Douglas C Wallace

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. doi request reprint Mitochondria and cancer
    Douglas C Wallace
    Children s Hospital of Philadelphia, Center for Mitochondrial and Epigenomic Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Cancer 12:685-98. 2012
  2. doi request reprint Bioenergetics and the epigenome: interface between the environment and genes in common diseases
    Douglas C Wallace
    The Department of Pathology and Laboratory Medicine, Center for Mitochondrial and Epigenomic Medicine, Children s Hospital of Philadelphia and University of Pennsylvania, 3501 Civic Center Blvd, Philadelphia, PA 19104 4302, USA
    Dev Disabil Res Rev 16:114-9. 2010
  3. pmc Mouse mtDNA mutant model of Leber hereditary optic neuropathy
    Chun Shi Lin
    Center for Mitochondrial and Epigenomic Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 109:20065-70. 2012
  4. pmc A mitochondrial bioenergetic etiology of disease
    Douglas C Wallace
    Center for Mitochondrial and Epigenomic Medicine, Children s Hospital of Philadelphia, and Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4302, USA
    J Clin Invest 123:1405-12. 2013
  5. pmc The epigenome and the mitochondrion: bioenergetics and the environment [corrected]
    Douglas C Wallace
    Center for Mitochondrial and Epigenomic Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 24:1571-3. 2010

Collaborators

  • Valerio Carelli
  • Alfredo A Sadun
  • Chun Shi Lin
  • Peter Baciu
  • Billy X Pan
  • Daniel W Gil
  • Meagan J McManus
  • Grant R MacGregor
  • Katrina G Waymire
  • Mark S Sharpley
  • Eric Sung
  • Weiwei Fan
  • Fred N Ross-Cisneros

Detail Information

Publications5

  1. doi request reprint Mitochondria and cancer
    Douglas C Wallace
    Children s Hospital of Philadelphia, Center for Mitochondrial and Epigenomic Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Cancer 12:685-98. 2012
    ..Cancer cells then reprogramme adjacent stromal cells to optimize the cancer cell environment. These alterations activate out-of-context programmes that are important in development, stress response, wound healing and nutritional status...
  2. doi request reprint Bioenergetics and the epigenome: interface between the environment and genes in common diseases
    Douglas C Wallace
    The Department of Pathology and Laboratory Medicine, Center for Mitochondrial and Epigenomic Medicine, Children s Hospital of Philadelphia and University of Pennsylvania, 3501 Civic Center Blvd, Philadelphia, PA 19104 4302, USA
    Dev Disabil Res Rev 16:114-9. 2010
    ..The most common genomic changes that interface with the environment and cause complex disease must, therefore, be mitochondrial and epigenomic in origin...
  3. pmc Mouse mtDNA mutant model of Leber hereditary optic neuropathy
    Chun Shi Lin
    Center for Mitochondrial and Epigenomic Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 109:20065-70. 2012
    ..Thus, LHON pathophysiology may result from oxidative stress...
  4. pmc A mitochondrial bioenergetic etiology of disease
    Douglas C Wallace
    Center for Mitochondrial and Epigenomic Medicine, Children s Hospital of Philadelphia, and Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4302, USA
    J Clin Invest 123:1405-12. 2013
    ....
  5. pmc The epigenome and the mitochondrion: bioenergetics and the environment [corrected]
    Douglas C Wallace
    Center for Mitochondrial and Epigenomic Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 24:1571-3. 2010
    ..Yoon and colleagues go on to validate their observations by extensively documenting the role of Wnt signaling in the regulation of mitochondrial function...