Eric J Topol

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Challenges in the phenotypic characterisation of patients in genetic studies of coronary artery disease
    Albert K Luo
    Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    J Med Genet 44:161-5. 2007
  2. ncbi request reprint Comment on "the predictive capacity of personal genome sequencing"
    Eric J Topol
    Scripps Translational Science Institute, The Scripps Research Institute, 3344 North Torrey Pines Court, La Jolla, CA 92037, USA
    Sci Transl Med 4:135le5. 2012
  3. pmc Individualized medicine from prewomb to tomb
    Eric J Topol
    The Scripps Translational Science Institute, The Scripps Research Institute and Scripps Health, La Jolla, CA 92037, USA Electronic address
    Cell 157:241-53. 2014
  4. pmc 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response
    Olivier Harismendy
    Department of Pediatrics and Rady s Children s Hospital, University of California at San Diego, School of Medicine, La Jolla, California 92093, USA
    Nature 470:264-8. 2011
  5. pmc Genome-wide association of implantable cardioverter-defibrillator activation with life-threatening arrhythmias
    Sarah S Murray
    Scripps Genomic Medicine, Scripps Translational Science Institute, La Jolla, California, United States of America
    PLoS ONE 7:e25387. 2012
  6. pmc Molecular genetics of atrial fibrillation
    Samir B Damani
    Division of Cardiovascular Diseases, Scripps Clinic, La Jolla, CA 92037, USA
    Genome Med 1:54. 2009
  7. pmc Development of a blood-based gene expression algorithm for assessment of obstructive coronary artery disease in non-diabetic patients
    Michael R Elashoff
    CardioDx, Inc, 2500 Faber Place, Palo Alto, CA 94602, USA
    BMC Med Genomics 4:26. 2011
  8. doi request reprint Rimonabant for prevention of cardiovascular events (CRESCENDO): a randomised, multicentre, placebo-controlled trial
    Eric J Topol
    Scripps Translational Science Institute, La Jolla, CA 92037, USA
    Lancet 376:517-23. 2010
  9. doi request reprint Pharmacy benefit managers, pharmacies, and pharmacogenomic testing: prescription for progress?
    Eric J Topol
    Scripps Translational Science Institute, Scripps Health, The Scripps Research Institute, and West Wireless Health Institute, La Jolla, CA 92037, USA
    Sci Transl Med 2:44cm22. 2010
  10. ncbi request reprint The genomics gold rush
    Eric J Topol
    Scripps Genomic Medicine, Scripps Health, and The Scripps Research Institute, La Jolla, California 92037, USA
    JAMA 298:218-21. 2007

Detail Information

Publications73

  1. pmc Challenges in the phenotypic characterisation of patients in genetic studies of coronary artery disease
    Albert K Luo
    Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    J Med Genet 44:161-5. 2007
    ..In this paper, salient issues to facilitate research in this important field are reviewed...
  2. ncbi request reprint Comment on "the predictive capacity of personal genome sequencing"
    Eric J Topol
    Scripps Translational Science Institute, The Scripps Research Institute, 3344 North Torrey Pines Court, La Jolla, CA 92037, USA
    Sci Transl Med 4:135le5. 2012
    ..and its coverage in the media, the notion that genetic information cannot with certainty predict disease in an individual is well known, but its precision will improve as more kinds of genetic variability can be ascertained...
  3. pmc Individualized medicine from prewomb to tomb
    Eric J Topol
    The Scripps Translational Science Institute, The Scripps Research Institute and Scripps Health, La Jolla, CA 92037, USA Electronic address
    Cell 157:241-53. 2014
    ....
  4. pmc 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response
    Olivier Harismendy
    Department of Pediatrics and Rady s Children s Hospital, University of California at San Diego, School of Medicine, La Jolla, California 92093, USA
    Nature 470:264-8. 2011
    ....
  5. pmc Genome-wide association of implantable cardioverter-defibrillator activation with life-threatening arrhythmias
    Sarah S Murray
    Scripps Genomic Medicine, Scripps Translational Science Institute, La Jolla, California, United States of America
    PLoS ONE 7:e25387. 2012
    ..those who did not over at least a 3-year period (controls)...
  6. pmc Molecular genetics of atrial fibrillation
    Samir B Damani
    Division of Cardiovascular Diseases, Scripps Clinic, La Jolla, CA 92037, USA
    Genome Med 1:54. 2009
    ..Additional susceptibility variants are anticipated that will have direct ramifications for prognosis and treatment of this highly pervasive and clinically significant disorder...
  7. pmc Development of a blood-based gene expression algorithm for assessment of obstructive coronary artery disease in non-diabetic patients
    Michael R Elashoff
    CardioDx, Inc, 2500 Faber Place, Palo Alto, CA 94602, USA
    BMC Med Genomics 4:26. 2011
    ..A non-invasive blood test that could reliably assess obstructive CAD likelihood would have diagnostic utility...
  8. doi request reprint Rimonabant for prevention of cardiovascular events (CRESCENDO): a randomised, multicentre, placebo-controlled trial
    Eric J Topol
    Scripps Translational Science Institute, La Jolla, CA 92037, USA
    Lancet 376:517-23. 2010
    ..We assessed whether rimonabant would improve major vascular event-free survival...
  9. doi request reprint Pharmacy benefit managers, pharmacies, and pharmacogenomic testing: prescription for progress?
    Eric J Topol
    Scripps Translational Science Institute, Scripps Health, The Scripps Research Institute, and West Wireless Health Institute, La Jolla, CA 92037, USA
    Sci Transl Med 2:44cm22. 2010
    ..But while clinicians have been reluctant to routinely use pharmacogenomic analyses to guide their prescribing practices, pharmacy benefit managers and drugstores are proceeding with major pharmacogenetic initiatives...
  10. ncbi request reprint The genomics gold rush
    Eric J Topol
    Scripps Genomic Medicine, Scripps Health, and The Scripps Research Institute, La Jolla, California 92037, USA
    JAMA 298:218-21. 2007
  11. pmc Transforming medicine via digital innovation
    Eric J Topol
    Scripps Translational Science Institute, Scripps Health, The Scripps Research Institute, and West Wireless Health Institute, La Jolla, CA 92037, USA
    Sci Transl Med 2:16cm4. 2010
    ..These devices have exceptional promise for changing the future of medicine because of their ability to produce exquisitely detailed individual biological and physiological data...
  12. doi request reprint Influence of genetic polymorphisms on the effect of high- and standard-dose clopidogrel after percutaneous coronary intervention: the GIFT (Genotype Information and Functional Testing) study
    Matthew J Price
    Division of Cardiovascular Diseases, Scripps Clinic, La Jolla, California 92037, USA
    J Am Coll Cardiol 59:1928-37. 2012
    ..This study sought to evaluate the influence of single nucleotide polymorphisms (SNPs) on the pharmacodynamic effect of high- or standard-dose clopidogrel after percutaneous coronary intervention (PCI)...
  13. pmc Population sequencing of two endocannabinoid metabolic genes identifies rare and common regulatory variants associated with extreme obesity and metabolite level
    Olivier Harismendy
    Moores UCSD Cancer Center, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Genome Biol 11:R118. 2010
    ....
  14. pmc Accurate detection and genotyping of SNPs utilizing population sequencing data
    Vikas Bansal
    Scripps Translational Science Institute, The Scripps Research Institute, La Jolla, CA 92037, USA
    Genome Res 20:537-45. 2010
    ..Collectively, these results suggest that analysis of population sequencing data is a powerful approach for the accurate detection of SNPs and the assignment of genotypes to individual samples...
  15. doi request reprint Standard- vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial
    Matthew J Price
    Scripps Clinic, La Jolla, California, USA
    JAMA 305:1097-105. 2011
    ..High platelet reactivity while receiving clopidogrel has been linked to cardiovascular events after percutaneous coronary intervention (PCI), but a treatment strategy for this issue is not well defined...
  16. pmc A covering method for detecting genetic associations between rare variants and common phenotypes
    Gaurav Bhatia
    Department of Computer Science and Engineering, University of California San Diego, La Jolla, California, USA
    PLoS Comput Biol 6:e1000954. 2010
    ..The data suggests that the RVs help disrupt the expression of the two genes, leading to lowered metabolism of the corresponding cannabinoids. Overall, our results point to the power of including RVs in measuring genetic associations...
  17. doi request reprint Human genetic variation and its contribution to complex traits
    Kelly A Frazer
    Scripps Genomic Medicine, Scripps Translational Science Institute and The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Rev Genet 10:241-51. 2009
    ..Technological advances, such as the ability to detect rare and structural variants, and a clear understanding of the challenges in linking different types of variation with phenotype, will be essential for future progress...
  18. doi request reprint Platelet reactivity and cardiovascular outcomes after percutaneous coronary intervention: a time-dependent analysis of the Gauging Responsiveness with a VerifyNow P2Y12 assay: Impact on Thrombosis and Safety (GRAVITAS) trial
    Matthew J Price
    Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA, USA
    Circulation 124:1132-7. 2011
    ..The aim of this analysis was to examine the relationship between outcomes and OTR over the course of the trial...
  19. doi request reprint Emerging genomic applications in coronary artery disease
    Samir B Damani
    Division of Cardiovascular Diseases, Scripps Clinic, Scripps Translational Science Institute and The Scripps Research Institute, La Jolla, California 92037, USA
    JACC Cardiovasc Interv 4:473-82. 2011
    ..However, only the individual clinician can ultimately enable the translation of these important discoveries to systematic implementation in clinical practice...
  20. pmc The importance of phase information for human genomics
    Ryan Tewhey
    The Scripps Translational Science Institute, 3344 North Torrey Pines Road, Suite 300, La Jolla, California 92037, USA
    Nat Rev Genet 12:215-23. 2011
    ..Thus, the existing technological impediments to obtaining phase information must be overcome if human genomics is to reach its full potential...
  21. doi request reprint Impact of direct-to-consumer genomic testing at long term follow-up
    Cinnamon S Bloss
    Scripps Genomic Medicine, Scripps Translational Science Institute, 3344 N Torrey Pines Court, Suite 300, La Jolla, CA 92037, USA
    J Med Genet 50:393-400. 2013
    ..This study aimed to determine the long term psychological, behavioural, and clinical impacts of genomic risk testing for common disease...
  22. pmc Genotype-based risk and pharmacogenetic sampling in clinical trials
    Nicholas J Schork
    Scripps Translational Science Institute and Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA
    J Biopharm Stat 20:315-33. 2010
    ..In addition, we also derive realistic bounds for samples sizes for clinical trials investigating pharmacogenetic effects that leverage genetic variations identified in recent association studies...
  23. pmc Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study
    Erin N Smith
    Scripps Genomic Medicine and Scripps Translational Science Institute, La Jolla, California, United States of America
    PLoS Genet 6:e1001094. 2010
    ....
  24. pmc Genetic structure of community acquired methicillin-resistant Staphylococcus aureus USA300
    Ryan Tewhey
    Scripps Genomic Medicine, Scripps Translational Science Institute, La Jolla, CA, USA
    BMC Genomics 13:508. 2012
    ..The broad range of disease severity may be influenced by bacterial genetic variation...
  25. pmc A common MECP2 haplotype associates with reduced cortical surface area in humans in two independent populations
    Alexander H Joyner
    Scripps Translational Science Institute, 3344 North Torrey Pines Court, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:15483-8. 2009
    ..Secondary analysis showed that this allele was also associated with reduced surface area in specific cortical regions (cuneus, fusiform gyrus, pars triangularis) in both populations...
  26. pmc Comparison of 24-hour Holter monitoring with 14-day novel adhesive patch electrocardiographic monitoring
    Paddy M Barrett
    Scripps Translational Science Institute, La Jolla, Calif
    Am J Med 127:95.e11-7. 2014
    ....
  27. pmc Common vs. rare allele hypotheses for complex diseases
    Nicholas J Schork
    Scripps Genomic Medicine, and Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, United States
    Curr Opin Genet Dev 19:212-9. 2009
    ..Both hypotheses have their place in current research efforts...
  28. pmc Direct-to-consumer personalized genomic testing
    Cinnamon S Bloss
    Scripps Genomic Medicine, Scripps Health, Scripps Translational Science Institute, 3344 N Torrey Pines Court, La Jolla, CA 92037, USA
    Hum Mol Genet 20:R132-41. 2011
    ..Either way, however, current knowledge needs to be extended and enhanced with respect to the delivery, impact and use of increasingly accurate and comprehensive individualized genomic data...
  29. pmc Annotating individual human genomes
    Ali Torkamani
    The Scripps Translational Science Institute, USA
    Genomics 98:233-41. 2011
    ..We therefore also consider directions and areas for further research in annotating genomic variants...
  30. pmc Genetic determinants of phenotypic diversity in humans
    Nazli G Rahim
    Scripps Genomic Medicine, The Scripps Research Institute, North Torrey Pines Road MEM 275, La Jolla, CA 92037, USA
    Genome Biol 9:215. 2008
    ..These same technologies have also resulted in the identification of common genetic variants associated with more than 30 human diseases and traits...
  31. pmc Association of direct-to-consumer genome-wide disease risk estimates and self-reported disease
    Cinnamon S Bloss
    Scripps Genomic Medicine, Scripps Translational Science Institute, La Jolla, California 92037, USA
    Genet Epidemiol 36:66-70. 2012
    ..Our study represents one of the first evaluations of the relationship between risk estimates from a commercially available DTC personal genomic test and self-reported health histories in the consumers of that test...
  32. doi request reprint The case for routine genotyping in dual-antiplatelet therapy
    Samir B Damani
    Division of Cardiovascular Diseases, Scripps Clinic, La Jolla, California 92037, USA
    J Am Coll Cardiol 56:109-11. 2010
    ....
  33. pmc Enrichment of sequencing targets from the human genome by solution hybridization
    Ryan Tewhey
    Scripps Genomic Medicine, Scripps Translational Science Institute, The Scripps Research Institute, 3344 N Torrey Pines Court, La Jolla, CA 92037, USA
    Genome Biol 10:R116. 2009
    ..9 Mb of sequence target. We demonstrate that the tiling probe frequency is important for generating sequence data with high uniform coverage of targets. We obtained 93% sensitivity to detect SNPs, with a calling accuracy greater than 99%...
  34. doi request reprint Consumer perceptions of direct-to-consumer personalized genomic risk assessments
    Cinnamon S Bloss
    Scripps Genomic Medicine, Scripps Translational Science Institute, and Scripps Health, La Jolla, California 92037, USA
    Genet Med 12:556-66. 2010
    ..To evaluate consumer perceptions of direct-to-consumer personalized genomic risk assessments and assess the extent to which consumer characteristics may be associated with attitudes toward testing...
  35. pmc Pathway analysis of seven common diseases assessed by genome-wide association
    Ali Torkamani
    Scripps Genomic Medicine, The Scripps Translational Science Institute, and Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Genomics 92:265-72. 2008
    ..Additionally, we analyze the genetic relationships between the seven diseases, and based upon similarities with respect to the associated genes and pathways affected in each, propose a new way of categorizing the diseases...
  36. pmc Effect of direct-to-consumer genomewide profiling to assess disease risk
    Cinnamon S Bloss
    Scripps Genomic Medicine, Scripps Translational Science Institute, and Scripps Health, La Jolla, CA 92037, USA
    N Engl J Med 364:524-34. 2011
    ..We examined the psychological, behavioral, and clinical effects of risk scanning with the Navigenics Health Compass, a commercially available test of uncertain clinical validity and utility...
  37. pmc Evaluation of next generation sequencing platforms for population targeted sequencing studies
    Olivier Harismendy
    Scripps Genomic Medicine, Scripps Translational Science Institute, The Scripps Research Institute, La Jolla, CA 92037, USA
    Genome Biol 10:R32. 2009
    ..To evaluate these platforms for this application, we analyzed human sequence generated by the Roche 454, Illumina GA, and the ABI SOLiD technologies for the same 260 kb in four individuals...
  38. pmc Characteristics of genomic test consumers who spontaneously share results with their health care provider
    Burcu F Darst
    a Scripps Genomic Medicine, Scripps Translational Science Institute, Scripps Health
    Health Commun 29:105-8. 2014
    ..Genomic risk itself does not appear to be a primary determinant of sharing behavior among consumers. ..
  39. doi request reprint The fibrillin-1 gene: unlocking new therapeutic pathways in cardiovascular disease
    Paddy M Barrett
    Scripps Translational Science Institute, 3344 N Torrey Pines Court Suite 300, La Jolla, CA 92037, USA
    Heart 99:83-90. 2013
    ..Knowledge of an FBN-1 gene mutation may allow actionable interventions earlier in the natural history of the condition...
  40. pmc Emerging clinical applications in cardiovascular pharmacogenomics
    Samir B Damani
    Division of Cardiovascular Diseases, Scripps Clinic, Scripps Translational Science Institute, La Jolla, CA, USA
    Wiley Interdiscip Rev Syst Biol Med 3:206-15. 2011
    ..Herein, we detail the most clinically compelling and robust examples of pharmacogenomics emerging in the field of cardiovascular disease and hopefully foretell how cardiovascular disease might be treated in the era of genomic medicine...
  41. ncbi request reprint Fluid phase biopsy for detection and characterization of circulating endothelial cells in myocardial infarction
    Kelly Bethel
    Scripps Clinic, Department of Pathology, 10660 North Torrey Pines Road, MC211C, La Jolla, CA 92037, USA
    Phys Biol 11:016002. 2014
    ..Our HD-CEC assay may be used as a robust diagnostic biomarker in MI patients. ..
  42. pmc Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients
    Steven Rosenberg
    CardioDx, Palo Alto, California, USA
    Ann Intern Med 153:425-34. 2010
    ..Previous studies have suggested that peripheral blood gene expression can indicate the presence of CAD...
  43. doi request reprint Direct-to-consumer pharmacogenomic testing is associated with increased physician utilisation
    Cinnamon S Bloss
    Scripps Genomic Medicine, Scripps Translational Science Institute, and Scripps Health, La Jolla, California, USA
    J Med Genet 51:83-9. 2014
    ..Direct-to-consumer (DTC) genomic testing has generated controversy, however the actual impact of testing on consumer behaviour has been understudied, particularly for pharmacogenomic (PGx) testing...
  44. pmc Characterization of circulating endothelial cells in acute myocardial infarction
    Samir Damani
    Scripps Translational Science Institute, La Jolla, CA 92037, USA
    Sci Transl Med 4:126ra33. 2012
    ..These data indicate that CEC counts may serve as a promising clinical measure for the prediction of atherosclerotic plaque rupture events...
  45. pmc Microdroplet-based PCR enrichment for large-scale targeted sequencing
    Ryan Tewhey
    Scripps Genomic Medicine, Scripps Translational Science Institute, The Scripps Research Institute, La Jolla, California, USA
    Nat Biotechnol 27:1025-31. 2009
    ..Our results demonstrate that microdroplet technology is well suited for processing DNA for massively parallel enrichment of specific subsets of the human genome for targeted sequencing...
  46. pmc Can hospital rounds with pocket ultrasound by cardiologists reduce standard echocardiography?
    Hashim A Khan
    Division of Cardiovascular Diseases, Scripps Clinic, Scripps Health, La Jolla, Calif Scripps Translational Science Institute, La Jolla, Calif
    Am J Med 127:669.e1-7. 2014
    ..The availability of a pocket mobile echocardiography device that can be incorporated on bedside rounds by cardiologists may be a useful and frugal alternative...
  47. ncbi request reprint Future use of genomics in coronary artery disease
    Samir B Damani
    Division of Cardiovascular Diseases, Scripps Clinic, La Jolla, California 92037, USA
    J Am Coll Cardiol 50:1933-40. 2007
    ....
  48. doi request reprint Evaluation of individualized clopidogrel therapy after drug-eluting stent implantation in patients with high residual platelet reactivity: design and rationale of the GRAVITAS trial
    Matthew J Price
    Division of Cardiovascular Diseases, Scripps Clinic and Scripps Advanced Clinical Trials, La Jolla, CA, USA
    Am Heart J 157:818-24, 824.e1. 2009
    ....
  49. ncbi request reprint Relation of platelet inactivation with intravenous glycoprotein IIb/IIIa antagonists to major bleeding (from the GOLD study)
    Michael R Tamberella
    Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA, USA
    Am J Cardiol 89:1429-31. 2002
  50. ncbi request reprint The genetics of health
    Joseph H Nadeau
    Department of Genetics, Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, Ohio 44106, USA
    Nat Genet 38:1095-8. 2006
    ..We propose testing specifically for modifier genes and protective alleles among at-risk individuals and studying the efficacy of therapeutics based on the genetics of health...
  51. ncbi request reprint The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke
    Anna Helgadottir
    deCODE Genetics, Sturlugata 8, Reykjavik, Iceland
    Nat Genet 36:233-9. 2004
    ..We conclude that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall...
  52. pmc Premature myocardial infarction novel susceptibility locus on chromosome 1P34-36 identified by genomewide linkage analysis
    Qing Wang
    Center for Cardiovascular Genetics, Department of Cardiovascular Medicine, Lerner Research Institute, The Cleveland Clinic Foundation, OH 44195, USA
    Am J Hum Genet 74:262-71. 2004
    ..The present study thus identifies a novel genetic-susceptibility locus for MI and provides a framework for the ultimate cloning of a gene for the complex disease MI...
  53. pmc Mutation of MEF2A in an inherited disorder with features of coronary artery disease
    Lejin Wang
    Center for Cardiovascular Genetics, Department of Cardiovascular Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA
    Science 302:1578-81. 2003
    ..These results identify a pathogenic gene for a familial vascular disease with features of CAD and implicate the MEF2A signaling pathway in the pathogenesis of CAD/MI...
  54. ncbi request reprint An ensemble method for gene discovery based on DNA microarray data
    Xia Li
    Department of Computer Science, Harbin Institute of Technology, Harbin 150001, China
    Sci China C Life Sci 47:396-405. 2004
    ..We also give a numerical application for (i) and (ii) using a public microarrary data set and set aside a separate paper to address (iii)...
  55. ncbi request reprint Genetic testing for coronary heart disease: the approaching frontier
    Ramtin Agah
    Cleveland Clinic Foundation, Dept of Cardiovascular Medicine, 9500 Euclid Ave F 25, Cleveland, OH 44195, USA
    Expert Rev Mol Diagn 2:448-60. 2002
    ..A brief overview of the present state of knowledge will follow the discussion of present approaches in discovering these genetic predispositions. The key issues that will likely shape the field in the near future will also be presented...
  56. ncbi request reprint Pharmacogenomics in cardiovascular diseases
    Debabrata Mukherjee
    Division of Cardiology, University of Michigan, Ann Arbor, MI, USA
    Curr Probl Cardiol 28:317-47. 2003
  57. ncbi request reprint Pharmacogenomics in cardiovascular diseases
    Debabrata Mukherjee
    Division of Cardiology, University of Michigan, Ann Arbor, USA
    Prog Cardiovasc Dis 44:479-98. 2002
    ..The goal of pharmaco-genomics is customization of drug therapy with administration of a medication in an optimum dose that will be safe and effective with reduction in morbidity and mortality...
  58. pmc Genetic linkage analysis of longitudinal hypertension phenotypes using three summary measures
    Shaoqi Rao
    Center for Cardiovascular Genetics, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, USA
    BMC Genet 4:S24. 2003
    ..Alternatively, we may consider using univariate transformation for linkage analysis of longitudinal repeated measures...
  59. pmc Transcription factor MEF2A mutations in patients with coronary artery disease
    M R Krishna Bhagavatula
    Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Hum Mol Genet 13:3181-8. 2004
    ..93%) may carry mutations in MEF2A, although further definition of the prevalence of MEF2A mutations is warranted...
  60. ncbi request reprint Aspirin resistance and a single gene
    Brian K Jefferson
    Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Cardiol 95:805-8. 2005
    ..Aspirin resistance was significantly associated with genetic variation in the platelet surface adenosine 5-diphosphate receptor gene P2Y1...
  61. doi request reprint Warfarin pharmacogenomics: a big step forward for individualized medicine: enlightened dosing of warfarin
    Darlene J Elias
    Eur J Hum Genet 16:532-4. 2008
  62. ncbi request reprint Validity of reported genetic risk factors for acute coronary syndrome
    Jeanette J McCarthy
    JAMA 298:1758; author reply 1759. 2007
  63. pmc An LRP8 variant is associated with familial and premature coronary artery disease and myocardial infarction
    Gong Qing Shen
    Department of Molecular Cardiology, Lerner Research Institute, Center for Cardiovascular Genetics, Cleveland, OH 44195, USA
    Am J Hum Genet 81:780-91. 2007
    ..This extensive study, involving multiple independent populations, provides the first evidence that genetic variants in LRP8 may contribute to the development of premature and familial CAD and MI...
  64. ncbi request reprint A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease
    May M Luke
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Arterioscler Thromb Vasc Biol 27:2030-6. 2007
    ..The purpose of this study was to identify genetic variants associated with severe coronary artery disease (CAD)...
  65. ncbi request reprint Thrombospondins, their polymorphisms, and cardiovascular disease
    Olga I Stenina
    Joseph J Jacobs Center for Thrombosis and Vascular Biology and Department of Molecular Cardiology, Cleveland Clinic, Cleveland, OH 44195, USA
    Arterioscler Thromb Vasc Biol 27:1886-94. 2007
    ..This review seeks to summarize current information that has emerged on each of these fronts...
  66. ncbi request reprint Redefining risk in acute coronary syndromes using molecular medicine
    Saif Anwaruddin
    Department of Cardiovascular Medicine, The Cleveland Clinic, Cleveland, Ohio, USA
    J Am Coll Cardiol 49:279-89. 2007
    ..We expound upon some of these factors and the potential they may carry in changing clinical medicine...
  67. ncbi request reprint Identification of atherosclerosis-modifying genes: pathogenic insights and therapeutic potential
    Jonathan D Smith
    Cleveland Clinic Lerner College of Medicine, Department of Cell Biology, Cleveland Clinic, Cleveland, OH 44195, USA
    Expert Rev Cardiovasc Ther 4:703-9. 2006
    ..This review will summarize the methods and results thus far in the identification of atherosclerosis-modifier genes...
  68. pmc The genetics of heart attack
    Eric J Topol
    Department of Genetics, BRB 724, Case Western Reserve University, Cleveland, OH 44106, USA
    Heart 92:855-61. 2006
  69. ncbi request reprint Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction
    Dov Shiffman
    Celera Inc, 1401 Harbor Bay Pkwy, Alameda, California 94502, USA
    Arterioscler Thromb Vasc Biol 26:1613-8. 2006
    ..Identify gene variants associated with early-onset myocardial infarction (MI)...
  70. ncbi request reprint A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction
    Anna Helgadottir
    deCODE Genetics, Inc, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nat Genet 38:68-74. 2006
    ..Interactions with other genetic or environmental risk factors that are more common in African Americans are likely to account for the greater relative risk conferred by HapK in this group...
  71. pmc Miscues on the "lack of MEF2A mutations" in coronary artery disease
    Qing Wang
    J Clin Invest 115:1399-400; author reply 1400-1. 2005
  72. pmc Towards precise classification of cancers based on robust gene functional expression profiles
    Zheng Guo
    Department of Computer Science, Harbin Institute of Technology, Harbin 150001, China
    BMC Bioinformatics 6:58. 2005
    ..Therefore, there is an open space for development of the timely and relevant computational algorithms that use robust functional expression profiles towards precise classification of complex human diseases at the modular level...
  73. doi request reprint Gaining insights in coronary disease genomics
    Sarah S Murray
    J Am Coll Cardiol 52:385-6. 2008