J Sutcliffe

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc TOGA: an automated parsing technology for analyzing expression of nearly all genes
    J G Sutcliffe
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 97:1976-81. 2000
  2. ncbi request reprint The hypocretins: excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding
    J G Sutcliffe
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci Res 62:161-8. 2000
  3. ncbi request reprint The hypocretins: setting the arousal threshold
    J Gregor Sutcliffe
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Rev Neurosci 3:339-49. 2002
  4. ncbi request reprint Not asleep, not quite awake
    J Gregor Sutcliffe
    Nat Med 10:673-4. 2004
  5. ncbi request reprint Mice lacking 5-HT receptors show specific impairments in contextual learning
    Amanda J Roberts
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Eur J Neurosci 19:1913-22. 2004
  6. ncbi request reprint 5-HT7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern
    Peter B Hedlund
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 58:831-7. 2005
  7. ncbi request reprint The hypocretins and sleep
    Luis de Lecea
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    FEBS J 272:5675-88. 2005
  8. ncbi request reprint Apolipoprotein D modulates arachidonic acid signaling in cultured cells: implications for psychiatric disorders
    Elizabeth A Thomas
    Department of Molecular Biology, The Scripps Research Institute, MB 10, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Prostaglandins Leukot Essent Fatty Acids 69:421-7. 2003
  9. ncbi request reprint Selective deficits in the expression of striatal-enriched mRNAs in Huntington's disease
    Paula A Desplats
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
    J Neurochem 96:743-57. 2006
  10. pmc The 5-HT7 receptor influences stereotypic behavior in a model of obsessive-compulsive disorder
    Peter B Hedlund
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neurosci Lett 414:247-51. 2007

Research Grants

  1. Gene Expression and Behavior in Mice
    J Gregor Sutcliffe; Fiscal Year: 2010
  2. GENE EXPRESSION IN RAT BRAIN
    J Sutcliffe; Fiscal Year: 2001
  3. GENE EXPRESSION IN RAT BRAIN
    J Sutcliffe; Fiscal Year: 2005
  4. Gene Expression and Behavior in Mice
    J Sutcliffe; Fiscal Year: 2007
  5. GENE EXPRESSION IN RAT BRAIN
    J Sutcliffe; Fiscal Year: 1992
  6. GENE EXPRESSION IN RAT BRAIN
    J Sutcliffe; Fiscal Year: 1993

Collaborators

Detail Information

Publications24

  1. pmc TOGA: an automated parsing technology for analyzing expression of nearly all genes
    J G Sutcliffe
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 97:1976-81. 2000
    ....
  2. ncbi request reprint The hypocretins: excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding
    J G Sutcliffe
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci Res 62:161-8. 2000
    ..These peptides appear to be part of a complex circuit that integrates aspects of energy metabolism, cardiovascular function, hormone homeostasis, and sleep-wake behaviors...
  3. ncbi request reprint The hypocretins: setting the arousal threshold
    J Gregor Sutcliffe
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Rev Neurosci 3:339-49. 2002
    ..The rapidity with which the hypocretin story has emerged is a testament to both the conceptual and the technical evolution of genomic science in the past two decades...
  4. ncbi request reprint Not asleep, not quite awake
    J Gregor Sutcliffe
    Nat Med 10:673-4. 2004
  5. ncbi request reprint Mice lacking 5-HT receptors show specific impairments in contextual learning
    Amanda J Roberts
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Eur J Neurosci 19:1913-22. 2004
    ..The results indicate an important role for the 5-HT(7) receptor in contextual hippocampal-dependent learning and suggest a possible neuronal correlate for such a role is present within the CA1 region of the hippocampus...
  6. ncbi request reprint 5-HT7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern
    Peter B Hedlund
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 58:831-7. 2005
    ....
  7. ncbi request reprint The hypocretins and sleep
    Luis de Lecea
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    FEBS J 272:5675-88. 2005
    ..Multiple lines of evidence suggest that the hypocretinergic system integrates homeostatic, metabolic and limbic information and provides a coherent output that results in stability of the states of vigilance...
  8. ncbi request reprint Apolipoprotein D modulates arachidonic acid signaling in cultured cells: implications for psychiatric disorders
    Elizabeth A Thomas
    Department of Molecular Biology, The Scripps Research Institute, MB 10, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Prostaglandins Leukot Essent Fatty Acids 69:421-7. 2003
    ..These results suggest that apoD acts to stabilize membrane-associated AA by preventing release and sequestering free AA in the cell. These actions of apoD may be beneficial to psychiatric patients...
  9. ncbi request reprint Selective deficits in the expression of striatal-enriched mRNAs in Huntington's disease
    Paula A Desplats
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
    J Neurochem 96:743-57. 2006
    ....
  10. pmc The 5-HT7 receptor influences stereotypic behavior in a model of obsessive-compulsive disorder
    Peter B Hedlund
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neurosci Lett 414:247-51. 2007
    ....
  11. pmc Searching for interferon-induced genes that inhibit hepatitis B virus replication in transgenic mouse hepatocytes
    Stefan F Wieland
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 77:1227-36. 2003
    ..We have already exploited this information by demonstrating that the antiviral activity of IFN-alpha/beta and IFN-gamma is proteasome dependent...
  12. pmc Inactivation of the 5-HT(7) receptor partially blocks phencyclidine-induced disruption of prepulse inhibition
    Svetlana Semenova
    Department of Psychiatry, University of California, San Diego, USA
    Biol Psychiatry 63:98-105. 2008
    ..Further, several antidepressant and antipsychotic drugs have high affinity for the 5-HT(7) receptor...
  13. ncbi request reprint Hypocretins/orexins as integrators of physiological information: lessons from mutant animals
    Luis de Lecea
    Departments of Molecular Biology and Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropeptides 36:85-95. 2002
    ..Here we review studies in humans and mutant animals that have provided clues about the functions of the hypocretinergic system, which appear to involve the coherent regulation of networks that dictate the states of arousal...
  14. ncbi request reprint Hypocretin is an early member of the incretin gene family
    Carlos E Alvarez
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neurosci Lett 324:169-72. 2002
    ..Our comparison of Hcrts to the most similar members of the incretin peptide superfamily leads us to conclude that HCRTs are indeed incretin paralogs that arose by a genetic circular permutation...
  15. ncbi request reprint Functional, molecular and pharmacological advances in 5-HT7 receptor research
    Peter B Hedlund
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Trends Pharmacol Sci 25:481-6. 2004
    ..Hypotheses driving current research indicate that this receptor might be involved in mood regulation, suggesting that the 5-HT7 receptor is a putative target in the treatment of depression...
  16. pmc Glycolipid and ganglioside metabolism imbalances in Huntington's disease
    Paula A Desplats
    Molecular Biology Department, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Neurobiol Dis 27:265-77. 2007
    ..These findings reveal novel disruptions in glycolipid/ganglioside metabolic pathways in the pathology of HD and suggest that the development of new targets to restore glycosphingolipid balance may act to ameliorate some symptoms of HD...
  17. ncbi request reprint Regulation of alpha-synuclein expression in limbic and motor brain regions of morphine-treated mice
    Barbara Ziolkowska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
    J Neurosci 25:4996-5003. 2005
    ..The observed changes in alpha-synuclein levels are discussed in connection with their putative role in mediating suppression of dopaminergic neurotransmission during opiate withdrawal...
  18. ncbi request reprint 8-OH-DPAT acts on both 5-HT1A and 5-HT7 receptors to induce hypothermia in rodents
    Peter B Hedlund
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Eur J Pharmacol 487:125-32. 2004
    ..3 mg/kg 8-OH-DPAT. Thus, both 5-HT(7) and 5-HT(1A) receptors are involved in a complex manner in thermoregulation, with the 5-HT(7) receptor being more important at lower, possibly more physiological, concentrations...
  19. ncbi request reprint A new UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase mRNA exhibits predominant expression in the hypothalamus, thalamus and amygdala of mouse forebrain
    P Austin Nelson
    Department of Molecular Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Brain Res Gene Expr Patterns 1:95-9. 2002
    ....
  20. ncbi request reprint Open system gene expression profiling and identification of novel genes for targeted vaccine delivery
    David Lo
    Digital Gene Technologies, Inc, La Jolla, CA 92037, USA
    Expert Rev Vaccines 1:95-100. 2002
    ..These receptors will be ideal for targeted delivery of new synthetic vaccines. In addition, gene expression profiling will provide important new information on the biology of the M-cell and mucosal immune mechanisms...
  21. ncbi request reprint Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotype
    Elizabeth A Thomas
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 54:136-41. 2003
    ..Progressive cognitive decline is the core clinical feature of AD and is associated with disturbances in the prefrontal cortex...
  22. ncbi request reprint The neurobiology of apolipoproteins in psychiatric disorders
    J Gregor Sutcliffe
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
    Mol Neurobiol 26:369-88. 2002
    ..Furthermore, the authors discuss the role of apoD in the pathology and pharmacotherapy of schizophrenia and bipolar disorder...
  23. ncbi request reprint Targeted disruption of RC3 reveals a calmodulin-based mechanism for regulating metaplasticity in the hippocampus
    Thomas Krucker
    Departments of Neuropharmacology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 22:5525-35. 2002
    ..We propose an mGluR-dependent CaM-based sliding threshold mechanism for metaplasticity that is governed by the phosphorylation states of RC3 and CaMKII...
  24. pmc Induction of Golli-MBP expression in CNS macrophages during acute LPS-induced CNS inflammation and experimental autoimmune encephalomyelitis (EAE)
    Tracey L Papenfuss
    Ohio State University, USA
    ScientificWorldJournal 7:112-20. 2007
    ..Taken altogether, these are consistent with the emerging picture that the phenotype of CNS macrophages is actively defined by their molecular interactions with the CNS microenvironment...

Research Grants20

  1. Gene Expression and Behavior in Mice
    J Gregor Sutcliffe; Fiscal Year: 2010
    ..The identities of the genes responsible for the QTs offer a powerful point of departure for the development of new pharmaceuticals to treat depression. ..
  2. GENE EXPRESSION IN RAT BRAIN
    J Sutcliffe; Fiscal Year: 2001
    ..We will test the promoters for anatomically restricted genes in transgenic mice and the effect of cAMP in oligodendrocyte inactivation. ..
  3. GENE EXPRESSION IN RAT BRAIN
    J Sutcliffe; Fiscal Year: 2005
    ....
  4. Gene Expression and Behavior in Mice
    J Sutcliffe; Fiscal Year: 2007
    ..The identities of the genes responsible for the QTs offer a powerful point of departure for the development of new pharmaceuticals to treat depression. ..
  5. GENE EXPRESSION IN RAT BRAIN
    J Sutcliffe; Fiscal Year: 1992
    ..Antisera to these peptides will be used to describe the biochemical features and anatomical locations of the protein. 7) We will measure the relative portion of brain mRNA whose expression has postnatal onset...
  6. GENE EXPRESSION IN RAT BRAIN
    J Sutcliffe; Fiscal Year: 1993
    ..We will test the promoters for anatomically restricted genes in transgenic mice and the effect of cAMP in oligodendrocyte inactivation...