:407-10. 2007
    ..Research targets on gene-nutrient interactions may give useful information for the development of a novel diet-based intervention for the at-risk population...
  20. ncbi request reprint Decreased MCF-7 breast cancer cell proliferation by serum from a selected line of beef cattle
    Michael S Updike
    Department of Animal Sciences, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 25:871-4. 2005
    ..In conclusion, model systems employing agricultural animals may provide novel insight into mechanisms of cell proliferation...
  21. pmc Conjugated linoleic acid induces apoptosis through estrogen receptor alpha in human breast tissue
    Li Shu Wang
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    BMC Cancer 8:208. 2008
    ..Our research interest is to examine the effects of CLA on the induction of apoptosis in human breast tissues...
  22. pmc Chemoprevention of esophageal squamous cell carcinoma
    Gary D Stoner
    Division of Hematology and Oncology, Department of Internal Medicine, Ohio State University College of Medicine and Comprehensive Cancer Center, Columbus, OH 43210, USA
    Toxicol Appl Pharmacol 224:337-49. 2007
    ..These observations have led to a clinical trial in China to evaluate the ability of freeze-dried strawberries to influence the progression of esophageal dysplasia to SCC...
  23. pmc Anthocyanins and their role in cancer prevention
    Li Shu Wang
    Department of Internal Medicine and Comprehensive Cancer Center, Ohio State University College of Medicine, Columbus, OH 43210, USA
    Cancer Lett 269:281-90. 2008
    ..Future studies aimed at enhancing the absorption of anthocyanins and/or their metabolites are likely to be necessary for their ultimate use for chemoprevention of human cancer...
  24. ncbi request reprint (-)-Gossypol reduces invasiveness in metastatic prostate cancer cells
    Yi Wen Huang
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH, U S A
    Anticancer Res 29:2179-88. 2009
    ..Gossypol, a polyphenolic compound present in cottonseeds, possesses anti-proliferative and proapoptotic effects in various cancer cells...
  25. doi request reprint Effects of a black raspberry diet on gene expression in the rat esophagus
    John F Lechner
    Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Nutr Cancer 60:61-9. 2008
    ..In conclusion, histological and molecular studies indicate that a 5% BRB diet produces only modest effects on the esophagus, the target tissue for NMBA carcinogenesis in the rat...
  26. pmc Profiling DNA methylomes from microarray to genome-scale sequencing
    Yi Wei Huang
    The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA
    Technol Cancer Res Treat 9:139-47. 2010
    ..With advances on next-generation sequencing technologies, it is now possible to globally map the DNA cytosine methylation at single-base resolution, providing new insights into the regulation and dynamics of DNA methylation in genomes...
  27. pmc An overview of epigenetics and chemoprevention
    Yi Wen Huang
    Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, United States
    FEBS Lett 585:2129-36. 2011
    ..Uncovering the human epigenome can lead us to better understand the dynamics of DNA methylation in disease progression which can further assist in cancer prevention...
  28. ncbi request reprint Keratinocyte growth factor (KGF) regulates estrogen receptor-alpha (ER-alpha) expression and cell apoptosis via phosphatidylinositol 3-kinase (PI3K)/Akt pathway in human breast cancer cells
    Hsiang Lin Chang
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 29:3195-205. 2009
    ..Therefore, we hypothesized that a possible mechanism for developing Tam resistance could be the regulation of ER-alpha and Bcl-2 family proteins through modulation of Akt activity...
  29. pmc Laboratory and clinical studies of cancer chemoprevention by antioxidants in berries
    Gary David Stoner
    Department of Internal Medicine, College of Medicine, The Ohio StateUniversity, Columbus, OH 43210, USA
    Carcinogenesis 29:1665-74. 2008
    ..This review article summarizes laboratory and human studies, demonstrating the protective effects of berries and berry constituents on oxidative and other cellular processes leading to cancer development...
  30. pmc Pharmacokinetics of protocatechuic acid in mouse and its quantification in human plasma using LC-tandem mass spectrometry
    Wei Chen
    Zhejiang Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province 310022, China
    J Chromatogr B Analyt Technol Biomed Life Sci 908:39-44. 2012
    ..Because PCA is derived from the anthocyanins in BRB, our method provides a useful analytical tool to further investigate the metabolism of anthocyanins, and the pharmacology of PCA in future pre-clinical and clinical studies...
  31. pmc Anthocyanins in black raspberries prevent esophageal tumors in rats
    Li Shu Wang
    Ohio State University Comprehensive Cancer Center, 2001 Polaris Parkway, Columbus, OH 43240, USA
    Cancer Prev Res (Phila) 2:84-93. 2009
    ....