Timothy L Tellinghuisen

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi Identification of residues required for RNA replication in domains II and III of the hepatitis C virus NS5A protein
    Timothy L Tellinghuisen
    Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Avenue, Box 64, New York, NY 10065, USA
    J Virol 82:1073-83. 2008
  2. ncbi Regulation of hepatitis C virion production via phosphorylation of the NS5A protein
    Timothy L Tellinghuisen
    The Scripps Research Institute, Scripps Florida, Jupiter, Florida, USA
    PLoS Pathog 4:e1000032. 2008
  3. ncbi Studying hepatitis C virus: making the best of a bad virus
    Timothy L Tellinghuisen
    The Scripps Research Institute, 5353 Parkside Drive, RF-2, Jupiter, FL 33458, USA
    J Virol 81:8853-67. 2007
  4. ncbi Reverse transcription PCR-based sequence analysis of hepatitis C virus replicon RNA
    Timothy L Tellinghuisen
    Department of Infectology, The Scripps Research Institute, Jupiter, FL, USA
    Methods Mol Biol 510:165-75. 2009
  5. ncbi Molecular and contextual markers of hepatitis C virus and drug abuse
    Paul Shapshak
    Division of Infectious Disease and International Medicine, Department of Internal Medicine, Tampa General Hospital, University of South Florida, College of Medicine, Tampa, Florida, USA
    Mol Diagn Ther 13:153-79. 2009
  6. ncbi The NS5A protein of bovine viral diarrhea virus contains an essential zinc-binding site similar to that of the hepatitis C virus NS5A protein
    Timothy L Tellinghuisen
    Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Virol 80:7450-8. 2006
  7. ncbi Complete replication of hepatitis C virus in cell culture
    Brett D Lindenbach
    Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 309:623-6. 2005
  8. ncbi Cellular cofactors affecting hepatitis C virus infection and replication
    Glenn Randall
    Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, and Howard Hughes Medical Institute, Laboratory of RNA Molecular Biology, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:12884-9. 2007
  9. ncbi Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase
    Timothy L Tellinghuisen
    Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Avenue Box 64, New York, New York 10021, USA
    Nature 435:374-9. 2005
  10. ncbi Interaction between hepatitis C virus proteins and host cell factors
    Timothy L Tellinghuisen
    Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Avenue, Box 64, New York, NY 10021, USA
    Curr Opin Microbiol 5:419-27. 2002

Research Grants

  1. Characterization of the Hepatitis C NS5a Kinase Complex
    Timothy Tellinghuisen; Fiscal Year: 2004
  2. Characterization of the HCV NS5A Protein
    Timothy Tellinghuisen; Fiscal Year: 2007

Collaborators

Detail Information

Publications11

  1. ncbi Identification of residues required for RNA replication in domains II and III of the hepatitis C virus NS5A protein
    Timothy L Tellinghuisen
    Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Avenue, Box 64, New York, NY 10065, USA
    J Virol 82:1073-83. 2008
    ..These results indicate that the entire domain III region and large portions of domain II of the NS5A protein are not required for the function of NS5A in HCV RNA replication...
  2. ncbi Regulation of hepatitis C virion production via phosphorylation of the NS5A protein
    Timothy L Tellinghuisen
    The Scripps Research Institute, Scripps Florida, Jupiter, Florida, USA
    PLoS Pathog 4:e1000032. 2008
    ..The ability to uncouple virus production from RNA replication, as described herein, may be useful in understanding HCV assembly and may be therapeutically important...
  3. ncbi Studying hepatitis C virus: making the best of a bad virus
    Timothy L Tellinghuisen
    The Scripps Research Institute, 5353 Parkside Drive, RF-2, Jupiter, FL 33458, USA
    J Virol 81:8853-67. 2007
  4. ncbi Reverse transcription PCR-based sequence analysis of hepatitis C virus replicon RNA
    Timothy L Tellinghuisen
    Department of Infectology, The Scripps Research Institute, Jupiter, FL, USA
    Methods Mol Biol 510:165-75. 2009
    ..The methods we describe permit rapid and robust determination of HCV RNA sequences from cell culture...
  5. ncbi Molecular and contextual markers of hepatitis C virus and drug abuse
    Paul Shapshak
    Division of Infectious Disease and International Medicine, Department of Internal Medicine, Tampa General Hospital, University of South Florida, College of Medicine, Tampa, Florida, USA
    Mol Diagn Ther 13:153-79. 2009
    ..In this review, we discuss recent findings concerning the impact of drug abuse, epidemiology, social behavior, virology, immunopathology, and genetics on HCV infection and the course of disease...
  6. ncbi The NS5A protein of bovine viral diarrhea virus contains an essential zinc-binding site similar to that of the hepatitis C virus NS5A protein
    Timothy L Tellinghuisen
    Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Virol 80:7450-8. 2006
    ..These data highlight the similarities between the Hepacivirus and Pestivirus NS5A proteins and suggest that both proteins perform a not-yet-defined function in RNA replication that requires coordination of a single zinc atom...
  7. ncbi Complete replication of hepatitis C virus in cell culture
    Brett D Lindenbach
    Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 309:623-6. 2005
    ..HCVcc replication was inhibited by interferon-alpha and by several HCV-specific antiviral compounds, suggesting that this in vitro system will aid in the search for improved antivirals...
  8. ncbi Cellular cofactors affecting hepatitis C virus infection and replication
    Glenn Randall
    Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, and Howard Hughes Medical Institute, Laboratory of RNA Molecular Biology, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:12884-9. 2007
    ..Our data define 26 host genes that modulate HCV infection and indicate that the requirement for functional RNAi for HCV replication is dominant over any antiviral activity this pathway may exert against HCV...
  9. ncbi Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase
    Timothy L Tellinghuisen
    Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Avenue Box 64, New York, New York 10021, USA
    Nature 435:374-9. 2005
    ..5-A resolution, which contains a novel fold, a new zinc-coordination motif and a disulphide bond. We use molecular surface analysis to suggest the location of protein-, RNA- and membrane-interaction sites...
  10. ncbi Interaction between hepatitis C virus proteins and host cell factors
    Timothy L Tellinghuisen
    Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Avenue, Box 64, New York, NY 10021, USA
    Curr Opin Microbiol 5:419-27. 2002
    ..The relevance of many of these interactions to hepatitis C biology remains to be demonstrated. This review discusses recent developments in this area of HCV research...
  11. ncbi The NS5A protein of hepatitis C virus is a zinc metalloprotein
    Timothy L Tellinghuisen
    Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 279:48576-87. 2004
    ..Collectively, these results indicate that NS5A is a zinc metalloprotein and that zinc coordination is likely required for NS5A function in the hepatitis C replicase...

Research Grants2

  1. Characterization of the Hepatitis C NS5a Kinase Complex
    Timothy Tellinghuisen; Fiscal Year: 2004
    ..abstract_text> ..
  2. Characterization of the HCV NS5A Protein
    Timothy Tellinghuisen; Fiscal Year: 2007
    ..abstract not provided ..