G Tononi

Summary

Affiliation: The Neurosciences Institute
Country: USA

Publications

  1. ncbi request reprint Neuronal gene expression in the waking state: a role for the locus coeruleus
    C Cirelli
    The Neurosciences Institute, 10640 J J Hopkins Drive, San Diego, CA 92121, USA
    Science 274:1211-5. 1996
  2. ncbi request reprint Schizophrenia and the mechanisms of conscious integration
    G Tononi
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA, USA
    Brain Res Brain Res Rev 31:391-400. 2000
  3. pmc Measures of degeneracy and redundancy in biological networks
    G Tononi
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 96:3257-62. 1999
  4. ncbi request reprint Consciousness and complexity
    G Tononi
    Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
    Science 282:1846-51. 1998
  5. pmc Investigating neural correlates of conscious perception by frequency-tagged neuromagnetic responses
    G Tononi
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 95:3198-203. 1998
  6. ncbi request reprint Differential expression of plasticity-related genes in waking and sleep and their regulation by the noradrenergic system
    C Cirelli
    The Neurosciences Institute, San Diego, California 92121, USA
    J Neurosci 20:9187-94. 2000
  7. ncbi request reprint Sleep and the fruit fly
    R J Greenspan
    The Neurosciences Institute, 10640 John Jay Hopkins Dr, San Diego, CA 92121, USA
    Trends Neurosci 24:142-5. 2001
  8. ncbi request reprint On the functional significance of c-fos induction during the sleep-waking cycle
    C Cirelli
    The Neurosciences Institute, San Diego, California 92121, USA
    Sleep 23:453-69. 2000
  9. ncbi request reprint Theoretical neuroanatomy: relating anatomical and functional connectivity in graphs and cortical connection matrices
    O Sporns
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Cereb Cortex 10:127-41. 2000
  10. ncbi request reprint Connectivity and complexity: the relationship between neuroanatomy and brain dynamics
    O Sporns
    The Neurosciences Institute, San Diego, CA 92121, USA
    Neural Netw 13:909-22. 2000

Detail Information

Publications21

  1. ncbi request reprint Neuronal gene expression in the waking state: a role for the locus coeruleus
    C Cirelli
    The Neurosciences Institute, 10640 J J Hopkins Drive, San Diego, CA 92121, USA
    Science 274:1211-5. 1996
    ..The reduced activity of locus coeruleus neurons may explain why the induction of certain transcription factors, with potential effects on plasticity and learning, does not occur during sleep...
  2. ncbi request reprint Schizophrenia and the mechanisms of conscious integration
    G Tononi
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA, USA
    Brain Res Brain Res Rev 31:391-400. 2000
    ..The possibility is raised that disruption of re-entrant interactions among cortical areas may contribute to the pathophysiology of schizophrenia...
  3. pmc Measures of degeneracy and redundancy in biological networks
    G Tononi
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 96:3257-62. 1999
    ..These measures promise to be useful in characterizing and understanding the functional robustness and adaptability of biological networks...
  4. ncbi request reprint Consciousness and complexity
    G Tononi
    Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
    Science 282:1846-51. 1998
    ..Applying measures of neural integration and complexity, together with an analysis of extensive neurological data, leads to a testable proposal-the dynamic core hypothesis-about the properties of the neural substrate of consciousness...
  5. pmc Investigating neural correlates of conscious perception by frequency-tagged neuromagnetic responses
    G Tononi
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 95:3198-203. 1998
    ..The results demonstrate a correlation between the conscious perception of a visual stimulus and the synchronous activity of large populations of neurons as reflected by steady-state neuromagnetic responses...
  6. ncbi request reprint Differential expression of plasticity-related genes in waking and sleep and their regulation by the noradrenergic system
    C Cirelli
    The Neurosciences Institute, San Diego, California 92121, USA
    J Neurosci 20:9187-94. 2000
    ..These molecular results complement behavioral evidence and provide a mechanism for the impairment of long-term memory acquisition during sleep...
  7. ncbi request reprint Sleep and the fruit fly
    R J Greenspan
    The Neurosciences Institute, 10640 John Jay Hopkins Dr, San Diego, CA 92121, USA
    Trends Neurosci 24:142-5. 2001
    ..The record of Drosophila in laying the foundations for subsequent studies in mammals argues in favor of the force of this new approach...
  8. ncbi request reprint On the functional significance of c-fos induction during the sleep-waking cycle
    C Cirelli
    The Neurosciences Institute, San Diego, California 92121, USA
    Sleep 23:453-69. 2000
    ....
  9. ncbi request reprint Theoretical neuroanatomy: relating anatomical and functional connectivity in graphs and cortical connection matrices
    O Sporns
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Cereb Cortex 10:127-41. 2000
    ..We hypothesize that adaptation to rich sensory environments and motor demands requires complex dynamics and that these dynamics are supported by neuroanatomical motifs that are characteristic of the cerebral cortex...
  10. ncbi request reprint Connectivity and complexity: the relationship between neuroanatomy and brain dynamics
    O Sporns
    The Neurosciences Institute, San Diego, CA 92121, USA
    Neural Netw 13:909-22. 2000
    ..Our theoretical findings offer new insight into the intricate relationship between connectivity and complexity in the nervous system...
  11. ncbi request reprint Modulation of brain gene expression during sleep and wakefulness: a review of recent findings
    G Tononi
    The Neurosciences Institute, 10640 John J. Hopkins Drive, San Diego, CA 92121, USA
    Neuropsychopharmacology 25:S28-35. 2001
    ....
  12. ncbi request reprint Gene expression in the brain across the sleep-waking cycle
    C Cirelli
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
    Brain Res 885:303-21. 2000
    ..Thus, significant changes in gene expression occur across behavioral states, which are likely to affect basic cellular functions such as RNA and protein synthesis, neural plasticity, neurotransmission, and metabolism...
  13. ncbi request reprint Differences in brain gene expression between sleep and waking as revealed by mRNA differential display and cDNA microarray technology
    C Cirelli
    Neurosciences Institute, San Diego, California, USA
    J Sleep Res 8:44-52. 1999
    ..A possible role for these known transcripts in mediating neural plasticity during waking is discussed...
  14. ncbi request reprint Differences in gene expression during sleep and wakefulness
    C Cirelli
    The Neurosciences Institute, San Diego, CA 92121, USA
    Ann Med 31:117-24. 1999
    ..The ongoing systematic screening of gene expression across behavioural states should prove crucial in elucidating the regulatory mechanisms of sleep homeostasis and the functions of sleep...
  15. ncbi request reprint Theoretical neuroanatomy and the connectivity of the cerebral cortex
    O Sporns
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Behav Brain Res 135:69-74. 2002
    ..The combined structural and functional analysis outlined in this chapter provides insight into the large-scale functional organization of distributed cortical systems...
  16. ncbi request reprint No evidence of brain cell degeneration after long-term sleep deprivation in rats
    C Cirelli
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
    Brain Res 840:184-93. 1999
    ..These results argue against the hypothesis that sustained waking can significantly damage brain cells through excitotoxic or oxidative mechanisms and that massive cell death may explain the fatal consequences of sleep deprivation...
  17. ncbi request reprint Some considerations on sleep and neural plasticity
    G Tononi
    Neurosciences Institute, San Diego, CA 92121, USA
    Arch Ital Biol 139:221-41. 2001
    ..A consideration of such molecular aspects could lead to more conclusive experiments concerning the relationship between sleep and plasticity...
  18. ncbi request reprint Correlates of sleep and waking in Drosophila melanogaster
    P J Shaw
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Science 287:1834-7. 2000
    ..These results implicate the catabolism of monoamines in the regulation of sleep and waking in the fly and suggest that Drosophila may serve as a model system for the genetic dissection of sleep...
  19. ncbi request reprint Uncoupling proteins and sleep deprivation
    C Cirelli
    Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison WI 53719, USA
    Arch Ital Biol 142:541-9. 2004
    ..Since the skeletal muscle is the largest tissue in the body, an elevated muscular expression of UCP2 is likely to affect the overall resting EE and may thus contribute to its increase after SD...
  20. ncbi request reprint c-Fos expression during wakefulness and sleep
    M Pompeiano
    Istituto di Chimica Biologica, Universita di Pisa, Italy
    Neurophysiol Clin 25:329-41. 1995
    ..Further work should explore the mechanisms leading to changes in the expression of c-fos, and possibly of its target genes, during the sleep-wake cycle...
  21. pmc Cortical metabolic rates as measured by 2-deoxyglucose-uptake are increased after waking and decreased after sleep in mice
    V V Vyazovskiy
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland
    Brain Res Bull 75:591-7. 2008
    ..The data are consistent with the prediction that sleep may reset cerebral metabolic rates to a lower level...