Alexis A Topjian

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. pmc Brain resuscitation in the drowning victim
    Alexis A Topjian
    The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Suite 7C23, Philadelphia, PA 19104, USA
    Neurocrit Care 17:441-67. 2012
  2. pmc Pediatric cardiopulmonary resuscitation: advances in science, techniques, and outcomes
    Alexis A Topjian
    Department of Anesthesia and Critical Care Medicine, University of Pennsylvania, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 122:1086-98. 2008
  3. pmc Induction and maintenance of therapeutic hypothermia after pediatric cardiac arrest: efficacy of a surface cooling protocol
    Alexis Topjian
    Department of Anesthesia, Critical Care, and Pediatrics, The Children s Hospital of Philadelphia CHOP, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pediatr Crit Care Med 12:e127-35. 2011
  4. pmc Women of child-bearing age have better inhospital cardiac arrest survival outcomes than do equal-aged men
    Alexis A Topjian
    Department of Anesthesia and Critical Care Medicine, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 38:1254-60. 2010
  5. ncbi request reprint Cardiopulmonary resuscitation in children
    Alexis A Topjian
    University of Pennsylvania School of Medicine, Department of Anesthesia and Critical Care Medicine, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Curr Opin Crit Care 15:203-8. 2009
  6. doi request reprint Neuron-specific enolase and S-100B are associated with neurologic outcome after pediatric cardiac arrest
    Alexis A Topjian
    Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Pediatr Crit Care Med 10:479-90. 2009
  7. pmc Outcome prediction by motor and pupillary responses in children treated with therapeutic hypothermia after cardiac arrest
    Nicholas S Abend
    Division of Neurology, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pediatr Crit Care Med 13:32-8. 2012
  8. pmc Early postresuscitation hypotension is associated with increased mortality following pediatric cardiac arrest
    Alexis A Topjian
    1Division of Critical Care Medicine, Department of Anesthesiology and Critical Medicine, Children s Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 2Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 3Division of Critical Care Medicine, Department of Pediatrics, CS Mott Children s Hospital, University of Michigan, Ann Arbor, MI 4Department of Pediatrics, University of Utah, Salt Lake City, UT
    Crit Care Med 42:1518-23. 2014
  9. pmc Nonconvulsive electrographic seizures are common in children with abusive head trauma*
    Daphne M Hasbani
    1Division of Neurology, The Children s Hospital of Philadelphia, Department of Pediatrics and Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 2Division of Critical Care Medicine, The Children s Hospital of Philadelphia, Department of Anesthesiology and Critical Care Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 3Division of Critical Care Medicine, St Louis Children s Hospital, Department of Pediatrics, Washington University in St Louis School of Medicine, St Louis, MO 4Division of Pediatrics, The Children s Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
    Pediatr Crit Care Med 14:709-15. 2013
  10. pmc Electrographic status epilepticus is associated with mortality and worse short-term outcome in critically ill children
    Alexis A Topjian
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Crit Care Med 41:215-23. 2013

Collaborators

Detail Information

Publications25

  1. pmc Brain resuscitation in the drowning victim
    Alexis A Topjian
    The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Suite 7C23, Philadelphia, PA 19104, USA
    Neurocrit Care 17:441-67. 2012
    ....
  2. pmc Pediatric cardiopulmonary resuscitation: advances in science, techniques, and outcomes
    Alexis A Topjian
    Department of Anesthesia and Critical Care Medicine, University of Pennsylvania, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 122:1086-98. 2008
    ..Outcomes from pediatric cardiac arrests are improving. Advances in resuscitation science and state-of-the-art implementation techniques provide the opportunity for further improvement in outcomes among children after cardiac arrest...
  3. pmc Induction and maintenance of therapeutic hypothermia after pediatric cardiac arrest: efficacy of a surface cooling protocol
    Alexis Topjian
    Department of Anesthesia, Critical Care, and Pediatrics, The Children s Hospital of Philadelphia CHOP, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pediatr Crit Care Med 12:e127-35. 2011
    ..To assess the feasibility, effectiveness, side effects, and adverse events associated with a standardized surface cooling protocol. Induced therapeutic hypothermia after pediatric cardiac arrest is an important intervention...
  4. pmc Women of child-bearing age have better inhospital cardiac arrest survival outcomes than do equal-aged men
    Alexis A Topjian
    Department of Anesthesia and Critical Care Medicine, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 38:1254-60. 2010
    ..Our objective was to determine whether women of child-bearing age are more likely than men to survive to hospital discharge after in-hospital cardiac arrest...
  5. ncbi request reprint Cardiopulmonary resuscitation in children
    Alexis A Topjian
    University of Pennsylvania School of Medicine, Department of Anesthesia and Critical Care Medicine, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Curr Opin Crit Care 15:203-8. 2009
    ..To summarize recent advances in pediatric cardiopulmonary arrest prevention, resuscitation and postresuscitation management...
  6. doi request reprint Neuron-specific enolase and S-100B are associated with neurologic outcome after pediatric cardiac arrest
    Alexis A Topjian
    Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Pediatr Crit Care Med 10:479-90. 2009
    ....
  7. pmc Outcome prediction by motor and pupillary responses in children treated with therapeutic hypothermia after cardiac arrest
    Nicholas S Abend
    Division of Neurology, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pediatr Crit Care Med 13:32-8. 2012
    ..We aimed to determine the prognostic value of motor and pupillary responses in children treated with therapeutic hypothermia after cardiac arrest...
  8. pmc Early postresuscitation hypotension is associated with increased mortality following pediatric cardiac arrest
    Alexis A Topjian
    1Division of Critical Care Medicine, Department of Anesthesiology and Critical Medicine, Children s Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 2Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 3Division of Critical Care Medicine, Department of Pediatrics, CS Mott Children s Hospital, University of Michigan, Ann Arbor, MI 4Department of Pediatrics, University of Utah, Salt Lake City, UT
    Crit Care Med 42:1518-23. 2014
    ..To describe the association of systolic hypotension during the first 6 hours after successful resuscitation from pediatric cardiopulmonary arrest with in-hospital mortality...
  9. pmc Nonconvulsive electrographic seizures are common in children with abusive head trauma*
    Daphne M Hasbani
    1Division of Neurology, The Children s Hospital of Philadelphia, Department of Pediatrics and Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 2Division of Critical Care Medicine, The Children s Hospital of Philadelphia, Department of Anesthesiology and Critical Care Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 3Division of Critical Care Medicine, St Louis Children s Hospital, Department of Pediatrics, Washington University in St Louis School of Medicine, St Louis, MO 4Division of Pediatrics, The Children s Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
    Pediatr Crit Care Med 14:709-15. 2013
    ..To determine the prevalence of nonconvulsive seizures in children with abusive head trauma...
  10. pmc Electrographic status epilepticus is associated with mortality and worse short-term outcome in critically ill children
    Alexis A Topjian
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Crit Care Med 41:215-23. 2013
    ..We aimed to determine whether electrographic seizures and electrographic status epilepticus are associated with higher mortality or worse short-term neurologic outcome...
  11. pmc Electrographic status epilepticus and long-term outcome in critically ill children
    Katherine L Wagenman
    From the Department of Anesthesia and Critical Care Medicine R A B, A A T, The Children s Hospital of Philadelphia and Perelman School of Medicine at The University of Pennsylvania, Philadelphia Division of Neurology K L W, S M S, D J D, N S A, The Children s Hospital of Philadelphia Departments of Neurology and Pediatrics D J D, N S A, Perelman School of Medicine at the University of Pennsylvania, Philadelphia Psychology Department T P B, M T S, Drexel University, Philadelphia, PA and Department of Pediatrics J R, Perelman School of Medicine at the University of Pennsylvania, The Children s Hospital of Philadelphia, PA
    Neurology 82:396-404. 2014
    ..We aimed to determine whether ES or ESE was associated with worse long-term outcomes...
  12. pmc Impact of continuous EEG monitoring on clinical management in critically ill children
    Nicholas S Abend
    Division of Neurology, The Children s Hospital of Philadelphia, 34th Street and Civic Center Blvd, Philadelphia, PA 19104, USA
    Neurocrit Care 15:70-5. 2011
    ..We aimed to determine prospectively the impact of cEEG on clinical management in critically ill children...
  13. pmc Density spectral array for seizure identification in critically ill children
    Alyssa D Pensirikul
    Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Clin Neurophysiol 30:371-5. 2013
    ....
  14. pmc Electroencephalogram monitoring in critically ill children: indications and strategies
    Ana M Gutierrez-Colina
    Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Pediatr Neurol 46:158-61. 2012
    ..14, and 0.43 patients with seizures per monitoring day performed, respectively. A brief-targeted strategy provides a high yield for nonconvulsive seizure identification, but would fail to diagnose some patients with seizures...
  15. pmc High frequency oscillation and airway pressure release ventilation in pediatric respiratory failure
    Nadir Yehya
    Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania
    Pediatr Pulmonol 49:707-15. 2014
    ..Our aim was to describe our experience with APRV and HFOV in refractory pediatric ALI, and to identify factors associated with survival...
  16. pmc Early lactate elevations following resuscitation from pediatric cardiac arrest are associated with increased mortality*
    Alexis A Topjian
    1Division of Pediatric Critical Care, The Children s Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 2Department of Pediatrics, University of Utah, Salt Lake City, UT 3Department of Pediatrics, Children s National Medical Center, Washington, DC 4Department of Pediatrics, Children s Hospital of New York, Columbia University, New York, NY 5Department of Pediatrics, C S Mott Children s Hospital, University of Michigan, Ann Arbor, MI
    Pediatr Crit Care Med 14:e380-7. 2013
    ..To describe the association of lactate levels within the first 12 hours after successful resuscitation from pediatric cardiopulmonary arrest with hospital mortality...
  17. ncbi request reprint Advances in recognition, resuscitation, and stabilization of the critically ill child
    Alexis A Topjian
    Department of Anesthesia and Critical Care Medicine, The Children s Hospital of Philadelphia, The University of Pennsylvania, Philadelphia, PA 19063, USA
    Pediatr Clin North Am 60:605-20. 2013
    ..Monitoring and quality improvement of each element in the system of resuscitation care are increasingly recognized as key factors in saving lives...
  18. pmc EEG monitoring during therapeutic hypothermia in neonates, children, and adults
    Nicholas S Abend
    Department of Neurology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Electroneurodiagnostic Technol 51:141-64. 2011
    ..We review data regarding indications for therapeutic hypothermia and electroencephalographic monitoring in neonatal, pediatric, and adult critical care units, and discuss technical aspects related to such monitoring...
  19. pmc Short-term outcome prediction by electroencephalographic features in children treated with therapeutic hypothermia after cardiac arrest
    Sudha Kilaru Kessler
    Division of Neurology, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Neurocrit Care 14:37-43. 2011
    ..We aimed to determine whether specific EEG features were predictive of short-term outcome in children treated with TH after CA, both during hypothermia and after return to normothermia...
  20. doi request reprint Resuscitation training in developing countries: a systematic review
    Peter A Meaney
    Department of Anesthesia and Critical Care, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Resuscitation 81:1462-72. 2010
    ..To evaluate whether the inclusion of any specific resuscitation training educational strategy in developing countries improves outcomes...
  21. doi request reprint To cool or not to cool during cardiopulmonary resuscitation
    Alexis A Topjian
    Department of Anesthesia and Critical Care Medicine, Critical Care, and Pediatrics, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    World J Pediatr Congenit Heart Surg 3:54-7. 2012
    ..It is reasonable for adolescents resuscitated from sudden, witnessed, out-of-hospital VF cardiac arrest." Ongoing research will help delineate whether induced hypothermia following pediatric cardiac arrest improves neurologic outcome. ..
  22. doi request reprint Bi-caval dual lumen venovenous extracorporeal membrane oxygenation and high-frequency percussive ventilatory support for postintubation tracheal injury and acute respiratory distress syndrome
    Julie C Fitzgerald
    Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Pediatr Surg 46:e11-5. 2011
    ....
  23. pmc Interdisciplinary ICU cardiac arrest debriefing improves survival outcomes*
    Heather Wolfe
    1Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 2Department of Pediatrics, Section of Critical Care Medicine, Children s Hospital Colorado, Aurora, CO
    Crit Care Med 42:1688-95. 2014
    ..Our objective is to evaluate the effectiveness of a novel, interdisciplinary, postevent quantitative debriefing program to improve survival outcomes after in-hospital pediatric chest compression events...
  24. ncbi request reprint Improved oxygenation 24 hours after transition to airway pressure release ventilation or high-frequency oscillatory ventilation accurately discriminates survival in immunocompromised pediatric patients with acute respiratory distress syndrome*
    Nadir Yehya
    1Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 2Division of Pediatric Critical Care Medicine, Department of Pediatrics and Public Health Science, Penn State Hershey Children s Hospital, Hershey, PA 3Division of Critical Care Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis, MO
    Pediatr Crit Care Med 15:e147-56. 2014
    ....
  25. doi request reprint CPR and E-CPR: What is New?
    Maryam Y Naim
    Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    World J Pediatr Congenit Heart Surg 3:48-53. 2012
    ..The use of extracorporeal membrane oxygenation in cardiopulmonary resuscitation (CPR) is also reviewed including the results of two recent large studies and preliminary reports on long-term neurologic outcome of survivors. ..