Susheela Tridandapani

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc The PtdIns 3-kinase/Akt pathway regulates macrophage-mediated ADCC against B cell lymphoma
    Trupti Joshi
    The Ohio State University Biochemistry Program, The Ohio State University, Columbus, Ohio, USA
    PLoS ONE 4:e4208. 2009
  2. pmc Akt and SHIP modulate Francisella escape from the phagosome and induction of the Fas-mediated death pathway
    Murugesan V S Rajaram
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 4:e7919. 2009
  3. pmc MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response
    Thomas J Cremer
    Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 4:e8508. 2009
  4. pmc LyGDI, a novel SHIP-interacting protein, is a negative regulator of FcγR-mediated phagocytosis
    Payal Mehta
    The Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 6:e21175. 2011
  5. ncbi request reprint TGF-beta 1 suppresses [correction of supresses] myeloid Fc gamma receptor function by regulating the expression and function of the common gamma-subunit
    Susheela Tridandapani
    Department of Internal Medicine and Dorothy M Davis Heart and Lung Research Institute, and The James Cancer Hospital and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    J Immunol 170:4572-7. 2003
  6. ncbi request reprint Src homology 2 domain-containing inositol polyphosphate phosphatase regulates NF-kappa B-mediated gene transcription by phagocytic Fc gamma Rs in human myeloid cells
    Susheela Tridandapani
    Department of Internal Medicine, Heart and Lung Research Institute, Room 405D, Ohio State University, 473 West Twelfth Avenue, Columbus, OH 43210, USA
    J Immunol 169:4370-8. 2002
  7. ncbi request reprint SHIP2 is recruited to the cell membrane upon macrophage colony-stimulating factor (M-CSF) stimulation and regulates M-CSF-induced signaling
    Yijie Wang
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, and The Dorothy M Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH 43210, USA
    J Immunol 173:6820-30. 2004
  8. ncbi request reprint Lipopolysaccharide-induced macrophage inflammatory response is regulated by SHIP
    Huiqing Fang
    Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA
    J Immunol 173:360-6. 2004
  9. pmc Colocalization of the IL-12 receptor and FcgammaRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-gamma
    Sri Vidya Kondadasula
    Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, The Arthur G James Comprehensive Cancer Center and Solove Research Institute, The Ohio State University, Columbus, OH, USA
    Blood 111:4173-83. 2008
  10. ncbi request reprint The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity
    Christopher P Baran
    Dorothy M Davis Heart and Lung Research Institute, Ohio State University, Columbus 43210, USA
    J Biol Chem 278:38628-36. 2003

Research Grants

  1. SHIP-2 influence on macrophage Fc receptor function
    Susheela Tridandapani; Fiscal Year: 2005
  2. SHIP-2 influence on macrophage Fc receptor function
    Susheela Tridandapani; Fiscal Year: 2006
  3. SHIP-2 influence on macrophage Fc receptor function
    Susheela Tridandapani; Fiscal Year: 2007
  4. SHIP-2 influence on macrophage Fc receptor function
    Susheela Tridandapani; Fiscal Year: 2009

Detail Information

Publications66

  1. pmc The PtdIns 3-kinase/Akt pathway regulates macrophage-mediated ADCC against B cell lymphoma
    Trupti Joshi
    The Ohio State University Biochemistry Program, The Ohio State University, Columbus, Ohio, USA
    PLoS ONE 4:e4208. 2009
    ..Taken together, these findings illustrate that the PtdIns 3-kinase/Akt pathway plays a critical role in macrophage ADCC through its influence on conjugate formation between macrophages and antibody-coated tumor cells...
  2. pmc Akt and SHIP modulate Francisella escape from the phagosome and induction of the Fas-mediated death pathway
    Murugesan V S Rajaram
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 4:e7919. 2009
    ..These data identify for the first time host cell signaling pathways that regulate the phagosomal escape of Francisella, leading to the induction of Fas and subsequent host cell death...
  3. pmc MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response
    Thomas J Cremer
    Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 4:e8508. 2009
    ..However, impaired miR-155 induction by SCHU S4 may help explain the lack of both SHIP down-regulation and pro-inflammatory response and may account for the virulence of Type A Francisella...
  4. pmc LyGDI, a novel SHIP-interacting protein, is a negative regulator of FcγR-mediated phagocytosis
    Payal Mehta
    The Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 6:e21175. 2011
    ..Consistent with this, suppression of LyGDI expression resulted in significantly enhanced FcγR-mediated phagocytosis...
  5. ncbi request reprint TGF-beta 1 suppresses [correction of supresses] myeloid Fc gamma receptor function by regulating the expression and function of the common gamma-subunit
    Susheela Tridandapani
    Department of Internal Medicine and Dorothy M Davis Heart and Lung Research Institute, and The James Cancer Hospital and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    J Immunol 170:4572-7. 2003
    ..These data provide insight into the regulation of immune responses by TGF-beta1 and demonstrate the selectivity of these effects...
  6. ncbi request reprint Src homology 2 domain-containing inositol polyphosphate phosphatase regulates NF-kappa B-mediated gene transcription by phagocytic Fc gamma Rs in human myeloid cells
    Susheela Tridandapani
    Department of Internal Medicine, Heart and Lung Research Institute, Room 405D, Ohio State University, 473 West Twelfth Avenue, Columbus, OH 43210, USA
    J Immunol 169:4370-8. 2002
    ..These findings both provide a molecular mechanism for SHIP association with native ITAM-bearing receptors and demonstrate that SHIP association with ITAM-FcgammaR serves to regulate gene expression during the phagocytic process...
  7. ncbi request reprint SHIP2 is recruited to the cell membrane upon macrophage colony-stimulating factor (M-CSF) stimulation and regulates M-CSF-induced signaling
    Yijie Wang
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, and The Dorothy M Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH 43210, USA
    J Immunol 173:6820-30. 2004
    ..Finally, fetal liver-derived macrophages from SHIP2 gene knockout mice enhanced activation of Akt in response to M-CSF treatment. These data suggest a novel regulatory role for SHIP2 in M-CSF-stimulated myeloid cells...
  8. ncbi request reprint Lipopolysaccharide-induced macrophage inflammatory response is regulated by SHIP
    Huiqing Fang
    Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA
    J Immunol 173:360-6. 2004
    ..These results are the first to demonstrate a role for SHIP in TLR4 signaling, and propose that SHIP is a positive regulator of LPS-induced inflammation...
  9. pmc Colocalization of the IL-12 receptor and FcgammaRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-gamma
    Sri Vidya Kondadasula
    Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, The Arthur G James Comprehensive Cancer Center and Solove Research Institute, The Ohio State University, Columbus, OH, USA
    Blood 111:4173-83. 2008
    ..These data suggest that dual recruitment of FcgammaRIIIa and the IL-12R to lipid raft microdomains allows for enhanced activation of downstream signaling events that lead to IFN-gamma production...
  10. ncbi request reprint The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity
    Christopher P Baran
    Dorothy M Davis Heart and Lung Research Institute, Ohio State University, Columbus 43210, USA
    J Biol Chem 278:38628-36. 2003
    ..These data provide the first evidence of the involvement of both SHIP-1 and Lyn in the negative regulation of M-CSF-R-induced Akt activation...
  11. pmc Reciprocal regulation of activating and inhibitory Fc{gamma} receptors by TLR7/8 activation: implications for tumor immunotherapy
    Jonathan P Butchar
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA
    Clin Cancer Res 16:2065-75. 2010
    ..Here, we wished to test the effect of TLR7/8 activation on monocyte Fcgamma receptor (FcgammaR) function, as they are critical mediators of antibody therapy...
  12. pmc FcgammaR-induced production of superoxide and inflammatory cytokines is differentially regulated by SHIP through its influence on PI3K and/or Ras/Erk pathways
    Latha P Ganesan
    Department of Internal Medicine, The Ohio State University Biochemistry Program, Columbus, USA
    Blood 108:718-25. 2006
    ..In contrast, inhibition of Ras/Erk, but not PI3K, suppressed IL-1beta production in these cells. Together, these data demonstrate that SHIP regulates phagocytosis-associated events through the inhibition of PI3K and Ras/Erk pathways...
  13. pmc Macrophage pro-inflammatory response to Francisella novicida infection is regulated by SHIP
    Kishore V L Parsa
    The Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio, USA
    PLoS Pathog 2:e71. 2006
    ..A detailed analysis of phosphoinositide signaling may provide valuable clues for better understanding the pathogenesis of tularemia...
  14. pmc CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain-engineered monoclonal antibody
    Farrukh T Awan
    Division of Hematology Oncology, Department of Medicine, College of Medicine, The Ohio State University, Columbus, OH, USA
    Blood 115:1204-13. 2010
    ..These findings provide strong support for further clinical development of XmAb5574 as both a monotherapy and in combination with lenalidomide for the therapy of CLL and related CD19(+) B-cell malignancies...
  15. ncbi request reprint Francisella tularensis induces IL-23 production in human monocytes
    Jonathan P Butchar
    Department of Internal Medicine, Division of Infectious Diseases, Ohio State University, 473 West 12th Avenue, Columbus, OH 43210, USA
    J Immunol 178:4445-54. 2007
    ..Finally, infection of human monocytes by the highly virulent Francisella SCHU S4 strain likewise led to IL-23 production, suggesting that the IL-23 response may be relevant during tularemia...
  16. ncbi request reprint Src homology 2-containing inositol 5'-phosphatase 1 negatively regulates IFN-gamma production by natural killer cells stimulated with antibody-coated tumor cells and interleukin-12
    Robin Parihar
    Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, OH 43210, USA
    Cancer Res 65:9099-107. 2005
    ....
  17. pmc Francisella gains a survival advantage within mononuclear phagocytes by suppressing the host IFNgamma response
    Kishore V L Parsa
    The Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA
    Mol Immunol 45:3428-37. 2008
    ..Importantly, the suppressive effect on IFNgamma-mediated host cell protection is most effective when IFNgamma is added post infection, suggesting that the bacteria establish a permissive environment within the host cell...
  18. ncbi request reprint Molecular analysis of expression and function of hFcgammaRIIbl and b2 isoforms in myeloid cells
    Trupti Joshi
    The Ohio State University Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA
    Mol Immunol 43:839-50. 2006
    ..Finally, both b1 and b2 isoforms of FcgammaRIIb downregulate phagocytosis to a similar extent. Thus we conclude that FcgammaRIIbl and b2 are both functional inhibitory receptors in the phagocytic process...
  19. ncbi request reprint The activation of natural killer cell effector functions by cetuximab-coated, epidermal growth factor receptor positive tumor cells is enhanced by cytokines
    Julie M Roda
    Integrated Biomedical Sciences Graduate Program, Arthur G James Comprehensive Cancer Center and Solove Research Institute, Ohio State University, Columbus, Ohio 43210, USA
    Clin Cancer Res 13:6419-28. 2007
    ..Cetuximab is a therapeutic monoclonal antibody directed against the HER1 antigen. We hypothesized that the NK cell response to cetuximab-coated tumor cells could be enhanced by the administration of NK cell-stimulatory cytokines...
  20. pmc The role of the NADPH oxidase complex, p38 MAPK, and Akt in regulating human monocyte/macrophage survival
    Yijie Wang
    Dorothy M Davis Heart and Lung Research Institute, Department of Internal Medicine, Ohio State University Medical Center, Columbus, OH 43210, USA
    Am J Respir Cell Mol Biol 36:68-77. 2007
    ..These findings demonstrate that ROS generated from the NADPH oxidase complex contribute to monocyte/macrophage survival induced by M-CSF via regulation of Akt and p38 MAPK...
  21. ncbi request reprint The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase
    Latha P Ganesan
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 279:54416-25. 2004
    ..These findings demonstrate a novel role for Akt in phagocytosis through the activation of p70S6 kinase...
  22. pmc The tyrosine kinase Syk promotes phagocytosis of Francisella through the activation of Erk
    Kishore V L Parsa
    Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA
    Mol Immunol 45:3012-21. 2008
    ..Collectively, these data identify Syk and Erk as key players in the phagocytosis of Francisella...
  23. ncbi request reprint Interleukin-21 enhances NK cell activation in response to antibody-coated targets
    Julie M Roda
    Integrated Biomedical Sciences Graduate Program, Department of Molecular Virology, Arthur G James Comprehensive Cancer Center and Solove Research Institute, Ohio State University, Columbus, OH 43210, USA
    J Immunol 177:120-9. 2006
    ..These findings demonstrate that IL-21 significantly enhances the NK cell response to Ab-coated targets and suggest that IL-21 would be an effective adjuvant to administer in combination with therapeutic mAbs...
  24. ncbi request reprint SHIP-2 inositol phosphatase is inducibly expressed in human monocytes and serves to regulate Fcgamma receptor-mediated signaling
    Ruma A Pengal
    Molecular, Cellular, and Developmental Biology Program, Dorothy M Davis Heart and Lung Institute, James Cancer Hospital, Ohio State University, Columbus 43210, USA
    J Biol Chem 278:22657-63. 2003
    ..These findings unravel a novel level of regulation of FcgammaR-mediated activation of human myeloid cells by the expression and function of the inositol phosphatase SHIP-2...
  25. ncbi request reprint Akt/Protein kinase B modulates macrophage inflammatory response to Francisella infection and confers a survival advantage in mice
    Murugesan V S Rajaram
    Dorothy M Davis Heart and Lung Research Institute, 473 West 12th Avenue, Columbus, OH 43210, USA
    J Immunol 177:6317-24. 2006
    ..novicida. Together, these observations indicate that Akt promotes proinflammatory cytokine production by F. novicida-infected macrophages through its influence on NF-kappaB, thereby contributing to immunity against F. novicida infection...
  26. pmc Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals
    Rosa Lapalombella
    Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Cancer Cell 21:694-708. 2012
    ....
  27. pmc Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion
    Jonathan P Butchar
    Division of Pulmonary and Critical Care, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 3:e2924. 2008
    ..This study identifies several new factors potentially important in host cell subversion by the virulent Type A F. tularensis that may serve as novel targets for drug discovery...
  28. pmc The humanized CD40 antibody SGN-40 demonstrates pre-clinical activity that is enhanced by lenalidomide in chronic lymphocytic leukaemia
    Rosa Lapalombella
    Department of Medicine, Division of Hematology Oncology, The Ohio State University, Columbus, OH 43210, USA
    Br J Haematol 144:848-55. 2009
    ..These data together provide justification for clinical trials of SGN-40 and lenalidomide in combination for CLL therapy...
  29. pmc The inositol phosphatase SHIP-2 down-regulates FcgammaR-mediated phagocytosis in murine macrophages independently of SHIP-1
    Jing Ai
    Molecular, Cellular, and Developmental Biology Program, The Ohio State University, USA
    Blood 107:813-20. 2006
    ..Thus, we conclude that SHIP-2 is a novel negative regulator of FcgammaR-mediated phagocytosis independent of SHIP-1...
  30. pmc Toll-like receptor 2 ligands regulate monocyte Fcγ receptor expression and function
    Prexy Shah
    Department of Internal Medicine, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 288:12345-52. 2013
    ..Taken together, these findings indicate that TLR2 activation can positively modulate FcγR and suggest that TLR2 agonists should be considered for testing as adjuvants for antitumor antibody therapy...
  31. ncbi request reprint The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-like receptor 4 signaling in murine peritoneal macrophages
    Xianhua Cao
    Biophysics Program, Ohio State University, Columbus, OH 43210, USA
    J Immunol 172:4851-7. 2004
    ..These findings are the first to demonstrate a role for PTEN in Fc gamma R- and TLR4-mediated macrophage inflammatory response...
  32. pmc IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro
    Aruna Gowda
    Division of Hematology Oncology, Department of Medicine, The Ohio State University, Columbus, USA
    Blood 111:4723-30. 2008
    ....
  33. pmc Analysis of human bronchial epithelial cell proinflammatory response to Burkholderia cenocepacia infection: inability to secrete il-1β
    Devyn D Gillette
    Integrated Biomedical Graduate Program, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 288:3691-5. 2013
    ..cenocepacia infection, suggesting that a deficiency in caspase-1 is responsible, at least in part, for the attenuated IL-1β secretion...
  34. pmc Comparative assessment of clinically utilized CD20-directed antibodies in chronic lymphocytic leukemia cells reveals divergent NK cell, monocyte, and macrophage properties
    Sarwish Rafiq
    Integrated Biomedical Science Graduate Program, The Ohio State University, Columbus, OH 43210, USA
    J Immunol 190:2702-11. 2013
    ..These findings bear relevance to potential combination strategies with each of these anti-CD20 Abs in the treatment of CLL...
  35. pmc An NF-κB-independent and Erk1/2-dependent mechanism controls CXCL8/IL-8 responses of airway epithelial cells to cadmium
    Estelle Cormet-Boyaka
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Dorothy M Davis Heart and Lung Research Institute, Columbus, OH 43210, USA
    Toxicol Sci 125:418-29. 2012
    ....
  36. pmc Pulmonary surfactant protein A regulates TLR expression and activity in human macrophages
    Lisa N Henning
    Center for Microbial Interface Biology, Ohio State University, Columbus, OH 43210, USA
    J Immunol 180:7847-58. 2008
    ..These data identify a critical role for SP-A in modulating the lung inflammatory response by regulating macrophage TLR activity...
  37. ncbi request reprint Lipopolysaccharide-induced production of interleukin-10 is promoted by the serine/threonine kinase Akt
    Ruma A Pengal
    Molecular, Cellular and Developmental Biology Program, The Ohio State University, Columbus, OH 43210, USA
    Mol Immunol 43:1557-64. 2006
    ..Taken together, these data demonstrate that Akt plays a critical role in LPS-induced production of IL-10...
  38. pmc Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells
    Rosa Lapalombella
    Division of Hematology Oncology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, USA
    Blood 112:5180-9. 2008
    ..In addition, they suggest that lenalidomide therapy might be useful to enhance targeted delivery of RNAi-based therapies using CD20 immunoliposomes in B-cell malignancies...
  39. pmc Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical
    Xiaobin Zhao
    Division of Hematology Oncology, Department of Medicine, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Blood 110:2569-77. 2007
    ..These findings provide strong justification for CD37 as a therapeutic target and introduce small modular immunopharmaceuticals as a novel class of targeted therapies for B-cell malignancies...
  40. pmc MiR-155 induction by microbes/microbial ligands requires NF-κB-dependent de novo protein synthesis
    Thomas J Cremer
    Molecular, Cellular, and Developmental Biology Program, The Ohio State University Columbus, OH, USA
    Front Cell Infect Microbiol 2:73. 2012
    ..This study provides new insight into the complex regulation of miR-155 during microbial infection...
  41. ncbi request reprint Sequence specificity of SHP-1 and SHP-2 Src homology 2 domains. Critical roles of residues beyond the pY+3 position
    Diana Imhof
    Department of Chemistry, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 281:20271-82. 2006
    ..Examination of pY motifs from known SHP-1 and SHP-2-binding proteins shows that many of the pY motifs contain a hydrophobic or positively charged residue(s) at the pY+4 and pY+5 positions...
  42. ncbi request reprint Regulated expression and inhibitory function of Fcgamma RIIb in human monocytic cells
    Susheela Tridandapani
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 277:5082-9. 2002
    ..We, therefore, propose that FcgammaRIIb serves to inhibit FcgammaRI/IIa-mediated macrophage activation using SHIP as its effector...
  43. pmc Macrophage microvesicles induce macrophage differentiation and miR-223 transfer
    Noura Ismail
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA
    Blood 121:984-95. 2013
    ..Furthermore, we find that microvesicles induce the differentiation of macrophages. Thus, defining key components of this response may identify novel targets to regulate host defense and inflammation...
  44. ncbi request reprint The protein-tyrosine phosphatase SHP-1 associates with the phosphorylated immunoreceptor tyrosine-based activation motif of Fc gamma RIIa to modulate signaling events in myeloid cells
    Latha P Ganesan
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, The Dorothy M Davis Heart and Lung Institute, and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 278:35710-7. 2003
    ..Finally, overexpression of wild-type SHP-1 but not catalytically deficient SHP-1 led to a down-regulation of NF kappa B-dependent gene transcription in THP-1 cells activated by clustering Fc gamma RIIa...
  45. ncbi request reprint Natural killer cells produce T cell-recruiting chemokines in response to antibody-coated tumor cells
    Julie M Roda
    Integrated Biomedical Sciences Graduate Program, The Arthur G James Comprehensive Cancer Center and Solove Research Institute, The Ohio State University, Columbus, Ohio, USA
    Cancer Res 66:517-26. 2006
    ....
  46. pmc miR-155 regulates IFN-γ production in natural killer cells
    Rossana Trotta
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    Blood 119:3478-85. 2012
    ..These findings may have clinical relevance for targeting miR-155 in neoplastic disease...
  47. ncbi request reprint Attenuation of myocardial ischemia-reperfusion injury by trimetazidine derivatives functionalized with antioxidant properties
    Vijay Kumar Kutala
    Davis Heart and Lung Research Institute, The Ohio State University, 420 W 12th Ave, Room 114, Columbus, OH 43210, USA
    J Pharmacol Exp Ther 317:921-8. 2006
    ..The protective effect of the TMZ derivatives could be due to the combined effects of antioxidant and anti-ischemic activities as well as enhanced pro-survival Akt activity...
  48. pmc Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection
    Anwari Akhter
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, OH, USA
    PLoS Pathog 5:e1000361. 2009
    ..These results reveal a new mechanism for caspase-7 activation downstream of the Nlrc4 inflammasome and present a novel biological role for caspase-7 in host defense against an intracellular bacterium...
  49. ncbi request reprint Differential expression of SHIP1 in CD56bright and CD56dim NK cells provides a molecular basis for distinct functional responses to monokine costimulation
    Rossana Trotta
    Department of Molecular Virology, Immunology, and Medical Genetics, Colelge of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
    Blood 105:3011-8. 2005
    ....
  50. pmc IFNgamma enhances IL-23 production during Francisella infection of human monocytes
    Jonathan P Butchar
    Division of Pulmonary and Critical Care, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    FEBS Lett 582:1044-8. 2008
    ..We propose that there exists an amplification loop between monocyte IL-23 and NK/T cell IFNgamma that leads to IL-12 p70 production...
  51. pmc Akt-mediated proinflammatory response of mononuclear phagocytes infected with Burkholderia cenocepacia occurs by a novel GSK3β-dependent, IκB kinase-independent mechanism
    Thomas J Cremer
    Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH 43210, USA
    J Immunol 187:635-43. 2011
    ..This novel mechanism of modulation of NF-κB activity may provide a unique therapeutic target for controlling excessive inflammation upon B. cenocepacia infection...
  52. ncbi request reprint Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains
    Michael C Sweeney
    Department of Chemistry, Ohio State Biochemistry Program, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA
    Biochemistry 44:14932-47. 2005
    ..The combinatorial library method should be generally applicable to other protein domains...
  53. pmc Francisella tularensis regulates autophagy-related host cell signaling pathways
    Thomas J Cremer
    Molecular, Cellular and Developmental Biology Program, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Autophagy 5:125-8. 2009
    ..Here, we discuss the implications in the context of Francisella virulence and host cell response, then conclude with potential future experiments...
  54. ncbi request reprint The role of ROS and RNS in regulating life and death of blood monocytes
    Christopher P Baran
    Division of Pulmonary and Critial Care Medicine, Dorothy M Davis Heart and Lung Research Institute Ohio State University, Columbus, OH 43210, USA
    Curr Pharm Des 10:855-66. 2004
    ..This review will address potential mechanisms by which ROS and RNS promote the survival of human monocytes and macrophages...
  55. ncbi request reprint C-reactive protein induces signaling through Fc gamma RIIa on HL-60 granulocytes
    Maoyen Chi
    Department of Microbiology, Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA
    J Immunol 168:1413-8. 2002
    ..The signaling events driven by CRP have the potential to regulate infiltrating neutrophil activities...
  56. ncbi request reprint Negative regulators of toll-like receptor 4-mediated macrophage inflammatory response
    Jonathan P Butchar
    Department of Internal Medicine, Dorothy M Davis Heart and Lung Research Institute and Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Curr Pharm Des 12:4143-53. 2006
    ..This review will summarize recent advances in our current understanding of molecular mechanisms that regulate macrophage TLR4 signaling...
  57. pmc Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK
    Nathan M Weir
    Davis Heart and Lung Research Institute and Comprehensive Cancer Center, Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA
    Cancer Biol Ther 6:178-84. 2007
    ..In summary, our results showed that curcumin inhibits the proliferation of cisplatin-resistant ovarian cancer cells through the induction of superoxide generation, G(2)/M arrest, and apoptosis...
  58. pmc Curcumin regulates airway epithelial cell cytokine responses to the pollutant cadmium
    Jessica Rennolds
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, The Ohio State University, Columbus, OH 43210, United States
    Biochem Biophys Res Commun 417:256-61. 2012
    ..Interestingly, the natural antioxidant curcumin could prevent both cadmium-induced IL-6 and IL-8 secretion by human airway epithelial cells. In conclusion, curcumin could be used to prevent airway inflammation due to cadmium inhalation...
  59. pmc Activation of nuclear factor of activated T cells by human T-lymphotropic virus type 1 accessory protein p12(I)
    Bjorn Albrecht
    Center for Retrovirus Research and Department of Veterinary Biosciences, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    J Virol 76:3493-501. 2002
    ..We propose a novel mechanism by which HTLV-1, a virus associated with lymphoproliferative disease, dysregulates common T-cell activation pathways critical for the virus to establish persistent infection...
  60. ncbi request reprint C-phycocyanin protects against ischemia-reperfusion injury of heart through involvement of p38 MAPK and ERK signaling
    Mahmood Khan
    Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Am J Physiol Heart Circ Physiol 290:H2136-45. 2006
    ..Overall, these results for the first time showed that PC attenuated I/R-induced cardiac dysfunction through its antioxidant and antiapoptotic actions and modulation of p38 MAPK and ERK1/2...
  61. ncbi request reprint Fcgamma receptor signaling in phagocytes
    Trupti Joshi
    Department of Internal Medicine, Dorothy M Davis Heart and Lung Research Institute and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Int J Hematol 84:210-6. 2006
    ..The purpose of this review is to revisit some of the well-established signaling pathways as well as to summarize the new findings in this field...
  62. pmc Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors
    Elliott D Crouser
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Dorothy M Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH, USA
    Crit Care Med 37:2000-9. 2009
    ..Thus, we hypothesized that the mitochondrial fraction of the cell, particularly N-formyl peptides, contributes significantly to the activation of monocytes by necrotic cells...
  63. pmc NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human
    Jianhua Yu
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio, USA
    J Clin Invest 121:1456-70. 2011
    ..Thus, IL-15 signaling and NKp46 may be useful targets in the treatment of patients with T-LGL or NKT leukemia...
  64. pmc Francisella Subverts Innate Immune Signaling: Focus On PI3K/Akt
    Thomas John Cremer
    Department of Internal Medicine, The Ohio State University Medical Center Columbus, OH, USA
    Front Microbiol 5:13. 2011
    ..Lastly, we discuss the emerging role of microRNAs (miRs), specifically miR-155, as a key regulator of host signaling and defense...
  65. pmc SHIP-1 increases early oxidative burst and regulates phagosome maturation in macrophages
    Lynn A Kamen
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 180:7497-505. 2008
    ..These direct measurements of individual organelles indicate that phagosomal SHIP-1 enhances the early oxidative burst through localized alteration of the membrane 3'-phosphoinositide composition...
  66. ncbi request reprint Palmitoylation at Cys595 is essential for PECAM-1 localisation into membrane microdomains and for efficient PECAM-1-mediated cytoprotection
    Caroline T Sardjono
    Kronheimer Building, Burnet Institute incorporating the Austin Research Institute, Studley Road, Heidelberg, Victoria, 3084 Australia
    Thromb Haemost 96:756-66. 2006
    ..These results show that cysteine 595 is required for constitutive association of PECAM-1 with membrane microdomains and PECAM-1-mediated cytoprotection, where it may act as a crucial regulator of signaling and apoptosis events...

Research Grants5

  1. SHIP-2 influence on macrophage Fc receptor function
    Susheela Tridandapani; Fiscal Year: 2005
    ..The proposed work holds promise for a better understanding of the IC-mediated inflammatory diseases at the molecular level, and paves the way for novel therapeutic targets. ..
  2. SHIP-2 influence on macrophage Fc receptor function
    Susheela Tridandapani; Fiscal Year: 2006
    ..The proposed work holds promise for a better understanding of the IC-mediated inflammatory diseases at the molecular level, and paves the way for novel therapeutic targets. ..
  3. SHIP-2 influence on macrophage Fc receptor function
    Susheela Tridandapani; Fiscal Year: 2007
    ..The proposed work holds promise for a better understanding of the IC-mediated inflammatory diseases at the molecular level, and paves the way for novel therapeutic targets. ..
  4. SHIP-2 influence on macrophage Fc receptor function
    Susheela Tridandapani; Fiscal Year: 2009
    ..The proposed work holds promise for a better understanding of the IC-mediated inflammatory diseases at the molecular level, and paves the way for novel therapeutic targets. ..