Caroline M Tanner

Summary

Affiliation: The Parkinson's Institute
Country: USA

Publications

  1. ncbi request reprint Effect of non-steroidal anti-inflammatory medications on the risk of amyotrophic lateral sclerosis
    Rita A Popat
    Department of Health Research and Policy, Division of Epidemiology, Stanford University School of Medicine, Stanford, CA 94305 5405, USA
    Amyotroph Lateral Scler 8:157-63. 2007
  2. doi request reprint Occupation and risk of parkinsonism: a multicenter case-control study
    Caroline M Tanner
    Department of Clinical Research, The Parkinson s Institute, Sunnyvale, California 94085, USA
    Arch Neurol 66:1106-13. 2009
  3. pmc Genetic modification of the association of paraquat and Parkinson's disease
    Samuel M Goldman
    The Parkinson s Institute, Sunnyvale, California 94085, USA
    Mov Disord 27:1652-8. 2012
  4. pmc Solvent exposures and Parkinson disease risk in twins
    Samuel M Goldman
    The Parkinson s Institute, 675 Almanor Avenue, Sunnyvale, CA 94085, USA
    Ann Neurol 71:776-84. 2012
  5. pmc Head injury, α-synuclein Rep1, and Parkinson's disease
    Samuel M Goldman
    The Parkinson s Institute, Sunnyvale, CA 94085, USA
    Ann Neurol 71:40-8. 2012
  6. pmc Rotenone, paraquat, and Parkinson's disease
    Caroline M Tanner
    The Parkinson s Institute, Sunnyvale, California 94085, USA
    Environ Health Perspect 119:866-72. 2011
  7. ncbi request reprint Smell identification ability in twin pairs discordant for Parkinson's disease
    Connie Marras
    The Parkinson s Institute, Sunnyvale, California, USA
    Mov Disord 20:687-93. 2005
  8. doi request reprint Exploring the electrocardiogram as a potential tool to screen for premotor Parkinson's disease
    Ruksana Azhu Valappil
    Clinical Research Department, The Parkinson s Institute and Clinical Center, Sunnyvale, California, USA
    Mov Disord 25:2296-303. 2010
  9. ncbi request reprint Head injury and Parkinson's disease risk in twins
    Samuel M Goldman
    The Parkinson s Institute, Sunnyvale, CA 94089, USA
    Ann Neurol 60:65-72. 2006
  10. doi request reprint Clinical features in early Parkinson disease and survival
    Raymond Y Lo
    The Parkinson s Institute and Clinical Center, Sunnyvale, CA 94085, USA
    Arch Neurol 66:1353-8. 2009

Research Grants

  1. PESTICIDES AND RISK IN THE AGRICUTURAL HEALTH STUDY
    Caroline Tanner; Fiscal Year: 2004
  2. TWINS AND RISK OF PD: A CLINICAL AND IMAGING STUDY
    Caroline Tanner; Fiscal Year: 2004
  3. Large Simple Neuroprotective Trials in Parkinson's Disease
    Caroline Tanner; Fiscal Year: 2007
  4. Epidemiology of Dystonia in a Multi-Ethnic Population
    Caroline Tanner; Fiscal Year: 2009
  5. Diagnostic Error in Dystonia
    Caroline Tanner; Fiscal Year: 2009
  6. Skin Pigmentation and Parkinson's Disease Risk
    Caroline Tanner; Fiscal Year: 2003
  7. Diagnostic Error in Dystonia
    Caroline M Tanner; Fiscal Year: 2010

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Effect of non-steroidal anti-inflammatory medications on the risk of amyotrophic lateral sclerosis
    Rita A Popat
    Department of Health Research and Policy, Division of Epidemiology, Stanford University School of Medicine, Stanford, CA 94305 5405, USA
    Amyotroph Lateral Scler 8:157-63. 2007
    ..This study did not find any evidence to suggest that NSAID use reduces the risk of ALS. The observed sex differences with non-aspirin NSAID use could be due to chance or an unmeasured confounder...
  2. doi request reprint Occupation and risk of parkinsonism: a multicenter case-control study
    Caroline M Tanner
    Department of Clinical Research, The Parkinson s Institute, Sunnyvale, California 94085, USA
    Arch Neurol 66:1106-13. 2009
    ..We examined risk of parkinsonism in occupations (agriculture, education, health care, welding, and mining) and toxicant exposures (solvents and pesticides) putatively associated with parkinsonism...
  3. pmc Genetic modification of the association of paraquat and Parkinson's disease
    Samuel M Goldman
    The Parkinson s Institute, Sunnyvale, California 94085, USA
    Mov Disord 27:1652-8. 2012
    ..GSTT1*0 is common and could potentially identify a large subpopulation at high risk of PD from oxidative stressors such as paraquat...
  4. pmc Solvent exposures and Parkinson disease risk in twins
    Samuel M Goldman
    The Parkinson s Institute, 675 Almanor Avenue, Sunnyvale, CA 94085, USA
    Ann Neurol 71:776-84. 2012
    ..We tested the hypothesis that exposure to specific solvents is associated with PD risk using a discordant twin pair design...
  5. pmc Head injury, α-synuclein Rep1, and Parkinson's disease
    Samuel M Goldman
    The Parkinson s Institute, Sunnyvale, CA 94085, USA
    Ann Neurol 71:40-8. 2012
    ..To test the hypothesis that variability in SNCA Rep1, a polymorphic dinucleotide microsatellite in the promoter region of the gene encoding α-synuclein, modifies the association between head injury and Parkinson's disease (PD) risk...
  6. pmc Rotenone, paraquat, and Parkinson's disease
    Caroline M Tanner
    The Parkinson s Institute, Sunnyvale, California 94085, USA
    Environ Health Perspect 119:866-72. 2011
    ..Certain pesticides may affect these mechanisms, but no pesticide has been definitively associated with PD in humans...
  7. ncbi request reprint Smell identification ability in twin pairs discordant for Parkinson's disease
    Connie Marras
    The Parkinson s Institute, Sunnyvale, California, USA
    Mov Disord 20:687-93. 2005
    ..Smell identification ability may not be a sensitive indicator of future PD 7 or more years before the development of motor signs, even in a theoretically at-risk population...
  8. doi request reprint Exploring the electrocardiogram as a potential tool to screen for premotor Parkinson's disease
    Ruksana Azhu Valappil
    Clinical Research Department, The Parkinson s Institute and Clinical Center, Sunnyvale, California, USA
    Mov Disord 25:2296-303. 2010
    ..Cardiac autonomic dysfunction is also impaired in PD, suggesting that impaired HRV may be an early sign of PD. HRV measured by routine electrocardiograms could be used to screen for Lewy body disorders such as PD...
  9. ncbi request reprint Head injury and Parkinson's disease risk in twins
    Samuel M Goldman
    The Parkinson s Institute, Sunnyvale, CA 94089, USA
    Ann Neurol 60:65-72. 2006
    ..Twin studies circumvent some of these problems, because twins are genetically and environmentally much more similar than typical cases and control subjects...
  10. doi request reprint Clinical features in early Parkinson disease and survival
    Raymond Y Lo
    The Parkinson s Institute and Clinical Center, Sunnyvale, CA 94085, USA
    Arch Neurol 66:1353-8. 2009
    ..To examine the association between demographic and clinical features in early Parkinson disease (PD) and length of survival in a multiethnic population...
  11. doi request reprint Advances in environmental epidemiology
    Caroline M Tanner
    Clinical Research, The Parkinson s Institute, Sunnyvale, California 94085, USA
    Mov Disord 25:S58-62. 2010
    ..The pathogenesis of PD may begin decades before motor symptoms. PD may have shared determinants with other neurodegenerative disorders involving abnormal protein aggregation...
  12. ncbi request reprint Marked variation in clinical presentation and age of onset in a family with a heterozygous parkin mutation
    Louis C Tan
    The Parkinson s Institute, Sunnyvale, California 84089, USA
    Mov Disord 18:758-63. 2003
    ..Clinicians should be aware that patients carrying a parkin gene mutation may present with dystonia-parkinsonism or very subtle parkinsonism with a markedly varied age of onset...
  13. doi request reprint Nicotine and Parkinson's disease: implications for therapy
    Maryka Quik
    The Parkinson s Institute, Sunnyvale, California, USA
    Mov Disord 23:1641-52. 2008
    ....
  14. doi request reprint Serial immune markers do not correlate with clinical exacerbations in pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections
    Harvey S Singer
    Division of Pediatric Neurology, Johns Hopkins Hospital, Rubenstein Child Health Building, Suite 2158, 200 N Wolfe St, Baltimore, MD 21287, USA
    Pediatrics 121:1198-205. 2008
    ....
  15. ncbi request reprint Predictors of deterioration in health-related quality of life in Parkinson's disease: results from the DATATOP trial
    Connie Marras
    Division of Neurology, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 23:653-9; quiz 776. 2008
    ..Our focus in clinical care needs to be broadened beyond assessing and treating Parkinsonism, recognizing the impact of mood, cognition and function on HRQOL...
  16. ncbi request reprint Association of olfactory dysfunction with risk for future Parkinson's disease
    G Webster Ross
    Veterans Affairs Pacific Islands Health Care System, University of Hawaii John A Burns School of Medicine, Honolulu, HI 96819, USA
    Ann Neurol 63:167-73. 2008
    ..This study examines the association of olfactory dysfunction with future development of PD in Honolulu-Asia Aging Study cohort members..
  17. ncbi request reprint Is the cause of Parkinson's disease environmental or hereditary? Evidence from twin studies
    Caroline M Tanner
    Parkinson s Institute, Sunnyvale, California, USA
    Adv Neurol 91:133-42. 2003
  18. ncbi request reprint Incidence of Parkinson's disease: variation by age, gender, and race/ethnicity
    Stephen K Van Den Eeden
    Division of Research, Kaiser Permanente, Oakland, CA 94612, USA
    Am J Epidemiol 157:1015-22. 2003
    ..0, 21.3), followed by non-Hispanic Whites (13.6, 95% CI: 11.5, 15.7), Asians (11.3, 95% CI: 7.2, 15.3), and Blacks (10.2, 95% CI: 6.4, 14.0). These data suggest that the incidence of Parkinson's disease varies by race/ethnicity...
  19. ncbi request reprint PD or not PD? That is the question
    Caroline M Tanner
    Neurology 61:5-6. 2003
  20. ncbi request reprint Parkinsonian signs and substantia nigra neuron density in decendents elders without PD
    G Webster Ross
    Honolulu Department of Veteran s Affairs, Honolulu, HI, USA
    Ann Neurol 56:532-9. 2004
    ..There was a significant association of increasing number of signs present with decreasing neuron density in both quadrants (p = 0.001 for trend). Low SN neuron density may be the basis for parkinsonian signs in the elderly without PD...
  21. ncbi request reprint A responsive outcome for Parkinson's disease neuroprotection futility studies
    Jordan J Elm
    Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA
    Ann Neurol 57:197-203. 2005
    ....
  22. pmc Verification of self-report of zygosity determined via DNA testing in a subset of the NAS-NRC twin registry 40 years later
    Terry Reed
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Twin Res Hum Genet 8:362-7. 2005
    ....
  23. ncbi request reprint Non-linearity of Parkinson's disease progression: implications for sample size calculations in clinical trials
    Paulo Guimaraes
    Dept of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, 135 Cannon St Suite 303, Charleston, SC 29425, USA
    Clin Trials 2:509-18. 2005
    ..Models can help better understand behavior of the UPDRS after initiation of symptomatic therapy when scores will improve and eventually start deteriorating again...
  24. ncbi request reprint Effect of reproductive factors and postmenopausal hormone use on the risk of amyotrophic lateral sclerosis
    Rita A Popat
    Department of Health Research and Policy, Division of Epidemiology, Stanford University School of Medicine, Stanford, Calif, USA
    Neuroepidemiology 27:117-21. 2006
    ..To examine the associations of reproductive factors and postmenopausal hormone use with the risk of amyotrophic lateral sclerosis (ALS) among women...
  25. pmc Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study
    Alexis Elbaz
    INSERM, Unit 708, Paris, France
    Lancet Neurol 5:917-23. 2006
    ..Small-scale replication studies were largely non-confirmatory, but a meta-analysis that included data from the original study could not exclude all SNP associations, leaving relevance of several markers uncertain...
  26. ncbi request reprint Plantation work and risk of Parkinson disease in a population-based longitudinal study
    Helen Petrovitch
    Department of Medicine, University of Hawaii John A Burns School of Medicine, USA
    Arch Neurol 59:1787-92. 2002
    ..Retrospective studies in humans demonstrate a link between exposure to agricultural lifestyle factors and PD...

Research Grants25

  1. PESTICIDES AND RISK IN THE AGRICUTURAL HEALTH STUDY
    Caroline Tanner; Fiscal Year: 2004
    ..The investigators believe that this work could provide a critical and dramatic next step in furthering our knowledge of environmental determinants of PD, and thereby take us closer to our goal of finding its cause(s). ..
  2. TWINS AND RISK OF PD: A CLINICAL AND IMAGING STUDY
    Caroline Tanner; Fiscal Year: 2004
    ..This in turn could help set the research agenda on the cause of Parkinson's disease for years to come. ..
  3. Large Simple Neuroprotective Trials in Parkinson's Disease
    Caroline Tanner; Fiscal Year: 2007
    ..These characteristics make the Parkinson's Institute an ideal participant in the proposed trial. ..
  4. Epidemiology of Dystonia in a Multi-Ethnic Population
    Caroline Tanner; Fiscal Year: 2009
    ..In addition, this cohort will provide a rich resource for future investigations including family studies, genetic analyses and further investigations of environmental risk factors. ..
  5. Diagnostic Error in Dystonia
    Caroline Tanner; Fiscal Year: 2009
    ..If successful, this approach could be applied in other medical care settings, as well as for other rare disorders, to improve medical care and efficiency, and reduce suffering. ..
  6. Skin Pigmentation and Parkinson's Disease Risk
    Caroline Tanner; Fiscal Year: 2003
    ..This could be an enormous breakthrough in our understanding of factors that influence the risk (and perhaps even the cause) of Parkinson's disease, and could lead to new strategies for disease prevention. ..
  7. Diagnostic Error in Dystonia
    Caroline M Tanner; Fiscal Year: 2010
    ..If successful, this approach could be applied in other medical care settings, as well as for other rare disorders, to improve medical care and efficiency, and reduce suffering. ..