Muttaiya Sundaralingam

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi request reprint Hydrogen and hydration of DNA and RNA oligonucleotides
    Muttaiya Sundaralingam
    Biological Macromolecular Structure Center, Department of Chemistry, and The Ohio State Biochemistry Program, The Ohio State University, 1060 Carmack Road, Columbus, OH 43210 1002, USA
    Biophys Chem 95:273-82. 2002
  2. ncbi request reprint Crystal structure of a bulged RNA tetraplex at 1.1 a resolution: implications for a novel binding site in RNA tetraplex
    Baocheng Pan
    Department of Chemistry and Biochemistry, The Ohio State University, 200 Johnston Lab, 176 West 19th Avenue, Columbus, OH, USA
    Structure 11:1423-30. 2003
  3. ncbi request reprint Structure of d(ITITACAC) complexed with distamycin at 1.6 A resolution
    Junpeng Deng
    Departments of Chemistry and Biochemistry, The Ohio State University, 200 Johnston Laboratory, 176 West 19th Avenue, Columbus, Ohio 43210, USA
    Acta Crystallogr D Biol Crystallogr 59:2342-4. 2003
  4. ncbi request reprint Structure of a B-form DNA/RNA chimera (dC)(rG)d(ATCG) complexed with daunomycin at 1.5 A resolution
    Ke Shi
    Departments of Chemistry and Biochemistry, The Ohio State University, 200 Johnston Laboratory, 176 West 19th Avenue, Columbus, OH 43210, USA
    Acta Crystallogr D Biol Crystallogr 59:1377-83. 2003
  5. pmc The crystal structure of an alternating RNA heptamer r(GUAUACA) forming a six base-paired duplex with 3'-end adenine overhangs
    Ke Shi
    Department of Chemistry, The Ohio State University, 200 Johnston Laboratory, Columbus, OH 43210, USA
    Nucleic Acids Res 31:1392-7. 2003
  6. ncbi request reprint Structure of the dodecamer r(GAUCACUUCGGU) with four 5'-overhang nucleotides
    Subramaniam Eswaramoorthy
    Department of Chemistry and Biochemistry, The Ohio State University, 200 Johnston Laboratory, 176 West 19th Avenue, Columbus, OH 43210, USA
    Acta Crystallogr D Biol Crystallogr 60:8-12. 2004
  7. ncbi request reprint Crystal structure of an RNA purine-rich tetraplex containing adenine tetrads: implications for specific binding in RNA tetraplexes
    Baocheng Pan
    Departments of Chemistry and Biochemistry, The Ohio State University, 200 Johnston Lab, 176 West 19th Avenue, Columbus, OH 43210, USA
    Structure 11:815-23. 2003
  8. ncbi request reprint An eight-stranded helical fragment in RNA crystal structure: implications for tetraplex interaction
    Baocheng Pan
    Departments of Chemistry and Biochemistry, The Ohio State University, 200 Johnston Lab, 176 West 19th Avenue, Columbus, OH 43210, USA
    Structure 11:825-31. 2003
  9. ncbi request reprint Structures of d(Gm5)CGm5CGCGC) and d(GCGCGm5CGm5C): effects of methylation on alternating DNA octamers
    Ke Shi
    Departments of Chemistry and Biochemistry, The Ohio State University, 200 Johnston Laboratory, 176 West 19th Avenue, Columbus, OH 43210, USA
    Acta Crystallogr D Biol Crystallogr 60:61-5. 2004
  10. pmc Base-tetrad swapping results in dimerization of RNA quadruplexes: implications for formation of the i-motif RNA octaplex
    Baocheng Pan
    Department of Chemistry, Ohio State University, 200 Johnston Laboratory, Columbus, 43210 1002, USA
    Proc Natl Acad Sci U S A 103:3130-4. 2006

Research Grants

  1. X-RAY STUDIES ON NUCLEIC ACID CONSTITUENTS
    Muttaiya Sundaralingam; Fiscal Year: 1990
  2. X-RAY STUDIES ON NUCLEIC ACID CONSTITUENTS
    Muttaiya Sundaralingam; Fiscal Year: 1993
  3. X RAY STUDIES OF NUCLEIC ACID CONSTITUENTS
    Muttaiya Sundaralingam; Fiscal Year: 2001

Collaborators

  • Yong Xiong
  • Junpeng Deng
  • Baocheng Pan
  • Ke Shi
  • Subramaniam Eswaramoorthy
  • Bernard J Premraj
  • Boopathy Ramakrishnan
  • Ramakrishna V Hosur
  • Narayanarao Yathindra
  • Sambhorao T Rao
  • Swaminathan Raja
  • Neel S Bhavesh
  • Douglas Tippin
  • Chandra Sekharudu

Detail Information

Publications16

  1. ncbi request reprint Hydrogen and hydration of DNA and RNA oligonucleotides
    Muttaiya Sundaralingam
    Biological Macromolecular Structure Center, Department of Chemistry, and The Ohio State Biochemistry Program, The Ohio State University, 1060 Carmack Road, Columbus, OH 43210 1002, USA
    Biophys Chem 95:273-82. 2002
    ....
  2. ncbi request reprint Crystal structure of a bulged RNA tetraplex at 1.1 a resolution: implications for a novel binding site in RNA tetraplex
    Baocheng Pan
    Department of Chemistry and Biochemistry, The Ohio State University, 200 Johnston Lab, 176 West 19th Avenue, Columbus, OH, USA
    Structure 11:1423-30. 2003
    ..In addition, both G(syn) tetrad and G(anti) tetrad have been observed. They display the same base-pairing pattern and similar C1'-C1' distance but different hydrogen-bonding patterns in the groove...
  3. ncbi request reprint Structure of d(ITITACAC) complexed with distamycin at 1.6 A resolution
    Junpeng Deng
    Departments of Chemistry and Biochemistry, The Ohio State University, 200 Johnston Laboratory, 176 West 19th Avenue, Columbus, Ohio 43210, USA
    Acta Crystallogr D Biol Crystallogr 59:2342-4. 2003
    ..The present structure emphasizes the features of alternating DNA octamers in interaction with distamycin...
  4. ncbi request reprint Structure of a B-form DNA/RNA chimera (dC)(rG)d(ATCG) complexed with daunomycin at 1.5 A resolution
    Ke Shi
    Departments of Chemistry and Biochemistry, The Ohio State University, 200 Johnston Laboratory, 176 West 19th Avenue, Columbus, OH 43210, USA
    Acta Crystallogr D Biol Crystallogr 59:1377-83. 2003
    ..A model of B-form RNA has been built based on the present structure. The model indicates that the interactions of the 2'-hydroxyl groups in the B-form duplex depend on their 3'-side nucleotides...
  5. pmc The crystal structure of an alternating RNA heptamer r(GUAUACA) forming a six base-paired duplex with 3'-end adenine overhangs
    Ke Shi
    Department of Chemistry, The Ohio State University, 200 Johnston Laboratory, Columbus, OH 43210, USA
    Nucleic Acids Res 31:1392-7. 2003
    ..Overhang adenine residues stack within the duplexes with C3'-endo sugar pucker and C2'-endo sugar pucker in duplexes 1 and 2, respectively. A Na+ ion in the crystal lattice is water bridged to two N1 atoms of symmetry-related A7 bases...
  6. ncbi request reprint Structure of the dodecamer r(GAUCACUUCGGU) with four 5'-overhang nucleotides
    Subramaniam Eswaramoorthy
    Department of Chemistry and Biochemistry, The Ohio State University, 200 Johnston Laboratory, 176 West 19th Avenue, Columbus, OH 43210, USA
    Acta Crystallogr D Biol Crystallogr 60:8-12. 2004
    ..O4(U) and a water bridge connecting the N(3) of the cytosine and uridine. The present study reinforces the concept of the stability of the conformation of UUCG in RNA double-helical structures...
  7. ncbi request reprint Crystal structure of an RNA purine-rich tetraplex containing adenine tetrads: implications for specific binding in RNA tetraplexes
    Baocheng Pan
    Departments of Chemistry and Biochemistry, The Ohio State University, 200 Johnston Lab, 176 West 19th Avenue, Columbus, OH 43210, USA
    Structure 11:815-23. 2003
    ..Ba(2+) ions prefer to bind guanine tetrads, and adenine tetrads can only be bound by Na(+) ions, illustrating the binding selectivity of metal ions for the tetraplex...
  8. ncbi request reprint An eight-stranded helical fragment in RNA crystal structure: implications for tetraplex interaction
    Baocheng Pan
    Departments of Chemistry and Biochemistry, The Ohio State University, 200 Johnston Lab, 176 West 19th Avenue, Columbus, OH 43210, USA
    Structure 11:825-31. 2003
    ..The conformational flexibility of adenine tetrad indicates that it can optimize its conformation in different interactions...
  9. ncbi request reprint Structures of d(Gm5)CGm5CGCGC) and d(GCGCGm5CGm5C): effects of methylation on alternating DNA octamers
    Ke Shi
    Departments of Chemistry and Biochemistry, The Ohio State University, 200 Johnston Laboratory, 176 West 19th Avenue, Columbus, OH 43210, USA
    Acta Crystallogr D Biol Crystallogr 60:61-5. 2004
    ....
  10. pmc Base-tetrad swapping results in dimerization of RNA quadruplexes: implications for formation of the i-motif RNA octaplex
    Baocheng Pan
    Department of Chemistry, Ohio State University, 200 Johnston Laboratory, Columbus, 43210 1002, USA
    Proc Natl Acad Sci U S A 103:3130-4. 2006
    ....
  11. ncbi request reprint Crystal structure of rGd(CGCGCG): a Z-DNA hexamer duplex with a 5'-(rG) overhang
    Baocheng Pan
    Departments of Chemistry and Biochemistry, 200 Johnston Laboratory, 176 West 19th Avenue, Columbus, Ohio 43210 1002, USA
    Acta Crystallogr D Biol Crystallogr 59:433-7. 2003
    ..G base pairing of the 5'-overhang dG (Pan et al., 1997). However, the replacement does not change the helix from Z-form to A-form or the water-structure motifs in the Z-DNA double-helical structure...
  12. ncbi request reprint Structure of an RNA dodecamer containing a fragment from SRP domain IV of Escherichia coli
    Junpeng Deng
    Department of Chemistry, The Ohio State University, 200 Johnston Laboratory, 176 West 19th Avenue, Columbus, Ohio 43210, USA
    Acta Crystallogr D Biol Crystallogr 59:1004-11. 2003
    ..Comparison with other crystal structures of fragments of 4.5S RNA indicates that the conformation of the symmetric loop is independent of the asymmetrical loop in domain IV...
  13. ncbi request reprint Near-atomic resolution crystal structure of an A-DNA decamer d(CCCGATCGGG): cobalt hexammine interaction with A-DNA
    Boopathy Ramakrishnan
    Department of Chemistry, The Ohio State University 200 Johnston Laboratory, 176 West 19th Avenue, Columbus, Ohio 43210 1002, USA
    Acta Crystallogr D Biol Crystallogr 59:67-72. 2003
    ..Analysis of thermal parameters (B factors) shows that the nucleotides involved in abutting crystal packing are thermally more stable than other nucleotides in the duplex...
  14. ncbi request reprint Solution structure of 2',5' d(G4C4). Relevance to topological restrictions and nature's choice of phosphodiester links
    Bernard J Premraj
    Department of Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai, India
    Eur J Biochem 271:2956-66. 2004
    ..It is therefore conceivable that selection pressure relating to the optimization of topological features might have been a factor in the rejection of 2',5' links in preference to 3',5' links...
  15. ncbi request reprint Crystal structure of an RNA quadruplex containing inosine tetrad: implications for the roles of NH2 group in purine tetrads
    Baocheng Pan
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    J Mol Biol 363:451-9. 2006
    ..We also discuss the roles of amino group in purine tetrads and the inter-quadruplex interactions in RNA molecules. These quadruplexes may interact with each other by stacking, groove binding and intercalation...

Research Grants12

  1. X-RAY STUDIES ON NUCLEIC ACID CONSTITUENTS
    Muttaiya Sundaralingam; Fiscal Year: 1990
    ..The work on oligonucleotides will provide useful information on sequence-dependent conformational variations in DNA structure which is important in understanding gene expression and regulation...
  2. X-RAY STUDIES ON NUCLEIC ACID CONSTITUENTS
    Muttaiya Sundaralingam; Fiscal Year: 1993
    ..This investigation will provide important details on the molecular geometries and conformations of DNAs which will be of fundamental importance in the understanding of the molecular basis of gene regulation and expression...
  3. X RAY STUDIES OF NUCLEIC ACID CONSTITUENTS
    Muttaiya Sundaralingam; Fiscal Year: 2001
    ..The structures will be solved by molecular replacement or by the heavy atom method and refined by XPLOR. The structural work will be invaluable to better understand health, gene regulation and rational drug design. ..