K R Tuttle

Summary

Affiliation: The Heart Institute of Spokane
Country: USA

Publications

  1. ncbi request reprint Effects of amino acids and glucagon on renal hemodynamics in type 1 diabetes
    Katherine R Tuttle
    Department of Research, The Heart Institute of Spokane, Spokane, Washington 99204 2340, USA
    Am J Physiol Renal Physiol 282:F103-12. 2002
  2. ncbi request reprint Treatment of atherosclerotic ostial renal artery stenosis with the intravascular stent
    K R Tuttle
    The Heart Institute of Spokane and Sacred Heart Medical Center, WA 99204, USA
    Am J Kidney Dis 32:611-22. 1998
  3. ncbi request reprint Amino acids injure mesangial cells by advanced glycation end products, oxidative stress, and protein kinase C
    Katherine R Tuttle
    The Heart Institute of Spokane and Sacred Heart Medical Center, Spokane, Washington 99204, USA
    Kidney Int 67:953-68. 2005
  4. ncbi request reprint Kidney outcomes in long-term studies of ruboxistaurin for diabetic eye disease
    Katherine R Tuttle
    Providence Medical Research Center and University of Washington School of Medicine, Spokane, Washington, USA
    Clin J Am Soc Nephrol 2:631-6. 2007
  5. ncbi request reprint Cardiovascular implications of albuminuria
    Katherine R Tuttle
    Research Department, The Heart Institute of Spokane, 122 West 7th Avenue, Suite 230, Spokane, WA 99204, USA
    J Clin Hypertens (Greenwich) 6:13-7. 2004
  6. ncbi request reprint A novel potential therapy for diabetic nephropathy and vascular complications: protein kinase C beta inhibition
    Katherine R Tuttle
    Heart Institute of Spokane, Research Department, Spokane, WA 99204 2340, USA
    Am J Kidney Dis 42:456-65. 2003
  7. ncbi request reprint Albuminuria reduction: the holy grail for kidney protection
    K R Tuttle
    Providence Medical Research Center at Sacred Heart Medical Center, Spokane, Washington 99224, USA
    Kidney Int 72:785-6. 2007
  8. ncbi request reprint Predictors of ARF after cardiac surgical procedures
    Katherine R Tuttle
    Research Department, Heart Institute of Spokane, Seattle, WA 99204 2340, USA
    Am J Kidney Dis 41:76-83. 2003
  9. ncbi request reprint Ischemic nephropathy
    K R Tuttle
    The Heart Institute of Spokane, Spokane, Washington 99204 2340, USA
    Curr Opin Nephrol Hypertens 10:167-73. 2001
  10. ncbi request reprint Urinary albumin and insulin as predictors of coronary artery disease: An angiographic study
    K R Tuttle
    Department of Research, The Heart Institute of Spokane, WA 99204 2340, USA
    Am J Kidney Dis 34:918-25. 1999

Detail Information

Publications36

  1. ncbi request reprint Effects of amino acids and glucagon on renal hemodynamics in type 1 diabetes
    Katherine R Tuttle
    Department of Research, The Heart Institute of Spokane, Spokane, Washington 99204 2340, USA
    Am J Physiol Renal Physiol 282:F103-12. 2002
    ..Glomerular hyperfiltration responses induced by amino acids or glucagon occur by divergent pathways in diabetes; only the response to glucagon is prostaglandin dependent...
  2. ncbi request reprint Treatment of atherosclerotic ostial renal artery stenosis with the intravascular stent
    K R Tuttle
    The Heart Institute of Spokane and Sacred Heart Medical Center, WA 99204, USA
    Am J Kidney Dis 32:611-22. 1998
    ..Control of hypertension improves in most patients. Renal function stabilizes or improves in the majority of patients, even those with severe renal failure. These favorable outcomes are maintained long term...
  3. ncbi request reprint Amino acids injure mesangial cells by advanced glycation end products, oxidative stress, and protein kinase C
    Katherine R Tuttle
    The Heart Institute of Spokane and Sacred Heart Medical Center, Spokane, Washington 99204, USA
    Kidney Int 67:953-68. 2005
    ..Increased levels of amino acids could injure cells by providing free amino groups for glycation reactions leading to advanced glycation end products (AGEs)...
  4. ncbi request reprint Kidney outcomes in long-term studies of ruboxistaurin for diabetic eye disease
    Katherine R Tuttle
    Providence Medical Research Center and University of Washington School of Medicine, Spokane, Washington, USA
    Clin J Am Soc Nephrol 2:631-6. 2007
    ..In contrast, in a trial of patients with diabetic retinopathy, investigators reported the adverse event "diabetic nephropathy" more frequently in patients who received RBX...
  5. ncbi request reprint Cardiovascular implications of albuminuria
    Katherine R Tuttle
    Research Department, The Heart Institute of Spokane, 122 West 7th Avenue, Suite 230, Spokane, WA 99204, USA
    J Clin Hypertens (Greenwich) 6:13-7. 2004
    ..Nevertheless, the measurement of albuminuria is clinically useful to identify high-risk individuals who should receive intensive risk factor management based on current treatment guidelines...
  6. ncbi request reprint A novel potential therapy for diabetic nephropathy and vascular complications: protein kinase C beta inhibition
    Katherine R Tuttle
    Heart Institute of Spokane, Research Department, Spokane, WA 99204 2340, USA
    Am J Kidney Dis 42:456-65. 2003
    ..Such therapies are needed to reduce the occurrence of devastating diabetic complications...
  7. ncbi request reprint Albuminuria reduction: the holy grail for kidney protection
    K R Tuttle
    Providence Medical Research Center at Sacred Heart Medical Center, Spokane, Washington 99224, USA
    Kidney Int 72:785-6. 2007
    ....
  8. ncbi request reprint Predictors of ARF after cardiac surgical procedures
    Katherine R Tuttle
    Research Department, Heart Institute of Spokane, Seattle, WA 99204 2340, USA
    Am J Kidney Dis 41:76-83. 2003
    ..However, the pilot study was performed in a small number of patients (n = 30) operated on by a single surgeon. The purpose of this study was to validate whether the serum ferritin level predicts ARF in a larger sample...
  9. ncbi request reprint Ischemic nephropathy
    K R Tuttle
    The Heart Institute of Spokane, Spokane, Washington 99204 2340, USA
    Curr Opin Nephrol Hypertens 10:167-73. 2001
    ..The role of medical therapies (statins, angiotensin-converting enzyme inhibitors, intensive control of blood pressure) and how to best utilize revascularization (which patients and when) remain to be defined...
  10. ncbi request reprint Urinary albumin and insulin as predictors of coronary artery disease: An angiographic study
    K R Tuttle
    Department of Research, The Heart Institute of Spokane, WA 99204 2340, USA
    Am J Kidney Dis 34:918-25. 1999
    ..In summary, urinary albumin excretion and the fasting serum insulin levels were directly related to angiographic evidence of CAD. Microalbuminuria and hyperinsulinemia predict a significantly elevated risk for coronary atherosclerosis...
  11. ncbi request reprint Endovascular stents for renal artery revascularization
    K R Tuttle
    Heart Institute of Spokane, WA 99204 2340, USA
    Curr Opin Nephrol Hypertens 7:695-701. 1998
    ..Technical success rates are excellent, and the impact on clinical outcomes (blood pressure, renal function, and cardiac complications) is promising...
  12. ncbi request reprint The effect of ruboxistaurin on nephropathy in type 2 diabetes
    Katherine R Tuttle
    Research Department, The Heart Institute and Sacred Heart Medical Center, Spokane, WA 99204 2340, USA
    Diabetes Care 28:2686-90. 2005
    ..Ruboxistaurin selectively inhibits protein kinase C-beta and ameliorates kidney disease in animal models of diabetes. The purpose of this study was to evaluate the effects of ruboxistaurin on diabetic nephropathy in humans...
  13. ncbi request reprint Diabetic nephropathy: implications for renal and cardiovascular outcomes
    L A Folan
    The Heart Institute of Spokane, Spokane, WA, USA
    Minerva Med 95:385-94. 2004
    ..Current clinical markers and possible future treatments are also discussed in the context of aiming to improve clinical outcomes in patients who are affected...
  14. doi request reprint Oxidative stress mediates protein kinase C activation and advanced glycation end product formation in a mesangial cell model of diabetes and high protein diet
    Katherine R Tuttle
    Providence Medical Research Center, Sacred Heart Medical Center, Spokane Seattle, WA 99204, USA
    Am J Nephrol 29:171-80. 2009
    ..The aim was to determine whether oxidative stress mediates bidirectional interactions between AGE and PKC ('cross-activation') in this model...
  15. ncbi request reprint Do agents that block the RAS truly offer renoprotective effects in early stage, nonproteinuric nephropathy?
    Radica Alicic
    Providence Medical Research Center, University of Washington School of Medicine, PO Box 2555, 101 West 8th Avenue, Spokane, WA 99220 2555, USA
    Curr Hypertens Rep 9:393-402. 2007
    ..Long-term studies with clinically relevant outcomes (death and loss of kidney function) are needed to clarify whether specific agents provide benefits beyond that of BP control in early stage, nonproteinuric nephropathy...
  16. ncbi request reprint Implications of chronic kidney disease for dietary treatment in cardiovascular disease
    Diane P Packard
    Providence Medical Research Center, Sacred Heart Medical Center, Spokane, WA 99204, USA
    J Ren Nutr 16:259-68. 2006
    ..Because many in this population have CKD, indicators of kidney damage and function are prespecified secondary end points. Results of this trial should provide insight into optimal dietary interventions for persons with both CVD and CKD...
  17. ncbi request reprint Amino acids induce indicators of response to injury in glomerular mesangial cells
    Rick L Meek
    Research Department, The Heart Institute of Spokane, Spokane, Washington 99204, USA
    Am J Physiol Renal Physiol 285:F79-86. 2003
    ..In conditions associated with increased circulating amino acids, such as diabetes and/or a high-protein diet, direct cellular effects could contribute to glomerular injury...
  18. doi request reprint Management of the diabetic patient with advanced chronic kidney disease
    Radica Z Alicic
    Providence Medical Research Center, Sacred Heart Medical Center, Spokane, WA 99204, USA
    Semin Dial 23:140-7. 2010
    ..However, with heightened awareness of risks and a multifactorial management approach, the impact of DKD on micro- and macrovascular complications and death can be reduced...
  19. ncbi request reprint Should albuminuria be a focus of antihypertensive therapy goals?
    Radica Z Alicic
    Providence Medical Research Center, Spokane, WA 99204, USA
    Curr Hypertens Rep 11:354-62. 2009
    ....
  20. doi request reprint Protein kinase C-beta inhibition for diabetic kidney disease
    Katherine R Tuttle
    Providence Medical Research Center at Sacred Heart Medical Center, Division of Nephrology, Department of Medicine, University of Washington School of Medicine, Spokane, WA 99204, USA
    Diabetes Res Clin Pract 82:S70-4. 2008
    ..Large-scale clinical trials will be required to confirm safety and to validate prospective benefits of ruboxistaurin on relevant clinical endpoints in DKD...
  21. doi request reprint Elevations in serum creatinine with RAAS blockade: why isn't it a sign of kidney injury?
    Michael J Ryan
    University of Washington, Seattle, WA 98104, USA
    Curr Opin Nephrol Hypertens 17:443-9. 2008
    ....
  22. doi request reprint Influence of glycemic control on the development of diabetic cardiovascular and kidney disease
    Sandeep A Saha
    Providence Medical Research Center, Spokane, WA 99204, USA
    Cardiol Clin 28:497-516. 2010
    ..This article discusses the various drug classes used to treat diabetes mellitus, and reviews the current clinical evidence linking glycemic control using these drug classes on diabetic kidney and cardiovascular disease...
  23. ncbi request reprint Clinical evidence for the influence of uric acid on hypertension, cardiovascular disease, and kidney disease: a statistical modeling perspective
    Robert A Short
    Research Department, The Heart Institute of Spokane, WA 99204 2340, USA
    Semin Nephrol 25:25-31. 2005
    ....
  24. ncbi request reprint Uric acid, microalbuminuria and cardiovascular events in high-risk patients
    Robert A Short
    The Heart Institute of Spokane and Sacred Heart Medical Center, Spokane, WA 99204 2340, USA
    Am J Nephrol 25:36-44. 2005
    ..The purpose of this study was to evaluate people at high risk for cardiovascular disease for the influence of uric acid and microalbuminuria on cardiovascular events...
  25. ncbi request reprint Effects of amino acids and glucose on mesangial cell aminopeptidase a and angiotensin receptors
    Robert F Chouinard
    Department of Research, The Heart Institute of Spokane, Spokane, Washington 99204 2340, USA
    Kidney Int 61:S106-9. 2002
    ..We evaluated whether amino acids and glucose alter expression of APA, AT1 receptor and AT2 receptor in a manner that further augments RAS activity...
  26. doi request reprint Can comprehensive lifestyle change alter the course of chronic kidney disease?
    Katherine R Tuttle
    Providence Medical Research Center at Sacred Heart Medical Center, Spokane, WA 99204, USA
    Semin Nephrol 29:512-23. 2009
    ....
  27. pmc Longitudinal relationships among coronary artery calcification, serum phosphorus, and kidney function
    Katherine R Tuttle
    Providence Medical Research Center, Spokane, WA 99224, USA
    Clin J Am Soc Nephrol 4:1968-73. 2009
    ..The study objective was to assess longitudinal relationships among CAC, kidney function, and traditional and putative cardiovascular disease (CVD) risk factors...
  28. doi request reprint Comparison of low-fat versus Mediterranean-style dietary intervention after first myocardial infarction (from The Heart Institute of Spokane Diet Intervention and Evaluation Trial)
    Katherine R Tuttle
    The Heart Institute of Spokane, Sacred Heart Medical Center, Spokane, Washington, USA
    Am J Cardiol 101:1523-30. 2008
    ..13 to 0.63, p = 0.002), respectively. In conclusion, active intervention with either a low-fat or a Mediterranean-style diet similarly and significantly benefits overall and cardiovascular-event-free survival after MI...
  29. ncbi request reprint The next generation of diabetic nephropathy therapies: an update
    Mark E Williams
    Joslin Diabetes Center, Boston, MA 02215, USA
    Adv Chronic Kidney Dis 12:212-22. 2005
    ..To determine whether clinical outcomes (mortality, renal, and cardiovascular events) are improved beyond the current standard of care, phase III trials are planned...
  30. ncbi request reprint Advanced glycation end products and nephrotoxicity of high-protein diets
    Jaime Uribarri
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Clin J Am Soc Nephrol 1:1293-9. 2006
    ..Future research should consider dietary AGE as a potential therapeutic target for kidney disease in obesity, diabetes, and perhaps other causes of chronic kidney disease...
  31. ncbi request reprint Effect of ruboxistaurin on urinary transforming growth factor-beta in patients with diabetic nephropathy and type 2 diabetes
    Richard E Gilbert
    Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 30:995-6. 2007
  32. ncbi request reprint Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?
    Richard J Johnson
    Division of Nephrology, Baylor College of Medicine, SM 1273, 6550 Fannin St, Houston, Tex 77030, USA
    Hypertension 41:1183-90. 2003
    ..Thus, it is time to reevaluate the role of uric acid as a risk factor for cardiovascular disease and hypertension and to design human studies to address this controversy...
  33. ncbi request reprint Protein kinase C beta inhibition: the promise for treatment of diabetic nephropathy
    Pamela W Anderson
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46234, USA
    Curr Opin Nephrol Hypertens 16:397-402. 2007
    ..Additional therapeutic agents are therefore urgently needed...
  34. ncbi request reprint Linking metabolism and immunology: diabetic nephropathy is an inflammatory disease
    Katherine R Tuttle
    J Am Soc Nephrol 16:1537-8. 2005
  35. ncbi request reprint NKF releases new KDOQI guidelines for diabetes and CKD
    Robert G Nelson
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Ariz, USA
    Nephrol News Issues 20:29. 2006
  36. ncbi request reprint The new KDOQI clinical practice guidelines and clinical practice recommendations for diabetes and CKD
    Robert G Nelson
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 East Indian School Road, Phoenix, AZ 85014, USA
    Blood Purif 25:112-4. 2007
    ..The National Kidney Foundation (NKF) recently published new guidelines and clinical practice recommendations for the diagnosis and management of patients with diabetes and chronic kidney disease (CKD)...