Douglas C Wallace

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. doi request reprint Mitochondria and cancer
    Douglas C Wallace
    Children s Hospital of Philadelphia, Center for Mitochondrial and Epigenomic Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Cancer 12:685-98. 2012
  2. doi request reprint Bioenergetics and the epigenome: interface between the environment and genes in common diseases
    Douglas C Wallace
    The Department of Pathology and Laboratory Medicine, Center for Mitochondrial and Epigenomic Medicine, Children s Hospital of Philadelphia and University of Pennsylvania, 3501 Civic Center Blvd, Philadelphia, PA 19104 4302, USA
    Dev Disabil Res Rev 16:114-9. 2010
  3. pmc Mitochondrial DNA genetics and the heteroplasmy conundrum in evolution and disease
    Douglas C Wallace
    Center for Mitochondrial and Epigenomic Medicine, The Children s Hospital of Philadelphia, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104
    Cold Spring Harb Perspect Biol 5:a021220. 2013
  4. pmc Bioenergetics in human evolution and disease: implications for the origins of biological complexity and the missing genetic variation of common diseases
    Douglas C Wallace
    Center of Mitochondrial and Epigenomic Medicine, Children s Hospital of Philadelphia, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Colket Translational Research Building, Room 6060, 3501 Civic Center Boulevard, Philadelphia, PA 19104 4302, USA
    Philos Trans R Soc Lond B Biol Sci 368:20120267. 2013
  5. pmc Mitochondrial disease genetic diagnostics: optimized whole-exome analysis for all MitoCarta nuclear genes and the mitochondrial genome
    Marni J Falk
    Division of Human Genetics and Division of Child Development and Metabolic Disease, Department of Pediatrics, The Children s Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Discov Med 14:389-99. 2012
  6. pmc Mouse mtDNA mutant model of Leber hereditary optic neuropathy
    Chun Shi Lin
    Center for Mitochondrial and Epigenomic Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 109:20065-70. 2012
  7. pmc A mitochondrial bioenergetic etiology of disease
    Douglas C Wallace
    Center for Mitochondrial and Epigenomic Medicine, Children s Hospital of Philadelphia, and Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4302, USA
    J Clin Invest 123:1405-12. 2013
  8. pmc The epigenome and the mitochondrion: bioenergetics and the environment [corrected]
    Douglas C Wallace
    Center for Mitochondrial and Epigenomic Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 24:1571-3. 2010

Collaborators

Detail Information

Publications8

  1. doi request reprint Mitochondria and cancer
    Douglas C Wallace
    Children s Hospital of Philadelphia, Center for Mitochondrial and Epigenomic Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Cancer 12:685-98. 2012
    ..Cancer cells then reprogramme adjacent stromal cells to optimize the cancer cell environment. These alterations activate out-of-context programmes that are important in development, stress response, wound healing and nutritional status...
  2. doi request reprint Bioenergetics and the epigenome: interface between the environment and genes in common diseases
    Douglas C Wallace
    The Department of Pathology and Laboratory Medicine, Center for Mitochondrial and Epigenomic Medicine, Children s Hospital of Philadelphia and University of Pennsylvania, 3501 Civic Center Blvd, Philadelphia, PA 19104 4302, USA
    Dev Disabil Res Rev 16:114-9. 2010
    ..The most common genomic changes that interface with the environment and cause complex disease must, therefore, be mitochondrial and epigenomic in origin...
  3. pmc Mitochondrial DNA genetics and the heteroplasmy conundrum in evolution and disease
    Douglas C Wallace
    Center for Mitochondrial and Epigenomic Medicine, The Children s Hospital of Philadelphia, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104
    Cold Spring Harb Perspect Biol 5:a021220. 2013
    ..Maternal inheritance and heteroplasmy also pose major challengers for the diagnosis and prevention of mtDNA disease. ..
  4. pmc Bioenergetics in human evolution and disease: implications for the origins of biological complexity and the missing genetic variation of common diseases
    Douglas C Wallace
    Center of Mitochondrial and Epigenomic Medicine, Children s Hospital of Philadelphia, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Colket Translational Research Building, Room 6060, 3501 Civic Center Boulevard, Philadelphia, PA 19104 4302, USA
    Philos Trans R Soc Lond B Biol Sci 368:20120267. 2013
    ..Furthermore, the missing genetic variation for common human diseases is primarily mtDNA variation plus regional nDNA variants, both of which have been missed by large, inter-population association studies...
  5. pmc Mitochondrial disease genetic diagnostics: optimized whole-exome analysis for all MitoCarta nuclear genes and the mitochondrial genome
    Marni J Falk
    Division of Human Genetics and Division of Child Development and Metabolic Disease, Department of Pediatrics, The Children s Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Discov Med 14:389-99. 2012
    ..The "1:100 Mito-Plus Whole-Exome" Agilent capture kit offers an optimized tool for whole-exome analysis of nuclear and mtDNA genes relevant to the diagnostic evaluation of mitochondrial disease...
  6. pmc Mouse mtDNA mutant model of Leber hereditary optic neuropathy
    Chun Shi Lin
    Center for Mitochondrial and Epigenomic Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 109:20065-70. 2012
    ..Thus, LHON pathophysiology may result from oxidative stress...
  7. pmc A mitochondrial bioenergetic etiology of disease
    Douglas C Wallace
    Center for Mitochondrial and Epigenomic Medicine, Children s Hospital of Philadelphia, and Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4302, USA
    J Clin Invest 123:1405-12. 2013
    ....
  8. pmc The epigenome and the mitochondrion: bioenergetics and the environment [corrected]
    Douglas C Wallace
    Center for Mitochondrial and Epigenomic Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 24:1571-3. 2010
    ..Yoon and colleagues go on to validate their observations by extensively documenting the role of Wnt signaling in the regulation of mitochondrial function...