E A Thomas

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Genome-wide identification of Bcl11b gene targets reveals role in brain-derived neurotrophic factor signaling
    Bin Tang
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 6:e23691. 2011
  2. ncbi request reprint Striatal specificity of gene expression dysregulation in Huntington's disease
    Elizabeth A Thomas
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci Res 84:1151-64. 2006
  3. ncbi request reprint Apolipoprotein D modulates arachidonic acid signaling in cultured cells: implications for psychiatric disorders
    Elizabeth A Thomas
    Department of Molecular Biology, The Scripps Research Institute, MB 10, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Prostaglandins Leukot Essent Fatty Acids 69:421-7. 2003
  4. ncbi request reprint Oleamide-induced modulation of 5-hydroxytryptamine receptor-mediated signaling
    E A Thomas
    Department of Molecular Biology, Scripps Research Institute, La Jolla, California 92037, USA
    Ann N Y Acad Sci 861:183-9. 1998
  5. ncbi request reprint Clozapine specifically alters the arachidonic acid pathway in mice lacking apolipoprotein D
    Elizabeth A Thomas
    Department of Molecular Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, MB 10, La Jolla, CA 92037, United States
    Schizophr Res 89:147-53. 2007
  6. ncbi request reprint From pharmacotherapy to pathophysiology: emerging mechanisms of apolipoprotein D in psychiatric disorders
    E A Thomas
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
    Curr Mol Med 3:408-18. 2003
  7. ncbi request reprint Molecular profiling of antipsychotic drug function: convergent mechanisms in the pathology and treatment of psychiatric disorders
    Elizabeth A Thomas
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
    Mol Neurobiol 34:109-28. 2006
  8. pmc The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice
    Elizabeth A Thomas
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:15564-9. 2008
  9. doi request reprint Focal nature of neurological disorders necessitates isotype-selective histone deacetylase (HDAC) inhibitors
    Elizabeth A Thomas
    Department of Molecular Biology, The Scripps Research Institute, MB 10, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Mol Neurobiol 40:33-45. 2009
  10. ncbi request reprint Antipsychotic drug treatment alters expression of mRNAs encoding lipid metabolism-related proteins
    E A Thomas
    1Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
    Mol Psychiatry 8:983-93, 950. 2003

Research Grants

Collaborators

Detail Information

Publications32

  1. pmc Genome-wide identification of Bcl11b gene targets reveals role in brain-derived neurotrophic factor signaling
    Bin Tang
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 6:e23691. 2011
    ..Specific targeting of the Bcl11b-DNA interaction could represent a novel therapeutic approach to lowering BDNF signaling specifically in striatal cells...
  2. ncbi request reprint Striatal specificity of gene expression dysregulation in Huntington's disease
    Elizabeth A Thomas
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci Res 84:1151-64. 2006
    ....
  3. ncbi request reprint Apolipoprotein D modulates arachidonic acid signaling in cultured cells: implications for psychiatric disorders
    Elizabeth A Thomas
    Department of Molecular Biology, The Scripps Research Institute, MB 10, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Prostaglandins Leukot Essent Fatty Acids 69:421-7. 2003
    ..These results suggest that apoD acts to stabilize membrane-associated AA by preventing release and sequestering free AA in the cell. These actions of apoD may be beneficial to psychiatric patients...
  4. ncbi request reprint Oleamide-induced modulation of 5-hydroxytryptamine receptor-mediated signaling
    E A Thomas
    Department of Molecular Biology, Scripps Research Institute, La Jolla, California 92037, USA
    Ann N Y Acad Sci 861:183-9. 1998
    ..Additionally, our data suggest that oleamide may act at an allosteric site on the 5-HT7 receptor and can elicit functional responses via activation of this site...
  5. ncbi request reprint Clozapine specifically alters the arachidonic acid pathway in mice lacking apolipoprotein D
    Elizabeth A Thomas
    Department of Molecular Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, MB 10, La Jolla, CA 92037, United States
    Schizophr Res 89:147-53. 2007
    ..We further report increases in LA, eicosadienoic acid and docosahexaenoic acid in apoD knock-out compared to wild-type mice. These findings implicate an important apoD/AA interaction, which may be necessary for clozapine function...
  6. ncbi request reprint From pharmacotherapy to pathophysiology: emerging mechanisms of apolipoprotein D in psychiatric disorders
    E A Thomas
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
    Curr Mol Med 3:408-18. 2003
    ....
  7. ncbi request reprint Molecular profiling of antipsychotic drug function: convergent mechanisms in the pathology and treatment of psychiatric disorders
    Elizabeth A Thomas
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
    Mol Neurobiol 34:109-28. 2006
    ..This article surveys both the convergent antipsychotic mechanisms and the genes that may be responsible for other effects elicited by antipsychotic drugs...
  8. pmc The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice
    Elizabeth A Thomas
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:15564-9. 2008
    ..These findings suggest that HDACi 4b, and possibly related HDAC inhibitors, may offer clinical benefit for HD patients and provide a novel set of potential biomarkers for clinical assessment...
  9. doi request reprint Focal nature of neurological disorders necessitates isotype-selective histone deacetylase (HDAC) inhibitors
    Elizabeth A Thomas
    Department of Molecular Biology, The Scripps Research Institute, MB 10, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Mol Neurobiol 40:33-45. 2009
    ..This review will summarize brain regions associated with various neurological disorders and factors affecting the consequences of HDAC inhibition...
  10. ncbi request reprint Antipsychotic drug treatment alters expression of mRNAs encoding lipid metabolism-related proteins
    E A Thomas
    1Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
    Mol Psychiatry 8:983-93, 950. 2003
    ..While antipsychotic drugs may affect several metabolic pathways, lipid metabolism/signaling pathways may be of particular importance in the mechanisms of antipsychotic drug action and in the pathophysiology of psychiatric disorders...
  11. pmc No hypothermic response to serotonin in 5-HT7 receptor knockout mice
    P B Hedlund
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:1375-80. 2003
    ....
  12. ncbi request reprint Clozapine increases apolipoprotein D expression in rodent brain: towards a mechanism for neuroleptic pharmacotherapy
    E A Thomas
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, USA
    J Neurochem 76:789-96. 2001
    ..These results suggest that apoD is a mediator in the mechanisms of clozapine and thus that deficiencies in aspects of lipid metabolism may be responsible for psychoses...
  13. ncbi request reprint Evolutionarily distinct classes of S27 ribosomal proteins with differential mRNA expression in rat hypothalamus
    E A Thomas
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Neurochem 74:2259-67. 2000
    ..Combined with the genetic evidence that S27 has extraribosomal functions in plants, the complexity of S27 biology observed here may suggest auxiliary functions for S27 proteins in the mammalian nervous system...
  14. ncbi request reprint Pertussis toxin treatment prevents 5-HT(5a) receptor-mediated inhibition of cyclic AMP accumulation in rat C6 glioma cells
    E A Thomas
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci Res 61:75-81. 2000
    ..These results demonstrate an efficient functional coupling of the rat 5HT(5a) receptor to the inhibition of adenylate cyclase via a pertussis toxin-sensitive G[alpha(i)], inhibitory G-protein...
  15. ncbi request reprint Apolipoprotein D mRNA expression is elevated in PDAPP transgenic mice
    E A Thomas
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, USA
    J Neurochem 79:1059-64. 2001
    ..These findings suggest that, although increases in apoD expression are a normal feature of brain aging, super-increases may represent a glial cell compensatory response to beta-amyloid deposition in Alzheimer's disease...
  16. pmc Increased CNS levels of apolipoprotein D in schizophrenic and bipolar subjects: implications for the pathophysiology of psychiatric disorders
    E A Thomas
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:4066-71. 2001
    ..Elevation of apoD expression selectively within central nervous system regions implicated in the pathology of these neuropsychiatric disorders suggests a focal compensatory response that neuroleptic drug regimens may augment...
  17. ncbi request reprint RGS9: a regulator of G-protein signalling with specific expression in rat and mouse striatum
    E A Thomas
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci Res 52:118-24. 1998
    ..Relatively strong signals were also detected in some hypothalamic nuclei. Its selective expression suggests that RGS9 may play an important role in modulation of the complex signalling pathways of the basal ganglia...
  18. pmc Disease- and age-related changes in histone acetylation at gene promoters in psychiatric disorders
    B Tang
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Transl Psychiatry 1:e64. 2011
    ..These findings may have therapeutic implications for the clinical use of HDAC inhibitors in psychiatric disorders...
  19. ncbi request reprint Insulin receptor substrate protein p53 localization in rats suggests mechanism for specific polyglutamine neurodegeneration
    E A Thomas
    Department of Molecular Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Neurosci Lett 309:145-8. 2001
    ..The expression of IRSp53 in regions similar to those that degenerate in DRPLA supports the notion that IRSp53 is a relevant atrophin-1 binding protein and may provide a mechanism for region-specific neurodegeneration...
  20. ncbi request reprint Fatty acid amide hydrolase, the degradative enzyme for anandamide and oleamide, has selective distribution in neurons within the rat central nervous system
    E A Thomas
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci Res 50:1047-52. 1997
    ..The FAAH distribution in the CNS suggests that degradation of neuromodulatory fatty acid amides at their sites of action influences their effects on sleep, euphoria, and analgesia...
  21. ncbi request reprint Differences in neuroanatomical sites of apoD elevation discriminate between schizophrenia and bipolar disorder
    E A Thomas
    Department of Molecular Biology, The Scripps Research Institute, 10550 Torrey Pines Road, La Jolla, CA, USA
    Mol Psychiatry 8:167-75. 2003
    ..7%). These data demonstrate that there is anatomical overlap in the pathophysiologies of schizophrenia and bipolar disorder, as well as areas of pathology that distinguish the two disorders...
  22. ncbi request reprint The neurobiology of apolipoproteins in psychiatric disorders
    J Gregor Sutcliffe
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
    Mol Neurobiol 26:369-88. 2002
    ..Furthermore, the authors discuss the role of apoD in the pathology and pharmacotherapy of schizophrenia and bipolar disorder...
  23. pmc Glycolipid and ganglioside metabolism imbalances in Huntington's disease
    Paula A Desplats
    Molecular Biology Department, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Neurobiol Dis 27:265-77. 2007
    ..These findings reveal novel disruptions in glycolipid/ganglioside metabolic pathways in the pathology of HD and suggest that the development of new targets to restore glycosphingolipid balance may act to ameliorate some symptoms of HD...
  24. ncbi request reprint A new UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase mRNA exhibits predominant expression in the hypothalamus, thalamus and amygdala of mouse forebrain
    P Austin Nelson
    Department of Molecular Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Brain Res Gene Expr Patterns 1:95-9. 2002
    ....
  25. ncbi request reprint Chronic haloperidol treatment results in a decrease in the expression of myelin/oligodendrocyte-related genes in the mouse brain
    Sujatha Narayan
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci Res 85:757-65. 2007
    ..In contrast, clozapine (10 mg/kg/day) had no effect on the expression of a subset of these genes. This has important implications for both disease pathology and the consideration of treatment options for patients...
  26. ncbi request reprint Increased levels of apolipoprotein E in the frontal cortex of subjects with schizophrenia
    Brian Dean
    Rebecca L Cooper Research Laboratories, The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
    Biol Psychiatry 54:616-22. 2003
    ..It is unclear whether altered expression of a specific isoform of apolipoprotein E (apoE) is associated with the pathology of schizophrenia...
  27. ncbi request reprint Selective deficits in the expression of striatal-enriched mRNAs in Huntington's disease
    Paula A Desplats
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
    J Neurochem 96:743-57. 2006
    ....
  28. ncbi request reprint Regulation of alpha-synuclein expression in limbic and motor brain regions of morphine-treated mice
    Barbara Ziolkowska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
    J Neurosci 25:4996-5003. 2005
    ..The observed changes in alpha-synuclein levels are discussed in connection with their putative role in mediating suppression of dopaminergic neurotransmission during opiate withdrawal...
  29. ncbi request reprint Association of plasma apolipoproteins D with RBC membrane arachidonic acid levels in schizophrenia
    Jeffrey K Yao
    Neurochemistry and Psychopharmacology Laboratory Bldg 13, VA Pittsburgh Healthcare System, 7180 Highland Dr, Pittsburgh, PA 15206, USA
    Schizophr Res 72:259-66. 2005
    ....
  30. ncbi request reprint Gene expression profiling in Brodmann's area 46 from subjects with schizophrenia
    Brian Dean
    Rebecca L Cooper Research Laboratories, Mental Health Research Institute of Victoria, Locked Bag 11, Parkville, VIC 3052, Australia
    Aust N Z J Psychiatry 41:308-20. 2007
    ..To identify altered gene expression in the dorsolateral prefrontal cortex obtained after death from subjects with schizophrenia...
  31. doi request reprint Regulator of G-protein signalling 4 expression is not altered in the prefrontal cortex in schizophrenia
    Andrew Stuart Gibbons
    Rebecca L Cooper Research Laboratories, Mental Health Research Institute of Victoria, Parkville, Vic, Australia
    Aust N Z J Psychiatry 42:740-5. 2008
    ..The aim of the present study was to reconcile these discrepancies by examining RGS4 expression in the dorsolateral prefrontal and parietal cortices from subjects with schizophrenia...
  32. ncbi request reprint Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotype
    Elizabeth A Thomas
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 54:136-41. 2003
    ..Progressive cognitive decline is the core clinical feature of AD and is associated with disturbances in the prefrontal cortex...

Research Grants12

  1. Towards Mechanistic Explanations of Striatal Disorders
    Elizabeth Thomas; Fiscal Year: 2006
    ..An important advantage of these potential pharmaceutical targets is that they would act only at the restricted site of expression, the striatum. ..
  2. Towards Mechanistic Explanations of Striatal Disorders
    Elizabeth Thomas; Fiscal Year: 2003
    ..An important advantage of these potential pharmaceutical targets is that they would act only at the restricted site of expression, the striatum. ..
  3. Towards Mechanistic Explanations of Striatal Disorders
    Elizabeth Thomas; Fiscal Year: 2004
    ..An important advantage of these potential pharmaceutical targets is that they would act only at the restricted site of expression, the striatum. ..
  4. Schizophrenia: Molecular Markers of Disease Progression
    Elizabeth Thomas; Fiscal Year: 2004
    ..Overall, these studies may lead to approaches that will favorably alter the course, treatment and outcome of schizophrenia. ..
  5. Towards Mechanistic Explanations of Striatal Disorders
    Elizabeth Thomas; Fiscal Year: 2009
    ..ARRA Request: 2 R01 NS044169-06A2 Thomas, Elizabeth A. ..
  6. Schizophrenia: Molecular Markers of Disease Progression
    Elizabeth Thomas; Fiscal Year: 2005
    ..Overall, these studies may lead to approaches that will favorably alter the course, treatment and outcome of schizophrenia. ..
  7. Schizophrenia: Molecular Markers of Disease Progression
    Elizabeth Thomas; Fiscal Year: 2006
    ..Overall, these studies may lead to approaches that will favorably alter the course, treatment and outcome of schizophrenia. ..
  8. Schizophrenia: Molecular Markers of Disease Progression
    Elizabeth Thomas; Fiscal Year: 2007
    ..Overall, these studies may lead to approaches that will favorably alter the course, treatment and outcome of schizophrenia. ..
  9. Towards Mechanistic Explanations of Striatal Disorders
    Elizabeth Thomas; Fiscal Year: 2002
    ..An important advantage of these potential pharmaceutical targets is that they would act only at the restricted site of expression, the striatum. ..
  10. Towards Mechanistic Explanations of Striatal Disorders
    Elizabeth Thomas; Fiscal Year: 2005
    ..An important advantage of these potential pharmaceutical targets is that they would act only at the restricted site of expression, the striatum. ..
  11. Towards Mechanistic Explanations of Striatal Disorders
    Elizabeth A Thomas; Fiscal Year: 2010
    ..ARRA Request: 2 R01 NS044169-06A2 Thomas, Elizabeth A. ..