D T Teachey

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. pmc The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL
    David T Teachey
    Division of Oncology, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Blood 107:1149-55. 2006
  2. pmc Advances in the management and understanding of autoimmune lymphoproliferative syndrome (ALPS)
    David T Teachey
    Children s Hospital of Philadelphia, University of Pennsylvania, 19104, USA
    Br J Haematol 148:205-16. 2010
  3. doi request reprint Diagnosis and management of autoimmune cytopenias in childhood
    David T Teachey
    Pediatric Hematology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 3501 Civic Center Boulevard, Philadelphia, PA 19104, USA Electronic address
    Pediatr Clin North Am 60:1489-511. 2013
  4. doi request reprint Treatment with sirolimus ameliorates tacrolimus-induced autoimmune cytopenias after solid organ transplant
    David T Teachey
    Division of Hematology, Children s Hospital of Philadelphia, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Pediatr Blood Cancer 53:1114-6. 2009
  5. pmc Mammalian target of rapamycin inhibitors and their potential role in therapy in leukaemia and other haematological malignancies
    David T Teachey
    Division of Paediatric Hematology, Children s Hospital of Philadelphia, 3615 Civic Centre Boulevard, Philadelphia, PA 19104, USA
    Br J Haematol 145:569-80. 2009
  6. pmc Treatment with sirolimus results in complete responses in patients with autoimmune lymphoproliferative syndrome
    David T Teachey
    Pediatric Hematology and Oncology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia PA 19104, USA
    Br J Haematol 145:101-6. 2009
  7. pmc mTOR inhibitors are synergistic with methotrexate: an effective combination to treat acute lymphoblastic leukemia
    David T Teachey
    Division of Oncology, Department of Pediatrics, Children s Hospital of Philadelphia, PA 19104, USA
    Blood 112:2020-3. 2008
  8. doi request reprint Saddle pulmonary embolism as a complication of vasectomy
    David T Teachey
    Department of Pediatric Hematology, Children s Hospital of Philadelphia, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA
    Urology 71:351.e5-6. 2008
  9. pmc Targeting Notch signaling in autoimmune and lymphoproliferative disease
    David T Teachey
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine 19104, USA
    Blood 111:705-14. 2008
  10. ncbi request reprint Pulmonary infection with microsporidia after allogeneic bone marrow transplantation
    D T Teachey
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Bone Marrow Transplant 33:299-302. 2004

Detail Information

Publications18

  1. pmc The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL
    David T Teachey
    Division of Oncology, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Blood 107:1149-55. 2006
    ..We conclude that MTIs can inhibit the growth of adult human ALL and deserve close examination as therapeutic agents against a disease that is often not curable with current therapy...
  2. pmc Advances in the management and understanding of autoimmune lymphoproliferative syndrome (ALPS)
    David T Teachey
    Children s Hospital of Philadelphia, University of Pennsylvania, 19104, USA
    Br J Haematol 148:205-16. 2010
    ..This review describes the clinical and laboratory manifestations found in ALPS patients, as well as the molecular basis for the disease and new advances in treatment...
  3. doi request reprint Diagnosis and management of autoimmune cytopenias in childhood
    David T Teachey
    Pediatric Hematology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 3501 Civic Center Boulevard, Philadelphia, PA 19104, USA Electronic address
    Pediatr Clin North Am 60:1489-511. 2013
    ....
  4. doi request reprint Treatment with sirolimus ameliorates tacrolimus-induced autoimmune cytopenias after solid organ transplant
    David T Teachey
    Division of Hematology, Children s Hospital of Philadelphia, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Pediatr Blood Cancer 53:1114-6. 2009
    ..Altering the immunosuppressive regimen to modify T-cell dysregulation may be beneficial for patients who develop post-transplant autoimmune disease and allow continued preservation of allograft...
  5. pmc Mammalian target of rapamycin inhibitors and their potential role in therapy in leukaemia and other haematological malignancies
    David T Teachey
    Division of Paediatric Hematology, Children s Hospital of Philadelphia, 3615 Civic Centre Boulevard, Philadelphia, PA 19104, USA
    Br J Haematol 145:569-80. 2009
    ..This review describes the rationale for using mTOR inhibitors in a variety of haematological diseases with a focus on their use in leukaemia...
  6. pmc Treatment with sirolimus results in complete responses in patients with autoimmune lymphoproliferative syndrome
    David T Teachey
    Pediatric Hematology and Oncology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia PA 19104, USA
    Br J Haematol 145:101-6. 2009
    ..Based on these significant responses, we recommend that sirolimus be considered as second-line therapy for patients with steroid-refractory disease...
  7. pmc mTOR inhibitors are synergistic with methotrexate: an effective combination to treat acute lymphoblastic leukemia
    David T Teachey
    Division of Oncology, Department of Pediatrics, Children s Hospital of Philadelphia, PA 19104, USA
    Blood 112:2020-3. 2008
    ..We found methotrexate and MTIs are an effective and potentially synergistic combination in ALL...
  8. doi request reprint Saddle pulmonary embolism as a complication of vasectomy
    David T Teachey
    Department of Pediatric Hematology, Children s Hospital of Philadelphia, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA
    Urology 71:351.e5-6. 2008
    ..This is the first report of a near fatal venous thromboembolic event resulting from vasectomy...
  9. pmc Targeting Notch signaling in autoimmune and lymphoproliferative disease
    David T Teachey
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine 19104, USA
    Blood 111:705-14. 2008
    ..Inhibiting the Notch signaling pathway may thus present an effective, novel, and well-tolerated treatment for autoimmune and lymphoproliferative diseases...
  10. ncbi request reprint Pulmonary infection with microsporidia after allogeneic bone marrow transplantation
    D T Teachey
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Bone Marrow Transplant 33:299-302. 2004
    ..Although rare, microsporidial infection should be considered in the differential diagnosis of unexplained pulmonary infection in bone marrow transplant patients...
  11. ncbi request reprint Development of cold agglutinin autoimmune hemolytic anemia during treatment for pediatric acute lymphoblastic leukemia
    David T Teachey
    Division of Hematology, Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Pediatr Hematol Oncol 27:397-9. 2005
    ..The authors describe a child with B-cell precursor ALL who developed cold agglutinin AIHA during maintenance treatment while in remission after infection with influenza B...
  12. pmc Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)
    David T Teachey
    Divisions of Oncology and Hematology, Children s Hospital of Philadelphia, ARC 902, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Blood 108:1965-71. 2006
    ..We conclude that rapamycin is an effective treatment for murine ALPS and should be explored as treatment for affected humans...
  13. ncbi request reprint Daclizumab for children with corticosteroid refractory graft-versus-host disease
    D T Teachey
    Division of Oncology in the Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Bone Marrow Transplant 37:95-9. 2006
    ..Daclizumab is a relatively safe and effective medication for corticosteroid refractory GVHD in children and larger studies are needed to evaluate its role in treatment...
  14. pmc Novel molecular and cellular therapeutic targets in acute lymphoblastic leukemia and lymphoproliferative disease
    Valerie I Brown
    Division of Oncology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, ARC 902, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA
    Immunol Res 42:84-105. 2008
    ....
  15. ncbi request reprint Unmasking Evans syndrome: T-cell phenotype and apoptotic response reveal autoimmune lymphoproliferative syndrome (ALPS)
    David T Teachey
    Division of Oncology, Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, ARC 902, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    Blood 105:2443-8. 2005
    ..Our data further suggest that a number of patients with ES may have ALPS, a novel finding with important therapeutic implications...
  16. ncbi request reprint Cell division rates of primary human precursor B cells in culture reflect in vivo rates
    Jonathan Cooperman
    Pathology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Stem Cells 22:1111-20. 2004
    ..These findings indicate that the stroma-based cultures faithfully replicate in vivo cell division rates and can be used to elucidate the pathways that regulate cell division of primary human precursor B cells...
  17. ncbi request reprint Use of rituximab in conjunction with immunosuppressive chemotherapy as a novel therapy for Epstein Barr virus-associated hemophagocytic lymphohistiocytosis
    Naomi J Balamuth
    Department of Pediatrics, Division of Oncology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Pediatr Hematol Oncol 29:569-73. 2007
    ..This patient demonstrated a rapid clinical response and an 18-fold reduction in EBV viral load within 24 hours of receiving rituximab. He remains free of disease 8 months after completing treatment...
  18. ncbi request reprint In vivo control of acute lymphoblastic leukemia by immunostimulatory CpG oligonucleotides
    Hisaki Fujii
    Department of Pediatrics, Division of Hematology Oncology Bone Marrow Transplantation, University of British Columbia and British Columbia s Children s Hospital, Vancouver, Canada
    Blood 109:2008-13. 2007
    ..These results suggest that CpG ODNs have potential as therapeutic agents for the treatment of ALL...