Research Topics
Genomes and Genes
| Susheela TridandapaniSummaryAffiliation: The Ohio State University Country: USA Publications
Research Grants
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Detail Information
Publications
Src homology 2 domain-containing inositol polyphosphate phosphatase regulates NF-kappa B-mediated gene transcription by phagocytic Fc gamma Rs in human myeloid cellsSusheela Tridandapani
Department of Internal Medicine, Heart and Lung Research Institute, Room 405D, Ohio State University, 473 West Twelfth Avenue, Columbus, OH 43210, USA
J Immunol 169:4370-8. 2002..These findings both provide a molecular mechanism for SHIP association with native ITAM-bearing receptors and demonstrate that SHIP association with ITAM-FcgammaR serves to regulate gene expression during the phagocytic process...- TGF-beta 1 suppresses [correction of supresses] myeloid Fc gamma receptor function by regulating the expression and function of the common gamma-subunitSusheela Tridandapani
Department of Internal Medicine and Dorothy M Davis Heart and Lung Research Institute, and The James Cancer Hospital and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
J Immunol 170:4572-7. 2003..These data provide insight into the regulation of immune responses by TGF-beta1 and demonstrate the selectivity of these effects... - SHIP2 is recruited to the cell membrane upon macrophage colony-stimulating factor (M-CSF) stimulation and regulates M-CSF-induced signalingYijie Wang
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, and The Dorothy M Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH 43210, USA
J Immunol 173:6820-30. 2004..Finally, fetal liver-derived macrophages from SHIP2 gene knockout mice enhanced activation of Akt in response to M-CSF treatment. These data suggest a novel regulatory role for SHIP2 in M-CSF-stimulated myeloid cells... - Lipopolysaccharide-induced macrophage inflammatory response is regulated by SHIPHuiqing Fang
Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA
J Immunol 173:360-6. 2004..These results are the first to demonstrate a role for SHIP in TLR4 signaling, and propose that SHIP is a positive regulator of LPS-induced inflammation... 
Colocalization of the IL-12 receptor and FcgammaRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-gammaSri Vidya Kondadasula
Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, The Arthur G James Comprehensive Cancer Center and Solove Research Institute, The Ohio State University, Columbus, OH, USA
Blood 111:4173-83. 2008..These data suggest that dual recruitment of FcgammaRIIIa and the IL-12R to lipid raft microdomains allows for enhanced activation of downstream signaling events that lead to IFN-gamma production...- CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain-engineered monoclonal antibodyFarrukh T Awan
Division of Hematology Oncology, Department of Medicine, College of Medicine, The Ohio State University, Columbus, OH, USA
Blood 115:1204-13. 2010..These findings provide strong support for further clinical development of XmAb5574 as both a monotherapy and in combination with lenalidomide for the therapy of CLL and related CD19(+) B-cell malignancies... - Akt and SHIP modulate Francisella escape from the phagosome and induction of the Fas-mediated death pathwayMurugesan V S Rajaram
Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
PLoS ONE 4:e7919. 2009..These data identify for the first time host cell signaling pathways that regulate the phagosomal escape of Francisella, leading to the induction of Fas and subsequent host cell death... - FcgammaR-induced production of superoxide and inflammatory cytokines is differentially regulated by SHIP through its influence on PI3K and/or Ras/Erk pathwaysLatha P Ganesan
Department of Internal Medicine, The Ohio State University Biochemistry Program, Columbus, USA
Blood 108:718-25. 2006..In contrast, inhibition of Ras/Erk, but not PI3K, suppressed IL-1beta production in these cells. Together, these data demonstrate that SHIP regulates phagocytosis-associated events through the inhibition of PI3K and Ras/Erk pathways... - The role of the NADPH oxidase complex, p38 MAPK, and Akt in regulating human monocyte/macrophage survivalYijie Wang
Dorothy M Davis Heart and Lung Research Institute, Department of Internal Medicine, Ohio State University Medical Center, Columbus, OH 43210, USA
Am J Respir Cell Mol Biol 36:68-77. 2007..These findings demonstrate that ROS generated from the NADPH oxidase complex contribute to monocyte/macrophage survival induced by M-CSF via regulation of Akt and p38 MAPK... - The activation of natural killer cell effector functions by cetuximab-coated, epidermal growth factor receptor positive tumor cells is enhanced by cytokinesJulie M Roda
Integrated Biomedical Sciences Graduate Program, Arthur G James Comprehensive Cancer Center and Solove Research Institute, Ohio State University, Columbus, Ohio 43210, USA
Clin Cancer Res 13:6419-28. 2007..Cetuximab is a therapeutic monoclonal antibody directed against the HER1 antigen. We hypothesized that the NK cell response to cetuximab-coated tumor cells could be enhanced by the administration of NK cell-stimulatory cytokines... - The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activityChristopher P Baran
Dorothy M Davis Heart and Lung Research Institute, Ohio State University, Columbus 43210, USA
J Biol Chem 278:38628-36. 2003..These data provide the first evidence of the involvement of both SHIP-1 and Lyn in the negative regulation of M-CSF-R-induced Akt activation... - Francisella gains a survival advantage within mononuclear phagocytes by suppressing the host IFNgamma responseKishore V L Parsa
The Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA
Mol Immunol 45:3428-37. 2008..Importantly, the suppressive effect on IFNgamma-mediated host cell protection is most effective when IFNgamma is added post infection, suggesting that the bacteria establish a permissive environment within the host cell... - Interleukin-21 enhances NK cell activation in response to antibody-coated targetsJulie M Roda
Integrated Biomedical Sciences Graduate Program, Department of Molecular Virology, Arthur G James Comprehensive Cancer Center and Solove Research Institute, Ohio State University, Columbus, OH 43210, USA
J Immunol 177:120-9. 2006..These findings demonstrate that IL-21 significantly enhances the NK cell response to Ab-coated targets and suggest that IL-21 would be an effective adjuvant to administer in combination with therapeutic mAbs... - Src homology 2-containing inositol 5'-phosphatase 1 negatively regulates IFN-gamma production by natural killer cells stimulated with antibody-coated tumor cells and interleukin-12Robin Parihar
Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, OH 43210, USA
Cancer Res 65:9099-107. 2005.... - Reciprocal regulation of activating and inhibitory Fc{gamma} receptors by TLR7/8 activation: implications for tumor immunotherapyJonathan P Butchar
Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA
Clin Cancer Res 16:2065-75. 2010..Here, we wished to test the effect of TLR7/8 activation on monocyte Fcgamma receptor (FcgammaR) function, as they are critical mediators of antibody therapy... - Molecular analysis of expression and function of hFcgammaRIIbl and b2 isoforms in myeloid cellsTrupti Joshi
The Ohio State University Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA
Mol Immunol 43:839-50. 2006..Finally, both b1 and b2 isoforms of FcgammaRIIb downregulate phagocytosis to a similar extent. Thus we conclude that FcgammaRIIbl and b2 are both functional inhibitory receptors in the phagocytic process... - Tetraspanin CD37 directly mediates transduction of survival and apoptotic signalsRosa Lapalombella
Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
Cancer Cell 21:694-708. 2012.... - The PtdIns 3-kinase/Akt pathway regulates macrophage-mediated ADCC against B cell lymphomaTrupti Joshi
The Ohio State University Biochemistry Program, The Ohio State University, Columbus, Ohio, USA
PLoS ONE 4:e4208. 2009..Taken together, these findings illustrate that the PtdIns 3-kinase/Akt pathway plays a critical role in macrophage ADCC through its influence on conjugate formation between macrophages and antibody-coated tumor cells... - Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversionJonathan P Butchar
Division of Pulmonary and Critical Care, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
PLoS ONE 3:e2924. 2008..This study identifies several new factors potentially important in host cell subversion by the virulent Type A F. tularensis that may serve as novel targets for drug discovery... - Francisella tularensis induces IL-23 production in human monocytesJonathan P Butchar
Department of Internal Medicine, Division of Infectious Diseases, Ohio State University, 473 West 12th Avenue, Columbus, OH 43210, USA
J Immunol 178:4445-54. 2007..Finally, infection of human monocytes by the highly virulent Francisella SCHU S4 strain likewise led to IL-23 production, suggesting that the IL-23 response may be relevant during tularemia... - The humanized CD40 antibody SGN-40 demonstrates pre-clinical activity that is enhanced by lenalidomide in chronic lymphocytic leukaemiaRosa Lapalombella
Department of Medicine, Division of Hematology Oncology, The Ohio State University, Columbus, OH 43210, USA
Br J Haematol 144:848-55. 2009..These data together provide justification for clinical trials of SGN-40 and lenalidomide in combination for CLL therapy... - The tyrosine kinase Syk promotes phagocytosis of Francisella through the activation of ErkKishore V L Parsa
Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA
Mol Immunol 45:3012-21. 2008..Collectively, these data identify Syk and Erk as key players in the phagocytosis of Francisella... - SHIP-2 inositol phosphatase is inducibly expressed in human monocytes and serves to regulate Fcgamma receptor-mediated signalingRuma A Pengal
Molecular, Cellular, and Developmental Biology Program, Dorothy M Davis Heart and Lung Institute, James Cancer Hospital, Ohio State University, Columbus 43210, USA
J Biol Chem 278:22657-63. 2003..These findings unravel a novel level of regulation of FcgammaR-mediated activation of human myeloid cells by the expression and function of the inositol phosphatase SHIP-2... - The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinaseLatha P Ganesan
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
J Biol Chem 279:54416-25. 2004..These findings demonstrate a novel role for Akt in phagocytosis through the activation of p70S6 kinase... - Akt/Protein kinase B modulates macrophage inflammatory response to Francisella infection and confers a survival advantage in miceMurugesan V S Rajaram
Dorothy M Davis Heart and Lung Research Institute, 473 West 12th Avenue, Columbus, OH 43210, USA
J Immunol 177:6317-24. 2006..novicida. Together, these observations indicate that Akt promotes proinflammatory cytokine production by F. novicida-infected macrophages through its influence on NF-kappaB, thereby contributing to immunity against F. novicida infection... - An NF-κB-independent and Erk1/2-dependent mechanism controls CXCL8/IL-8 responses of airway epithelial cells to cadmiumEstelle Cormet-Boyaka
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Dorothy M Davis Heart and Lung Research Institute, Columbus, OH 43210, USA
Toxicol Sci 125:418-29. 2012.... - Lipopolysaccharide-induced production of interleukin-10 is promoted by the serine/threonine kinase AktRuma A Pengal
Molecular, Cellular and Developmental Biology Program, The Ohio State University, Columbus, OH 43210, USA
Mol Immunol 43:1557-64. 2006..Taken together, these data demonstrate that Akt plays a critical role in LPS-induced production of IL-10... - Pulmonary surfactant protein A regulates TLR expression and activity in human macrophagesLisa N Henning
Center for Microbial Interface Biology, Ohio State University, Columbus, OH 43210, USA
J Immunol 180:7847-58. 2008..These data identify a critical role for SP-A in modulating the lung inflammatory response by regulating macrophage TLR activity... - Macrophage microvesicles induce macrophage differentiation and miR-223 transferNoura Ismail
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA
Blood 121:984-95. 2013..Furthermore, we find that microvesicles induce the differentiation of macrophages. Thus, defining key components of this response may identify novel targets to regulate host defense and inflammation... - Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cellsRosa Lapalombella
Division of Hematology Oncology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, USA
Blood 112:5180-9. 2008..In addition, they suggest that lenalidomide therapy might be useful to enhance targeted delivery of RNAi-based therapies using CD20 immunoliposomes in B-cell malignancies... - IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitroAruna Gowda
Division of Hematology Oncology, Department of Medicine, The Ohio State University, Columbus, USA
Blood 111:4723-30. 2008.... - Macrophage pro-inflammatory response to Francisella novicida infection is regulated by SHIPKishore V L Parsa
The Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio, USA
PLoS Pathog 2:e71. 2006..A detailed analysis of phosphoinositide signaling may provide valuable clues for better understanding the pathogenesis of tularemia... - The protein-tyrosine phosphatase SHP-1 associates with the phosphorylated immunoreceptor tyrosine-based activation motif of Fc gamma RIIa to modulate signaling events in myeloid cellsLatha P Ganesan
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, The Dorothy M Davis Heart and Lung Institute, and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
J Biol Chem 278:35710-7. 2003..Finally, overexpression of wild-type SHP-1 but not catalytically deficient SHP-1 led to a down-regulation of NF kappa B-dependent gene transcription in THP-1 cells activated by clustering Fc gamma RIIa... 
Comparative assessment of clinically utilized CD20-directed antibodies in chronic lymphocytic leukemia cells reveals divergent NK cell, monocyte, and macrophage propertiesSarwish Rafiq
Integrated Biomedical Science Graduate Program, The Ohio State University, Columbus, OH 43210, USA
J Immunol 190:2702-11. 2013..These findings bear relevance to potential combination strategies with each of these anti-CD20 Abs in the treatment of CLL...- Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceuticalXiaobin Zhao
Division of Hematology Oncology, Department of Medicine, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
Blood 110:2569-77. 2007..These findings provide strong justification for CD37 as a therapeutic target and introduce small modular immunopharmaceuticals as a novel class of targeted therapies for B-cell malignancies... - Sequence specificity of SHP-1 and SHP-2 Src homology 2 domains. Critical roles of residues beyond the pY+3 positionDiana Imhof
Department of Chemistry, Ohio State University, Columbus, Ohio 43210, USA
J Biol Chem 281:20271-82. 2006..Examination of pY motifs from known SHP-1 and SHP-2-binding proteins shows that many of the pY motifs contain a hydrophobic or positively charged residue(s) at the pY+4 and pY+5 positions... - Attenuation of myocardial ischemia-reperfusion injury by trimetazidine derivatives functionalized with antioxidant propertiesVijay Kumar Kutala
Davis Heart and Lung Research Institute, The Ohio State University, 420 W. 12th Ave, Room 114, Columbus, OH 43210, USA
J Pharmacol Exp Ther 317:921-8. 2006..The protective effect of the TMZ derivatives could be due to the combined effects of antioxidant and anti-ischemic activities as well as enhanced pro-survival Akt activity... - The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-like receptor 4 signaling in murine peritoneal macrophagesXianhua Cao
Biophysics Program, Ohio State University, Columbus, OH 43210, USA
J Immunol 172:4851-7. 2004..These findings are the first to demonstrate a role for PTEN in Fc gamma R- and TLR4-mediated macrophage inflammatory response... - Akt-mediated proinflammatory response of mononuclear phagocytes infected with Burkholderia cenocepacia occurs by a novel GSK3β-dependent, IκB kinase-independent mechanismThomas J Cremer
Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH 43210, USA
J Immunol 187:635-43. 2011..This novel mechanism of modulation of NF-κB activity may provide a unique therapeutic target for controlling excessive inflammation upon B. cenocepacia infection... - Regulated expression and inhibitory function of Fcgamma RIIb in human monocytic cellsSusheela Tridandapani
Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
J Biol Chem 277:5082-9. 2002..We, therefore, propose that FcgammaRIIb serves to inhibit FcgammaRI/IIa-mediated macrophage activation using SHIP as its effector... - IFNgamma enhances IL-23 production during Francisella infection of human monocytesJonathan P Butchar
Division of Pulmonary and Critical Care, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
FEBS Lett 582:1044-8. 2008..We propose that there exists an amplification loop between monocyte IL-23 and NK/T cell IFNgamma that leads to IL-12 p70 production... - Natural killer cells produce T cell-recruiting chemokines in response to antibody-coated tumor cellsJulie M Roda
Integrated Biomedical Sciences Graduate Program, The Arthur G. James Comprehensive Cancer Center and Solove Research Institute, The Ohio State University, Columbus, Ohio, USA
Cancer Res 66:517-26. 2006.... - Differential expression of SHIP1 in CD56bright and CD56dim NK cells provides a molecular basis for distinct functional responses to monokine costimulationRossana Trotta
Department of Molecular Virology, Immunology, and Medical Genetics, Colelge of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
Blood 105:3011-8. 2005.... - The role of ROS and RNS in regulating life and death of blood monocytesChristopher P Baran
Division of Pulmonary and Critial Care Medicine, Dorothy M Davis Heart and Lung Research Institute Ohio State University, Columbus, OH 43210, USA
Curr Pharm Des 10:855-66. 2004..This review will address potential mechanisms by which ROS and RNS promote the survival of human monocytes and macrophages... - miR-155 regulates IFN-γ production in natural killer cellsRossana Trotta
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
Blood 119:3478-85. 2012..These findings may have clinical relevance for targeting miR-155 in neoplastic disease... - Francisella tularensis regulates autophagy-related host cell signaling pathwaysThomas J Cremer
Molecular, Cellular and Developmental Biology Program, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
Autophagy 5:125-8. 2009..Here, we discuss the implications in the context of Francisella virulence and host cell response, then conclude with potential future experiments... - Negative regulators of toll-like receptor 4-mediated macrophage inflammatory responseJonathan P Butchar
Department of Internal Medicine, Dorothy M. Davis Heart and Lung Research Institute and Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
Curr Pharm Des 12:4143-53. 2006..This review will summarize recent advances in our current understanding of molecular mechanisms that regulate macrophage TLR4 signaling... - Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPKNathan M Weir
Davis Heart and Lung Research Institute and Comprehensive Cancer Center, Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA
Cancer Biol Ther 6:178-84. 2007..In summary, our results showed that curcumin inhibits the proliferation of cisplatin-resistant ovarian cancer cells through the induction of superoxide generation, G(2)/M arrest, and apoptosis... - Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infectionAnwari Akhter
Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, OH, USA
PLoS Pathog 5:e1000361. 2009..These results reveal a new mechanism for caspase-7 activation downstream of the Nlrc4 inflammasome and present a novel biological role for caspase-7 in host defense against an intracellular bacterium... - Analysis of human bronchial epithelial cell proinflammatory response to Burkholderia cenocepacia infection: inability to secrete il-1βDevyn D Gillette
Integrated Biomedical Graduate Program, The Ohio State University, Columbus, Ohio 43210, USA
J Biol Chem 288:3691-5. 2013..cenocepacia infection, suggesting that a deficiency in caspase-1 is responsible, at least in part, for the attenuated IL-1β secretion... - Curcumin regulates airway epithelial cell cytokine responses to the pollutant cadmiumJessica Rennolds
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, The Ohio State University, Columbus, OH 43210, United States
Biochem Biophys Res Commun 417:256-61. 2012..Interestingly, the natural antioxidant curcumin could prevent both cadmium-induced IL-6 and IL-8 secretion by human airway epithelial cells. In conclusion, curcumin could be used to prevent airway inflammation due to cadmium inhalation... - Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domainsMichael C Sweeney
Department of Chemistry, Ohio State Biochemistry Program, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA
Biochemistry 44:14932-47. 2005..The combinatorial library method should be generally applicable to other protein domains... - Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptorsElliott D Crouser
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Dorothy M Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH, USA
Crit Care Med 37:2000-9. 2009..Thus, we hypothesized that the mitochondrial fraction of the cell, particularly N-formyl peptides, contributes significantly to the activation of monocytes by necrotic cells... - C-phycocyanin protects against ischemia-reperfusion injury of heart through involvement of p38 MAPK and ERK signalingMahmood Khan
Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
Am J Physiol Heart Circ Physiol 290:H2136-45. 2006..Overall, these results for the first time showed that PC attenuated I/R-induced cardiac dysfunction through its antioxidant and antiapoptotic actions and modulation of p38 MAPK and ERK1/2... - Fcgamma receptor signaling in phagocytesTrupti Joshi
Department of Internal Medicine, Dorothy M. Davis Heart and Lung Research Institute and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
Int J Hematol 84:210-6. 2006..The purpose of this review is to revisit some of the well-established signaling pathways as well as to summarize the new findings in this field... - Activation of nuclear factor of activated T cells by human T-lymphotropic virus type 1 accessory protein p12(I)Bjorn Albrecht
Center for Retrovirus Research and Department of Veterinary Biosciences, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
J Virol 76:3493-501. 2002..We propose a novel mechanism by which HTLV-1, a virus associated with lymphoproliferative disease, dysregulates common T-cell activation pathways critical for the virus to establish persistent infection... - C-reactive protein induces signaling through Fc gamma RIIa on HL-60 granulocytesMaoyen Chi
Department of Microbiology, Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA
J Immunol 168:1413-8. 2002..The signaling events driven by CRP have the potential to regulate infiltrating neutrophil activities... - NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and humanJianhua Yu
Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio, USA
J Clin Invest 121:1456-70. 2011..Thus, IL-15 signaling and NKp46 may be useful targets in the treatment of patients with T-LGL or NKT leukemia... - Francisella Subverts Innate Immune Signaling: Focus On PI3K/AktThomas John Cremer
Department of Internal Medicine, The Ohio State University Medical Center Columbus, OH, USA
Front Microbiol 5:13. 2011..Lastly, we discuss the emerging role of microRNAs (miRs), specifically miR-155, as a key regulator of host signaling and defense... - The inositol phosphatase SHIP-2 down-regulates FcgammaR-mediated phagocytosis in murine macrophages independently of SHIP-1Jing Ai
Molecular, Cellular, and Developmental Biology Program, The Ohio State University, USA
Blood 107:813-20. 2006..Thus, we conclude that SHIP-2 is a novel negative regulator of FcgammaR-mediated phagocytosis independent of SHIP-1... - SHIP-1 increases early oxidative burst and regulates phagosome maturation in macrophagesLynn A Kamen
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Immunol 180:7497-505. 2008..These direct measurements of individual organelles indicate that phagosomal SHIP-1 enhances the early oxidative burst through localized alteration of the membrane 3'-phosphoinositide composition... - Palmitoylation at Cys595 is essential for PECAM-1 localisation into membrane microdomains and for efficient PECAM-1-mediated cytoprotectionCaroline T Sardjono
Kronheimer Building, Burnet Institute incorporating the Austin Research Institute, Studley Road, Heidelberg, Victoria, 3084 Australia
Thromb Haemost 96:756-66. 2006..These results show that cysteine 595 is required for constitutive association of PECAM-1 with membrane microdomains and PECAM-1-mediated cytoprotection, where it may act as a crucial regulator of signaling and apoptosis events...
Research Grants
- SHIP-2 influence on macrophage Fc receptor functionSusheela Tridandapani; Fiscal Year: 2009..The proposed work holds promise for a better understanding of the IC-mediated inflammatory diseases at the molecular level, and paves the way for novel therapeutic targets. ..