Affiliation: The Ohio State University
Elavazhagan S, Fatehchand K, Santhanam V, Fang H, Ren L, Gautam S, et al
. Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity. J Immunol. 2015;194:2786-95 pubmed publisher
..Hence we have identified granzyme B as an important mediator of FcÎ³R function in human monocytes and have uncovered another mechanism by which TLR8 agonists may enhance FcÎ³R-based therapies. ..
Ren L, Campbell A, Fang H, Gautam S, Elavazhagan S, Fatehchand K, et al
. Analysis of the Effects of the Bruton's tyrosine kinase (Btk) Inhibitor Ibrutinib on Monocyte FcÎ³ Receptor (FcÎ³R) Function. J Biol Chem. 2016;291:3043-52 pubmed publisher
..These results suggest that combining ibrutinib with monoclonal antibody therapy could enhance chronic lymphocytic leukemia cell killing without affecting macrophage effector function. ..
Tridandapani S, Wang Y, Marsh C, Anderson C. Src homology 2 domain-containing inositol polyphosphate phosphatase regulates NF-kappa B-mediated gene transcription by phagocytic Fc gamma Rs in human myeloid cells. J Immunol. 2002;169:4370-8 pubmed
..These findings both provide a molecular mechanism for SHIP association with native ITAM-bearing receptors and demonstrate that SHIP association with ITAM-FcgammaR serves to regulate gene expression during the phagocytic process. ..
Tridandapani S, Wardrop R, Baran C, Wang Y, Opalek J, Caligiuri M, et al
. TGF-beta 1 suppresses [correction of supresses] myeloid Fc gamma receptor function by regulating the expression and function of the common gamma-subunit. J Immunol. 2003;170:4572-7 pubmed
..These data provide insight into the regulation of immune responses by TGF-beta1 and demonstrate the selectivity of these effects. ..
Fatehchand K, Ren L, Elavazhagan S, Fang H, Mo X, Vasilakos J, et al
. Toll-like Receptor 4 Ligands Down-regulate FcÎ³ Receptor IIb (FcÎ³RIIb) via MARCH3 Protein-mediated Ubiquitination. J Biol Chem. 2016;291:3895-904 pubmed publisher
..These data suggest that activation of TLR4 on monocytes can induce a rapid down-regulation of FcÎ³RIIb protein and that this involves ubiquitination. ..
Gautam S, Fatehchand K, Elavazhagan S, Reader B, Ren L, Mo X, et al
. Reprogramming Nurse-like Cells with Interferon ? to Interrupt Chronic Lymphocytic Leukemia Cell Survival. J Biol Chem. 2016;291:14356-62 pubmed publisher
..These results suggest that IFN? can re-educate NLCs and shift them toward an effector-like state and that therapies promoting local IFN? production may be effective adjuvants for antibody therapy in CLL. ..
Fatehchand K, McMichael E, Reader B, Fang H, Santhanam R, Gautam S, et al
. Interferon-Î³ Promotes Antibody-mediated Fratricide of Acute Myeloid Leukemia Cells. J Biol Chem. 2016;291:25656-25666 pubmed
..Taken together, these studies show a novel mechanism of daratumumab-mediated killing and a possible new therapeutic strategy for AML. ..