INDER MOHAN VERMA

Summary

Affiliation: The Salk Institute
Country: USA

Publications

  1. ncbi request reprint From one experiment to the next
    Inder M Verma
    Salk Institute for Biological Studies, San Diego, CA, USA
    Biotechniques 39:443. 2005
  2. ncbi request reprint Gene therapy: twenty-first century medicine
    Inder M Verma
    Laboratory of Genetics, The Salk Institute, La Jolla, California 92037, USA
    Annu Rev Biochem 74:711-38. 2005
  3. pmc Neprilysin protects neurons against Abeta peptide toxicity
    Salim S El-Amouri
    Department of Molecular and Cellular Biochemistry, Medical University of South Carolina, Charleston, SC 29425, USA
    Brain Res 1152:191-200. 2007
  4. pmc Targeted delivery of proteins across the blood-brain barrier
    Brian J Spencer
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:7594-9. 2007
  5. pmc Neprilysin: an enzyme candidate to slow the progression of Alzheimer's disease
    Salim S El-Amouri
    Department of Molecular and Cellular Biochemistry, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Pathol 172:1342-54. 2008
  6. pmc Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice
    Brian Spencer
    Department of Neurosciences, University of California San Diego, La Jolla, California 92093, USA
    BMC Neurosci 9:109. 2008
  7. pmc Genic regions of a large salamander genome contain long introns and novel genes
    Jeramiah J Smith
    Department of Biology and Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40506, USA
    BMC Genomics 10:19. 2009
  8. pmc Microarray and cDNA sequence analysis of transcription during nerve-dependent limb regeneration
    James R Monaghan
    Department of Biology and Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40506, USA
    BMC Biol 7:1. 2009
  9. ncbi request reprint Inflammation-associated cancer: NF-kappaB is the lynchpin
    Qiutang Li
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Trends Immunol 26:318-25. 2005
  10. pmc Nuclear factor (NF)-kappaB proteins: therapeutic targets
    I M Verma
    The Salk Institute, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Ann Rheum Dis 63:ii57-ii61. 2004

Research Grants

  1. Lentiviral Vectors for Gene Transfer
    Inder Verma; Fiscal Year: 2007
  2. REGULATION OF NF-KAPPA B
    Inder Verma; Fiscal Year: 2007
  3. GENE THERAPY FOR HEMOPHILIA A AND B
    Inder Verma; Fiscal Year: 2003
  4. NHF Fifth Workshop on Gene Therapies for Hemophilia
    Inder Verma; Fiscal Year: 2002
  5. REGULATION OF NF-KAPPA B
    INDER MOHAN VERMA; Fiscal Year: 2010

Collaborators

Detail Information

Publications58

  1. ncbi request reprint From one experiment to the next
    Inder M Verma
    Salk Institute for Biological Studies, San Diego, CA, USA
    Biotechniques 39:443. 2005
  2. ncbi request reprint Gene therapy: twenty-first century medicine
    Inder M Verma
    Laboratory of Genetics, The Salk Institute, La Jolla, California 92037, USA
    Annu Rev Biochem 74:711-38. 2005
    ..Despite some initial success in these trials, vector development remains a seminal concern for improved gene therapy technologies...
  3. pmc Neprilysin protects neurons against Abeta peptide toxicity
    Salim S El-Amouri
    Department of Molecular and Cellular Biochemistry, Medical University of South Carolina, Charleston, SC 29425, USA
    Brain Res 1152:191-200. 2007
    ....
  4. pmc Targeted delivery of proteins across the blood-brain barrier
    Brian J Spencer
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:7594-9. 2007
    ..This approach proved to be feasible for delivery of the protein and could possibly be used as a general method for delivery of therapeutic proteins to the CNS...
  5. pmc Neprilysin: an enzyme candidate to slow the progression of Alzheimer's disease
    Salim S El-Amouri
    Department of Molecular and Cellular Biochemistry, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Pathol 172:1342-54. 2008
    ..These data suggest that restoring NEP levels in the brain at the early stages of AD is an effective strategy to prevent or attenuate disease progression...
  6. pmc Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice
    Brian Spencer
    Department of Neurosciences, University of California San Diego, La Jolla, California 92093, USA
    BMC Neurosci 9:109. 2008
    ..However the effects of long-term neprilysin gene transfer on other aspects of Abeta associated pathology have not been explored yet in APP transgenic mice...
  7. pmc Genic regions of a large salamander genome contain long introns and novel genes
    Jeramiah J Smith
    Department of Biology and Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40506, USA
    BMC Genomics 10:19. 2009
    ..Sixteen BAC clones from the Mexican axolotl (Ambystoma mexicanum: c-value = 32 x 10(9) bp) were isolated and sequenced to characterize the structure of genic regions...
  8. pmc Microarray and cDNA sequence analysis of transcription during nerve-dependent limb regeneration
    James R Monaghan
    Department of Biology and Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40506, USA
    BMC Biol 7:1. 2009
    ..Innervated (NR) and denervated (DL) forelimbs of Mexican axolotls were amputated and transcripts were sampled after 0, 5, and 14 days of regeneration...
  9. ncbi request reprint Inflammation-associated cancer: NF-kappaB is the lynchpin
    Qiutang Li
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Trends Immunol 26:318-25. 2005
    ..This emphasizes the importance of NF-kappaB inhibitors as immunotherapeutic agents for chronic inflammation and suggests that these reagents might prevent, or at least inhibit, chronic inflammation-associated tumorigenesis...
  10. pmc Nuclear factor (NF)-kappaB proteins: therapeutic targets
    I M Verma
    The Salk Institute, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Ann Rheum Dis 63:ii57-ii61. 2004
  11. ncbi request reprint Gene therapy with viral vectors
    Neeltje A Kootstra
    Laboratory of Genetics, The Salk Institute, La Jolla, California 92037 1099, USA
    Annu Rev Pharmacol Toxicol 43:413-39. 2003
    ..Even though the results of these trials are encouraging, vector development is still required to improve and refine future treatment of hereditary disorders...
  12. ncbi request reprint Neprilysin gene transfer reduces human amyloid pathology in transgenic mice
    Robert A Marr
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 23:1992-6. 2003
    ..These data further support a role for neprilysin in regulating cerebral amyloid deposition and suggest that gene transfer approaches might have potential for the development of alternative therapies for Alzheimer's disease...
  13. ncbi request reprint Efficient production of human FVIII in hemophilic mice using lentiviral vectors
    Neeltje A Kootstra
    Laboratory of Genetics, The Salk Institute, La Jolla, California 92037, USA
    Mol Ther 7:623-31. 2003
    ..The challenge is to overcome the immune barriers to the therapeutic gene product...
  14. ncbi request reprint Adenovirus-mediated overexpression of follistatin enlarges intact liver of adult rats
    Kazuaki Takabe
    The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA 92037, USA
    Hepatology 38:1107-15. 2003
    ..In conclusion, our results suggest that activin plays a critical role in maintaining optimal liver size and implicates the endogenous activin system as a therapeutic target in the treatment of liver disease...
  15. pmc Adeno-associated virus effectively mediates conditional gene modification in the brain
    Brian K Kaspar
    Laboratory of Genetics, Molecular Neurobiology Laboratory, and Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:2320-5. 2002
    ..This approach will greatly facilitate the study of genetic modifications in the mouse brain...
  16. ncbi request reprint Development of ecdysone-regulated lentiviral vectors
    Francesco Galimi
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10110 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Ther 11:142-8. 2005
    ..Moreover, our work provides hints on the design of lentiviral vectors containing multiple expression cassettes with multiple promoters...
  17. ncbi request reprint Rapid generation of knockdown transgenic mice by silencing lentiviral vectors
    Oded Singer
    The Salk Institute for Biological Studies, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Protoc 1:286-92. 2006
    ..These methodologies offer the possibility of large-scale generation of knockdown transgenic mice for functional genomic studies and enable the production of transgenic mice in 7 weeks...
  18. pmc Applications of lentiviral vectors for shRNA delivery and transgenesis
    Oded Singer
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Curr Gene Ther 8:483-8. 2008
    ..In this review, we will discuss two examples of in vivo applications for the use of lentiviral vectors expressing shRNAs: Gene therapy of neurological disorders and generation of transgenic knockdown animals...
  19. pmc A fourth IkappaB protein within the NF-kappaB signaling module
    Soumen Basak
    Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 128:369-81. 2007
    ..Our results have important implications for physiological and pathological scenarios in which inflammatory and developmental signals converge...
  20. pmc Abrogation of postentry restriction of HIV-1-based lentiviral vector transduction in simian cells
    Neeltje A Kootstra
    Laboratory of Genetics and Infectious Disease Laboratory, The Salk Institute, La Jolla, CA 92037 1099, USA
    Proc Natl Acad Sci U S A 100:1298-303. 2003
    ..Overall, the findings demonstrate that the host range of HIV-1-based LV can be altered by modifications in the packaging construct...
  21. ncbi request reprint Gene therapy: therapeutic gene causing lymphoma
    Niels Bjarne Woods
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 440:1123. 2006
    ..Gene-therapy trials for X-SCID, which have been based on the assumption that IL2RG is minimally oncogenic, may therefore pose some risk to patients...
  22. pmc Restoration of spermatogenesis by lentiviral gene transfer: offspring from infertile mice
    Masahito Ikawa
    Laboratory of Genetics, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:7524-9. 2002
    ..We propose that lentiviral vectors can be used for gene therapy of male infertility without the risk of germ-line transmission...
  23. ncbi request reprint Choroidal neovascularization in transgenic mice expressing prokineticin 1: an animal model for age-related macular degeneration
    Nobushige Tanaka
    Laboratory of Genetics, The Salk Institute, La Jolla, CA, USA
    Mol Ther 13:609-16. 2006
    ..hPK1 could be one of the causative factors of AMD and the transgenic mouse exhibiting CNV may be useful to establish treatments for the wet form of AMD...
  24. ncbi request reprint Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice
    Iiris Hovatta
    The Salk Institute for Biological Studies, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 438:662-6. 2005
    ..Both of these genes are involved in oxidative stress metabolism, linking this pathway with anxiety-related behaviour...
  25. ncbi request reprint Distinct roles of IkappaB proteins in regulating constitutive NF-kappaB activity
    Vinay Tergaonkar
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Nat Cell Biol 7:921-3. 2005
    ..We also show that in the absence of IkappaBalpha, IkappaBbeta and IkappaBepsilon proteins, cytoplasmic retention of NF-kappaB by other cellular proteins renders the pathway unresponsive to activation...
  26. pmc Transgenesis by lentiviral vectors: lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos
    Alexander Pfeifer
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:2140-5. 2002
    ..Ability to transfer foreign genes into human ES cells has potential relevance for the development of gene and cell-based therapies...
  27. ncbi request reprint Inflammatory tales of liver cancer
    Alexander Hoffmann
    Signaling Systems Laboratory, University of California, San Diego, La Jolla, CA 92093, USA
    Cancer Cell 11:99-101. 2007
    ..These studies suggest careful examination of NF-kappaB inhibitors as a therapeutic modality for cancer...
  28. ncbi request reprint Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model
    Oded Singer
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Neurosci 8:1343-9. 2005
    ....
  29. ncbi request reprint NF-kappaB regulation in the immune system
    Qiutang Li
    The Salk Institute, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Immunol 2:725-34. 2002
    ..We also discuss the role of NF-kappaB proteins as potential therapeutic targets in clinical applications...
  30. ncbi request reprint Gene therapy of Fanconi anemia: preclinical efficacy using lentiviral vectors
    Francesco Galimi
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Blood 100:2732-6. 2002
    ..This study strongly supports the use of lentiviral vectors for FA gene therapy in humans...
  31. ncbi request reprint Generation of transgenic mice using lentiviral vectors: a novel preclinical assessment of lentiviral vectors for gene therapy
    Masahito Ikawa
    Laboratory of Genetics, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Mol Ther 8:666-73. 2003
    ..We conclude that the generation of transgenic mice using lentiviral vectors is a simple and robust method to evaluate the promoter specificity in lentiviral vectors in vivo prior to undertaking a gene therapy strategy...
  32. pmc IkappaB kinase-independent IkappaBalpha degradation pathway: functional NF-kappaB activity and implications for cancer therapy
    Vinay Tergaonkar
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell Biol 23:8070-83. 2003
    ..These results reveal an additional pathway of activating NF-kappaB during the course of anticancer therapy and provide a mechanistic basis for the observation that proteasome inhibitors could be used as adjuvants in chemotherapy...
  33. ncbi request reprint Design and cloning of lentiviral vectors expressing small interfering RNAs
    Gustavo Tiscornia
    The Salk Institute for Biological Studies, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Protoc 1:234-40. 2006
    ..Here we present two possible protocols describing the design and cloning of silencing lentiviral vectors. These protocols can be completed in less than 3 weeks...
  34. pmc Enhanced NF-kappaB activation and cellular function in macrophages lacking IkappaB kinase 1 (IKK1)
    Qiutang Li
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:12425-30. 2005
    ..We hypothesize that IKK1 plays a checkpoint role in the proper control of IkappaBalpha kinase activity in innate and adaptive immunity...
  35. pmc Development of a novel mouse glioma model using lentiviral vectors
    Tomotoshi Marumoto
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Nat Med 15:110-6. 2009
    ..We suggest that the use of Cre-loxP-controlled lentiviral vectors is a novel way to generate a mouse glioblastoma multiforme model in a region- and cell type-specific manner in adult mice...
  36. ncbi request reprint Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival
    Sourav Ghosh
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Cancer Cell 10:215-26. 2006
    ..These results provide evidence for a crosstalk between the TSC/Rheb/mTOR pathway and the NF-kappaB induction pathways and indicate that NF-kappaB functions as an important survival factor that regulates TSC2-dependent cell survival...
  37. ncbi request reprint Production and purification of lentiviral vectors
    Gustavo Tiscornia
    The Salk Institute for Biological Studies, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Protoc 1:241-5. 2006
    ....
  38. pmc A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA
    Gustavo Tiscornia
    Laboratory of Genetics, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:1844-8. 2003
    ..We believe that this approach of generating "knockdown" mice will aid in functional genomics...
  39. ncbi request reprint Zebrafish IkappaB kinase 1 negatively regulates NF-kappaB activity
    Ricardo G Correa
    The Salk Institute for Biological Studies, La Jolla, CA 92037 1099, USA
    Curr Biol 15:1291-5. 2005
    ..Here, we report that Ikk1 negatively regulates NF-kappaB by sequestering NEMO from active IKK complexes, indicating that IKK1 can function as a repressor of NF-kappaB...
  40. ncbi request reprint Effect of adenovirus-mediated overexpression of follistatin and extracellular domain of activin receptor type II on gonadotropin secretion in vitro and in vivo
    Angela M O Leal
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Endocrinology 143:964-9. 2002
    ....
  41. pmc Characterization of NF-kappa B/I kappa B proteins in zebra fish and their involvement in notochord development
    Ricardo G Correa
    Salk Institute for Biological Studies, La Jolla, CA 92037 1099, USA
    Mol Cell Biol 24:5257-68. 2004
    ..Our study illustrates the conservation and compatibility of NF-kappa B/I kappa B proteins among vertebrates and the importance of NF-kappa B pathway in mesoderm formation during early embryogenesis...
  42. ncbi request reprint Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit
    Jeanette L Ducut Sigala
    Salk Institute for Biological Sciences, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 304:1963-7. 2004
    ..These cells were also not protected from apoptosis in response to cytokines. ELKS likely functions by recruiting IkappaBalpha to the IKK complex and thus serves a regulatory function for IKK activation...
  43. ncbi request reprint A role for bone marrow-derived cells in the vasculature of noninjured CNS
    Francesco Galimi
    Laboratory of Genetics, The Salk Institute, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 105:2400-2. 2005
    ..Bone marrow-derived, vasculature-associated cells in the noninjured adult CNS are distinct from endothelial cells, but play an active role in vascular structures...
  44. pmc CRE recombinase-inducible RNA interference mediated by lentiviral vectors
    Gustavo Tiscornia
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:7347-51. 2004
    ..We foresee multiple applications of this system both in vitro and in vivo to down-regulate specific targets in a tissue-specific and localized manner...
  45. ncbi request reprint Long-term lowering of plasma cholesterol levels in LDL-receptor-deficient WHHL rabbits by gene therapy
    Hanna M Kankkonen
    A I Virtanen Institute for Molecular Sciences, Department of Biotechnology and Molecular Medicine, University of Kuopio, Neulaniementie 2, FIN 70210 Kuopio, Finland
    Mol Ther 9:548-56. 2004
    ....
  46. ncbi request reprint Biodistribution and toxicity studies of VSVG-pseudotyped lentiviral vector after intravenous administration in mice with the observation of in vivo transduction of bone marrow
    Dao Pan
    Department of Pediatrics and Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Mol Ther 6:19-29. 2002
    ..The observation of bone marrow transduction after intravenous vector administration suggests the possibility of an in vivo approach to stem cell gene therapy...
  47. ncbi request reprint Sustained correction of disease in naive and AAV2-pretreated hemophilia B dogs: AAV2/8-mediated, liver-directed gene therapy
    Lili Wang
    Medical Genetics Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 105:3079-86. 2005
    ..No significant liver toxicity or cFIX-specific antibodies have been detected in these animals. Studies here have demonstrated the safety and improved efficacy of AAV2/8 vector in large-animal models for liver-directed gene therapy...
  48. ncbi request reprint A gene therapy institute for NIH?
    Inder M Verma
    Mol Ther 5:213. 2002
  49. ncbi request reprint Hypothesis-driven science
    Inder M Verma
    Mol Ther 6:1. 2002
  50. ncbi request reprint Success and setback: another adverse event
    Inder M Verma
    Mol Ther 6:565-6. 2002
  51. pmc Sustained suppression of Bcr-Abl-driven lymphoid leukemia by microRNA mimics
    Jami McLaughlin
    Department of Microbiology, Immunology, and Molecular Genetics and Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:20501-6. 2007
    ..Only methods capable of such dramatic sustained reduction in the level of expression of highly activated kinase oncogenes are likely to be effective in controlling malignant cell populations...
  52. ncbi request reprint Making the promise a reality
    Inder M Verma
    Mol Ther 6:695. 2002
  53. ncbi request reprint Efficient transduction of liver and muscle after in utero injection of lentiviral vectors with different pseudotypes
    Tippi C MacKenzie
    Children s Institute for Surgical Science, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Mol Ther 6:349-58. 2002
    ..m. and i.h. injection of all three vectors. Our findings of long-term transduction of skeletal myocytes and cardiomyocytes after in utero administration suggest a novel strategy for the treatment of congenital muscular dystrophies...
  54. ncbi request reprint A voluntary moratorium?
    Inder M Verma
    Mol Ther 7:141. 2003
  55. ncbi request reprint Efficient transgenic rat production by a lentiviral vector
    Mieczyslaw Michalkiewicz
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 293:H881-94. 2007
    ..Thus lentiviral transgenesis provides a powerful tool for the production of transgenic inbred rats and will enhance the usefulness of this species in gene discovery and target validation studies...
  56. ncbi request reprint Interview with Dr Verma
    Inder M Verma
    Gene Ther 12:950-3. 2005
  57. ncbi request reprint Doping, gene transfer and sport
    Inder M Verma
    Mol Ther 10:405. 2004
  58. pmc Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease
    Jean Cosme Dodart
    Neuroscience Discovery Research, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Proc Natl Acad Sci U S A 102:1211-6. 2005
    ..Our data demonstrate rapid apoE isoform-dependent effects on brain Abeta burden in a mouse model of AD. Gene delivery of apoE2 may prevent or reduce brain Abeta burden and the subsequent development of neuritic plaques...

Research Grants17

  1. Lentiviral Vectors for Gene Transfer
    Inder Verma; Fiscal Year: 2007
    ..We strongly believe that continued improvement of lentiviral vectors for gene transfer is an important and challenging goal to pursue. ..
  2. REGULATION OF NF-KAPPA B
    Inder Verma; Fiscal Year: 2007
    ..The detailed knowledge of this important signal pathway will allow us to develop strategies for curing diseases ranging from inflammation to cancer. ..
  3. GENE THERAPY FOR HEMOPHILIA A AND B
    Inder Verma; Fiscal Year: 2003
    ..Finally, we believe that the knowledge gained from gene therapy of hemophilia will serve as an excellent model system for many genetic diseases. ..
  4. NHF Fifth Workshop on Gene Therapies for Hemophilia
    Inder Verma; Fiscal Year: 2002
    ..abstract_text> ..
  5. REGULATION OF NF-KAPPA B
    INDER MOHAN VERMA; Fiscal Year: 2010
    ..We propose to study the molecular mechanism of inflammatory processes by studying the regulation of NF-?B a seminal molecule in the induction of inflammation. ..