Research Topics
Genomes and GenesSpecies | Francisco VegaSummaryAffiliation: The University of Texas Country: USA Publications
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Publications
Detection of ABCC1 expression in classical Hodgkin lymphoma is associated with increased risk of treatment failure using standard chemotherapy protocolsWesley Greaves
Department of Hematopathology, Unit 72, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA
J Hematol Oncol 5:47. 2012..ATP-binding cassette (ABC) transporters confer multidrug resistance in various cancers and ABCC1 overexpression has been shown to contribute to drug resistance in the CHL cell line, KMH2...
Angioimmunoblastic T-cell lymphoma in bone marrow: a morphologic and immunophenotypic studyFaisal A Khokhar
Department of Hematopathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Hum Pathol 41:79-87. 2010..By contrast, programed death-1 immunohistochemical staining and double labeling using antibodies specific for BCL-6 and CD3 were helpful in appreciating the follicular T-helper cell immunophenotype of angioimmunoblastic T-cell lymphoma...- Side population of a murine mantle cell lymphoma model contains tumour-initiating cells responsible for lymphoma maintenance and disseminationFrancisco Vega
Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Cell Mol Med 14:1532-45. 2010.... - Splenic marginal zone lymphomas are characterized by loss of interstitial regions of chromosome 7q, 7q31.32 and 7q36.2 that include the protection of telomere 1 (POT1) and sonic hedgehog (SHH) genesFrancisco Vega
Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Br J Haematol 142:216-26. 2008..In conclusion, SMZL, but not NMZL, demonstrates large genomic imbalances and frequent loss of the 7q31.32 and 7q36.2 regions involving POT1 and SHH, respectively. In NMZL, loss of FADD and gain of GLI1 are frequent events... - Sonic hedgehog signaling pathway is activated in ALK-positive anaplastic large cell lymphomaRajesh R Singh
Department of Hematopathology and School of Health Sciences, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Cancer Res 69:2550-8. 2009..There is a positive synergistic effect between the SHH/GLI1 and PI3K/AKT pathways that contributes to the lymphomagenic effect of NPM-ALK... - Quantification of bcl-2/JH fusion sequences and a control gene by multiplex real-time PCR coupled with automated amplicon sizing by capillary electrophoresisBeatriz Sanchez-Vega
Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston 77030-4095, Texas, USA
J Mol Diagn 4:223-9. 2002..This multiplex PCR assay is equally sensitive to previous assays, allows more accurate quantification of bcl-2/JH fusion sequences, and is more convenient... - Sonic hedgehog signaling proteins and ATP-binding cassette G2 are aberrantly expressed in diffuse large B-cell lymphomaJi Eun Kim
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Mod Pathol 22:1312-20. 2009..These findings also provide evidence that dysregulation of the SHH pathway may be involved in the pathogenesis of diffuse large B-cell lymphoma... - Glioma-associated oncogene homologue 3, a hedgehog transcription factor, is highly expressed in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphomaWesley O Greaves
Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Hum Pathol 42:1643-52. 2011..Our data provide a rationale to further investigate the biologic significance of glioma-associated oncogene homologue 3 in classical Hodgkin lymphoma biology... - Expression of serine 194-phosphorylated Fas-associated death domain protein correlates with proliferation in B-cell non-Hodgkin lymphomasElias Drakos
Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Hum Pathol 42:1117-24. 2011..9, P < .0001). These data provide evidence that serine 194 phosphorylated Fas-associated death domain protein is involved in the proliferation of normal and neoplastic B cells and has features of a novel proliferation marker... 
Tissue-specific function of lymph node fibroblastic reticulum cellsFrancisco Vega
Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Pathobiology 73:71-81. 2006..CONCLUSIONS: Cultured FRC showed an overall transcriptional profile similar to cultured DF, including parallel responsiveness to TNF, but with differences in the expression of chemotactic chemokines, which reflect their biological roles...- Constitutive BR3 receptor signaling in diffuse, large B-cell lymphomas stabilizes nuclear factor-κB-inducing kinase while activating both canonical and alternative nuclear factor-κB pathwaysLan V Pham
Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Blood 117:200-10. 2011..These results further elucidate mechanisms involved in abnormal NF-κB activation in DLBCL, and should contribute to better future therapeutic approaches for patients with DLBCL... - The stromal composition of malignant lymphoid aggregates in bone marrow: variations in architecture and phenotype in different B-cell tumoursFrancisco Vega
Division of Pathology and Laboratory Medicine, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Br J Haematol 117:569-76. 2002..In FL, expression of follicular dendritic cell-associated markers is modulated in pre-existing marrow stromal cells... - Over-expression of Thioredoxin-1 mediates growth, survival, and chemoresistance and is a druggable target in diffuse large B-cell lymphomaChangping Li
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Oncotarget 3:314-26. 2012..These results indicate that Trx-1 plays a key role in cell growth and survival, as well as chemoresistance, and is a potential target to overcome drug resistance in relapsed/refractory DLBCL... - Chronic lymphocytic leukemia with t(14;19)(q32;q13) is characterized by atypical morphologic and immunophenotypic features and distinctive genetic featuresYang O Huh
Dept of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
Am J Clin Pathol 135:686-96. 2011..Our results indicate that t(14;19)(q32;q13) identifies a subset of CLL/SLL with distinctive clinicopathologic and genetic features. Furthermore, t(14;19) may represent an early, possibly primary, genetic event... - Nodular lymphocyte predominant Hodgkin lymphoma with clusters of LP Cells, acute inflammation, and fibrosis: a syncytial variantElias Drakos
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Am J Surg Pathol 33:1725-31. 2009..Recognition of this rare variant, facilitated by immunohistochemical studies in this case, further expands the morphologic spectrum of NLPHL... - Leukemia cutisJeong Hee Cho-Vega
Department of Pathology, The Methodist Hospital, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Am J Clin Pathol 129:130-42. 2008..We review the literature and recent advances pertaining to LC, with special emphasis on the immunohistochemical assessment and possible mechanisms involved in skin tropism by leukemic cells... - t(8;13)-positive bilineal lymphomas: report of 6 casesFrancisco Vega
Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Am J Surg Pathol 32:14-20. 2008..They likely arise from an early hematopoietic cell with potential to differentiate along T-cell and myeloid pathways... - Clonal heterogeneity in mycosis fungoides and its relationship to clinical courseFrancisco Vega
Division of Pathology and Laboratory Medicine, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Blood 100:3369-73. 2002..Demonstration of identical clonal GRs in multiple biopsy specimens at the time of diagnosis may provide prognostic information related to disease progression... - Immunohistochemical markers for tumor associated macrophages and survival in advanced classical Hodgkin's lymphomaBeatriz Sánchez-Espiridión
Department of Pathology, M D Anderson Cancer Center, Houston, TX, USA
Haematologica 97:1080-4. 2012..In conclusion, individual tumor associated macrophage markers cannot be used to predict outcome before technical standardization and prospective validation in independent series of patients with comparable stages and treatments... - Defining causative factors contributing in the activation of hedgehog signaling in diffuse large B-cell lymphomaElisa Ramírez
Molecular Genetic Technology Program, School of Health Sciences, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Leuk Res 36:1267-73. 2012..In conclusion, our data support the hypothesis that aberrant activation of Hh signaling in DLBCL mainly results from integration of deregulated oncogenic signaling inputs converging into Hh signaling... - Phenotypic modulation of the stromal reticular network in normal and neoplastic lymph nodes: tissue transglutaminase reveals coordinate regulation of multiple cell typesVilmos A Thomazy
Department of Hematopathology, University of Texas M.D. Anderson Cancer Center, and the Department of Pathology, University of Texas, Houston Medical School, Houston, Texas, USA
Am J Pathol 163:165-74. 2003..Using TG as a stromal marker, we have identified differential modulation of the phenotype of the lymph node reticular network that parallels change in the B-cell compartment... - Lymphomas involving the pleura: a clinicopathologic study of 34 cases diagnosed by pleural biopsyFrancisco Vega
Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, Tex 77030, USA
Arch Pathol Lab Med 130:1497-502. 2006..The most frequent type is diffuse large B-cell lymphoma, followed by follicular lymphoma. Cytologic examination can have negative results in patients with pleural involvement by lymphoma... - Primary cutaneous marginal zone B-cell lymphomaJeong Hee Cho-Vega
Department of Pathology, The Methodist Hospital, Houston, TX, USA
Am J Clin Pathol 125:S38-49. 2006..The t(14;18)(q32;q21) and t(11;18)(q21;q21) have been shown to activate the NF-kappaB pathway... - Expression of dicarbonyl/L-xylulose reductase (DCXR) in human skin and melanocytic lesions: morphological studies supporting cell adhesion function of DCXRJeong Hee Cho-Vega
Department of Pathology, The Methodist Hospital, Houston, TX, USA
J Cutan Pathol 34:535-42. 2007..It has been proposed that dicarbonyl/L-xylulose reductase (DCXR) is increased in prostate cancer. Also, when compared with normal skin, a virtual northern blot shows increased expression of DCXR in melanomas... - Hepatosplenic and other gammadelta T-cell lymphomasFrancisco Vega
Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Am J Clin Pathol 127:869-80. 2007..In contrast with HSTCL, non-HSTCL gammadelta T-cell lymphomas frequently have an activated cytotoxic phenotype and most likely are not a single disease entity... - MYC translocation in chronic lymphocytic leukaemia is associated with increased prolymphocytes and a poor prognosisYang O Huh
Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Br J Haematol 142:36-44. 2008..In summary, MYC rearrangement, which occurs rarely in CLL patients, is associated with increased prolymphocytes, complex cytogenetic abnormalities, and a poor prognosis... - Real-Time t(14;18)(q32;q21) PCR assay combined with high-resolution capillary electrophoresis: a novel and rapid approach that allows accurate quantitation and size determination of bcl-2/JH fusion sequencesBeatriz Sanchez-Vega
Division of Pathology and Laboratory Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77054, USA
Mod Pathol 15:448-53. 2002..The JH-NED primer did not interfere with the TaqMan probe fluorescent signal or target detection and allowed subsequent amplicon size determination by semiautomated high-resolution capillary electrophoresis... - Molecular genetic methods in the diagnosis of hematologic neoplasmsFiliz Sen
Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA
Semin Diagn Pathol 19:72-93. 2002..In this review, we focus on chromosomal translocations in hematologic neoplasms and the techniques used for their detection. We also briefly discuss tumor suppressor genes and assessment of clonality in lymphoid neoplasms... - Extranodal NK/T-cell lymphoma, nasal type: a report of 73 cases at MD Anderson Cancer CenterShaoying Li
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Am J Surg Pathol 37:14-23. 2013..The International Prognostic Index score, anatomic site of disease, and proliferation rate had prognostic value in this patient cohort... - Essential role of TAK1 in regulating mantle cell lymphoma survivalDaniela Buglio
Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Blood 120:347-55. 2012..Collectively, our data demonstrate an essential role for TAK1 in regulating critical survival mechanisms in lymphoma and suggest that it may serve as a therapeutic target... - N-terminal PAX8 polyclonal antibody shows cross-reactivity with N-terminal region of PAX5 and is responsible for reports of PAX8 positivity in malignant lymphomasLucas Moretti
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Mod Pathol 25:231-6. 2012..We conclude that positivity for PAX8 reported by others in B-cell lymphomas is likely due to cross-reactivity between the N-terminal regions of PAX8 and PAX5, due to the high sequence homology of these two regions... - Early-stage mycosis fungoides variants: case-based reviewJeong Hee Cho-Vega
St Joseph Dermatopathology, Houston, TX 77030, USA
Ann Diagn Pathol 14:369-85. 2010..In addition, we discuss the role of molecular studies, which are highly sensitive and recently more applicable to routinely processed skin biopsy specimens in the diagnosis of MF... - Precursor T-cell acute lymphoblastic leukemia in adults: age-related immunophenotypic, cytogenetic, and molecular subsetsMihaela Onciu
Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA
Am J Clin Pathol 117:252-8. 2002..Within this group, CD1a expression correlated with age 28 to 60 years. These results illustrate considerable age-related heterogeneity in adult T-ALL, which may reflect differences in tumor cell maturation... - Extranodal lymphomas of the head and neckFrancisco Vega
Department of Hematopathology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
Ann Diagn Pathol 9:340-50. 2005.... - High-grade B cell lymphoma, unclassifiable, with blastoid features: an unusual morphological subgroup associated frequently with BCL2 and/or MYC gene rearrangements and a poor prognosisRashmi Kanagal-Shamanna
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Histopathology 61:945-54. 2012..At a haematopathology workshop, experts had suggested the term 'high-grade B cell lymphoma, unclassifiable, with blastoid features', and recommended further studies... - Epstein-Barr virus-positive B-cell lymphoproliferative disorders arising in immunodeficient patients previously treated with fludarabine for low-grade B-cell neoplasmsLynne V Abruzzo
Department of Hematopathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Am J Surg Pathol 26:630-6. 2002..Most are clonally distinct from the underlying low-grade B-cell neoplasm. A subset of these lesions may regress without systemic therapy... - Chromosomal translocations and their role in the pathogenesis of non-Hodgkin's lymphomasFrancisco Vega
Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
Pathology 34:397-409. 2002..This review examines the involved genes in chromosomal translocations and current evidence and postulated mechanisms for their role in the pathogenesis of non-Hodgkin's lymphomas... - CD4-CD8-"Double-negative" cutaneous T-cell lymphomas share common histologic features and an aggressive clinical courseDan Jones
Division of Pathology and Laboratory Medicine, Department of Lymphoma, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, U S A
Am J Surg Pathol 26:225-31. 2002..CD4-CD8-"double-negative" CTCL has distinctive histologic features and cytomorphology with a marked propensity for rapid multifocal cutaneous dissemination... - Atypical NK-cell proliferation of the gastrointestinal tract in a patient with antigliadin antibodies but not celiac diseaseFrancisco Vega
Department of Pathology, Baylor College of Medicine, The Methodist Hospital, Houston, TX 77030, USA
Am J Surg Pathol 30:539-44. 2006..It is as yet unknown whether this process occurs more commonly in patients with gluten sensitivity, or in other settings, and the pathogenesis is as yet undetermined... - Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphomaFrancisco Vega
Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Cancer Res 66:6589-97. 2006..These findings suggest that the mTOR pathway contributes to nucleophosmin-ALK/PI3K/AKT-mediated tumorigenesis and that inhibition of mTOR represents a potential therapeutic strategy in ALK+ ALCL... - Extracavitary/solid variant of primary effusion lymphomaYoonjung Kim
Department of Hematopathology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
Ann Diagn Pathol 16:441-6. 2012..These cases highlight the importance of assessing HHV8 in an anaplastic tumor that arises in a human immunodeficiency virus-positive patient and further contributes to the limited literature currently available for extracavitary PEL...