John P Sundberg

Summary

Affiliation: The Jackson Laboratory
Country: USA

Publications

  1. pmc Ancient papillomavirus-host co-speciation in Felidae
    Annabel Rector
    Laboratory of Clinical and Epidemiological Virology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    Genome Biol 8:R57. 2007
  2. pmc Avian papillomaviruses: the parrot Psittacus erithacus papillomavirus (PePV) genome has a unique organization of the early protein region and is phylogenetically related to the chaffinch papillomavirus
    Ruth Tachezy
    Department of Experimental Virology, Instittute of Hematology and Blood Transfusion, Prague, Czech Republic
    BMC Microbiol 2:19. 2002
  3. ncbi request reprint Analysis of hair follicles in mutant laboratory mice
    John P Sundberg
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    J Investig Dermatol Symp Proc 10:264-70. 2005
  4. ncbi request reprint Mouse alopecia areata models: an array of data on mechanisms and genetics
    John P Sundberg
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    J Investig Dermatol Symp Proc 8:173-5. 2003
  5. ncbi request reprint Major locus on mouse chromosome 17 and minor locus on chromosome 9 are linked with alopecia areata in C3H/HeJ mice
    John P Sundberg
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    J Invest Dermatol 120:771-5. 2003
  6. ncbi request reprint Adult-onset Alopecia areata is a complex polygenic trait in the C3H/HeJ mouse model
    John P Sundberg
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    J Invest Dermatol 123:294-7. 2004
  7. pmc Development, structure, and keratin expression in C57BL/6J mouse eccrine glands
    D K Taylor
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 1500, USA
    Vet Pathol 49:146-54. 2012
  8. ncbi request reprint Development and progression of psoriasiform dermatitis and systemic lesions in the flaky skin (fsn) mouse mutant
    J P Sundberg
    Jackson Laboratory, Bar Harbor, ME 04609 1500, USA
    Pathobiology 65:271-86. 1997
  9. ncbi request reprint Animal models for male pattern (androgenetic) alopecia
    J P Sundberg
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 1500, USA
    Eur J Dermatol 11:321-5. 2001
  10. pmc Asebia-2J (Scd1(ab2J)): a new allele and a model for scarring alopecia
    J P Sundberg
    Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    Am J Pathol 156:2067-75. 2000

Detail Information

Publications90

  1. pmc Ancient papillomavirus-host co-speciation in Felidae
    Annabel Rector
    Laboratory of Clinical and Epidemiological Virology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    Genome Biol 8:R57. 2007
    ....
  2. pmc Avian papillomaviruses: the parrot Psittacus erithacus papillomavirus (PePV) genome has a unique organization of the early protein region and is phylogenetically related to the chaffinch papillomavirus
    Ruth Tachezy
    Department of Experimental Virology, Instittute of Hematology and Blood Transfusion, Prague, Czech Republic
    BMC Microbiol 2:19. 2002
    ..The nucleotide sequence, genome organization, and phylogenetic position of the Psittacus erithacus papillomavirus (PePV) were determined. This PePV sequence represents the first complete avian papillomavirus genome defined...
  3. ncbi request reprint Analysis of hair follicles in mutant laboratory mice
    John P Sundberg
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    J Investig Dermatol Symp Proc 10:264-70. 2005
    ..A variety of systematic approaches to analysis of the pilosebacous unit are provided here...
  4. ncbi request reprint Mouse alopecia areata models: an array of data on mechanisms and genetics
    John P Sundberg
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    J Investig Dermatol Symp Proc 8:173-5. 2003
    ..Regardless of some of the controversies, much insight has been gained from studying these and other rodent and domestic animal models which has opened up new ideas and discussions of AA and its treatment...
  5. ncbi request reprint Major locus on mouse chromosome 17 and minor locus on chromosome 9 are linked with alopecia areata in C3H/HeJ mice
    John P Sundberg
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    J Invest Dermatol 120:771-5. 2003
    ..0) around D9Mit206, 20 cM from the centromere. The interval on mouse Chromosome 17 contains several orthologous genes potentially associated with human alopecia areata...
  6. ncbi request reprint Adult-onset Alopecia areata is a complex polygenic trait in the C3H/HeJ mouse model
    John P Sundberg
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    J Invest Dermatol 123:294-7. 2004
    ..These results indicate the necessity of integrating both gene association and genome-wide linkage studies in both mice and humans to understand the complex nature of these and other polygenic diseases...
  7. pmc Development, structure, and keratin expression in C57BL/6J mouse eccrine glands
    D K Taylor
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 1500, USA
    Vet Pathol 49:146-54. 2012
    ..These data serve as a valuable reference for investigators who use genetically engineered mice for skin research...
  8. ncbi request reprint Development and progression of psoriasiform dermatitis and systemic lesions in the flaky skin (fsn) mouse mutant
    J P Sundberg
    Jackson Laboratory, Bar Harbor, ME 04609 1500, USA
    Pathobiology 65:271-86. 1997
    ..This spontaneous mouse mutation provides a useful model for modulating neovascularization and keratinocyte hyperproliferation, especially since the cutaneous changes resemble some forms of psoriasis in humans...
  9. ncbi request reprint Animal models for male pattern (androgenetic) alopecia
    J P Sundberg
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 1500, USA
    Eur J Dermatol 11:321-5. 2001
    ....
  10. pmc Asebia-2J (Scd1(ab2J)): a new allele and a model for scarring alopecia
    J P Sundberg
    Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    Am J Pathol 156:2067-75. 2000
    ....
  11. ncbi request reprint Lanceolate hair-J (lahJ): a mouse model for human hair disorders
    J P Sundberg
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    Exp Dermatol 9:206-18. 2000
    ..Homozygotes for either of these allelic mouse mutations have elevated serum IgE levels, a feature also common with human Netherton's syndrome...
  12. ncbi request reprint Morphology of hair in normal and mutant laboratory mice
    J P Sundberg
    Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 1500, USA
    Eur J Dermatol 11:357-61. 2001
    ..Examples of characterized mutant mice with abnormal pilosebaceous unit phenotypes are presented to illustrate the value of these animals as models to help understand human diseases of the skin and hair...
  13. ncbi request reprint Feline papillomas and papillomaviruses
    J P Sundberg
    The Jackson Laboratory, Bar Harbor, ME 04609 1500, USA
    Vet Pathol 37:1-10. 2000
    ..domesticus, FdPV-1; and snow leopard, P. uncia, PuPV-2)...
  14. pmc Restricted MHC-peptide repertoire predisposes to autoimmunity
    Nadezda N Logunova
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Exp Med 202:73-84. 2005
    ..Our findings may help to explain the link between MHC class I responses that are involved in major autoimmune diseases and the well-established genetic linkage of these diseases with MHC class II...
  15. doi request reprint Chronic proliferative dermatitis in Sharpin null mice: development of an autoinflammatory disease in the absence of B and T lymphocytes and IL4/IL13 signaling
    Christopher S Potter
    The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS ONE 9:e85666. 2014
    ..Both the cutaneous and systemic inflammation is enhanced by loss of IL4 and IL13 signaling indicating that these cytokines normally play an anti-inflammatory role in SHARPIN-deficient mice...
  16. ncbi request reprint Cdcs1, a major colitogenic locus in mice, regulates innate and adaptive immune response to enteric bacterial antigens
    Jason Beckwith
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    Gastroenterology 129:1473-84. 2005
    ..We developed reciprocal Cdcs1 congenic stocks on both interleukin 10-deficient backgrounds to identify the susceptibility gene and its function...
  17. pmc A mouse model of generalized non-Herlitz junctional epidermolysis bullosa
    Jason A Bubier
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    J Invest Dermatol 130:1819-28. 2010
    ..This model faithfully recapitulates human JEB and provides an important preclinical tool to test therapeutic approaches...
  18. pmc The C3H/HeJ mouse and DEBR rat models for alopecia areata: review of preclinical drug screening approaches and results
    Jing Sun
    The Jackson Laboratory, Bar Harbor, ME 04609 1500, USA
    Exp Dermatol 17:793-805. 2008
    ..Some drugs commonly used to treat human AA patients work equally as well in both rodent models validating their usefulness as models for drug efficacy and safety for humanAA...
  19. pmc The Mouse Tumor Biology database
    Debra M Krupke
    Jackson Laboratory, Mouse Tumour Biology Database, 600 Main Street, Bar Harbor, Maine 04609, USA
    Nat Rev Cancer 8:459-65. 2008
    ..Tools to integrate, locate and visualize these data are crucial to aid researchers in their investigations. The Mouse Tumor Biology database (http://tumor.informatics.jax.org) seeks to address that need...
  20. pmc Loss of function of the mouse Sharpin gene results in Peyer's patch regression
    Rosemarie Seymour
    The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS ONE 8:e55224. 2013
    ..These findings indicate that SHARPIN expression is required for the normal development and maintenance, but not initiation, of PP...
  21. pmc A direct method to determine the strength of the dermal-epidermal junction in a mouse model for epidermolysis bullosa
    Thomas J Sproule
    The Jackson Laboratory, Bar Harbor, ME, USA
    Exp Dermatol 21:453-5. 2012
    ....
  22. doi request reprint Comparisons of mouse models for hair follicle reconstitution
    Yanhua Liang
    The Jackson Laboratory, Bar Harbor, ME, USA
    Exp Dermatol 20:1011-5. 2011
    ..The chamber assay was the most labour-intensive and cell number-dependent procedure but follicles developed in a dense, clinically normal manner...
  23. pmc Proteotypic classification of spontaneous and transgenic mammary neoplasms
    Igor Mikaelian
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Breast Cancer Res 6:R668-79. 2004
    ....
  24. ncbi request reprint Training mouse pathologists: five years of pathology of mouse models of human disease workshops
    John P Sundberg
    The Jackson Laboratory, Bar Harbor, ME 04609 1500, USA
    Toxicol Pathol 35:447-8. 2007
  25. pmc A mouse by any other name
    John P Sundberg
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Invest Dermatol 129:1599-601. 2009
    ..This is both an educational and a regulatory task, one in which it is vital to succeed if we are to efficiently and accurately share and use the huge volume of data emerging in the biosciences...
  26. doi request reprint Skin diseases in laboratory mice: approaches to drug target identification and efficacy screening
    John P Sundberg
    The Jackson Laboratory, Bar Harbor, ME, USA
    Methods Mol Biol 602:193-213. 2010
    ..Basic approaches to handling mice, applying compounds, and quantifying effects of the treatment are presented...
  27. doi request reprint The Cinderella effect: searching for the best fit between mouse models and human diseases
    John P Sundberg
    The Jackson Laboratory, Bar Harbor, Maine, USA
    J Invest Dermatol 133:2509-13. 2013
    ..Closely coordinated human and model organism studies are essential to provide traction for translational research. ..
  28. ncbi request reprint Alopecia areata: updates from the mouse perspective
    John P Sundberg
    1 Department of Research, The Jackson Laboratory, Bar Harbor, Maine, USA 2 Division of Dermatology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Investig Dermatol Symp Proc 16:S23-4. 2013
    ..Comparing these model systems with human and mouse clinical disease, for both discovery and validation of the discoveries, continues to resolve the complex questions surrounding AA. ..
  29. pmc Mouse Tumor Biology Database (MTB): status update and future directions
    Dale A Begley
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, USA
    Nucleic Acids Res 35:D638-42. 2007
    ..A new pathology data submission tool allows users to submit, edit and release data to the MTB system...
  30. pmc Recombinant human hepatitis B vaccine initiating alopecia areata: testing the hypothesis using the C3H/HeJ mouse model
    John P Sundberg
    The Jackson Laboratory, Bar Harbor, ME 04609 1500, USA
    Vet Dermatol 20:99-104. 2009
    ....
  31. ncbi request reprint Resistance to alopecia areata in C3H/HeJ mice is associated with increased expression of regulatory cytokines and a failure to recruit CD4+ and CD8+ cells
    Kevin J McElwee
    Department of Dermatology, Philipp University, Marburg, Germany The Jackson Laboratory, Bar Harbor, ME, USA
    J Invest Dermatol 119:1426-33. 2002
    ....
  32. ncbi request reprint The Mouse Tumor Biology Database: a public resource for cancer genetics and pathology of the mouse
    Dieter Naf
    Mouse Genome Informatics, The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Cancer Res 62:1235-40. 2002
    ..We outline current content, data acquisition strategies, and query mechanisms for MTB. MTB is accessible on-line at http://tumor.informatics.jax.org...
  33. doi request reprint Molecular identification of collagen 17a1 as a major genetic modifier of laminin gamma 2 mutation-induced junctional epidermolysis bullosa in mice
    Thomas J Sproule
    The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS Genet 10:e1004068. 2014
    ..Overall the results provide an explanation for how normally innocuous allelic variants can act epistatically with a disease causing mutation to impact the severity of a rare, heritable mechanobullous disorder. ..
  34. pmc Rhabdomyosarcomas in aging A/J mice
    Roger B Sher
    The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS ONE 6:e23498. 2011
    ..These studies suggest that A strains of mice can be useful models for dissecting the molecular genetic basis for development, progression, and ultimately for testing novel anticancer therapeutic agents dealing with rhabdomyosarcoma...
  35. ncbi request reprint Role of COL4A1 in small-vessel disease and hemorrhagic stroke
    Douglas B Gould
    Howard Hughes Medical Institute, Bar Harbor, ME, USA
    N Engl J Med 354:1489-96. 2006
    ..We concluded that mutation of COL4A1 may cause a spectrum of cerebrovascular phenotypes and that persons with COL4A1 mutations may be predisposed to hemorrhage, especially after environmental stress...
  36. ncbi request reprint Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration
    Jeong Woong Lee
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Nature 443:50-5. 2006
    ..These findings demonstrate that disruption of translational fidelity in terminally differentiated neurons leads to the accumulation of misfolded proteins and cell death, and provide a novel mechanism underlying neurodegeneration...
  37. pmc Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity
    Peter B Stranges
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Immunity 26:629-41. 2007
    ..Thus, Fas-dependent elimination of APCs is a major regulatory mechanism curbing autoimmune responses and acts in concert with Fas-mediated regulation of chronically activated autoimmune T cells...
  38. doi request reprint Early gene expression differences in inbred mouse strains with susceptibility to pulmonary adenomas
    Timothy M Stearns
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Exp Mol Pathol 93:455-61. 2012
    ..Finally, the identified genes have previously been reported for human non-small cell lung cancer suggesting that molecular pathways may be shared between these two cancer types...
  39. pmc Inhibition of NF-κB signaling retards eosinophilic dermatitis in SHARPIN-deficient mice
    Yanhua Liang
    The Jackson Laboratory, Bar Harbor, Maine, USA
    J Invest Dermatol 131:141-9. 2011
    ..These results indicate that absence of SHARPIN causes IHES with eosinophilic dermatitis by NF-κB activation, and bortezomib may be an effective treatment for skin problems of IHES...
  40. pmc Integrating mouse anatomy and pathology ontologies into a phenotyping database: tools for data capture and training
    John P Sundberg
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 1500, USA
    Mamm Genome 19:413-9. 2008
    ..MoDIS is an open source and freely available program (http://research.jax.org/faculty/sundberg/index.html). This provides a valuable tool for setting up a mouse pathology phenotyping program...
  41. ncbi request reprint Absence of CD5 dramatically reduces progression of pulmonary inflammatory lesions in SHP-1 protein-tyrosine phosphatase-deficient 'viable motheaten' mice
    Melissa J Joliat
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Autoimmun 18:105-17. 2002
    ..Study of CD5(null)me(v)/ me(v) mice may provide further insight into the role of CD5 in cell signaling and may help explain the observed association of CD5(+) B-cells with autoimmune disease...
  42. pmc Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels
    Rong Yuan
    The Jackson Aging Center at The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Aging Cell 8:277-87. 2009
    ..53, P < 0.01). These results support the hypothesis that the IGF1 pathway plays a key role in regulating longevity in mice and indicates that common genetic mechanisms may exist for regulating IGF1 levels and lifespan...
  43. pmc Surgical methods for full-thickness skin grafts to induce alopecia areata in C3H/HeJ mice
    Kathleen A Silva
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Comp Med 63:392-7. 2013
    ..This standard protocol can be used for many other purposes when studying abnormal skin phenotypes in laboratory mice. ..
  44. pmc R164C mutation in FOXQ1 H3 domain affects formation of the hair medulla
    Baojin Wu
    The Jackson Laboratory, Bar Harbor, ME, USA Laboratory of Experimental Animal Science, Hangzhou Normal University, Hangzhou, China
    Exp Dermatol 22:234-6. 2013
    ..Morphologic changes were similar to those seen in Hoxc13 transgenic and targeted mutant mice. This new allelic mutation provides yet another tool to investigate formation of the interior structures of hair shafts...
  45. ncbi request reprint Developing a comprehensive mouse pathology program
    John P Sundberg
    The Jackson Laboratory, Bar Harbor, Maine 04679 1500, USA
    Comp Med 54:617-21. 2004
  46. ncbi request reprint Antibodies that label paraffin-embedded mouse tissues: a collaborative endeavor
    Igor Mikaelian
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    Toxicol Pathol 32:181-91. 2004
    ..Regularly updated information on immunohistochemistry of normal and neoplastic mouse tissues is accessible online at (http://tumor.informatics.jax.org); links to antibody suppliers' web sites are provided...
  47. ncbi request reprint Aberrant actin cytoskeleton leads to accelerated proliferation of corneal epithelial cells in mice deficient for destrin (actin depolymerizing factor)
    Sakae Ikeda
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Hum Mol Genet 12:1029-37. 2003
    ..Our results suggest an in vivo connection between remodeling of the actin cytoskeleton and the control of cell proliferation, and a new pathway through which an aberrant actin cytoskeleton can cause epithelial hyperproliferation...
  48. ncbi request reprint Intraocular teratoma in a mouse
    Richard S Smith
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Comp Med 52:68-72. 2002
    ..Many normal intraocular structures were absent. To our knowledge, this represents the first reported intraocular teratoma in a mouse...
  49. ncbi request reprint Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris
    Ana Kljuic
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Cell 113:249-60. 2003
    ..We provide evidence that desmoglein 4 is a key mediator of keratinocyte cell adhesion in the hair follicle, where it coordinates the transition from proliferation to differentiation...
  50. doi request reprint Alopecia areata
    Lloyd E King
    Division of Dermatology, Vanderbilt University Medical Center, Nashville, TN 37203, USA
    Curr Dir Autoimmun 10:280-312. 2008
    ..Other organ specific autoimmune diseases will surely benefit from the rapid progress in understanding AA...
  51. pmc A position effect on TRPS1 is associated with Ambras syndrome in humans and the Koala phenotype in mice
    Katherine A Fantauzzo
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Hum Mol Genet 17:3539-51. 2008
    ..Collectively, these results describe a position effect that downregulates TRPS1 expression as the probable cause of hypertrichosis in AS in humans and the Koa phenotype in mice...
  52. ncbi request reprint Mice expressing a mutant Krt75 (K6hf) allele develop hair and nail defects resembling pachyonychia congenita
    Jiang Chen
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    J Invest Dermatol 128:270-9. 2008
    ....
  53. ncbi request reprint Glycerol regulates stratum corneum hydration in sebaceous gland deficient (asebia) mice
    Joachim W Fluhr
    Dermatology Services, Veterans Administration Medical Center, and Department of Dermatology University of California, San Francisco, California, USA
    J Invest Dermatol 120:728-37. 2003
    ..These results show that sebaceous-gland-derived glycerol is a major contributor to stratum corneum hydration...
  54. ncbi request reprint Topical mechlorethamine restores autoimmune-arrested follicular activity in mice with an alopecia areata-like disease by targeting infiltrated lymphocytes
    Liren Tang
    Division of Dermatology, Department of Surgery, University of British Columbia and Vancouver General Hospital, Vancouver, Canada
    J Invest Dermatol 120:400-6. 2003
    ..Our findings support that mechlorethamine restores follicular activity by selectively targeting infiltrated lymphocytes in vivo in alopecia-areata-affected mice...
  55. ncbi request reprint Vitamin D(3) receptor ablation sensitizes skin to chemically induced tumorigenesis
    Glendon M Zinser
    Department of Biology, University of Notre Dame, IN 46556, USA
    Carcinogenesis 23:2103-9. 2002
    ....
  56. ncbi request reprint 'Cyclic alopecia' in Msx2 mutants: defects in hair cycling and hair shaft differentiation
    Liang Ma
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Development 130:379-89. 2003
    ..Thus, the combinatorial defects in hair cycling and differentiation, together with concealed skin domains, account for the cyclic alopecia phenotype...
  57. pmc Targeted ablation of the abcc6 gene results in ectopic mineralization of connective tissues
    John F Klement
    Department of Dermatology, Jefferson Medical College, 233 S 10th Street, Suite 322 BLSB, Philadelphia, PA 19107, USA
    Mol Cell Biol 25:8299-310. 2005
    ..These data demonstrate aberrant mineralization of soft tissues in PXE-affected organs, and, consequently, these mice recapitulate features of this complex disease...
  58. ncbi request reprint Genetics of colitis susceptibility in IL-10-deficient mice: backcross versus F2 results contrasted by principal component analysis
    Michael Mahler
    Institute for Laboratory Animal Science and Central Animal Facility, Medical School Hannover, Germany
    Genomics 80:274-82. 2002
    ..These findings show the complexity of inheritance underlying susceptibility to colitis and illustrate why detection of human inflammatory bowel disease loci has proven to be so difficult...
  59. ncbi request reprint Gene array profiling and immunomodulation studies define a cell-mediated immune response underlying the pathogenesis of alopecia areata in a mouse model and humans
    Joseph M Carroll
    Genetics Institute Wyeth Research, Cambridge, Massachusetts, USA
    J Invest Dermatol 119:392-402. 2002
    ....
  60. doi request reprint Klebsiella oxytoca: opportunistic infections in laboratory rodents
    Andre Bleich
    Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Lab Anim 42:369-75. 2008
    ..In conclusion, K. oxytoca is an opportunistic pathogen capable of inducing pathological lesions in different rodent species...
  61. ncbi request reprint The ichq mutant mouse, a model for the human skin disorder harlequin ichthyosis: mapping, keratinocyte culture, and consideration of candidate genes involved in epidermal growth regulation
    Martine Dunnwald
    Department of Oral Biology, University of Washington, Seattle, WA, USA
    Exp Dermatol 12:245-54. 2003
    ..Sequence of RELA in five unrelated human HI cases was normal. The results provide compelling evidence that none of these genes are the primary defect in the ichq mouse and that CAPN1 and RELA are not mutated in the human disorder...
  62. ncbi request reprint Development and progression of alopecia in the vitamin D receptor null mouse
    Daniel D Bikle
    Department of Medicine, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, USA
    J Cell Physiol 207:340-53. 2006
    ..These changes are associated with increased expression of Hr, suggesting a role for VDR in regulating Hr expression. Both Hr and VDR are required for normal hair follicle cycling...
  63. pmc Pathbase: a database of mutant mouse pathology
    Paul N Schofield
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Nucleic Acids Res 32:D512-5. 2004
    ..The database interface is designed to have optimal browser and platform compatibility and to interact directly with other web-based mouse genetic resources...
  64. ncbi request reprint Reduced expression of interleukin-2 decreases the frequency of alopecia areata onset in C3H/HeJ mice
    Pia Freyschmidt-Paul
    Department of Dermatology, Philipp University, Marburg, Germany
    J Invest Dermatol 125:945-51. 2005
    ..Taken together, our data suggest that AA resistance of IL-2+/- mice is because of the failure of activated leukocyte recruitment, thus pointing toward an involvement of IL-2 in AA pathogenesis...
  65. ncbi request reprint Restoration of hair growth with topical diphencyprone in mouse and rat models of alopecia areata
    Liren Tang
    Division of Dermatology, University of British Columbia, Vancouver Hospital and Health Sciences Center, 835 W 10th Avenue, Vancouver, BC, Canada V5Z 4E8
    J Am Acad Dermatol 49:1013-9. 2003
    ..The contact sensitizer, diphencyprone (DPCP), is one of the most effective therapies for the more severe forms of alopecia areata (AA)...
  66. ncbi request reprint Targeted deletion of the sciellin gene resulted in normal development and maturation
    Howard P Baden
    Department of Dermatology, Cutaneous Biology Research Center, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    Genesis 42:219-28. 2005
    ..We conclude that sciellin null mice had no structural anomalies and the transgenic mice did not act as a dominant-negative mutation...
  67. ncbi request reprint Characterization of the progressive skin disease and inflammatory cell infiltrate in mice with inhibited NF-kappaB signaling
    Max van Hogerlinden
    Department of Bioscience at Novum, Karolinska Institutet, Novum, Huddinge, Sweden
    J Invest Dermatol 123:101-8. 2004
    ..This genetically engineered mouse mutation may be a useful tool to test the efficacy of cytokine therapies for SCC in the future...
  68. ncbi request reprint Refined histopathologic scoring system improves power to detect colitis QTL in mice
    Andre Bleich
    Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, 30625 Hannover, Germany
    Mamm Genome 15:865-71. 2004
    ....
  69. ncbi request reprint Pathbase: a new reference resource and database for laboratory mouse pathology
    Paul N Schofield
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Radiat Prot Dosimetry 112:525-8. 2004
    ..The database currently has over 1000 images on-line with 2000 more under curation and presents a paradigm for the development of future databases dedicated to aspects of experimental biology...
  70. ncbi request reprint Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis
    Kristin M Braun
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 130:5241-55. 2003
    ..We conclude that LRC are more sensitive to some proliferative stimuli than others and that changes in lineage can occur with or without recruitment of LRC into cycle...
  71. ncbi request reprint Expression of chitinase-like proteins in the skin of chronic proliferative dermatitis (cpdm/cpdm) mice
    Harm HogenEsch
    Department of Veterinary Pathobiology, Purdue University, 725 Harrison Street, West Lafayette, IN 47907, USA
    Exp Dermatol 15:808-14. 2006
    ..Eosinophils and neutrophils did not contain detectable concentrations of these proteins. Treatment of macrophages and mast cells in vitro with interleukin-4 induced expression of Chi3l3 and Chi3l4 mRNA...
  72. ncbi request reprint Increased expression of chemokines in the skin of chronic proliferative dermatitis mutant mice
    Matthew L Renninger
    Department of Veterinary Pathobiology, Purdue University, West Lafayette, IN 47907, USA
    Exp Dermatol 14:906-13. 2005
    ..The cpdm/cpdm mutant mouse is a potentially useful model to determine the role of various chemokines in eosinophil accumulation in chronic inflammation...
  73. ncbi request reprint Animal and in vitro models for the study of hair follicles
    Valerie A Randall
    Department of Biomedical Sciences, University of Bradford, Bradford, West Yorkshire BD7 1DP UK
    J Investig Dermatol Symp Proc 8:39-45. 2003
    ..Each system has advantages and disadvantages for studying particular aspects of follicular function and some are potentially useful for the development of novel treatments for hair disorders...
  74. ncbi request reprint Immunolocalization of enzymes, binding proteins, and receptors sufficient for retinoic acid synthesis and signaling during the hair cycle
    Helen B Everts
    Department of Biochemistry, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Invest Dermatol 127:1593-604. 2007
    ..This complex pattern of RA biosynthesis and signaling identified by immunolocalization suggests that endogenous RA regulates specific aspects of hair follicle growth, differentiation, and cycling...
  75. ncbi request reprint The near-naked hairless (Hr(N)) mutation disrupts hair formation but is not due to a mutation in the Hairless coding region
    Yutao Liu
    Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA
    J Invest Dermatol 127:1605-14. 2007
    ..Therefore, Hr(N) does not appear to be an allele of Hr but may result from a mutation in a closely linked gene or from a regulatory mutation in Hr...
  76. ncbi request reprint Hair cycle-specific immunolocalization of retinoic acid synthesizing enzymes Aldh1a2 and Aldh1a3 indicate complex regulation
    Helen B Everts
    Department of Biochemistry, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Invest Dermatol 123:258-63. 2004
    ..The expression patterns of these two similar retinoic acid synthesizing enzymes at specific follicular sites suggest that they mediate and are regulated by different epithelial proliferation and differentiation signaling pathways...
  77. ncbi request reprint Substance P as an immunomodulatory neuropeptide in a mouse model for autoimmune hair loss (alopecia areata)
    Frank Siebenhaar
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Invest Dermatol 127:1489-97. 2007
    ..These data suggest that SP, NEP, and NK-1R serve as important regulators in the molecular signaling network modulating inflammatory response in autoimmune hair loss...
  78. ncbi request reprint Fas-deficient C3.MRL-Tnfrsf6(lpr) mice and Fas ligand-deficient C3H/HeJ-Tnfsf6(gld) mice are relatively resistant to the induction of alopecia areata by grafting of alopecia areata-affected skin from C3H/HeJ mice
    Pia Freyschmidt-Paul
    Department of Dermatology, Philipp University, Marburg, Germany
    J Investig Dermatol Symp Proc 8:104-8. 2003
    ..The results suggest that the Fas/Fas ligand pathway plays an important pathogenetic role in alopecia areata...
  79. ncbi request reprint Atrichia with papular lesions resulting from mutations in the rhesus macaque (Macaca mulatta) hairless gene
    Wasim Ahmad
    Department of Dermatology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Lab Anim 36:61-7. 2002
    ....
  80. ncbi request reprint Prostate pathology of genetically engineered mice: definitions and classification. The consensus report from the Bar Harbor meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology Committee
    Scott B Shappell
    Department of Pathology and Vanderbilt Prostate Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37210, USA
    Cancer Res 64:2270-305. 2004
    ....
  81. ncbi request reprint Equine papillomavirus type 1: complete nucleotide sequence and characterization of recombinant virus-like particles composed of the EcPV-1 L1 major capsid protein
    Shin Je Ghim
    Laboratory of Vaccinology, John Graham Brown Cancer Center, University of Louisville Health Science Center, Louisville, KY, USA
    Biochem Biophys Res Commun 324:1108-15. 2004
    ..Recombinant EcPV-1 VLPs offer the potential of a noninfectious vaccine to prevent and eradicate equine cutaneous papillomatosis...
  82. ncbi request reprint Interleukin-10-deficient mice are less susceptible to the induction of alopecia areata
    Pia Freyschmidt-Paul
    J Invest Dermatol 119:980-2. 2002
  83. ncbi request reprint The pathogenesis of alopecia areata in rodent models
    Kevin J McElwee
    Department of Dermatology, Philipp University, Marburg, Germany
    J Investig Dermatol Symp Proc 8:6-11. 2003
    ..Each of these events is vulnerable to therapeutic intervention, and rodent models will be fundamentally involved in developing new treatments for AA...
  84. ncbi request reprint Old wine in new bottles: reviving old therapies for alopecia areata using rodent models
    Liren Tang
    Division of Dermatology, University of British Columbia, Vancouver, Canada
    J Investig Dermatol Symp Proc 8:212-6. 2003
    ..These visible, accessible, and unilaterally treated animal model systems are ideal for studying novel alopecia areata therapies, particularly in terms of their in vivo molecular mechanisms of action...
  85. ncbi request reprint Evidence that the satin hair mutant gene Foxq1 is among multiple and functionally diverse regulatory targets for Hoxc13 during hair follicle differentiation
    Christopher S Potter
    Departments of Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 281:29245-55. 2006
    ....
  86. ncbi request reprint Necropsy procedures with histopathologic evaluation of tissues are fundamentally the same regardless of species
    John P Sundberg
    Vet Pathol 40:222. 2003
  87. pmc Cataracts in transgenic mice caused by a human papillomavirus type 18 E7 oncogene driven by KRT1-14
    Shinje Ghim
    John Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA
    Exp Mol Pathol 85:77-82. 2008
    ..These cells were hyperplastic not neoplastic. Other HPV transgenic stocks develop cataracts suggesting this virus may have a broad cellular tropism...
  88. pmc Utility of antiPax5 in the diagnosis of lymphoproliferative disorders and neoplasia in mice
    Jerold E Rehg
    St Jude Children s Research Hospital, Pathology Department, Memphis, TN, USA
    Comp Med 58:246-52. 2008
    ..Here we describe the use of an antibody to human Pax5 in diagnostic pathology with formalin-fixed, paraffin-embedded mouse tissue...
  89. ncbi request reprint Complete genomic characterization of a murine papillomavirus isolated from papillomatous lesions of a European harvest mouse (Micromys minutus)
    Koenraad Van Doorslaer
    Laboratory of Clinical and Epidemiological Virology, Rega Institute for Medical Research, University of Leuven, Belgium
    J Gen Virol 88:1484-8. 2007
    ..The availability of the complete genomic sequence of a mouse PV should allow researchers to use MmPV as a model for PV carcinogenesis...
  90. ncbi request reprint Mutant laboratory mice with abnormalities in pigmentation: annotated tables
    Motonobu Nakamura
    Department of Dermatology, University Hospital Eppendorf, University of Hamburg, Germany
    J Dermatol Sci 28:1-33. 2002
    ..In summary, this annotated table should serve as a useful reference for anyone interested in the molecular controls of pigmentation...