Gary Tong

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. ncbi request reprint Modulation of NMDA receptor properties and synaptic transmission by the NR3A subunit in mouse hippocampal and cerebrocortical neurons
    Gary Tong
    Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Neurophysiol 99:122-32. 2008
  2. pmc Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits
    Juan C Piña-Crespo
    Molecular Neurobiology Laboratory, Salk Institute, and Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Neurosci 30:11501-5. 2010
  3. pmc Neuroprotection by the NR3A subunit of the NMDA receptor
    Nobuki Nakanishi
    Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Neurosci 29:5260-5. 2009
  4. pmc Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
    Maria Talantova
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 110:E2518-27. 2013
  5. pmc Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin
    Shu ichi Okamoto
    Center for Neuroscience, Aging and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, California, USA
    Nat Med 15:1407-13. 2009
  6. pmc Hypoxia enhances S-nitrosylation-mediated NMDA receptor inhibition via a thiol oxygen sensor motif
    Hiroto Takahashi
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 53:53-64. 2007
  7. ncbi request reprint Calnuc binds to Alzheimer's beta-amyloid precursor protein and affects its biogenesis
    Ping Lin
    Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California 92037, USA
    J Neurochem 100:1505-14. 2007

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Modulation of NMDA receptor properties and synaptic transmission by the NR3A subunit in mouse hippocampal and cerebrocortical neurons
    Gary Tong
    Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Neurophysiol 99:122-32. 2008
    ..Taken together, these results show that NR3A subunits contribute to NMDAR responses from both synaptic and extrasynaptic receptors, likely composed of NR1, NR2, and NR3 subunits...
  2. pmc Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits
    Juan C Piña-Crespo
    Molecular Neurobiology Laboratory, Salk Institute, and Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Neurosci 30:11501-5. 2010
    ..d-Serine responses were abrogated in NR3A-deficient mice. Our results suggest the presence of functional NR1/NR3 receptors in CNS myelin...
  3. pmc Neuroprotection by the NR3A subunit of the NMDA receptor
    Nobuki Nakanishi
    Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Neurosci 29:5260-5. 2009
    ..These data suggest that endogenous NR3A protects neurons, and exogenously added NR3A increases neuroprotection and could be potentially exploited as a therapeutic...
  4. pmc Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
    Maria Talantova
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 110:E2518-27. 2013
    ..Importantly, the improved NMDAR antagonist NitroMemantine, which selectively inhibits extrasynaptic over physiological synaptic NMDAR activity, protects synapses from Aβ-induced damage both in vitro and in vivo. ..
  5. pmc Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin
    Shu ichi Okamoto
    Center for Neuroscience, Aging and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, California, USA
    Nat Med 15:1407-13. 2009
    ..Our findings offer a rational therapeutic approach for protecting susceptible neurons in Huntington's disease...
  6. pmc Hypoxia enhances S-nitrosylation-mediated NMDA receptor inhibition via a thiol oxygen sensor motif
    Hiroto Takahashi
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 53:53-64. 2007
    ..These thiols may be nitrosylated preferentially during increasing hypoxia or stroke conditions, thus preventing excessive activity associated with cytotoxicity while avoiding blockade of physiologically active NMDARs...
  7. ncbi request reprint Calnuc binds to Alzheimer's beta-amyloid precursor protein and affects its biogenesis
    Ping Lin
    Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California 92037, USA
    J Neurochem 100:1505-14. 2007
    ..Our results suggest a novel function of calnuc in modulating the levels of APP and its proteolytic metabolites, which may further affect the patho/physiological functions of APP including AD pathogenesis...