Research Topics
| Alexey V TerskikhSummaryAffiliation: The Burnham Institute Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Mammalian stem cellsAlexey V Terskikh
Burnham Institute for Medical Research, La Jolla, CA 92037, USA
Pediatr Res 59:13R-20R. 2006..For the complimentary information about various stem cells and their properties we recommend consulting the National Institutes of Health stem cell resources (http://stemcells.nih.gov/info/basics)...
Primary cilia regulate proliferation of amplifying progenitors in adult hippocampus: implications for learning and memoryAlejandro Amador-Arjona
Department of Stem Cells and Regeneration, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
J Neurosci 31:9933-44. 2011..This novel mouse model provides evidences that cognitive deficits associated with ciliary defects (ciliopathies) might be, in part, mediated by the deficiency of primary cilia in adult hippocampal stem/progenitor cells...
Maternal embryonic leucine zipper kinase is upregulated and required in mammary tumor-initiating cells in vivoLionel W Hebbard
Tumor Development Program, Cancer Research Center, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
Cancer Res 70:8863-73. 2010..Our findings identify MELK as a potential target in breast tumor-initiating cells...
hESC derived neuro-epithelial rosettes recapitulate early mammalian neurulation events; an in vitro modelCarol Lynn Curchoe
The Burnham Institute for Medical Research, La Jolla, CA 92037, USA
Stem Cell Res 8:239-46. 2012..e., symmetric to asymmetric NE cell division) demonstrated by polarized MKLP particle inheritance and distribution using junction type as a measure of stage...
Human ESC-derived neural crest model reveals a key role for SOX2 in sensory neurogenesisFlavio Cimadamore
Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Cell Stem Cell 8:538-51. 2011..We found that SOX2 binds directly to NGN1 and MASH1 promoters and is required for their expression. Our data suggest that SOX2 plays a key role for NGN1-dependent acquisition of neuronal fates in sensory ganglia...
Efficient propagation of single cells Accutase-dissociated human embryonic stem cellsRuchi Bajpai
Burnham Institute for Medical Research, La Jolla, California 92037, USA
Mol Reprod Dev 75:818-27. 2008..Additionally, Accutase-passaged undifferentiated hESCs could be grown as monolayers without the need for monitoring and/or selection for quality hESC colonies...
Nicotinamide rescues human embryonic stem cell-derived neuroectoderm from parthanatic cell deathFlavio Cimadamore
Burnham Institute for Medical Research, La Jolla, California 92037, USA
Stem Cells 27:1772-81. 2009..We argue that small natural metabolites provide a powerful physiological tool to optimize hESC differentiation compatible with the requirements of regenerative medicine...
Cryopreservation by slow cooling with DMSO diminished production of Oct-4 pluripotency marker in human embryonic stem cellsIgor I Katkov
UCSD Cancer Center, San Diego, CA 92122, USA; Stem Cell Center Core, Burnham Institute for Medical Research (BIMR, La Jolla, CA 92037, USA
Cryobiology 53:194-205. 2006..It is concluded that new protocols and media are required for freezing hESC and safe storage at -80 degrees C as well as studies of the mechanisms of stress-related events associated with cell cryopreservation...
Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1Jean Marie Bruey
Burnham Institute for Medical Research, La Jolla, CA 92037, USA
Cell 129:45-56. 2007..The findings reveal an interaction of host defense and apoptosis machinery...
Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populationsMathew C Easterday
Interdepartmental Program for Neuroscience, UCLA, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Dev Biol 264:309-22. 2003..Taken together, these studies identify many genes not previously associated with neural progenitor cell biology and also provide a rational scheme for stratification of microarray data for functional analysis...
Research Grants
- Separation of Stem Cells From Differentiated CellsAlexey Terskikh; Fiscal Year: 2005..The genetic labeling approach will address this issue providing a clear marker for the genetically defined stem cell population, whose developmental fate could then be precisely addressed both in vitro and in vivo. ..
- Protein Acetylation Signature of ES Cell DifferentiationAlexey Terskikh; Fiscal Year: 2007..Naturally, experiments with mouse ES cells will lay the foundation for the work to modulate self-renewal or induce differentiation of human ES cells. ..
