Alexey V Terskikh

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. pmc Early acquisition of neural crest competence during hESCs neuralization
    Carol Lynn Curchoe
    Sanford Burnham Institute for Medical Research, La Jolla, California, United States of America
    PLoS ONE 5:e13890. 2010
  2. ncbi request reprint Mammalian stem cells
    Alexey V Terskikh
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Pediatr Res 59:13R-20R. 2006
  3. pmc SOX2-LIN28/let-7 pathway regulates proliferation and neurogenesis in neural precursors
    Flavio Cimadamore
    Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 110:E3017-26. 2013
  4. ncbi request reprint Human ESC-derived neural crest model reveals a key role for SOX2 in sensory neurogenesis
    Flavio Cimadamore
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Stem Cell 8:538-51. 2011
  5. pmc Maternal embryonic leucine zipper kinase is upregulated and required in mammary tumor-initiating cells in vivo
    Lionel W Hebbard
    Tumor Development Program, Cancer Research Center, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    Cancer Res 70:8863-73. 2010
  6. pmc Primary cilia regulate proliferation of amplifying progenitors in adult hippocampus: implications for learning and memory
    Alejandro Amador-Arjona
    Department of Stem Cells and Regeneration, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Neurosci 31:9933-44. 2011
  7. ncbi request reprint Cryopreservation by slow cooling with DMSO diminished production of Oct-4 pluripotency marker in human embryonic stem cells
    Igor I Katkov
    UCSD Cancer Center, San Diego, CA 92122, USA Stem Cell Center Core, Burnham Institute for Medical Research BIMR, La Jolla, CA 92037, USA
    Cryobiology 53:194-205. 2006
  8. doi request reprint Nicotinamide rescues human embryonic stem cell-derived neuroectoderm from parthanatic cell death
    Flavio Cimadamore
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Stem Cells 27:1772-81. 2009
  9. doi request reprint hESC derived neuro-epithelial rosettes recapitulate early mammalian neurulation events; an in vitro model
    Carol Lynn Curchoe
    The Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Stem Cell Res 8:239-46. 2012
  10. ncbi request reprint Efficient propagation of single cells Accutase-dissociated human embryonic stem cells
    Ruchi Bajpai
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Mol Reprod Dev 75:818-27. 2008

Research Grants

Collaborators

Detail Information

Publications12

  1. pmc Early acquisition of neural crest competence during hESCs neuralization
    Carol Lynn Curchoe
    Sanford Burnham Institute for Medical Research, La Jolla, California, United States of America
    PLoS ONE 5:e13890. 2010
    ....
  2. ncbi request reprint Mammalian stem cells
    Alexey V Terskikh
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Pediatr Res 59:13R-20R. 2006
    ..For the complimentary information about various stem cells and their properties we recommend consulting the National Institutes of Health stem cell resources (http://stemcells.nih.gov/info/basics)...
  3. pmc SOX2-LIN28/let-7 pathway regulates proliferation and neurogenesis in neural precursors
    Flavio Cimadamore
    Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 110:E3017-26. 2013
    ..In conclusion, we discovered the SOX2-LIN28/let-7 pathway as a unique molecular mechanism governing NPC proliferation and neurogenic potential. ..
  4. ncbi request reprint Human ESC-derived neural crest model reveals a key role for SOX2 in sensory neurogenesis
    Flavio Cimadamore
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Stem Cell 8:538-51. 2011
    ..We found that SOX2 binds directly to NGN1 and MASH1 promoters and is required for their expression. Our data suggest that SOX2 plays a key role for NGN1-dependent acquisition of neuronal fates in sensory ganglia...
  5. pmc Maternal embryonic leucine zipper kinase is upregulated and required in mammary tumor-initiating cells in vivo
    Lionel W Hebbard
    Tumor Development Program, Cancer Research Center, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    Cancer Res 70:8863-73. 2010
    ..Our findings identify MELK as a potential target in breast tumor-initiating cells...
  6. pmc Primary cilia regulate proliferation of amplifying progenitors in adult hippocampus: implications for learning and memory
    Alejandro Amador-Arjona
    Department of Stem Cells and Regeneration, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Neurosci 31:9933-44. 2011
    ..This novel mouse model provides evidences that cognitive deficits associated with ciliary defects (ciliopathies) might be, in part, mediated by the deficiency of primary cilia in adult hippocampal stem/progenitor cells...
  7. ncbi request reprint Cryopreservation by slow cooling with DMSO diminished production of Oct-4 pluripotency marker in human embryonic stem cells
    Igor I Katkov
    UCSD Cancer Center, San Diego, CA 92122, USA Stem Cell Center Core, Burnham Institute for Medical Research BIMR, La Jolla, CA 92037, USA
    Cryobiology 53:194-205. 2006
    ..It is concluded that new protocols and media are required for freezing hESC and safe storage at -80 degrees C as well as studies of the mechanisms of stress-related events associated with cell cryopreservation...
  8. doi request reprint Nicotinamide rescues human embryonic stem cell-derived neuroectoderm from parthanatic cell death
    Flavio Cimadamore
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Stem Cells 27:1772-81. 2009
    ..We argue that small natural metabolites provide a powerful physiological tool to optimize hESC differentiation compatible with the requirements of regenerative medicine...
  9. doi request reprint hESC derived neuro-epithelial rosettes recapitulate early mammalian neurulation events; an in vitro model
    Carol Lynn Curchoe
    The Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Stem Cell Res 8:239-46. 2012
    ..e., symmetric to asymmetric NE cell division) demonstrated by polarized MKLP particle inheritance and distribution using junction type as a measure of stage...
  10. ncbi request reprint Efficient propagation of single cells Accutase-dissociated human embryonic stem cells
    Ruchi Bajpai
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Mol Reprod Dev 75:818-27. 2008
    ..Additionally, Accutase-passaged undifferentiated hESCs could be grown as monolayers without the need for monitoring and/or selection for quality hESC colonies...
  11. ncbi request reprint Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1
    Jean Marie Bruey
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Cell 129:45-56. 2007
    ..The findings reveal an interaction of host defense and apoptosis machinery...
  12. ncbi request reprint Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations
    Mathew C Easterday
    Interdepartmental Program for Neuroscience, UCLA, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Dev Biol 264:309-22. 2003
    ..Taken together, these studies identify many genes not previously associated with neural progenitor cell biology and also provide a rational scheme for stratification of microarray data for functional analysis...

Research Grants3

  1. Separation of Stem Cells From Differentiated Cells
    Alexey Terskikh; Fiscal Year: 2005
    ..The genetic labeling approach will address this issue providing a clear marker for the genetically defined stem cell population, whose developmental fate could then be precisely addressed both in vitro and in vivo. ..
  2. Protein Acetylation Signature of ES Cell Differentiation
    Alexey Terskikh; Fiscal Year: 2007
    ..Naturally, experiments with mouse ES cells will lay the foundation for the work to modulate self-renewal or induce differentiation of human ES cells. ..