ENG TAN

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Autoantibodies, autoimmune disease, and the birth of immune diagnostics
    Eng M Tan
    The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 122:3835-6. 2012
  2. pmc Identification of an autoantibody panel to separate lung cancer from smokers and nonsmokers
    William N Rom
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Radiology, Thoracic Surgery, and Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA
    BMC Cancer 10:234. 2010
  3. pmc Identification of kinectin as a novel Behçet's disease autoantigen
    Yu Lu
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    Arthritis Res Ther 7:R1133-9. 2005
  4. pmc Relative paradigms between autoantibodies in lupus and autoantibodies in cancer
    E M Tan
    W M Keck Autoimmune Disease Center, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Clin Exp Immunol 134:169-77. 2003
  5. pmc Autoantibodies to tumor-associated antigens: reporters from the immune system
    Eng M Tan
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Immunol Rev 222:328-40. 2008
  6. ncbi request reprint Enhancement of antibody detection in cancer using panel of recombinant tumor-associated antigens
    Jian Ying Zhang
    W M Keck Autoimmune Disease Center, The Scripps Research Institute, La Jolla, California 92037, USA
    Cancer Epidemiol Biomarkers Prev 12:136-43. 2003
  7. ncbi request reprint Recursive partitioning as an approach to selection of immune markers for tumor diagnosis
    James A Koziol
    Division of Biomathematics, The Scripps Research Institute, La Jolla, California 92037, USA
    Clin Cancer Res 9:5120-6. 2003
  8. ncbi request reprint Preferential humoral immune response in prostate cancer to cellular proteins p90 and p62 in a panel of tumor-associated antigens
    Fu Dong Shi
    Department of Molecular and Experimental Medicine, W M Keck Autoimmune Disease Center, The Scripps Research Institute, La Jolla, California, USA
    Prostate 63:252-8. 2005
  9. ncbi request reprint Analyses of autoantibodies against tumor-associated antigens in patients with hepatocellular carcinoma
    Takashi Himoto
    W M Keck Autoimmune Disease Center, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Int J Oncol 27:1079-85. 2005
  10. ncbi request reprint Significance of autoantibodies against insulin-like growth factor II mRNA-binding proteins in patients with hepatocellular carcinoma
    Takashi Himoto
    W M Keck Autoimmune Disease Center, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Int J Oncol 26:311-7. 2005

Research Grants

Collaborators

  • Edward K Chan
  • Jian Ying Zhang
  • Carlos A Casiano
  • Yu Lu
  • Naomi Rothfield
  • J A Hardin
  • Marvin J Fritzler
  • A S Wiik
  • Oystein Bruserud
  • Y Muro
  • F D Shi
  • Takashi Himoto
  • William N Rom
  • Kok Sun Looi
  • Elisabeth Ersvaer
  • Mikio Nishioka
  • Shigeki Kuriyama
  • Roxanne Megliorino
  • Akihiro Watanabe
  • Xuan Xian Peng
  • Kazumitsu Sugiura
  • Ralph C Williams
  • James A Koziol
  • Bernard Crawford
  • Ellen Eylers
  • Judith D Goldberg
  • Daorong Liu
  • Heather N Watson
  • Alissa K Greenberg
  • David P Naidich
  • Doreen Addrizzo-Harris
  • Michael Khilkin
  • Igor C Almeida
  • Raquel A de Diaz
  • Ernesto S Nakayasu
  • Bjørn Tore Gjertsen
  • Astrid Olsnes
  • Nina Anensen
  • Emmet McCormack
  • Naohito Uchida
  • Yasuhiko Kimura
  • Xiao Wang
  • Tsutomu Masaki
  • Masanari Kodera
  • Toshikazu Usuda
  • Yasushi Tomita
  • Yoshinari Takasaki
  • Anne C Feng

Detail Information

Publications18

  1. pmc Autoantibodies, autoimmune disease, and the birth of immune diagnostics
    Eng M Tan
    The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 122:3835-6. 2012
    ..Recently, autoantibodies to tumor-associated antigens have been identified in cancer, and these findings have expanded the field of cancer immunodiagnostics...
  2. pmc Identification of an autoantibody panel to separate lung cancer from smokers and nonsmokers
    William N Rom
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Radiology, Thoracic Surgery, and Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA
    BMC Cancer 10:234. 2010
    ..Sera from lung cancer patients contain autoantibodies that react with tumor associated antigens (TAAs) that reflect genetic over-expression, mutation, or other anomalies of cell cycle, growth, signaling, and metabolism pathways...
  3. pmc Identification of kinectin as a novel Behçet's disease autoantigen
    Yu Lu
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    Arthritis Res Ther 7:R1133-9. 2005
    ..Sera from controls showed no reactivity. The significance of kinectin as a participant in autoimmune pathogenesis in BD and the potential use of autoantibody to kinectin in serodiagnostics are discussed...
  4. pmc Relative paradigms between autoantibodies in lupus and autoantibodies in cancer
    E M Tan
    W M Keck Autoimmune Disease Center, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Clin Exp Immunol 134:169-77. 2003
  5. pmc Autoantibodies to tumor-associated antigens: reporters from the immune system
    Eng M Tan
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Immunol Rev 222:328-40. 2008
    ..The immune system of cancer patients reveals the immune interactive sites or the autoepitopes of participants in tumorigenesis, and this information should be used in the design of immunotherapy...
  6. ncbi request reprint Enhancement of antibody detection in cancer using panel of recombinant tumor-associated antigens
    Jian Ying Zhang
    W M Keck Autoimmune Disease Center, The Scripps Research Institute, La Jolla, California 92037, USA
    Cancer Epidemiol Biomarkers Prev 12:136-43. 2003
    ....
  7. ncbi request reprint Recursive partitioning as an approach to selection of immune markers for tumor diagnosis
    James A Koziol
    Division of Biomathematics, The Scripps Research Institute, La Jolla, California 92037, USA
    Clin Cancer Res 9:5120-6. 2003
    ..We used recursive partitioning to assess whether we could accurately classify individuals as either cancer patients or normals on the basis of the profile of antibody reactivity to the seven TAAs for each individual...
  8. ncbi request reprint Preferential humoral immune response in prostate cancer to cellular proteins p90 and p62 in a panel of tumor-associated antigens
    Fu Dong Shi
    Department of Molecular and Experimental Medicine, W M Keck Autoimmune Disease Center, The Scripps Research Institute, La Jolla, California, USA
    Prostate 63:252-8. 2005
    ..Cytoplasmic p90 autoantigen was recently cloned from a cDNA expression library using serum antibody from a cancer patient. The humoral immune response to p90 in prostate cancer and benign prostatic hyperplasia (BPH) was examined...
  9. ncbi request reprint Analyses of autoantibodies against tumor-associated antigens in patients with hepatocellular carcinoma
    Takashi Himoto
    W M Keck Autoimmune Disease Center, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Int J Oncol 27:1079-85. 2005
    ....
  10. ncbi request reprint Significance of autoantibodies against insulin-like growth factor II mRNA-binding proteins in patients with hepatocellular carcinoma
    Takashi Himoto
    W M Keck Autoimmune Disease Center, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Int J Oncol 26:311-7. 2005
    ....
  11. ncbi request reprint Autoimmune response to anti-apoptotic protein survivin and its association with antibodies to p53 and c-myc in cancer detection
    Roxanne Megliorino
    Department of Biological Sciences, The University of Texas, El Paso, TX, USA
    Cancer Detect Prev 29:241-8. 2005
    ..3% (149/546) for the total group of cancer patients. It became apparent from our data that the combination of antibodies might acquire higher sensitivity...
  12. pmc Tumor-associated antigen arrays for the serological diagnosis of cancer
    Carlos A Casiano
    Center for Health Disparities Research and Department of Biochemistry and Microbiology, Loma Linda University School of Medicine, California 92350, USA
    Mol Cell Proteomics 5:1745-59. 2006
    ....
  13. pmc Antibody detection using tumor-associated antigen mini-array in immunodiagnosing human hepatocellular carcinoma
    Jian Ying Zhang
    Department of Biological Sciences, The University of Texas at El Paso, El Paso, TX, USA
    J Hepatol 46:107-14. 2007
    ..The panel of eight TAAs includes Imp1, p62, Koc, p53, c-myc, cyclin B1, survivin and p16 full-length recombinant proteins...
  14. ncbi request reprint Cyclin B1 is commonly expressed in the cytoplasm of primary human acute myelogenous leukemia cells and serves as a leukemia-associated antigen associated with autoantibody response in a subset of patients
    Elisabeth Ersvaer
    Institute of Medicine, University of Bergen, Bergen, Norway
    Eur J Haematol 79:210-25. 2007
    ..We therefore investigated (i) whether a similar expression pattern could be detected in native human acute myelogenous leukemia (AML) cells and (ii) whether cyclin B1 specific antibodies could be detected in AML...
  15. ncbi request reprint Antibodies to microtubule-associated protein 2 in patients with neuropsychiatric systemic lupus erythematosus
    Ralph C Williams
    University of New Mexico School of Medicine, Albuquerque, USA
    Arthritis Rheum 50:1239-47. 2004
    ..We undertook this study to examine the presence of autoantibodies to MAP-2 in neuropsychiatric systemic lupus erythematosus (NPSLE)...
  16. pmc Using proteomic approach to identify tumor-associated antigens as markers in hepatocellular carcinoma
    Kok Sun Looi
    Department of Biological Sciences, The University of Texas at El Paso, El Paso, TX 79968, USA
    J Proteome Res 7:4004-12. 2008
    ....
  17. ncbi request reprint Anti-DFS70 antibodies in 597 healthy hospital workers
    Akihiro Watanabe
    Nagoya University Graduate School of Medicine, Nagoya, Japan
    Arthritis Rheum 50:892-900. 2004
    ..We undertook this study to examine the frequency of anti-DFS70 antibodies in a large number of healthy people...
  18. ncbi request reprint A critical evaluation of enzyme immunoassay kits for detection of antinuclear autoantibodies of defined specificities. II. Potential for quantitation of antibody content
    Eng M Tan
    Autoantibody Standardization Committee in Rheumatic and Related Disorders of the International Union of Immunological Societies, The World Health Organization, The Arthritis Foundation, and Centers for Disease Control and Prevention
    J Rheumatol 29:68-74. 2002
    ..To analyze the performance of different commercial enzyme immunoassay (EIA) kits for measuring antibody levels of antinuclear antibodies (ANA) specific for double stranded (ds) DNA, SSB/La, Sm, and Scl-70...

Research Grants13

  1. AUTOANTIBODIES IN HEPATOCELLULAR CARCINOMA
    ENG TAN; Fiscal Year: 2000
    ..Patients converting to HCC can be immediately identified and serum and liver biopsies obtained for these studies. ..
  2. AUTOANTIBODIES IN HEPATOCELLULAR CARCINOMA
    ENG TAN; Fiscal Year: 1993
    ..If certain regulatory pathways associated with cell growth are perturbed in carcinogenesis, identification of components of these pathways might be achieved by using autoantibodies...
  3. ANTIBODIES AND ANTIGENS IN HEPATOCELLULAR CARCINOMA
    ENG TAN; Fiscal Year: 2005
    ..Other studies are to determine the target genes(s) of SG2NA and potential protein binding partners. Elucidation of the properties and function of these proteins might contribute to understanding co-activating factors in carcinogenesis. ..