Research Topics | Philippe TaupinSummaryAffiliation: The Salk Institute Country: USA Publications
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Publications
Adult neurogenesis and neural stem cells of the central nervous system in mammalsPhilippe Taupin
Laboratory of Genetics, The Salk Institute, La Jolla, California 92037-1099, USA
J Neurosci Res 69:745-9. 2002
Neurogenesis in the adult central nervous systemPhilippe Taupin
National Neuroscience Institute, Singapore, 11 Jalan Tan Tock Seng, Singapore 308433
C R Biol 329:465-75. 2006..Thus, not only neurogenesis contributes to reshaping the adult brain, it will ultimately lead us to redefine our knowledge and understanding of the nervous system...
Neural progenitor and stem cells in the adult central nervous systemPhilippe Taupin
National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore
Ann Acad Med Singapore 35:814-20. 2006..We will discuss their contribution and significance to CNS pathophysiology, and for cellular therapy...
Autologous transplantation in the central nervous systemPhilippe Taupin
National Neuroscience Institute, National University of Singapore and Nanyang Technological University, Singapore
Indian J Med Res 124:613-8. 2006....
Protocols for studying adult neurogenesis: insights and recent developmentsPhilippe Taupin
National Neuroscience Institute, National University of Singapore and Nanyang Technological University, Singapore
Regen Med 2:51-62. 2007..I will review these techniques, and discuss their implications for the field of adult neurogenesis...
Adult neural stem cells, neurogenic niches, and cellular therapyPhilippe Taupin
National Neuroscience Institute, Singapore
Stem Cell Rev 2:213-9. 2006..Hence, neurogenic niches may not only hold the key to our understanding of neurogenesis in the adult brain, but also of the developmental potential of adult NSCs, and their potential for cellular therapy...
Stem cells engineering for cell-based therapyPhilippe Taupin
National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore
J Neural Eng 4:R59-63. 2007..In this review, I will review, in two examples, how investigators are applying cell engineering to stem cell biology to circumvent stem cells' ethical and political constraints and bolster stem cell research and therapy...
Therapeutic potential of adult neural stem cellsPhilippe Taupin
National Neuroscience Institute, Singapore
Recent Pat CNS Drug Discov 1:299-303. 2006..In this manuscript, we will review the recent developments in adult neurogenesis and NSCs, and patent applications filed in relation to discoveries made in this new field of research...
Adult neurogenesis pharmacology in neurological diseases and disordersPhilippe Taupin
National Neuroscience Institute National University of Singapore Nanyang Technological University, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore
Expert Rev Neurother 8:311-20. 2008..This shows that adult neurogenesis is not only important for our understanding of development and therapy, but also for the physiopathology of the CNS and its pharmacology...
Alzheimer's disease, aneuploidy and neurogenesisPhilippe Taupin
Med Sci Monit 14:LE6-6. 2008
The therapeutic potential of adult neural stem cellsPhilippe Taupin
National Neuroscience Institute, National University of Singapore, 11 Jalan Tan Tock Seng, 308433 Singapore
Curr Opin Mol Ther 8:225-31. 2006....
[Derivation of embryonic stem cells]Philippe Taupin
Med Sci (Paris) 22:478-80. 2006
Expression and function of orphan nuclear receptor TLX in adult neural stem cellsYanhong Shi
Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Nature 427:78-83. 2004..TLX can silence glia-specific expression of the astrocyte marker GFAP in neural stem cells, suggesting that transcriptional repression may be crucial in maintaining the undifferentiated state of these cells...
[Control of maintenance of neural stem cells in mammals]Philippe Taupin
Med Sci (Paris) 20:748-9. 2004
Microfabricated platform for studying stem cell fatesVicki I Chin
Department of Bioengineering, 9500 Gilman Dr. MC, University of California, San Diego, La Jolla, California 92093-0412, USA
Biotechnol Bioeng 88:399-415. 2004....
Adult neurogenesis in the mammalian central nervous system: functionality and potential clinical interestPhilippe Taupin
National Neuroscience Institute, Singapore, Singapore
Med Sci Monit 11:RA247-252. 2005..Neural stem cells also hold the promise to cure a broad range of neurological diseases and injuries. Cell therapeutic interventions may involve both cell transplantation and the stimulation of endogenous neural progenitor cells...
Consideration of adult neurogenesis from basic science to therapyPhilippe Taupin
Med Sci Monit 11:LE16-17. 2005
Stroke-induced neurogenesis: physiopathology and mechanismsPhilippe Taupin
National Neuroscience Institute, Singapore, National University of Singapore, Nanyang Technological University, Singapore
Curr Neurovasc Res 3:67-72. 2006..In this manuscript, we will review the studies on adult neurogenesis in cerebral strokes, discuss the contribution of adult neurogenesis to the physiopathology of strokes, and its underlying mechanisms...
Adult neurogenesis and neuroplasticityPhilippe Taupin
National Neuroscience Institute, Singapore
Restor Neurol Neurosci 24:9-15. 2006..Thus, injury-induced neurogenesis may contribute to the recovery and plasticity of the CNS...
Derivation of embryonic stem cells for cellular therapy: challenges and new strategiesPhilippe Taupin
National Neuroscience Institute, Singapore
Med Sci Monit 12:RA75-8. 2006..In this manuscript, we will review and discuss these developments that may unlock ES cell research and therapy...
HuCNS-SC (StemCells)Philippe Taupin
National Neuroscience Institute, National University of Singapore, 11 Jalan Tan Tock Seng, Singapore
Curr Opin Mol Ther 8:156-63. 2006..A phase I trial of HuCNS-SC for infantile and late-infantile NCL has been initiated, following the March 2006 U.S. Food and Drug Administration approval of StemCells' investigational new drug application...
Adult neurogenesis, neuroinflammation and therapeutic potential of adult neural stem cellsPhilippe Taupin
Fighting Blindness Vision Research Institute, National Institute for Cellular Biotechnology, Glasnevin Dublin 9
Int J Med Sci 5:127-32. 2008..We will discuss the role and contribution of neuroinflammation and adult neurogenesis to neurological diseases and disorders, and for the therapeutic potential of adult NSCs...
