Saul Suster

..Synovial sarcoma should be considered in the differential diagnosis of biphasic and monophasic spindle cell neoplasms of the mediastinum...

..The histologic features and diagnostic criteria used for distinguishing among these conditions can often be subtle and subjective...

..Herein, the current status of malignant mesothelioma diagnosis is reviewed, including the possible contributions of modern molecular techniques for their diagnosis...

..Diffuse pulmonary meningotheliomatosis should be considered in the clinical differential diagnosis of diffuse interstitial pulmonary infiltrates...

..Thus, miR-1 has potential therapeutic application against lung cancers...

..Recognition of this growth pattern is important for prognosis and avoiding misdiagnosis with papillary renal cell carcinoma and other tumors...

..The study herein described highlights that all thymomas had the potential to become invasive tumors...

..This panel may additionally be of assistance in the diagnosis of myofibroblastic sarcoma...

..Awareness of such features and their recognition are of importance to avoid a misdiagnosis of malignancy...

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..We suggest that NAMA is a noncoding RNA associated with growth arrest...

..Sclerosing paraganglioma should be included in the differential diagnosis of sclerosing lesions of the head and neck region and mediastinum. Appropriate immunohistochemical stains may be of aid for establishing the correct diagnosis...

..At present, it appears that treatment by complete surgical resection with negative margins alone is appropriate and adequate...

..Gene expression analysis indicated that AK023948 is significantly down-regulated in most PTC tumors. The putative noncoding RNA gene AK023948 is a candidate susceptibility gene for PTC...

..044 and .016 for overall and recurrence-free survival, respectively. We consider that our proposed staging system offers better stratification of cases and improved histologic definitions for proper staging of cases of thymoma...

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..We highlight the importance of recognizing the phenomenon of rebound thymic hyperplasia, as it can mimic residual or recurrent malignancy, especially in the setting of altered chest anatomy...

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..Overall, the general trend for these LS subsets is progressive disease, metastatic disease for ML and PL with a much shorter interval for PL, and metastatic disease and local recurrence for DDL...

..Two patients remain alive and well after follow-up ranging from 6 to 18 months and 1 patient died of tumor 18 years after initial diagnosis...

..The cases herein described highlight the importance of recognizing this unusual pattern of spindle cell thymomas to avoid misdiagnosis with other tumors, namely, when dealing with small mediastinoscopic biopsies...

..This review will focus on pulmonary histiocytic proliferations of uncertain histogenesis. Other histiocytic lesions will be dealt with in brief...

..Immunohistochemical and ultrastructural studies may be of aid in identifying the characteristic features of mesothelial cells and to avoid mistaking this lesion for more ominous conditions...

..However, CDX2 is not a sensitive marker for poorly differentiated colorectal carcinoma...

..The authors' experience was reviewed at a large academic medical center over a 30-year period (1971-2000) with metastases to soft tissue...

..Neurogenic tumors should be added in the differential diagnosis of spindle cell tumors capable of displaying prominent signet-ring cell features...

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..Herein we review current concepts regarding the classification of these neoplasms and the role of this classification in our daily practice and discuss how it may impact treatment...

..Pulmonary artery sarcoma is an uncommon entity with a poor prognosis. The role of early diagnosis, histologic classification, surgical treatment, and adjuvant therapy in patient outcome is discussed...

..Evidence-based pathology promotes the use of systematic reviews of literature and meta-analysis of data to synthesize the results of multiple publications...

..We conclude that up-regulation of several miRs and regulation of KIT are involved in PTC pathogenesis, and that sequence changes in genes targeted by miRNAs can contribute to their regulation...

..The extensive myxoid/signet ring cell change represents a heretofore-unreported histologic variant of gastric schwannoma...

..To our knowledge, this is the first report that describes the computed tomographic features of this rare lesion...

..No follow-up information was obtained in 4 patients. The current morphologic appearance has not been previously emphasized in thymomas, which is important to recognize to avoid misdiagnosis with other mediastinal neoplasms...

..Immunohistochemically, the tumor cells showed strong positive reactions for keratin and neuroendocrine markers, ie, chromogranin and synaptophysin. Both patients were alive after periods of 12 and 18 months...

..This growth inhibition is associated with alterations in cell cycle progression and the induction of apoptosis...

..Myofibroma involving the jaw bones represents a unique diagnostic and therapeutic challenge, and accurate diagnosis and management is predicated on careful correlation of radiographic and pathologic findings...

..The designation "malignant gastrointestinal neuroectodermal tumor" is proposed for this tumor type...

..Although these lesions are not part of the gamut of neoplastic conditions affecting the lung, they are nonetheless important to recognize, as their outcome may not necessarily be an innocuous one...

..The present cases highlight the ubiquitous distribution of soft tissue giant cell tumors and the importance of considering these tumors in the differential diagnosis of posterior mediastinal neoplasms...

..Close clinical correlation and appropriate treatment are important to improve the survival rate in this group of patients...

..We propose replacing the term testicular carcinoid with neuroendocrine carcinoma, which better reflects the nature of these neoplasms...

..This review will focus on current criteria for diagnosis of these tumors, with a review of the various histopathologic appearances that they can adopt...

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..The purpose of this review is to address these problem areas, in particular as it relates to terminology, histopathologic criteria for diagnosis, and the prognostic significance for the various categories of the WHO schema...

..The base of the lesion showed features of adenomyomatous hyperplasia. The possible relationships of this lesion with adenomyomatous hyperplasia and other stromal lesions of the gallbladder are reviewed...

..Examination of the areas of disagreement reveals significant opportunities for collaborative study to resolve unanswered questions...

..The present cases highlight an important histopathologic feature of thymomas, which can pose problems in diagnosis, namely when dealing with small mediastinoscopic biopsy specimens...

..We review the current status of thymoma classification and comment on problem areas and future trends that may offer a more pragmatic approach to these tumors...

..Recognition of the different patterns of LCH, particularly cases with subtle involvement, is important for recognizing this disease and separating LCH from other more common causes of lymphadenopathy...

..All the tumors examined showed variable positive reaction for those antibodies. The cases highlight the importance of keeping primary parathyroid tumors in the differential diagnosis of anterior mediastinal tumors...

..The possible relationship of the rhabdomyomatous component of this tumor with the myoid cells of the thymus is discussed...

..Both cases highlight the ubiquitous distribution of ALHE/EH and underscore the importance of keeping these lesions in the differential diagnosis of vascular and lymphoid lesions of the lung...

..Recognition of this unusual morphologic appearance is of importance to avoid mistaking these lesions for other types of malignant neoplasm...

..These data have demonstrated the growth-suppressor characteristics of PTPRO that are unique to a classical tumor suppressor...

..These cases highlight an unusual phenomenon, that of primary papillary carcinomas of the lung with a prominent morular component...

..The purpose of this study was to test the hypothesis that PPARgamma ligand therapy might inhibit tumor growth and progression in human breast cancer...

..A review of the literature with a discussion of the histologic and radiologic differential diagnosis of these lesions is presented...

..001). On the basis of our findings, the presence of SC appears to represent a poor prognostic sign for GCTs of gonadal and extragonadal origin...

..Dirty necrosis was a constant histologic finding in intestine mucinous carcinomas involving the skin, and this feature may serve as a clue to an intestinal origin...

..The sarcomatous component in this case is most consistent with a poorly differentiated follicular dendritic cell sarcoma based upon the morphologic and ultrastructural findings...

..We conclude that myxoinflammatory fibroblastic sarcoma is a distinct soft tissue tumor of low-grade malignancy and, until now, described only in extremities, although not confined to acral sites...

..A large number of histologic variants have been described. In general, these tumors remain a diagnosis of exclusion and, as a group, represent high-grade neoplasms with a very aggressive clinical behavior and an often-ominous prognosis...