Research Topics
Genomes and GenesSpecies | Vicente ValeroSummaryAffiliation: The University of Texas Country: USA Publications
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Publications
Managing ixabepilone adverse events with dose reductionVicente Valero
Department of Breast Medical Oncology, Division of Cancer Medicine, The Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Clin Breast Cancer 13:1-6. 2013..More information is required on dosage and scheduling of ixabepilone in combination with other agents, including novel targeted therapies...
Maintenance of clinical efficacy after dose reduction of ixabepilone plus capecitabine in patients with anthracycline- and taxane-resistant metastatic breast cancer: a retrospective analysis of pooled data from 2 phase III randomized clinical trialsVicente Valero
The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Clin Breast Cancer 12:240-6. 2012..This retrospective analysis aimed to determine whether early dose reduction impacts the efficacy of ixabepilone plus capecitabine in women with metastatic breast cancer (MBC)...
Circulating tumor cells as prognostic and predictive markers in metastatic breast cancer patients receiving first-line systemic treatmentMario Giuliano
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
Breast Cancer Res 13:R67. 2011..We assessed the prognostic impact of CTCs according to different first-line systemic treatments, and explored their potential predictive value in MBC patients...
Effect of training-sample size and classification difficulty on the accuracy of genomic predictorsVlad Popovici
Bioinformatics Core Facility, Swiss Institute of Bioinformatics, Genopode Building, Quartier Sorge, Lausanne CH 1015, Switzerland
Breast Cancer Res 12:R5. 2010....
Multicenter phase III randomized trial comparing docetaxel and trastuzumab with docetaxel, carboplatin, and trastuzumab as first-line chemotherapy for patients with HER2-gene-amplified metastatic breast cancer (BCIRG 007 study): two highly active therapeuVicente Valero
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Clin Oncol 29:149-56. 2011..Preclinical findings of synergy between docetaxel, carboplatin, and trastuzumab (TCH) prompted a phase III randomized trial comparing TCH with TH in patients with HER2-amplified MBC...
Primary chemotherapy with docetaxel for the management of breast cancerVicente Valero
Department of Breast Medical Oncology, The University of Texas, M D Anderson Cancer Center, Houston 77030 4009, USA
Oncology (Williston Park) 16:35-43. 2002..Preliminary results have shown that incorporation of docetaxel can improve the rate of breast preservation surgery and the overall clinical and pathologic complete response rates...
Primary chemotherapy in the treatment of breast cancer: the University of Texas M. D. Anderson Cancer Center experienceVicente Valero
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Clin Breast Cancer 3:S63-8. 2002..The history of clinical trials focusing on primary therapy in breast cancer at the M. D. Anderson Cancer Center will be reviewed...
CD40 signaling predicts response to preoperative trastuzumab and concomitant paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide in HER-2-overexpressing breast cancerFrancisco J Esteva
Department of Breast Medical Oncology, Unit 1354, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Breast Cancer Res 9:R87. 2007..We performed gene expression analysis to identify molecular predictors of resistance to preoperative concomitant trastuzumab and paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide (T/FEC)...
Genomic index of sensitivity to endocrine therapy for breast cancerW Fraser Symmans
Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
J Clin Oncol 28:4111-9. 2010..We hypothesize that measurement of gene expression related to estrogen receptor α (ER; gene name ESR1) within a breast cancer sample represents intrinsic tumoral sensitivity to adjuvant endocrine therapy...
Postmastectomy radiation improves local-regional control and survival for selected patients with locally advanced breast cancer treated with neoadjuvant chemotherapy and mastectomyEugene H Huang
Department of Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
J Clin Oncol 22:4691-9. 2004..Radiation should be considered for these patients regardless of their response to initial chemotherapy...
Predictors of locoregional recurrence in patients with locally advanced breast cancer treated with neoadjuvant chemotherapy, mastectomy, and radiotherapyEugene H Huang
Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 62:351-7. 2005..Patients with three or more of these factors may benefit from research protocols investigating alternative treatment strategies...
Her2/neu-positive disease does not increase risk of locoregional recurrence for patients treated with neoadjuvant doxorubicin-based chemotherapy, mastectomy, and radiotherapyThomas A Buchholz
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 97, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 59:1337-42. 2004..We retrospectively studied whether Her2/neu-positive disease was associated with locoregional recurrence (LRR) after postmastectomy radiotherapy (RT) for breast cancer...
Long-term cardiac tolerability of trastuzumab in metastatic breast cancer: the M.D. Anderson Cancer Center experienceValentina Guarneri
Department of Breast Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
J Clin Oncol 24:4107-15. 2006..In patients who have experienced a CE, additional treatment with trastuzumab can be considered after recovery of cardiac function...
T3 disease at presentation or pathologic involvement of four or more lymph nodes predict for locoregional recurrence in stage II breast cancer treated with neoadjuvant chemotherapy and mastectomy without radiotherapyAmit K Garg
Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 59:138-45. 2004..For most patients with clinical T1 or T2 disease and one to three positive lymph nodes, the 5-year risk for LRR was low, and the routine inclusion of postmastectomy radiotherapy does not appear to be justified...
Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancerRoshan Agarwal
The University of Texas M D Anderson Cancer Center MDACC, Houston, Texas, USA
Clin Cancer Res 15:3654-62. 2009..We studied the expression levels of cyclins B1, D1, and E1 and the implications of cyclin overexpression for patient outcomes in distinct breast cancer subtypes defined by clinical variables and transcriptional profiling...
Prognostic value of pathologic complete response after primary chemotherapy in relation to hormone receptor status and other factorsValentina Guarneri
Department of Breast Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77230-1439, USA
J Clin Oncol 24:1037-44. 2006..36 times the risk of death. CONCLUSION: pCR is associated with better outcome regardless of HR status in breast cancer patients who receive PC...
Phase 2 trial of primary systemic therapy with doxorubicin and docetaxel followed by surgery, radiotherapy, and adjuvant chemotherapy with cyclophosphamide, methotrexate, and 5-fluorouracil based on clinical and pathologic response in patients with stage Ricardo H Alvarez
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Cancer 116:1210-7. 2010....
Efficacy of neoadjuvant therapy with trastuzumab concurrent with anthracycline- and nonanthracycline-based regimens for HER2-positive breast cancerSoley Bayraktar
Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 118:2385-93. 2012....
Pharmacogenomic predictor of sensitivity to preoperative chemotherapy with paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide in breast cancerKenneth R Hess
Department of Biostatistics and Applied Mathematics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77230-1439, USA
J Clin Oncol 24:4236-44. 2006..This test correctly identified all but one of the patients who achieved pCR (12 of 13 patients) and all but one of those who were predicted to have residual disease had residual cancer (27 of 28 patients)...
Nomograms to predict pathologic complete response and metastasis-free survival after preoperative chemotherapy for breast cancerRoman Rouzier
Department of Breast Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77230-1439, USA
J Clin Oncol 23:8331-9. 2005..72 in the validation set and outperformed other prediction tools (P = .02). CONCLUSION: Our nomograms predict pCR accurately and can serve as a basis to integrate future molecular markers into a clinical prediction model...
Phase III trial evaluating weekly paclitaxel versus docetaxel in combination with capecitabine in operable breast cancerCatherine M Kelly
The University of Texas MD Anderson Cancer Center, Houston, TX, USA
J Clin Oncol 30:930-5. 2012..We investigated whether capecitabine and docetaxel followed by fluorouracil, epirubicin, and cyclophosphamide (FEC) or weekly paclitaxel (WP) followed by FEC would improve relapse-free survival (RFS) in operable breast cancer...
Neoadjuvant therapy with paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide chemotherapy and concurrent trastuzumab in human epidermal growth factor receptor 2-positive operable breast cancer: an update of the initial randomized studyAman U Buzdar
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 13:228-33. 2007..All data were updated through November 2005...
Inflammatory breast cancer (IBC) and patterns of recurrence: understanding the biology of a unique diseaseMassimo Cristofanilli
Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 110:1436-44. 2007..The authors compared the prognostic features of IBC and non-IBC locally advanced breast cancer (LABC) to gain insight into the biology of this disease entity...
Molecular anatomy of breast cancer stroma and its prognostic value in estrogen receptor-positive and -negative cancersGiampaolo Bianchini
Department of Breast Medical Oncology, Unit 1354, The University of Texas M D Anderson Cancer Center, PO Box 301439, Houston, TX 77230 1439, USA
J Clin Oncol 28:4316-23. 2010....
Genomic grade index is associated with response to chemotherapy in patients with breast cancerCornelia Liedtke
DPhil, Departments of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
J Clin Oncol 27:3185-91. 2009....
Locoregional treatment outcomes for inoperable anthracycline-resistant breast cancerEugene Huang
Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 53:1225-33. 2002..Alternative therapeutic strategies such as novel systemic agents, use of planned myocutaneous repair for closure, or radiation combined with radiosensitizing agents, should be considered in this class of patients...
Phase III randomized trial of dose intensive neoadjuvant chemotherapy with or without G-CSF in locally advanced breast cancer: long-term resultsBanu K Arun
Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Oncologist 16:1527-34. 2011....
Weekly paclitaxel improves pathologic complete remission in operable breast cancer when compared with paclitaxel once every 3 weeksMarjorie C Green
The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 424, Houston, TX 77030, USA
J Clin Oncol 23:5983-92. 2005....
Measurement of residual breast cancer burden to predict survival after neoadjuvant chemotherapyW Fraser Symmans
Department of Pathology, Unit 85, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
J Clin Oncol 25:4414-22. 2007..To measure residual disease after neoadjuvant chemotherapy in order to improve the prognostic information that can be obtained from evaluating pathologic response...
Relationship between lymphocytopenia and circulating tumor cells as prognostic factors for overall survival in metastatic breast cancerUgo De Giorgi
Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Clin Breast Cancer 12:264-9. 2012....
PIK3CA-activating mutations and chemotherapy sensitivity in stage II-III breast cancerCornelia Liedtke
Department of Breast Medical Oncology, University of Texas M, d, Anderson Cancer Center, Houston, TX, USA
Breast Cancer Res 10:R27. 2008..In vitro evidence suggests that PIK3CA (phosphatidylinositol 3-kinase, catalytic, alpha polypeptide) activation may be associated with altered chemotherapy sensitivity in cancer...
Phase I study of capecitabine in combination with temozolomide in the treatment of patients with brain metastases from breast carcinomaEdgardo Rivera
Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Cancer 107:1348-54. 2006..A single-institution Phase I clinical trial was conducted to determine the maximum tolerated dose (MTD) and define the safety profile of temozolomide and capecitabine when used in combination to treat brain metastases from breast cancer...
Outcome after pathologic complete eradication of cytologically proven breast cancer axillary node metastases following primary chemotherapyBryan T Hennessy
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Clin Oncol 23:9304-11. 2005..The purpose of this study was to determine long-term outcome in patients achieving pCR of cytologically proven axillary lymph node (ALN) metastases...
Phase 3 study comparing the use of docetaxel on an every-3-week versus weekly schedule in the treatment of metastatic breast cancerEdgardo Rivera
Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 112:1455-61. 2008..The varying efficacy results and toxicity profiles noted in these earlier studies led to a comparison of the schedules to determine which was safer and more efficacious...
Clinical features associated with a favorable outcome following neoadjuvant chemotherapy in women with localized breast cancer aged 35 years or youngerYesim Eralp
Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, USA
J Cancer Res Clin Oncol 135:141-8. 2009..The aim of this study is to evaluate the impact of body mass index (BMI) and various prognostic factors on pathologic response and survival in young patients with localized breast cancer...
Combined-modality treatment for isolated recurrences of breast carcinoma: update on 30 years of experience at the University of Texas M.D. Anderson Cancer Center and assessment of prognostic factorsEmer O Hanrahan
Department of Breast Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
Cancer 104:1158-71. 2005..The only significant independent prognostic factor was the number of involved axillary lymph nodes at initial diagnosis...
A nonreplicating adenoviral vector that contains the wild-type p53 transgene combined with chemotherapy for primary breast cancer: safety, efficacy, and biologic activity of a novel gene-therapy approachMassimo Cristofanilli
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77230, USA
Cancer 107:935-44. 2006....
Randomized trial of high-dose chemotherapy and autologous hematopoietic stem cell support for high-risk primary breast carcinoma: follow-up at 12 yearsEmer O Hanrahan
Department of Breast Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
Cancer 106:2327-36. 2006....
Phase II, randomized trial to compare anastrozole combined with gefitinib or placebo in postmenopausal women with hormone receptor-positive metastatic breast cancerMassimo Cristofanilli
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 1439, USA
Clin Cancer Res 16:1904-14. 2010..This phase II randomized trial evaluated the efficacy and tolerability of anastrozole combined with gefitinib or anastrozole with placebo in women with hormone receptor-positive metastatic breast cancer (MBC)...
The natural history of breast carcinoma in patients with > or = 10 metastatic axillary lymph nodes before and after the advent of adjuvant therapy: a multiinstitutional retrospective studyAlberto J Montero
Division of Cancer Medicine, Department of Breast Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 104:229-35. 2005..However, despite such improvements, survival rates remained low, and innovative therapeutic approaches are, therefore, needed to improve clinical outcomes...
A randomized phase 2 trial comparing 3-hour versus 96-hour infusion schedules of paclitaxel for the treatment of metastatic breast cancerStacy L Moulder
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, PO Box 301438, Houston, TX 77030, USA
Cancer 116:814-21. 2010..This study was performed to compare efficacy and toxicity profiles of paclitaxel using 3-hour versus 96-hour infusion schedules...
Effective local control and long-term survival in patients with T4 locally advanced breast cancer treated with breast conservation therapyJeannie Shen
Department of Surgical Oncology, Unit 444, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Ann Surg Oncol 11:854-60. 2004..These patients have favorable rates of long-term local control and survival. Mastectomy is not mandatory for all patients with breast cancer who present with skin involvement...
Phase II study of pegylated liposomal doxorubicin in combination with gemcitabine in patients with metastatic breast cancerEdgardo Rivera
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 424, Houston, TX 77030 4009, USA
J Clin Oncol 21:3249-54. 2003..We conducted a phase II clinical trial to determine the clinical efficacy and safety of pegylated liposomal doxorubicin in combination with gemcitabine in patients with metastatic breast cancer...
Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristicsBryan T Hennessy
Department of Gynecologic Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Cancer Res 69:4116-24. 2009..PIK3CA mutations, EMT, and stem cell-like characteristics likely contribute to the poor outcomes of MBC and suggest novel therapeutic targets...
Women age < or = 35 years with primary breast carcinoma: disease features at presentationAna M Gonzalez-Angulo
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 103:2466-72. 2005..The purpose of the current study was to describe a population of young patients with breast carcinoma, their characteristics at the time of diagnosis, and the association of these characteristics with disease recurrence and survival...
Pretreatment staging positron emission tomography/computed tomography in patients with inflammatory breast cancer influences radiation treatment field designsGary V Walker
Department of Radiation Oncology, The Morgan Welch Inflammatory Breast Cancer Clinic, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Int J Radiat Oncol Biol Phys 83:1381-6. 2012..The purpose of this study was to define how pretreatment PET/CT studies affected postmastectomy radiation treatment (PMRT) planning decisions for IBC...
Age and associated fibrocystic changes are prognostically significant in patients with small node-negative (T1a,bN0) invasive breast cancerMerih Guray Durak
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
Breast J 17:462-9. 2011..Age at diagnosis and associated FCC are significant factors in predicting recurrence in patients with T1a,bN0 IBC. Adjuvant systemic therapy should be discussed with and considered for young patients with T1a,bN0 IBC...
Phase I study of prolonged-infusion gemcitabine combined with cyclophosphamide in patients with metastatic carcinoma of the breast: tolerability of an optimal dose scheduleFadi Estephan
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Tex, USA
Oncology 77:63-70. 2009..A phase I study was initiated to determine the maximum tolerated dose (MTD) of prolonged-infusion gemcitabine combined with cyclophosphamide in patients with metastatic breast carcinoma (MBC)...
A detailed evaluation of cardiac toxicity: a phase II study of doxorubicin and one- or three-hour-infusion paclitaxel in patients with metastatic breast cancerSharon H Giordano
Department of Breast Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 8:3360-8. 2002..4%) who received a dose < or = 360 mg/m2 (P = 0.002). CONCLUSIONS: When the doxorubicin dose exceeds 360 mg/m2, the combination of bolus doxorubicin and paclitaxel presents unacceptable cardiac risk...
Canalicular stenosis secondary to weekly versus every-3-weeks docetaxel in patients with metastatic breast cancerBita Esmaeli
Ophthalmology Section, Department of Plastic Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Ophthalmology 109:1188-91. 2002..Once complete or near complete stenosis of the canaliculi occurs, placement of a permanent Pyrex glass tube may become necessary to overcome the blockage of tear outflow...
Evaluation of paclitaxel in adjuvant chemotherapy for patients with operable breast cancer: preliminary data of a prospective randomized trialAman U Buzdar
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
Clin Cancer Res 8:1073-9. 2002..In this prospective randomized trial, the role of paclitaxel was evaluated in an adjuvant setting to determine its impact on reducing the risk of recurrence in patients with operable breast cancer...
A Phase I study of docetaxel plus cyclophosphamide in solid tumors followed by a Phase II study as first-line therapy in metastatic breast cancerJonathan C Trent
Departments of Sarcoma Medical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 9:2426-34. 2003..In view of the high activity and lack of cardiotoxicity, this combination warrants additional investigation in early stage breast cancer and in combination with trastuzumab...
Disease-free and overall survival after pathologic complete disease remission of cytologically proven inflammatory breast carcinoma axillary lymph node metastases after primary systemic chemotherapyBryan T Hennessy
Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 106:1000-6. 2006..The purpose of the current study was to determine long-term outcome in patients achieving a pCR of cytologically proven inflammatory breast carcinoma ALN metastases after primary chemotherapy...
Factors predictive of distant metastases in patients with breast cancer who have a pathologic complete response after neoadjuvant chemotherapyAna M Gonzalez-Angulo
Department of Breast Medical Oncology, Unit 424, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
J Clin Oncol 23:7098-104. 2005..To identify clinicopathological factors predictive of distant metastasis in patients who had a pathologic complete response (pCR) after neoadjuvant chemotherapy (NC)...
High risk of recurrence for patients with breast cancer who have human epidermal growth factor receptor 2-positive, node-negative tumors 1 cm or smallerAna M Gonzalez-Angulo
Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
J Clin Oncol 27:5700-6. 2009..To evaluate the risk of recurrence in women diagnosed with T1a and T1b, node-negative, human epidermal growth factor receptor 2 (HER2) -positive breast cancer...
Invasive lobular carcinoma classic type: response to primary chemotherapy and survival outcomesMassimo Cristofanilli
Department of Breast Medical Oncology, Unit 424, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
J Clin Oncol 23:41-8. 2005..To investigate the impact of histologic type invasive lobular carcinoma (ILC) versus invasive ductal carcinoma (IDC) on response to primary chemotherapy (PC) and long-term outcome...
Using response to primary chemotherapy to select postoperative therapy: long-term results from a prospective phase II trial in locally advanced primary breast cancerAna Maria Gonzalez-Angulo
Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
Clin Breast Cancer 8:516-21. 2008....
A Phase II study of intravenous exatecan mesylate (DX-8951f) administered daily for 5 days every 3 weeks to patients with metastatic breast carcinomaFrancisco J Esteva
Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 424, Houston, TX 77030, USA
Cancer 98:900-7. 2003..The objective of the current study was to determine the antitumor activity, safety, and pharmacokinetic (PK) profile of exatecan mesylate in patients with anthracycline-resistant and taxane-resistant, metastatic breast carcinoma...
Squamous cell carcinoma of the breastBryan T Hennessy
Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
J Clin Oncol 23:7827-35. 2005..D. Anderson Cancer Center (Houston, TX) and a series of 137 patients identified through the Surveillance, Epidemiology, and End Results (SEER) database to make therapy recommendations...
Phase I study of eniluracil and oral 5-fluorouracil in combination with docetaxel in the treatment of patients with metastatic breast carcinomaEdgardo Rivera
Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
Cancer 94:2321-6. 2002....
Ixabepilone for the treatment of breast cancerRicardo H Alvarez
Department of Breast Medical Oncology, University of Texas, MD Anderson Cancer Center Houston, USA
Ann Med 43:477-86. 2011..The clinical activity of ixabepilone combined with bevacizumab for advanced breast cancer was very promising...
Polycomb group protein EZH2 is frequently expressed in inflammatory breast cancer and is predictive of worse clinical outcomeYun Gong
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 117:5476-84. 2011..In this retrospective study, the authors examined EZH2 expression in IBC tumors and evaluated the relation between EZH2 expression and patient survival...
Bisphosphonates and pathologic complete response to taxane- and anthracycline-based neoadjuvant chemotherapy in patients with breast cancerMariana Chavez-MacGregor
Divison of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 4009, USA
Cancer 118:326-32. 2012..In the current study, the authors sought to evaluate whether the use of bisphosphonates increased the rate of pathological complete response (pCR) in patients with breast cancer...
Overall survival and cause-specific mortality of patients with stage T1a,bN0M0 breast carcinomaEmer O Hanrahan
Departments of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Unit 10, Houston, TX 77030, USA
J Clin Oncol 25:4952-60. 2007....
Pathologic complete response in breast cancer patients receiving anthracycline- and taxane-based neoadjuvant chemotherapy: evaluating the effect of race/ethnicityMariana Chavez-MacGregor
Division of Cancer Medicine, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
Cancer 116:4168-77. 2010..The current study was conducted to evaluate the influence of race/ethnicity and tumor subtype in pathologic complete response (pCR) following treatment with neoadjuvant chemotherapy...
Circulating tumor cells in metastatic breast cancer: from prognostic stratification to modification of the staging system?Shaheenah Dawood
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Cancer 113:2422-30. 2008..The aim of the current study was to assess the prognostic value of baseline circulating tumor cells (CTCs) in a large cohort of patients with newly diagnosed metastatic breast cancer (MBC)...
Different gene expressions are associated with the different molecular subtypes of inflammatory breast cancerTakayuki Iwamoto
Breast Cancer Translational Research Laboratory, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Breast Cancer Res Treat 125:785-95. 2011..IBC tumors can be divided into molecular and clinical subtypes similar to those of non-IBC. Clinical subtypes of IBC show molecular differences compared with similar subtypes of non-IBC...
Blockage of the lacrimal drainage apparatus as a side effect of docetaxel therapyBita Esmaeli
Section of Ophthalmology, Department of Plastic Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 98:504-7. 2003..The current study was conducted to report the severity and management of canalicular and nasolacrimal duct stenosis as a side effect of docetaxel therapy and to report the outcomes of surgical intervention for this condition...
Neoadjuvant systemic therapy for breast cancer: an overview and review of recent clinical trialsEmer O Hanrahan
Department of Breast Medical Oncology, Unit 1354, UT MD Anderson Cancer Center, PO Box 301439, Houston, Texas 77230-1439, USA
Expert Opin Pharmacother 6:1477-91. 2005....
Chemotherapy-induced apoptosis and Bcl-2 levels correlate with breast cancer response to chemotherapyThomas A Buchholz
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer J 9:33-41. 2003..We investigated whether changes in tumor cell apoptosis and Bcl-2 expression immediately after chemotherapy correlated with response to breast cancer treatment...
Locoregional treatment outcomes for breast cancer patients with ipsilateral supraclavicular metastases at diagnosisEugene H Huang
Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 67:490-6. 2007..To evaluate the locoregional efficacy of multimodality treatment for breast cancer patients who present with ipsilateral supraclavicular (SCV) disease without systemic metastases...
Nodal status and clinical outcomes in a large cohort of patients with triple-negative breast cancerLeonel F Hernandez-Aya
Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
J Clin Oncol 29:2628-34. 2011..To evaluate the clinical outcomes and relationship between tumor size, lymph node status, and prognosis in a large cohort of patients with confirmed triple receptor-negative breast cancer (TNBC)...
Mammographic features of triple receptor-negative primary breast cancers in young premenopausal womenWei Tse Yang
Department of Diagnostic Radiology, The University of Texas M D Anderson Cancer Center, Houston, TX, 77230, USA
Breast Cancer Res Treat 111:405-10. 2008..The aim of this study was to compare the mammographic breast density, visibility, and tumor features of different breast cancer immunophenotypes...
Differences in survival among women with stage III inflammatory and noninflammatory locally advanced breast cancer appear early: a large population-based studyShaheenah Dawood
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Cancer 117:1819-26. 2011....
Docetaxel for treatment of solid tumours: a systematic review of clinical dataAlberto Montero
Department of Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
Lancet Oncol 6:229-39. 2005..Here, we review major randomised phase III trials with docetaxel in the treatment of solid malignant disease...
Phase I and II study of exisulind in combination with capecitabine in patients with metastatic breast cancerLajos Pusztai
Box 424, Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
J Clin Oncol 21:3454-61. 2003..We studied the safety and clinical activity of exisulind in combination with capecitabine in 35 patients with metastatic breast cancer (MBC)...
Residual ductal carcinoma in situ in patients with complete eradication of invasive breast cancer after neoadjuvant chemotherapy does not adversely affect patient outcomeChafika Mazouni
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
J Clin Oncol 25:2650-5. 2007..To determine whether residual ductal carcinoma in situ (DCIS) after completion of preoperative chemotherapy affects the outcome of patients with histologically defined complete eradication of invasive cancer...
Phase II study of liposomal annamycin in the treatment of doxorubicin-resistant breast cancerDaniel J Booser
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 424, Houston, Texas 77030 4095, USA
Cancer Chemother Pharmacol 50:6-8. 2002..L-AN at this dose and on this schedule had no detectable antitumor activity in patients with doxorubicin-resistant metastatic breast cancer...
Global gene expression changes during neoadjuvant chemotherapy for human breast cancerThomas A Buchholz
Department of Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer J 8:461-8. 2002..A remarkable diversity in transcriptional response was observed for individual cases. Further data are needed to determine whether gene profiling can predict response to chemotherapy...
Prognosis and management of patients with node-negative invasive breast carcinoma that is 1 cm or smaller in size (stage 1; T1a,bN0M0): a review of the literatureEmer O Hanrahan
Department of Breast Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77230-1439, USA
J Clin Oncol 24:2113-22. 2006..More reliable tools are needed to assess the prognosis of patients with stage T1a,bN0M0 breast cancer and their potential to benefit from specific therapeutic agents...
Clinical course of 771 patients with bilateral breast cancer: characteristics associated with overall and recurrence-free survivalGarth Beinart
Department of Cancer Medicine, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Clin Breast Cancer 7:867-74. 2007..The aim of our study was to describe tumor properties, patient characteristics, and method of cancer detection for a large cohort of patients with bilateral breast cancer and to assess the associations of these factors with OS and RFS...
Phase I trial of dose-dense docetaxel and doxorubicin with or without sargramostim in patients with metastatic breast cancerAlberto Montero
Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77230-1439, USA
Drugs R D 6:299-305. 2005
A phase I and pharmacokinetic study of TAS-108 in postmenopausal female patients with locally advanced, locally recurrent inoperable, or progressive metastatic breast cancerL Johnetta Blakely
Breast Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 10:5425-31. 2004..The drug has linear pharmacokinetics, and in this heavily treated patient population, there was evidence of biological antitumor activity. A multi-institutional phase II study is planned...
Lack of activity of stealth liposomal doxorubicin in the treatment of patients with anthracycline-resistant breast cancerEdgardo Rivera
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
Cancer Chemother Pharmacol 49:299-302. 2002..We conducted a single-institution phase II clinical trial to determine the objective response rate, duration of response, time to progression, and overall survival in patients with anthracycline-resistant breast cancer treated with Doxil...
Minimal clinical benefit of single agent Orathecin (Rubitecan) in heavily pretreated metastatic breast cancerSilwan Chedid
Department of Breast Medical Oncology, M. D. Anderson Cancer Center, The University of Texas, 1515 Holcombe Boulevard, Unit 424, Houston, TX, 77030-4095, USA
Cancer Chemother Pharmacol 57:540-4. 2006..Accurate risk stratification strategies can improve patients' selection and contribute to determine the appropriate benefit of therapies in MBC...
Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancerFrancisco J Esteva
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
J Clin Oncol 20:1800-8. 2002..To evaluate the safety and efficacy of weekly docetaxel plus trastuzumab in women with HER-2-overexpressing metastatic breast cancer. Efficacy was correlated with serum HER-2 extracellular domain (ECD) levels...
Determination of oestrogen-receptor status and ERBB2 status of breast carcinoma: a gene-expression profiling studyYun Gong
Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Lancet Oncol 8:203-11. 2007..Our goal was to establish a new method to assign oestrogen receptor and ERBB2-receptor status to breast carcinoma based on mRNA expression measured using Affymetrix U133A gene-expression profiling...
Positive surgical margins and ipsilateral breast tumor recurrence predict disease-specific survival after breast-conserving therapyFunda Meric
Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Cancer 97:926-33. 2003....
Comparison of ductal lavage and random periareolar fine needle aspiration as tissue acquisition methods in early breast cancer prevention trialsBanu Arun
Breast Medical Oncology, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 13:4943-8. 2007..The optimum method to retrieve adequate samples and the most accepted method by study participants is not known...
Phase I study of vinorelbine and docetaxel with granulocyte colony-stimulating factor support in the treatment of metastatic breast cancerNuhad K Ibrahim
Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston 77030 4009, USA
Cancer Invest 20:29-37. 2002..The aim of this study was to determine the MTD of vinorelbine and docetaxel given in combination with G-CSF...
Caregiver symptom burden: the risk of caring for an underserved patient with advanced cancerGuadalupe R Palos
Department of Symptom Research, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 117:1070-9. 2011..In this longitudinal study, the authors assessed changes in symptom severity in caregivers and underserved minority patients diagnosed with advanced solid tumors who were being treated at public hospitals...
Capecitabine-induced pancreatitisKellie L Jones
University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Pharmacotherapy 23:1076-8. 2003..Clinicians should be aware of this potential adverse effect, particularly in patients with preexisting risk factors for pancreatitis who are prescribed capecitabine...
Donepezil for cancer fatigue: a double-blind, randomized, placebo-controlled trialEduardo Bruera
Department of Palliative Care and Rehabilitation Medicine, Unit 008, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Clin Oncol 25:3475-81. 2007..To evaluate the effectiveness of donepezil compared with placebo in cancer patients with fatigue as measured by the Functional Assessment for Chronic Illness Therapy-Fatigue (FACIT-F)...
HER-2/neu and p53 overexpression as biomarkers of breast carcinoma in women age 30 years and youngerDipen Maru
Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 103:900-5. 2005..HER-2/neu overexpression was associated significantly with lymph node involvement and, thus, may be a marker for aggressive clinical behavior in patients with breast carcinoma age < or = 30 years...
Patient-controlled methylphenidate for cancer fatigue: a double-blind, randomized, placebo-controlled trialEduardo Bruera
Department of Palliative Care and Rehabilitation Medicine, Unit 0008, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
J Clin Oncol 24:2073-8. 2006..To evaluate the effectiveness of patient-controlled methylphenidate as compared with placebo in cancer patients with fatigue, as measured by the Functional Assessment for Chronic Illness Therapy-Fatigue (FACIT-F)...
Reversibility of trastuzumab-related cardiotoxicity: new insights based on clinical course and response to medical treatmentMichael S Ewer
Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
J Clin Oncol 23:7820-6. 2005..However, trastuzumab is associated with cardiotoxicity that has not yet been fully explored. We present our experience with patients who developed trastuzumab-related cardiotoxicity...
A management algorithm and practical oncoplastic surgical techniques for repairing partial mastectomy defectsSteven J Kronowitz
Department of Plastic and Reconstructive Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Plast Reconstr Surg 122:1631-47. 2008..In patients undergoing a partial mastectomy, choosing the best method with which to repair the defect is essential to optimizing outcomes and minimizing the potential for postoperative complications...
Phase I/II study of G3139 (Bcl-2 antisense oligonucleotide) in combination with doxorubicin and docetaxel in breast cancerStacy L Moulder
Department of Breast Medical Oncology, Pathology, Surgical Oncology, Radiation Oncology and Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 14:7909-16. 2008..We evaluated the efficacy and safety of a Bcl-2 antisense oligonucleotide, G3139, in combination with doxorubicin (A) and docetaxel (T) in patients with locally advanced breast cancer (LABC)...
Pain education for underserved minority cancer patients: a randomized controlled trialKaren O Anderson
Department of Symptom Research, The University of Texas M D Anderson Cancer Center, 1100 Holcombe Blvd, Box 221, Houston, TX 77030, USA
J Clin Oncol 22:4918-25. 2004..Previous studies found that African American and Hispanic cancer patients are at risk for undertreatment of pain. We evaluated the efficacy of a pain education intervention for underserved minority patients...
Pathologic tumor size and lymph node status predict for different rates of locoregional recurrence after mastectomy for breast cancer patients treated with neoadjuvant versus adjuvant chemotherapyThomas A Buchholz
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 53:880-8. 2002..To compare the pathologic factors associated with postmastectomy locoregional recurrence (LRR) in breast cancer patients not receiving radiation who were treated with neoadjuvant chemotherapy (NEO) vs. adjuvant chemotherapy (ADJ)...
Cancer pain management among underserved minority outpatients: perceived needs and barriers to optimal controlKaren O Anderson
Department of Symptom Research, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 94:2295-304. 2002..Structured interviews allowed the authors to probe for previously unidentified barriers to pain management in these populations...
