L N Sutton

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. ncbi request reprint In utero surgery for hydrocephalus
    Cornelia S von Koch
    Department of Neurological Surgery, University of California San Francisco, Room M 779, 505 Parnassus Avenue, Box 0112, San Francisco, CA 94143 0112, USA
    Childs Nerv Syst 19:574-86. 2003
  2. ncbi request reprint Improvement in hindbrain herniation demonstrated by serial fetal magnetic resonance imaging following fetal surgery for myelomeningocele
    L N Sutton
    Department of Neurosurgery, Children s Hospital of Phildelphia, 10194, USA
    JAMA 282:1826-31. 1999
  3. ncbi request reprint Fetal neurosurgery
    L N Sutton
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, USA
    Neurosurgery 48:124-42; discussion 142-4. 2001
  4. pmc Fetal surgery for neural tube defects
    Leslie N Sutton
    Department of Neurosurgery, Children s Hospital of Philadelphia, 6th Floor Wood Bldg, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
    Best Pract Res Clin Obstet Gynaecol 22:175-88. 2008
  5. ncbi request reprint Fetal surgery for myelomeningocele
    Leslie N Sutton
    Division of Neurosurgery, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19087, USA
    Childs Nerv Syst 19:587-91. 2003
  6. ncbi request reprint The effect of intrauterine myelomeningocele repair on the incidence of shunt-dependent hydrocephalus
    Noel Tulipan
    Department of Neurosurgery, Vanderbilt University Medical Center, A 2219 Medical Center North, Nashville, TN 37232 2380, USA
    Pediatr Neurosurg 38:27-33. 2003
  7. ncbi request reprint The Rationale for in utero repair of myelomeningocele
    D S Walsh
    Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, PA 19104, USA
    Fetal Diagn Ther 16:312-22. 2001
  8. ncbi request reprint Fetal head biometry following in-utero repair of myelomeningocele
    E Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Ultrasound Obstet Gynecol 24:606-11. 2004
  9. ncbi request reprint Fetal myelomeningocele repair: short-term clinical outcomes
    Mark P Johnson
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadephia, PA 19104, USA
    Am J Obstet Gynecol 189:482-7. 2003
  10. pmc A randomized trial of prenatal versus postnatal repair of myelomeningocele
    N Scott Adzick
    Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    N Engl J Med 364:993-1004. 2011

Collaborators

Detail Information

Publications40

  1. ncbi request reprint In utero surgery for hydrocephalus
    Cornelia S von Koch
    Department of Neurological Surgery, University of California San Francisco, Room M 779, 505 Parnassus Avenue, Box 0112, San Francisco, CA 94143 0112, USA
    Childs Nerv Syst 19:574-86. 2003
    ..Neonatal hydrocephalus is one of the most common congenital anomalies affecting the nervous system...
  2. ncbi request reprint Improvement in hindbrain herniation demonstrated by serial fetal magnetic resonance imaging following fetal surgery for myelomeningocele
    L N Sutton
    Department of Neurosurgery, Children s Hospital of Phildelphia, 10194, USA
    JAMA 282:1826-31. 1999
    ..Hindbrain herniation occurs in a large percentage of children with myelomeningocele and is the leading cause of death in this population. The effect of early fetal closure of myelomeningocele on hindbrain herniation is unknown...
  3. ncbi request reprint Fetal neurosurgery
    L N Sutton
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, USA
    Neurosurgery 48:124-42; discussion 142-4. 2001
    ..The challenge is to define which patients might benefit from such radical procedures before these techniques are accepted as standard care...
  4. pmc Fetal surgery for neural tube defects
    Leslie N Sutton
    Department of Neurosurgery, Children s Hospital of Philadelphia, 6th Floor Wood Bldg, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
    Best Pract Res Clin Obstet Gynaecol 22:175-88. 2008
    ..A randomized prospective trial (the MOMS trial) is currently being conducted by three centers in the United States, and is estimated to be completed in 2009...
  5. ncbi request reprint Fetal surgery for myelomeningocele
    Leslie N Sutton
    Division of Neurosurgery, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19087, USA
    Childs Nerv Syst 19:587-91. 2003
    ..Although in utero treatment of myelomeningocele shows promise in decreasing the morbidity of this disease, the risks to the fetus are significant, and the benefits are unproven...
  6. ncbi request reprint The effect of intrauterine myelomeningocele repair on the incidence of shunt-dependent hydrocephalus
    Noel Tulipan
    Department of Neurosurgery, Vanderbilt University Medical Center, A 2219 Medical Center North, Nashville, TN 37232 2380, USA
    Pediatr Neurosurg 38:27-33. 2003
    ..However, the existing cohort of IUMR patients has not yet been systematically compared to a comparable group of conventionally treated controls...
  7. ncbi request reprint The Rationale for in utero repair of myelomeningocele
    D S Walsh
    Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, PA 19104, USA
    Fetal Diagn Ther 16:312-22. 2001
    ..CONCLUSIONS: In utero repair of myelomeningocele may improve neurologic outcomes and reduce hindbrain herniation in selected patients...
  8. ncbi request reprint Fetal head biometry following in-utero repair of myelomeningocele
    E Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Ultrasound Obstet Gynecol 24:606-11. 2004
    ..To evaluate the impact of prenatal myelomeningocele repair on fetal head biometry...
  9. ncbi request reprint Fetal myelomeningocele repair: short-term clinical outcomes
    Mark P Johnson
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadephia, PA 19104, USA
    Am J Obstet Gynecol 189:482-7. 2003
    ..The study was undertaken to evaluate short-term clinical outcomes with antenatal myelomeningocele (MMC) repair...
  10. pmc A randomized trial of prenatal versus postnatal repair of myelomeningocele
    N Scott Adzick
    Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    N Engl J Med 364:993-1004. 2011
    ..Prenatal repair of myelomeningocele, the most common form of spina bifida, may result in better neurologic function than repair deferred until after delivery. We compared outcomes of in utero repair with standard postnatal repair...
  11. ncbi request reprint Anticancer effects of the novel 1alpha, 25-dihydroxyvitamin D3 hybrid analog QW1624F2-2 in human neuroblastoma
    C Damodar Reddy
    Division of Neurosurgery, The Children s Hospital of Philadelphia and The Abramson Family Cancer Research Institute, Philadelphia, PA 19104, USA
    J Cell Biochem 97:198-206. 2006
    ..In summary, the low-calcemic hybrid analog QW showed significant anti-tumor activity in vivo and thus exhibits potential as a novel cancer therapeutic...
  12. ncbi request reprint Anticancer effects of fenretinide in human medulloblastoma
    C Damodar Reddy
    Division of Neuro Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Cancer Lett 231:262-9. 2006
    ..These results suggest that pharmacologically achievable concentrations of fenretinide are effective in killing MB cells and thus show its therapeutic potential to treat human MB...
  13. ncbi request reprint Maternal-fetal surgery for myelomeningocele: neurodevelopmental outcomes at 2 years of age
    Mark Paul Johnson
    The Center for Fetal Diagnosis and Treatment, Philadelphia, PA 19104, USA
    Am J Obstet Gynecol 194:1145-50; discussion 1150-2. 2006
    ..This study was undertaken to examine short-term neurodevelopmental outcomes in children with myelomeningocele (MMC) who underwent in utero neurosurgical closure...
  14. ncbi request reprint Cervical chordoma in a patient with tuberous sclerosis presenting with shoulder pain
    Phillip B Storm
    Department of Neurosurgery, University of Pennsylvania and Children s Hospital of Philadelphia, PA 19104 4399, USA
    Pediatr Neurosurg 43:167-9. 2007
  15. ncbi request reprint Does a myelomeningocele sac compared to no sac result in decreased postnatal leg function following maternal fetal surgery for spina bifida aperta?
    R Douglas Wilson
    Department of Surgery and Obstetrics and Gynecology, Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4399, USA
    Fetal Diagn Ther 22:348-51. 2007
    ..A fetus with large sac S1 myelomeningocele (MMC) but bilateral talipes prompted the question, 'Does the presence or size of an MMC sac affect postnatal leg function?'..
  16. pmc Energy expenditure in obesity associated with craniopharyngioma
    Roy J Kim
    Division of Endocrinology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Childs Nerv Syst 26:913-7. 2010
    ..Obesity is a common yet incompletely understood complication of childhood craniopharyngioma. We hypothesized that craniopharyngioma is associated with specific defects in energy balance compared to obese control children...
  17. ncbi request reprint All-trans-retinoic acid-induced apoptosis in human medulloblastoma: activation of caspase-3/poly(ADP-ribose) polymerase 1 pathway
    Kiranmai Gumireddy
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Clin Cancer Res 9:4052-9. 2003
    ....
  18. ncbi request reprint Dermoid inclusion cysts and early spinal cord tethering after fetal surgery for myelomeningocele
    Catherine A Mazzola
    Department of Neurosurgery, University of Pittsburgh and Children s Hospital of Pittsburgh, Pittsburgh 15213, USA
    N Engl J Med 347:256-9. 2002
  19. ncbi request reprint Development of the Spitz-Holter valve in Philadelphia
    J A Boockvar
    Division of Neurosurgery, Children s Hospital of Philadelphia, Pennsylvania, USA
    J Neurosurg 95:145-7. 2001
    ..Sc. (Hon) and Eugene Spitz. M.D., and on a review of the available literature, the authors narrate the exciting story of the development of the Spitz-Holter valve, which took place in Philadelphia during the early 1950s...
  20. doi request reprint Lower extremity neuromotor function and short-term ambulatory potential following in utero myelomeningocele surgery
    Enrico Danzer
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Fetal Diagn Ther 25:47-53. 2009
    ..To evaluate lower extremity neuromotor function (LENF) and short-term ambulatory potential following fetal myelomeningocele (fMMC) closure...
  21. ncbi request reprint Overexpression of cyclooxygenase-2 (COX-2) in human primitive neuroectodermal tumors: effect of celecoxib and rofecoxib
    Ratnakar Patti
    Division of Neuro Oncology, Joseph Stokes Research Institute 515G, 3516 Civic Center Blvd, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Cancer Lett 180:13-21. 2002
    ..Growth inhibition by celecoxib and rofecoxib was independent of Bcl-2 expression. Celecoxib suppressed the expression of Akt and activated the caspase-3 in DAOY and PFSK, whereas rofecoxib did not have such an effect...
  22. ncbi request reprint Fetal head biometry assessed by fetal magnetic resonance imaging following in utero myelomeningocele repair
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Fetal Diagn Ther 22:1-6. 2007
    ..To examine the impact of fetal myelomeningocele (MMC) repair on fetal head biometry and cerebrospinal fluid (CSF) spaces assessed by magnetic resonance imaging (MR) studies...
  23. doi request reprint Intradural inclusion cysts following in utero closure of myelomeningocele: clinical implications and follow-up findings
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Neurosurg Pediatr 2:406-13. 2008
    ..The goal in this study was to evaluate the incidence and clinical implications of the development of cutaneously derived intradural inclusion cysts (ICs) following fetal myelomeningocele (fMMC) closure...
  24. ncbi request reprint Fetal surgery for myelomeningocele
    Leslie N Sutton
    University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, USA
    Clin Neurosurg 51:155-62. 2004
  25. ncbi request reprint A new look at myelomeningoceles: functional level, vertebral level, shunting, and the implications for fetal intervention
    Natalie E Rintoul
    Divisions of Neonatology, Philadelphia, Pennsylvania 10194, USA
    Pediatrics 109:409-13. 2002
    ..We sought to determine the distribution of postnatally repaired MMC lesions as characterized by both functional and radiologic assessment, as well as the incidence of shunting when patients were categorized according to these 2 methods...
  26. ncbi request reprint Prenatal diagnosis of terminal myelocystocele in the fetal surgery era: case report
    Paola Midrio
    Department of Surgery, The Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4399, USA
    Neurosurgery 50:1152-4; discussion 1154-5. 2002
    ..This case exemplifies the importance of performing a multidisciplinary evaluation and magnetic resonance imaging in the patient with suspected meningomyelocele when fetal surgery is being considered...
  27. doi request reprint Efficacy of spinal instrumentation and fusion in the prevention of postlaminectomy spinal deformity in children with intramedullary spinal cord tumors
    Scott L Simon
    Department of Neurosurgery, The University of Pennsylvania, Philadelphia, PA, USA
    J Pediatr Orthop 28:244-9. 2008
    ..05). Removal of greater than 4 laminae (P = 0.03) was found to be associated with the development of postresection spinal deformity...
  28. ncbi request reprint Fetal posterior fossa volume: assessment with MR imaging
    Sara C Chen
    Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Radiology 238:997-1003. 2006
    ..To retrospectively determine the relationship between posterior fossa volume (PFV) and estimated gestational age (EGA) and/or femur length (FL) during pregnancy for the purpose of developing a normal growth curve...
  29. ncbi request reprint Surgery with or without radiation therapy in the management of craniopharyngiomas in children and young adults
    Diana C H Stripp
    Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Int J Radiat Oncol Biol Phys 58:714-20. 2004
    ..The optimal management of craniopharyngiomas remains controversial, especially in children and young adults. This study reports a single institution's experience with such patients...
  30. ncbi request reprint Ventriculosagittal sinus shunt placement: technical case report
    Uzma Samadani
    Division of Neurosurgery, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Neurosurgery 53:778-9; discussion 780. 2003
    ..Determining an appropriate site for distal catheter placement for ventricular shunting for some hydrocephalic patients can be difficult. We describe a simplification of the technique for sagittal sinus shunt placement using a guidewire...
  31. pmc Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene
    Angela J Sievert
    Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Brain Pathol 19:449-58. 2009
    ..Further studies are required to determine the role of this fusion gene in downstream MAPK signaling and its role in development of pediatric low-grade astrocytomas...
  32. doi request reprint Endovascular and surgical treatment of ruptured cerebral aneurysms in pediatric patients
    Michael F Stiefel
    Department of Neurosurgery and Division of Interventional Neuroradiology, University of Pennsylvania Medical Center, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Neurosurgery 63:859-65; discussion 865-6. 2008
    ..Pediatric cerebral aneurysms are rare. There are very few recent studies that focus on the multidisciplinary treatment of ruptured aneurysms. We reviewed our pediatric endovascular and surgical experience with ruptured cerebral aneurysms...
  33. ncbi request reprint Intramedullary cervical spine germinoma: case report
    Jason H Huang
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Neurosurgery 55:1432. 2004
    ..We report an extremely rare case of primary intramedullary germinoma in the cervical spinal cord arising in an 18-year-old man who had not undergone previous surgery or irradiation...
  34. ncbi request reprint Childhood intracranial ependymoma: twenty-year experience from a single institution
    Hui Kuo G Shu
    Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 30322, USA
    Cancer 110:432-41. 2007
    ..In this article, they report their 20-year institutional experience with this disease...
  35. doi request reprint Chiari I malformation presenting with hearing loss: surgical treatment and literature review
    Gregory G Heuer
    Division of Neurosurgery, Children s Hospital of Philadelphia, Wood Center, 6th Floor, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA
    Childs Nerv Syst 24:1063-6. 2008
    ..Chiari I malformations can present with a number of clinical signs and symptoms...
  36. ncbi request reprint Conus medulla-cauda compression from nerve root hypertrophy in a child with Dejerine-Sottas syndrome: improvement with laminectomy and duraplasty. Case report
    Kleopas A Kleopa
    Division of Neurology, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    J Neurosurg 97:244-7. 2002
    ..Magnetic resonance imaging of the spine revealed nerve root hypertrophy resulting in compression of the conus medullaris and cauda equina. Decompressive surgery was successful in reversing some of his deficits...
  37. ncbi request reprint Anti-proliferative effects of 20-epi-vitamin-D3 analogue, KH1060 in human neuroblastoma: induction of RAR-beta and p21(Cip1)
    Kiranmai Gumireddy
    Department of Pediatrics, Brown University School of Medicine, Providence, RI 02905, USA
    Cancer Lett 190:51-60. 2003
    ..Taken together, all the six NB cells were more susceptible to growth inhibition by KH1060 than 1,25-D(3), suggesting its possible use in NB to potentiate the action of retinoids, which are in clinical use for this disease...
  38. ncbi request reprint Effect of 20-epi-1alpha,25-dihydroxyvitamin D3 on the proliferation of human neuroblastoma: role of cell cycle regulators and the Myc-Id2 pathway
    Kiranmai Gumireddy
    Department of Pediatrics, Brown University School of Medicine, Providence, RI 02905, USA
    Biochem Pharmacol 65:1943-55. 2003
    ..In sum, we show that 20-epi-1,25(OH)(2)D(3) exerts strong antiproliferative effects by regulating key growth control networks (Myc-Id2-pRB) in NB cells...
  39. ncbi request reprint Delayed cranial vault reconstruction for sagittal synostosis in older children: an algorithm for tailoring the reconstructive approach to the craniofacial deformity
    Jeffrey Weinzweig
    Department of Surgery, Brown University School of Medicine, Rhode Island Hospital, Providence, USA
    Plast Reconstr Surg 110:397-408. 2002
    ..However, it is essential that the extent of the deformity be carefully evaluated preoperatively to permit selection of the appropriate technique for reconstruction...
  40. ncbi request reprint Spina bifida
    Laura E Mitchell
    Institute of BioScience and Technology, The Texas A and M University System Health Science Center, TX 77030 3303, USA
    Lancet 364:1885-95. 2004
    ..Medical management is a lifelong necessity for individuals with spina bifida, and should be provided by a multidisciplinary team...