- Mitochondria and cancerDouglas C Wallace
Children s Hospital of Philadelphia, Center for Mitochondrial and Epigenomic Medicine, Philadelphia, Pennsylvania 19104, USA
Nat Rev Cancer 12:685-98. 2012..Cancer cells then reprogramme adjacent stromal cells to optimize the cancer cell environment. These alterations activate out-of-context programmes that are important in development, stress response, wound healing and nutritional status...
- Bioenergetics and the epigenome: interface between the environment and genes in common diseasesDouglas C Wallace
The Department of Pathology and Laboratory Medicine, Center for Mitochondrial and Epigenomic Medicine, Children s Hospital of Philadelphia and University of Pennsylvania, 3501 Civic Center Blvd, Philadelphia, PA 19104 4302, USA
Dev Disabil Res Rev 16:114-9. 2010..The most common genomic changes that interface with the environment and cause complex disease must, therefore, be mitochondrial and epigenomic in origin...
- The epigenome and the mitochondrion: bioenergetics and the environment [corrected]Douglas C Wallace
Center for Mitochondrial and Epigenomic Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Genes Dev 24:1571-3. 2010..Yoon and colleagues go on to validate their observations by extensively documenting the role of Wnt signaling in the regulation of mitochondrial function...