Peter Vanderklish

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Dendritic spines elongate after stimulation of group 1 metabotropic glutamate receptors in cultured hippocampal neurons
    Peter W Vanderklish
    Department of Neurobiology, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:1639-44. 2002
  2. pmc Cold stress-induced protein Rbm3 binds 60S ribosomal subunits, alters microRNA levels, and enhances global protein synthesis
    John Dresios
    Department of Neurobiology, The Scripps Research Institute and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:1865-70. 2005
  3. pmc Widespread regulation of miRNA biogenesis at the Dicer step by the cold-inducible RNA-binding protein, RBM3
    Julie Pilotte
    Department of Neurobiology, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 6:e28446. 2011
  4. ncbi request reprint Differential translation and fragile X syndrome
    P W Vanderklish
    Department of Neurobiology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Genes Brain Behav 4:360-84. 2005
  5. pmc Quantitative proteomic analysis of primary neurons reveals diverse changes in synaptic protein content in fmr1 knockout mice
    Lujian Liao
    Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:15281-6. 2008
  6. ncbi request reprint BDNF induces widespread changes in synaptic protein content and up-regulates components of the translation machinery: an analysis using high-throughput proteomics
    Lujian Liao
    Departments of Cell Biology and Neurobiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Proteome Res 6:1059-71. 2007
  7. pmc BDNF induces translocation of initiation factor 4E to mRNA granules: evidence for a role of synaptic microfilaments and integrins
    Fiona M Smart
    Department of Neurobiology, The Scripps Research Institute, and The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:14403-8. 2003
  8. pmc The fragile X mental retardation protein and group I metabotropic glutamate receptors regulate levels of mRNA granules in brain
    Armaz Aschrafi
    Department of Neurobiology, The Scripps Research Institute, and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, SBR 14, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:2180-5. 2005
  9. pmc The brain-derived neurotrophic factor enhances synthesis of Arc in synaptoneurosomes
    Yong Yin
    Department of Neurobiology, The Scripps Research Institute and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:2368-73. 2002
  10. ncbi request reprint Early postnatal plasticity in neocortex of Fmr1 knockout mice
    Niraj S Desai
    The Neurosciences Fine Institute, San Diego, CA 92121, USA
    J Neurophysiol 96:1734-45. 2006

Research Grants

Collaborators

Detail Information

Publications11

  1. pmc Dendritic spines elongate after stimulation of group 1 metabotropic glutamate receptors in cultured hippocampal neurons
    Peter W Vanderklish
    Department of Neurobiology, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:1639-44. 2002
    ..The results suggest that in vivo activation of group 1 mGluRs by synaptically released glutamate affects spine shape in a protein synthesis-dependent manner...
  2. pmc Cold stress-induced protein Rbm3 binds 60S ribosomal subunits, alters microRNA levels, and enhances global protein synthesis
    John Dresios
    Department of Neurobiology, The Scripps Research Institute and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:1865-70. 2005
    ....
  3. pmc Widespread regulation of miRNA biogenesis at the Dicer step by the cold-inducible RNA-binding protein, RBM3
    Julie Pilotte
    Department of Neurobiology, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 6:e28446. 2011
    ....
  4. ncbi request reprint Differential translation and fragile X syndrome
    P W Vanderklish
    Department of Neurobiology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Genes Brain Behav 4:360-84. 2005
    ..We discuss several potential mechanisms for differential translation and the notion that FXS represents an exaggeration of one 'channel' in a set of translation-dependent consolidation responses...
  5. pmc Quantitative proteomic analysis of primary neurons reveals diverse changes in synaptic protein content in fmr1 knockout mice
    Lujian Liao
    Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:15281-6. 2008
    ..These studies provide insights into the potential origins of synaptic abnormalities in FXS and a demonstration of a methodology that can be used to explore neuronal protein changes in neurological disorders...
  6. ncbi request reprint BDNF induces widespread changes in synaptic protein content and up-regulates components of the translation machinery: an analysis using high-throughput proteomics
    Lujian Liao
    Departments of Cell Biology and Neurobiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Proteome Res 6:1059-71. 2007
    ..The data demonstrate that BDNF increases the synthesis of a wide variety of synaptic proteins and suggest that the neurotrophin may enhance the translational capacity of synapses...
  7. pmc BDNF induces translocation of initiation factor 4E to mRNA granules: evidence for a role of synaptic microfilaments and integrins
    Fiona M Smart
    Department of Neurobiology, The Scripps Research Institute, and The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:14403-8. 2003
    ..Integrins, which are known to be essential for stabilizing certain forms of synaptic plasticity, may be critical regulators of local translation events at synapses...
  8. pmc The fragile X mental retardation protein and group I metabotropic glutamate receptors regulate levels of mRNA granules in brain
    Armaz Aschrafi
    Department of Neurobiology, The Scripps Research Institute, and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, SBR 14, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:2180-5. 2005
    ..Together, these data suggest that although large, polysome-containing granules can form in the absence of FMRP, their use in response to mGluR-induced translation is exaggerated...
  9. pmc The brain-derived neurotrophic factor enhances synthesis of Arc in synaptoneurosomes
    Yong Yin
    Department of Neurobiology, The Scripps Research Institute and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:2368-73. 2002
    ..The results suggest there is a synergy between neurotrophic and ionotropic mechanisms that may influence the specificity and duration of changes in synaptic efficacy at glutamatergic synapses...
  10. ncbi request reprint Early postnatal plasticity in neocortex of Fmr1 knockout mice
    Niraj S Desai
    The Neurosciences Fine Institute, San Diego, CA 92121, USA
    J Neurophysiol 96:1734-45. 2006
    ..These findings underscore the ideas that Fmr1 has highly selective effects on plasticity and that abnormal postnatal development is an important component of the disorder...
  11. ncbi request reprint Two isoforms of the cold-inducible mRNA-binding protein RBM3 localize to dendrites and promote translation
    Fiona Smart
    Department of Neurobiology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurochem 101:1367-79. 2007
    ..These data suggest that RBM3 plays a distinctive role in enhancing translation in neurons...

Research Grants4

  1. Links among synaptic activity, translation and structure
    Peter Vanderklish; Fiscal Year: 2003
    ....
  2. Circadian regulation of microRNA biogenesis and function
    Peter Vanderklish; Fiscal Year: 2009
    ..Our studies will define a mechanistic link between circadian rhythm and protein synthesis in neurons, providing fundamental insights into the control of brain function and neurological diseases. ..
  3. Circadian regulation of microRNA biogenesis and function
    Peter W Vanderklish; Fiscal Year: 2010
    ..Our studies will define a mechanistic link between circadian rhythm and protein synthesis in neurons, providing fundamental insights into the control of brain function and neurological diseases. ..
  4. Circadian regulation of microRNA biogenesis and function
    Peter W Vanderklish; Fiscal Year: 2010
    ..Our studies will define a mechanistic link between circadian rhythm and protein synthesis in neurons, providing fundamental insights into the control of brain function and neurological diseases. ..