Argyrios N Theofilopoulos

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. doi request reprint Sensors of the innate immune system: their link to rheumatic diseases
    Argyrios N Theofilopoulos
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Nat Rev Rheumatol 6:146-56. 2010
  2. pmc Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice
    Marie Laure Santiago-Raber
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 197:777-88. 2003
  3. pmc Intracellular nucleic acid sensors and autoimmunity
    Argyrios N Theofilopoulos
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92137, USA
    J Interferon Cytokine Res 31:867-86. 2011
  4. pmc TLRs and IFNs: critical pieces of the autoimmunity puzzle
    Argyrios N Theofilopoulos
    Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 122:3464-6. 2012
  5. pmc The role of IFN-gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity
    A N Theofilopoulos
    The Scripps Research Institute, Department of Immunology IMM3, La Jolla, CA 92037, USA
    Arthritis Res 3:136-41. 2001
  6. ncbi request reprint Type I interferons (alpha/beta) in immunity and autoimmunity
    Argyrios N Theofilopoulos
    Immunology Department, The Scripps Research Institute, La Jolla, California 92037, USA
    Annu Rev Immunol 23:307-36. 2005
  7. pmc Role of nucleic acid-sensing TLRs in diverse autoantibody specificities and anti-nuclear antibody-producing B cells
    Yi Ting Koh
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 190:4982-90. 2013
  8. pmc Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
    Dwight H Kono
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:12061-6. 2009
  9. pmc The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation
    M Katarina Haraldsson
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Immunity 28:40-51. 2008
  10. ncbi request reprint Inhibition of lupus by genetic alteration of the interferon-alpha/beta receptor
    Dwight H Kono
    Department of Immunology IMM3, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Autoimmunity 36:503-10. 2003

Research Grants

  1. TYPE I INTERFERONS IN LUPUS
    Argyrios N Theofilopoulos; Fiscal Year: 2010
  2. T Cell Homeostasis in Systemic Autoimmunity
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2004
  3. T Cell Homeostasis in Systemic Autoimmunity
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2003
  4. GENETIC BASIS OF SYSTEMIC AUTOIMMUNITY
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2002
  5. CELL CYCLE AND APOPTOSIS GENES IN IMMUNOLOGIC SENESCENCE
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2002
  6. T Cell Homeostasis in Systemic Autoimmunity
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2002
  7. GENETIC BASIS OF SYSTEMIC AUTOIMMUNITY
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2001
  8. MURINE MODELS OF GENERALIZED AUTOIMMUNITY
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2001
  9. CELL CYCLE AND APOPTOSIS GENES IN IMMUNOLOGIC SENESCENCE
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2001
  10. GENETIC BASIS OF SYSTEMIC AUTOIMMUNITY
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2000

Detail Information

Publications48

  1. doi request reprint Sensors of the innate immune system: their link to rheumatic diseases
    Argyrios N Theofilopoulos
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Nat Rev Rheumatol 6:146-56. 2010
    ..These findings have resulted in a critical reappraisal of pathogenetic mechanisms, and provide a basis for the development of novel diagnostic and therapeutic modalities for these diseases...
  2. pmc Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice
    Marie Laure Santiago-Raber
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 197:777-88. 2003
    ..The data indicate that type-I IFNs are important mediators in the pathogenesis of murine lupus, and that reducing their activity in the human counterpart may be beneficial...
  3. pmc Intracellular nucleic acid sensors and autoimmunity
    Argyrios N Theofilopoulos
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92137, USA
    J Interferon Cytokine Res 31:867-86. 2011
    ..Evidence, as reviewed here, strongly indicates that these sensors are primary contributors to autoimmune disease pathogenesis, spearheading efforts toward development of novel therapeutics for these disorders...
  4. pmc TLRs and IFNs: critical pieces of the autoimmunity puzzle
    Argyrios N Theofilopoulos
    Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 122:3464-6. 2012
    ..These insights will permit the development of novel treatment modalities for these disorders...
  5. pmc The role of IFN-gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity
    A N Theofilopoulos
    The Scripps Research Institute, Department of Immunology IMM3, La Jolla, CA 92037, USA
    Arthritis Res 3:136-41. 2001
    ....
  6. ncbi request reprint Type I interferons (alpha/beta) in immunity and autoimmunity
    Argyrios N Theofilopoulos
    Immunology Department, The Scripps Research Institute, La Jolla, California 92037, USA
    Annu Rev Immunol 23:307-36. 2005
    ....
  7. pmc Role of nucleic acid-sensing TLRs in diverse autoantibody specificities and anti-nuclear antibody-producing B cells
    Yi Ting Koh
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 190:4982-90. 2013
    ..In particular, our findings suggest that targeting of NA-TLR signaling in B cells alone would be sufficient to specifically block production of a broad diversity of autoantibodies...
  8. pmc Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
    Dwight H Kono
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:12061-6. 2009
    ..Importantly, this helps provide an explanation for the high frequency of anti-nucleic acid Abs in lupus-like systemic autoimmunity...
  9. pmc The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation
    M Katarina Haraldsson
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Immunity 28:40-51. 2008
    ..Our results demonstrate that Coronin-1A is required for the development of systemic lupus and identify actin-cytoskeleton regulatory proteins as potential targets for modulating autoimmune diseases...
  10. ncbi request reprint Inhibition of lupus by genetic alteration of the interferon-alpha/beta receptor
    Dwight H Kono
    Department of Immunology IMM3, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Autoimmunity 36:503-10. 2003
    ..These findings strongly support the targeting of IFN-alphabeta in SLE and suggest that definition of the specific pathways critical for disease induction will be important for optimal intervention...
  11. pmc Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice
    Djemel Ait-Azzouzene
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 185:1015-27. 2010
    ....
  12. ncbi request reprint Paucity of V-D-D-J rearrangements and VH replacement events in lupus prone and nonautoimmune TdT-/- and TdT+/+ mice
    Lisa C Watson
    The Scripps Research Institute, Department of Immunology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Immunol 177:1120-8. 2006
    ....
  13. pmc Deficiency of the cyclin kinase inhibitor p21(WAF-1/CIP-1) promotes apoptosis of activated/memory T cells and inhibits spontaneous systemic autoimmunity
    Brian R Lawson
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 199:547-57. 2004
    ..Thus, modulation of the cell cycle pathway may be a novel approach to reduce apoptosis-resistant pathogenic lymphocytes and to ameliorate systemic autoimmunity...
  14. pmc An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence
    Michael Berger
    Department of Genetics, The Scripps Research Institute, La Jolla, California, USA
    Nat Immunol 11:335-43. 2010
    ..Our findings identify a physiological role for Slfn2 in the defense against pathogens through the regulation of quiescence in T cells and monocytes...
  15. pmc Critical role of transmethylation in TLR signaling and systemic lupus erythematosus
    Virginie Tardif
    Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA
    Clin Immunol 147:133-43. 2013
    ..DZ2002 treatment initiated during active disease significantly improved outcomes in both in vivo models, suggesting methylation inhibition as a novel approach for the treatment of autoimmune/inflammatory diseases...
  16. pmc The Lbw2 locus promotes autoimmune hemolytic anemia
    John C Scatizzi
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 188:3307-14. 2012
    ..Delineation of the Lbw2 genes should yield new insights into both the pathogenesis of AIHA and the nature of epistatic interactions of lupus-modifying genetic variants...
  17. ncbi request reprint TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
    Roberto Baccala
    The Scripps Research Institute, Department of Immunology, La Jolla, California 93037, USA
    Nat Med 13:543-51. 2007
    ....
  18. ncbi request reprint Autoimmune alterations induced by the New Zealand Black Lbw2 locus in BWF1 mice
    Maria K Haraldsson
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 174:5065-73. 2005
    ..These findings establish the importance of Lbw2 in the BWF1 hybrid and indicate that Lbw2, by enhancing B cell hyperactivity, promotes the early polyclonal activation of B cells and subsequent production of autoantibodies...
  19. pmc T cell homeostatic proliferation elicits effective antitumor autoimmunity
    Wolfgang Dummer
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 110:185-92. 2002
    ..The results indicate that concomitant induction of the physiologic processes of homeostatic T cell proliferation and tumor antigen presentation in lymph nodes triggers a beneficial antitumor autoimmune response...
  20. pmc Anti-IFN-α/β receptor antibody treatment ameliorates disease in lupus-predisposed mice
    Roberto Baccala
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 189:5976-84. 2012
    ..The combined findings suggest that IFN-α/β receptor blockade, particularly when started at early disease stages, may be a useful treatment approach for human systemic lupus erythematosus and other autoimmune syndromes...
  21. ncbi request reprint Sensors of the innate immune system: their mode of action
    Roberto Baccala
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Nat Rev Rheumatol 5:448-56. 2009
    ..Although this sensing is beneficial to the host, excessive activation and/or engagement by self molecules might induce autoimmune and other inflammatory disorders...
  22. pmc Systemic autoimmunity and lymphoproliferation are associated with excess IL-7 and inhibited by IL-7Rα blockade
    Rosana Gonzalez-Quintial
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 6:e27528. 2011
    ....
  23. ncbi request reprint Tumor immunity via homeostatic T cell proliferation: mechanistic aspects and clinical perspectives
    Roberto Baccala
    Department of Immunology, IMM 3, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Springer Semin Immunopathol 27:75-85. 2005
    ..In its simplicity, this approach is likely to have application in humans, since it relies on conventional lymphopenia-inducing cancer therapies, infusion of autologous lymphocytes and, optimally, tumor-specific vaccination...
  24. pmc Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus
    Roberto Baccala
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 110:2940-5. 2013
    ..Thus, IRF8 and SLC15A4 may provide important targets for therapeutic intervention in human lupus...
  25. pmc Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery
    Michael J Barnes
    Department of Genetics, The Scripps Research Institute, La Jolla, CA, USA
    PLoS Biol 7:e51. 2009
    ..Furthermore, we show that peripheral T(reg) cells are a dynamic population that may expand to limit immunopathology or promote chronic infection...
  26. ncbi request reprint Terminal deoxynucleotidyltransferase deficiency decreases autoimmune disease in diabetes-prone nonobese diabetic mice and lupus-prone MRL-Fas(lpr) mice
    Ian F Robey
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 172:4624-9. 2004
    ..We suggest that the paucity of autoreactive specificities created in the N region-lacking repertoire, and the resultant protection afforded to the newborn, may be the reason that TdT expression is delayed in ontogeny...
  27. ncbi request reprint TLRs and interferons: a central paradigm in autoimmunity
    Dwight H Kono
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, United States Electronic address
    Curr Opin Immunol 25:720-7. 2013
    ..These priming events are responsible for initiating the adaptive responses that ultimately mediate the pathogenic process. ..
  28. ncbi request reprint Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors
    Roberto Baccala
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 174:4606-12. 2005
    ..Thus, gamma delta T cell homeostasis is maintained by trophic cytokines commonly used by other types of lymphoid cells, as well as by additional, as yet unidentified, gamma delta-specific factors...
  29. pmc Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice
    Katharina Brandl
    Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 109:12650-5. 2012
    ..These studies support a tissue- and organ-specific function for Yipf6 in the maintenance of intestinal homeostasis and implicate the orthologous human gene as a disease susceptibility locus...
  30. ncbi request reprint Interferons as pathogenic effectors in autoimmunity
    Roberto Baccala
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Immunol Rev 204:9-26. 2005
    ....
  31. pmc Transmethylation in immunity and autoimmunity
    Brian R Lawson
    The Scripps Research Institute, Department of Immunology and Microbial Science, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Clin Immunol 143:8-21. 2012
    ..Further work in defining methylation effects in the immune system is likely to lead to a more detailed understanding of the immune system and may point to the development of novel therapeutic approaches...
  32. ncbi request reprint The new paradigm of T-cell homeostatic proliferation-induced autoimmunity
    Roberto Baccala
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Trends Immunol 26:5-8. 2005
    ..A recent study in a diabetes-prone mouse model has provided strong evidence to support this hypothesis...
  33. ncbi request reprint Contribution of histidine-rich glycoprotein in clearance of immune complexes and apoptotic cells: implications for ameliorating autoimmune diseases
    Nick N Gorgani
    Department of Immunology IMM3, The Scripps Research Institut, La Jolla, CA 92037, USA
    Autoimmunity 40:260-6. 2007
    ..Properties of HRG and possible protective actions of HRG-dependent clearance mechanisms are discussed...
  34. ncbi request reprint Genetics of SLE in mice
    Dwight H Kono
    Department of Immunology IMM3, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA
    Springer Semin Immunopathol 28:83-96. 2006
    ..Mouse models of lupus should continue to serve as a vital approach to defining the genetics of SLE...
  35. ncbi request reprint Deletion of p21 (WAF-1/Cip1) does not induce systemic autoimmunity in female BXSB mice
    Brian R Lawson
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 168:5928-32. 2002
    ....
  36. ncbi request reprint Histidine-rich glycoprotein binds to DNA and Fc gamma RI and potentiates the ingestion of apoptotic cells by macrophages
    Nick N Gorgani
    Department of Immunology IMM3, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 169:4745-51. 2002
    ..The findings indicate that HRG, by acting as a bridge between DNA on apoptotic cells and FcgammaRI on HMDM, is a key physiological mediator of apoptotic cell clearance by macrophages...
  37. ncbi request reprint Genetic complementation in female (BXSB x NZW)F2 mice
    Dwight H Kono
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 171:6442-7. 2003
    ....
  38. pmc Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger
    Ben A Croker
    Department of Genetics, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:15028-33. 2008
    ..The SHP1-deficient phenotype is driven by microbes, which activate TLR signaling pathways to elicit IL-1 production. IL-1 signaling via MyD88 elicits inflammatory disease...
  39. ncbi request reprint Inhibition of transmethylation down-regulates CD4 T cell activation and curtails development of autoimmunity in a model system
    Brian R Lawson
    Diazyme Laboratories Division, General Atomics, San Diego, CA 92186, USA
    J Immunol 178:5366-74. 2007
    ..The data suggest that transmethylation is required for CD4 T cell activation, and its inhibition may be a novel approach in the treatment of multiple sclerosis, and other CD4-mediated autoimmune diseases...
  40. pmc Immune pathology associated with altered actin cytoskeleton regulation
    Dilki C Wickramarachchi
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Autoimmunity 43:64-75. 2010
    ....
  41. ncbi request reprint Proliferative arrest and cell cycle regulation in CD8(+)CD28(-) versus CD8(+)CD28(+) T cells
    Urban J Scheuring
    Department of Immunology, The Scripps Research Institute, La Jolla, CA, USA
    Hum Immunol 63:1000-9. 2002
    ..Defects in TCR signaling were associated with altered TCR zeta-chain phosphorylation...
  42. pmc Thymic dendritic cells traffic to thymi of allogeneic recipients and prolong graft survival
    Steven R Duncan
    Department of Immunology, The Scripps Research Institute, La Jolla, California, USA
    J Clin Invest 109:755-64. 2002
    ....
  43. ncbi request reprint A regenerative approach to the treatment of multiple sclerosis
    Vishal A Deshmukh
    Department of Chemistry, The Scripps Research Institute, 10550, North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 502:327-32. 2013
    ..These studies should facilitate the development of effective new therapies for the treatment of multiple sclerosis that complement established immunosuppressive approaches. ..
  44. pmc Discovery of peptoid ligands for anti-aquaporin 4 antibodies
    Bindu L Raveendra
    Departments of Chemistry and Cancer Biology, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
    Chem Biol 20:351-9. 2013
    ..This finding validates, in a well-defined human disease, that synthetic, unnatural ligands for the antigen-binding site of a disease-linked antibody can be isolated by high-throughput screening...
  45. ncbi request reprint Oligoclonal CD4(+) T cell expansions in lung transplant recipients with obliterative bronchiolitis
    Steven R Duncan
    Department of Immunology, Scripps Research Institute, La Jolla, CA, USA
    Am J Respir Crit Care Med 165:1439-44. 2002
    ..Furthermore, the close association of CD4(+) expansions with OB raises possibilities of development of novel diagnostic and therapeutic approaches...
  46. ncbi request reprint Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway
    Edith Janssen
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Immunity 24:787-99. 2006
    ....
  47. ncbi request reprint Characterization of reciprocal Lmb1-4 interval MRL-Faslpr and C57BL/6-Faslpr congenic mice reveals significant effects from Lmb3
    Marie Laure Santiago-Raber
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    J Immunol 178:8195-202. 2007
    ..Identification of the underlying genetic alteration responsible for this quantitative trait locus should provide new insights into lupus-modifying genes...
  48. pmc Lack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T-cell immunity
    Dirk Homann
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center Mail stop B140, P O Box 6511, Aurora, CO 80045, USA
    J Virol 80:270-80. 2006
    ..These findings have implications for the physiologic, pathological, and therapeutic regulation of costimulation...

Research Grants44

  1. TYPE I INTERFERONS IN LUPUS
    Argyrios N Theofilopoulos; Fiscal Year: 2010
    ..These studies will advance our knowledge of the mechanisms by which IFNs promote systemic autoimmunity and may contribute to the development of novel therapies for lupus and other autoimmune diseases. ..
  2. T Cell Homeostasis in Systemic Autoimmunity
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2004
    ..These results will further define the biology of homeostatic anti-self T cell proliferation, land may provide a new paradigm for understanding autoimmune syndromes, including lupus. ..
  3. T Cell Homeostasis in Systemic Autoimmunity
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2003
    ..These results will further define the biology of homeostatic anti-self T cell proliferation, land may provide a new paradigm for understanding autoimmune syndromes, including lupus. ..
  4. GENETIC BASIS OF SYSTEMIC AUTOIMMUNITY
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2002
    ..Findings generated from these studies, they expect, will significantly enhance efforts to define the etiopathogenesis of autoimmunity, and may lead to new approaches in the diagnosis and therapy of human SLE. ..
  5. CELL CYCLE AND APOPTOSIS GENES IN IMMUNOLOGIC SENESCENCE
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2002
    ..These studies of cell cycle and apoptosis of aged T-cells will be instrumental to defining the molecular defects associated with immunologic senescence. ..
  6. T Cell Homeostasis in Systemic Autoimmunity
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2002
    ..These results will further define the biology of homeostatic anti-self T cell proliferation, land may provide a new paradigm for understanding autoimmune syndromes, including lupus. ..
  7. GENETIC BASIS OF SYSTEMIC AUTOIMMUNITY
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2001
    ..Findings generated from these studies, they expect, will significantly enhance efforts to define the etiopathogenesis of autoimmunity, and may lead to new approaches in the diagnosis and therapy of human SLE. ..
  8. MURINE MODELS OF GENERALIZED AUTOIMMUNITY
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2001
    ..Additional studies using reciprocal adoptive transfers will test the influence of environment on generation and survival of membory T cells. ..
  9. CELL CYCLE AND APOPTOSIS GENES IN IMMUNOLOGIC SENESCENCE
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2001
    ..These studies of cell cycle and apoptosis of aged T-cells will be instrumental to defining the molecular defects associated with immunologic senescence. ..
  10. GENETIC BASIS OF SYSTEMIC AUTOIMMUNITY
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2000
    ..Findings generated from these studies, they expect, will significantly enhance efforts to define the etiopathogenesis of autoimmunity, and may lead to new approaches in the diagnosis and therapy of human SLE. ..
  11. T Cell Homeostasis in Systemic Autoimmunity
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2005
    ..These results will further define the biology of homeostatic anti-self T cell proliferation, land may provide a new paradigm for understanding autoimmune syndromes, including lupus. ..
  12. T Cell Homeostasis in Systemic Autoimmunity
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2006
    ..These results will further define the biology of homeostatic anti-self T cell proliferation, land may provide a new paradigm for understanding autoimmune syndromes, including lupus. ..
  13. T Cell Homeostasis in Systemic Autoimmunity
    Argyrios N Theofilopoulos; Fiscal Year: 2010
    ..Aside from providing a new mechanistic concept, blockade of these mediators may constitute a novel therapeutic approach for lupus and other autoimmune diseases. ..
  14. TYPE I INTERFERONS IN LUPUS
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2009
    ..These studies will advance our knowledge of the mechanisms by which IFNs promote systemic autoimmunity and may contribute to the development of novel therapies for lupus and other autoimmune diseases. ..
  15. T Cell Homeostasis in Systemic Autoimmunity
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2009
    ..Aside from providing a new mechanistic concept, blockade of these mediators may constitute a novel therapeutic approach for lupus and other autoimmune diseases. ..
  16. GENETIC BASIS OF SYSTEMIC AUTOIMMUNITY
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2007
    ..These studies should yield significant new insights into the etiopathogenesis of systemic autoimmunity, and may lead to new diagnostic and therapeutic approaches for human SLE. ..
  17. TYPE I INTERFERONS IN LUPUS
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2007
    ..These studies will advance our knowledge of the mechanisms by which IFNs promote systemic autoimmunity and may contribute to the development of novel therapies for lupus and other autoimmune diseases. ..
  18. TYPE I INTERFERONS IN LUPUS
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2006
    ..These studies will advance our knowledge of the mechanisms by which IFNs promote systemic autoimmunity and may contribute to the development of novel therapies for lupus and other autoimmune diseases. ..
  19. MURINE MODELS OF GENERALIZED AUTOIMMUNITY
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2000
    ..Additional studies using reciprocal adoptive transfers will test the influence of environment on generation and survival of membory T cells. ..
  20. CELL CYCLE AND APOPTOSIS GENES IN IMMUNOLOGIC SENESCENCE
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 2000
    ..These studies of cell cycle and apoptosis of aged T-cells will be instrumental to defining the molecular defects associated with immunologic senescence. ..
  21. CELL CYCLE AND APOPTOSIS GENES IN IMMUNOLOGIC SENESCENCE
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 1999
    ..These studies of cell cycle and apoptosis of aged T-cells will be instrumental to defining the molecular defects associated with immunologic senescence. ..
  22. MURINE MODELS OF GENERALIZED AUTOIMMUNITY
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 1990
    ....
  23. GENETIC BASIS OF SYSTEMIC AUTOIMMUNITY
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 1999
    ..Findings generated from these studies, they expect, will significantly enhance efforts to define the etiopathogenesis of autoimmunity, and may lead to new approaches in the diagnosis and therapy of human SLE. ..
  24. MURINE MODELS OF GENERALIZED AUTOIMMUNITY
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 1999
    ..Additional studies using reciprocal adoptive transfers will test the influence of environment on generation and survival of membory T cells. ..
  25. T CELL ANTIGEN RECEPTOR GENES IN AUTOIMMUNITY
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 1992
    ..Identification of aberrancies in this central event is expected to have a significant impact on our ability to molecularly define autoimmune diseases and to devise specific and accurate means for their management...
  26. T CELL ANTIGEN RECEPTOR GENES IN AUTOIMMUNITY
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 1990
    ..Identification of aberrancies in this central event is expected to have a significant impact on our ability to molecularly define autoimmune diseases and to devise specific and accurate means for their management...
  27. GENETIC BASIS OF SYSTEMIC AUTOIMMUNITY
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 1993
    ..Creation of linkage maps and identification of pleotropic or specific autoimmune trait-associated genes will ultimately provide the means by which the molecular basis of lupus can be defined...
  28. MURINE MODELS OF GENERALIZED AUTOIMMUNITY
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 1993
    ....
  29. MURINE MODELS OF GENERALIZED AUTOIMMUNITY
    ARGYRIOS THEOFILOPOULOS; Fiscal Year: 1992
    ....