MICHAEL TAFFE

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Effect of ambient temperature on the thermoregulatory and locomotor stimulant effects of 4-methylmethcathinone in Wistar and Sprague-Dawley rats
    M Jerry Wright
    Committee on Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California, USA
    PLoS ONE 7:e44652. 2012
  2. pmc Δ⁹Tetrahydrocannabinol impairs visuo-spatial associative learning and spatial working memory in rhesus macaques
    Michael A Taffe
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA
    J Psychopharmacol 26:1299-306. 2012
  3. pmc Δ9-Tetrahydrocannabinol attenuates MDMA-induced hyperthermia in rhesus monkeys
    M A Taffe
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuroscience 201:125-33. 2012
  4. pmc Rhesus monkeys employ a procedural strategy to reduce working memory load in a self-ordered spatial search task
    Michael A Taffe
    Committee on the Neurobiology of Addictive Disorders The Scripps Research Institute, La Jolla, CA, USA
    Brain Res 1413:43-50. 2011
  5. pmc A comparison of intraperitoneal and subcutaneous temperature in freely moving rhesus macaques
    Michael A Taffe
    Committee on Neurobiology of Addictive Disorders, SP30 2400, 10550 North Torrey Pines Road, The Scripps Research Institute, La Jolla, CA 92037, USA
    Physiol Behav 103:440-4. 2011
  6. pmc Hyperthermia induced by 3,4-methylenedioxymethamphetamine in unrestrained rhesus monkeys
    Michael A Taffe
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Drug Alcohol Depend 82:276-81. 2006
  7. ncbi request reprint Modeling a task that is sensitive to dementia of the Alzheimer's type: individual differences in acquisition of a visuo-spatial paired-associate learning task in rhesus monkeys
    Michael A Taffe
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Behav Brain Res 149:123-33. 2004
  8. ncbi request reprint Effects of parametric feeding manipulations on behavioral performance in macaques
    Michael A Taffe
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Physiol Behav 81:59-70. 2004
  9. ncbi request reprint Functional consequences of repeated (+/-)3,4-methylenedioxymethamphetamine (MDMA) treatment in rhesus monkeys
    M A Taffe
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 24:230-9. 2001
  10. ncbi request reprint Differential muscarinic and NMDA contributions to visuo-spatial paired-associate learning in rhesus monkeys
    Michael A Taffe
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 160:253-62. 2002

Collaborators

Detail Information

Publications26

  1. pmc Effect of ambient temperature on the thermoregulatory and locomotor stimulant effects of 4-methylmethcathinone in Wistar and Sprague-Dawley rats
    M Jerry Wright
    Committee on Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California, USA
    PLoS ONE 7:e44652. 2012
    ....
  2. pmc Δ⁹Tetrahydrocannabinol impairs visuo-spatial associative learning and spatial working memory in rhesus macaques
    Michael A Taffe
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA
    J Psychopharmacol 26:1299-306. 2012
    ..These results and the lack of specific effect of Δ⁹THC in prior visual recognition studies imply a sensitivity of spatial memory processing and/or working memory to endocannabinoid perturbation...
  3. pmc Δ9-Tetrahydrocannabinol attenuates MDMA-induced hyperthermia in rhesus monkeys
    M A Taffe
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuroscience 201:125-33. 2012
    ..Relatively little scientific evidence on the thermoregulatory effects of THC in monkeys is available...
  4. pmc Rhesus monkeys employ a procedural strategy to reduce working memory load in a self-ordered spatial search task
    Michael A Taffe
    Committee on the Neurobiology of Addictive Disorders The Scripps Research Institute, La Jolla, CA, USA
    Brain Res 1413:43-50. 2011
    ..It is concluded that the effect of utilizing the strategy on this locomotion-free, laboratory task is to enhance accuracy by reducing demands on spatial working memory resources...
  5. pmc A comparison of intraperitoneal and subcutaneous temperature in freely moving rhesus macaques
    Michael A Taffe
    Committee on Neurobiology of Addictive Disorders, SP30 2400, 10550 North Torrey Pines Road, The Scripps Research Institute, La Jolla, CA 92037, USA
    Physiol Behav 103:440-4. 2011
    ..Existing literature encompasses data using intraperitoneal (IP) and subcutaneous (SC) implantation locations which may affect inferences about body temperature...
  6. pmc Hyperthermia induced by 3,4-methylenedioxymethamphetamine in unrestrained rhesus monkeys
    Michael A Taffe
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Drug Alcohol Depend 82:276-81. 2006
    ..Neurotoxicology 24, 379-390]. This study was therefore conducted to determine if racemic MDMA and its enantiomers induce hyperthermia and increase spontaneous locomotor activity in unrestrained rhesus monkeys...
  7. ncbi request reprint Modeling a task that is sensitive to dementia of the Alzheimer's type: individual differences in acquisition of a visuo-spatial paired-associate learning task in rhesus monkeys
    Michael A Taffe
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Behav Brain Res 149:123-33. 2004
    ..Comparison of performance on vsPAL with performance on other memory tasks in the battery will be of more general use in differentiating mechanisms involved in various aspects of mnemonic function...
  8. ncbi request reprint Effects of parametric feeding manipulations on behavioral performance in macaques
    Michael A Taffe
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Physiol Behav 81:59-70. 2004
    ..Furthermore, it is shown that maintenance of weekly chow intake in the range of 70-85% of National Research Council recommendations for metabolizable energy is necessary for consistent behavioral responding...
  9. ncbi request reprint Functional consequences of repeated (+/-)3,4-methylenedioxymethamphetamine (MDMA) treatment in rhesus monkeys
    M A Taffe
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 24:230-9. 2001
    ..Both CSF 5-HIAA concentrations and evoked potential latencies were normalized four months after treatment. These findings indicate that serotonergic alterations associated with MDMA use may result in persisting changes in brain function...
  10. ncbi request reprint Differential muscarinic and NMDA contributions to visuo-spatial paired-associate learning in rhesus monkeys
    Michael A Taffe
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 160:253-62. 2002
    ..Translation of this cognitive task to a non-human model may therefore provide an improved tool for study of the etiology and treatment of dementia...
  11. ncbi request reprint MDMA exposure alters cognitive and electrophysiological sensitivity to rapid tryptophan depletion in rhesus monkeys
    Michael A Taffe
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines, La Jolla, CA 92037, USA
    Pharmacol Biochem Behav 76:141-52. 2003
    ..The BSAEP response and spatial working memory appear particularly sensitive to lasting functional differences associated with MDMA exposure...
  12. ncbi request reprint Ketamine impairs multiple cognitive domains in rhesus monkeys
    Michael A Taffe
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Drug Alcohol Depend 68:175-87. 2002
    ..Ketamine also slowed RT and BMS performance and interfered with PR performance at the 1.78 mg/kg dose. Overall the present findings confirm that ketamine interferes with multiple aspects of cognition at subanesthetic doses in monkeys...
  13. ncbi request reprint Cognitive performance of MDMA-treated rhesus monkeys: sensitivity to serotonergic challenge
    Michael A Taffe
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 27:993-1005. 2002
    ..These observations suggest that large depletions of brain 5-HT produced by MDMA can persistently alter behavioral sensitivity to the disrupting effects of serotonergic agents...
  14. ncbi request reprint Impaired performance on a rhesus monkey neuropsychological testing battery following simian immunodeficiency virus infection
    Michael R Weed
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    AIDS Res Hum Retroviruses 20:77-89. 2004
    ....
  15. ncbi request reprint Controlled and behaviorally relevant levels of oral ethanol intake in rhesus macaques using a flavorant-fade procedure
    Simon N Katner
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 28:873-83. 2004
    ..Flavorant-fading procedures can initiate and maintain oral ethanol intake in rodents. The present study developed a similar procedure to achieve controlled and behaviorally relevant levels of ethanol intake in monkeys...
  16. pmc Differential contributions of dopaminergic D1- and D2-like receptors to cognitive function in rhesus monkeys
    Stefani N Von Huben
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 188:586-96. 2006
    ....
  17. pmc Effects of nicotine and mecamylamine on cognition in rhesus monkeys
    Simon N Katner
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 175:225-40. 2004
    ..Prior work has typically focused on assays of spatial working memory in rodent studies and visual recognition memory in monkey studies...
  18. pmc Long-lasting reduction in hippocampal neurogenesis by alcohol consumption in adolescent nonhuman primates
    Michael A Taffe
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:11104-9. 2010
    ..This lasting effect, observed 2 mo after alcohol discontinuation, may underlie the deficits in hippocampus-associated cognitive tasks that are observed in alcoholics...
  19. pmc Robust and stable drinking behavior following long-term oral alcohol intake in rhesus macaques
    Simon N Katner
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
    Drug Alcohol Depend 91:236-43. 2007
    ..It is concluded that models with excellent face validity (flavored beverages) can produce reliable ethanol intake in patterns that are highly consistent with ethanol-seeking behavior...
  20. pmc Oral administration of (+/-)3,4-methylenedioxymethamphetamine and (+)methamphetamine alters temperature and activity in rhesus macaques
    Rebecca D Crean
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Pharmacol Biochem Behav 87:11-9. 2007
    ....
  21. pmc Chronic alcohol consumption generates a vulnerable immune environment during early SIV infection in rhesus macaques
    Maria Cecilia G Marcondes
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California, USA
    Alcohol Clin Exp Res 32:1583-92. 2008
    ..However, the elements of the virus-host interaction that are modulated by ethanol are poorly dissected...
  22. pmc Impact of ambient temperature on hyperthermia induced by (+/-)3,4-methylenedioxymethamphetamine in rhesus macaques
    Stefani N Von Huben
    1Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 32:673-81. 2007
    ..Monkey temperature responses to MDMA appear to be more similar to humans than to rodents and therefore the monkey may offer an improved model of effects related to MDMA-induced hyperthermia...
  23. ncbi request reprint Acute SIV infection of the brain leads to upregulation of IL6 and interferon-regulated genes: expression patterns throughout disease progression and impact on neuroAIDS
    Eleanor S Roberts
    Department of Neuropharmacology, CVN 1, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Neuroimmunol 157:81-92. 2004
    ....
  24. pmc Regulation of indoleamine 2,3-dioxygenase expression in simian immunodeficiency virus-infected monkey brains
    E M E Burudi
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 76:12233-41. 2002
    ..In vitro studies on mouse microglia reveal that IFN-gamma is the primary inducer of IDO expression. These findings demonstrate the link between IDO expression, IFN-gamma levels, and brain pathology signs observed in neuro-AIDS...
  25. pmc Induction of pathogenic sets of genes in macrophages and neurons in NeuroAIDS
    Eleanor S Roberts
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Am J Pathol 162:2041-57. 2003
    ....
  26. ncbi request reprint Host response and dysfunction in the CNS during chronic simian immunodeficiency virus infection
    Eleanor S Roberts
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California, 92037, USA
    J Neurosci 26:4577-85. 2006
    ..We have identified an altered state of the CNS at an important stage of the viral-host interaction, likely arising to protect against the virus but in the long term leading to damaging processes...

Research Grants20

  1. BEHAVIORAL TOXICITY OF MDMA IN RHESUS MONKEYS
    MICHAEL TAFFE; Fiscal Year: 2009
    ..Specific Aim IV: To determine if a history of MDMA exposure impairs acquisition and performance of a battery of neuropsychological tests. ..
  2. Behavioral Toxicity of Chronic Alcohol Drinking in Peri-Adolescent Monkeys
    MICHAEL TAFFE; Fiscal Year: 2009
    ..These studies seek to identify the mechanisms by which alcohol drinking can interfere with learning, memory, attention and other critical cognitive functions. ..
  3. Behavioral Toxicity of Chronic Alcohol Drinking in Peri-Adolescent Monkeys
    Michael A Taffe; Fiscal Year: 2010
    ..These studies seek to identify the mechanisms by which alcohol drinking can interfere with learning, memory, attention and other critical cognitive functions. ..
  4. NEUROPHARMACOLOGY OF PRIMATE COGNITION
    MICHAEL TAFFE; Fiscal Year: 2002
    ..abstract_text> ..
  5. SIV Behavioral Pathology: Manipulation of Viral Load
    MICHAEL TAFFE; Fiscal Year: 2004
    ..abstract_text> ..
  6. COGNITIVE EFFECTS OF ALCOHOL IN PERI-ADOLESCENT MONKEYS
    MICHAEL TAFFE; Fiscal Year: 2006
    ..This exploratory study will provide evidence regarding the risks posed to cognition by heavy alcohol drinking in the peri-adolescent period. ..
  7. Immunopharmacotherapy for Methamphetamine Addiction
    Michael A Taffe; Fiscal Year: 2010
    ..Finally, it will be determined if MCV immunization can attenuate the reinforcing properties of METH using a rat intravenous self-administration procedure. ..