Genomes and Genes
Susana T Valente
Affiliation: The Scripps Research Institute
- Didehydro-Cortistatin A Inhibits HIV-1 Tat Mediated Neuroinflammation and Prevents Potentiation of Cocaine Reward in Tat Transgenic MiceSonia Mediouni
Department of Infectious Diseases, The Scripps Research Institute, 130 Scripps Way, 3C1, Jupiter, FL 33458, USA
Curr HIV Res 13:64-79. 2015..Our results suggest that adding a Tat inhibitor, such as dCA, to current antiretroviral therapy may reduce HIV-1-related neuropathogenesis. ..
- HIV-1 mRNA 3' end processing is distinctively regulated by eIF3f, CDK11, and splice factor 9G8Susana T Valente
Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, HHSC 1310c, 701 West 168th Street, New York, NY 10032, USA
Mol Cell 36:279-89. 2009..eIF3f affects HIV-1 3' end processing by modulating the sequence-specific recognition of the HIV-1 pre-mRNA by 9G8...
- Inhibition of HIV-1 replication by eIF3fSusana T Valente
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, HHSC 1310c, 701 West 168th Street, New York, NY 10032, USA
Proc Natl Acad Sci U S A 106:4071-8. 2009..Our results suggest a role of eIF3f in mRNA maturation and that it can specifically interfere with the 3' end processing of HIV-1 mRNAs...
- Targeting HIV transcription: the quest for a functional cureGuillaume Mousseau
Department of Infectious Diseases, The Scripps Research Institute, Jupiter, FL, 33458, USA
Curr Top Microbiol Immunol 389:121-45. 2015..Finally, we discuss the impact of extracellular Tat in HIV-associated neurocognitive disorders and cancers. ..
- An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcriptionGuillaume Mousseau
Department of Infectology, The Scripps Research Institute, Scripps Florida, Jupiter, 33458, USA
Cell Host Microbe 12:97-108. 2012..Thus, dCA defines a unique class of anti-HIV drugs that may inhibit viral production from stable reservoirs and reduce residual viremia during HAART...
- Inhibition of HIV-1 gene expression by a fragment of hnRNP USusana T Valente
Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, HHSC 1310c, 701 West 168th Street, New York, New York 10032, USA
Mol Cell 23:597-605. 2006..The results suggest that HIV-1 requires machinery for the nuclear export of viral mRNAs that can be specifically blocked by an interfering gene...
- Somatic cell genetic analyses to identify HIV-1 host restriction factorsSusana T Valente
Department of Biochemistry, Columbia University, Howard Hughes Medical Institute College of Physicians and Surgeons, New York NY, USA
Methods Mol Biol 485:235-55. 2009..Here we report the strategy and techniques to prepare a library and isolate HIV antiviral genes, using the identification of N-86-HnRNPU as an example...
- The Tat Inhibitor Didehydro-Cortistatin A Prevents HIV-1 Reactivation from LatencyGuillaume Mousseau
Department of Immunology and Microbial Sciences, The Scripps Research Institute, Jupiter, Florida, USA
MBio 6:e00465. 2015..Our results suggest that inclusion of a Tat inhibitor in current ART regimens may contribute to a functional HIV-1 cure by reducing low-level viremia and preventing viral reactivation from latent reservoirs...