Shi Yong Sun

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells
    Jae Hoon Chang
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 13:481-90. 2012
  2. pmc Regulation of antiviral innate immunity by deubiquitinase CYLD
    Minying Zhang
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cell Mol Immunol 8:502-4. 2011
  3. pmc The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling
    Jin Jin
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 13:1101-9. 2012
  4. pmc OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3
    Hongbo Hu
    Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, BOX 902, Houston, Texas 77030, USA
    Nature 494:371-4. 2013
  5. pmc Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation
    Yichuan Xiao
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Med 19:595-602. 2013
  6. pmc The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity
    Mikyoung Chang
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 12:1002-9. 2011
  7. pmc Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production
    Mikyoung Chang
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 10:1089-95. 2009
  8. pmc Regulation of nuclear factor-κB in autoimmunity
    Shao Cong Sun
    Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, BOX 902, Houston TX 77030, USA
    Trends Immunol 34:282-9. 2013
  9. pmc The noncanonical NF-κB pathway
    Shao Cong Sun
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Immunol Rev 246:125-40. 2012
  10. ncbi request reprint Controlling the fate of NIK: a central stage in noncanonical NF-kappaB signaling
    Shao Cong Sun
    Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, BOX 902, Houston, TX 77030, USA
    Sci Signal 3:pe18. 2010

Research Grants

Collaborators

Detail Information

Publications42

  1. pmc Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells
    Jae Hoon Chang
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 13:481-90. 2012
    ..Collectively, our findings suggest that the Ubc13-IKK signaling axis regulates the molecular program that maintains Treg cell function and prevents Treg cells from acquiring inflammatory phenotypes...
  2. pmc Regulation of antiviral innate immunity by deubiquitinase CYLD
    Minying Zhang
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cell Mol Immunol 8:502-4. 2011
    ..These findings establish CYLD as a novel regulator of antiviral innate immunity and suggest a role for CYLD in regulating IFN receptor signaling...
  3. pmc The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling
    Jin Jin
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 13:1101-9. 2012
    ..Our findings establish TBK1 as a pivotal negative regulator of the noncanonical NF-κB pathway and identify a unique mechanism that controls IgA production...
  4. pmc OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3
    Hongbo Hu
    Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, BOX 902, Houston, Texas 77030, USA
    Nature 494:371-4. 2013
    ..These findings establish OTUD7B as a crucial regulator of signal-induced non-canonical NF-κB activation and indicate a mechanism of immune regulation that involves OTUD7B-mediated deubiquitination and stabilization of TRAF3...
  5. pmc Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation
    Yichuan Xiao
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Med 19:595-602. 2013
    ..These findings establish Peli1 as a microglia-specific mediator of autoimmune neuroinflammation and suggest a previously unknown signaling mechanism of Peli1 function...
  6. pmc The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity
    Mikyoung Chang
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 12:1002-9. 2011
    ..Our results identify Peli1 as a critical factor in the maintenance of peripheral T cell tolerance and demonstrate a previously unknown mechanism of c-Rel regulation...
  7. pmc Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production
    Mikyoung Chang
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 10:1089-95. 2009
    ..Our findings suggest that Peli1 is a ubiquitin ligase needed for the transmission of TRIF-dependent TLR signals...
  8. pmc Regulation of nuclear factor-κB in autoimmunity
    Shao Cong Sun
    Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, BOX 902, Houston TX 77030, USA
    Trends Immunol 34:282-9. 2013
    ..This review focuses on recent progress regarding NF-κB regulation and its association with autoimmunity...
  9. pmc The noncanonical NF-κB pathway
    Shao Cong Sun
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Immunol Rev 246:125-40. 2012
    ..This review discusses both the historical perspectives and the recent progress in the regulation and biological function of the noncanonical NF-κB pathway...
  10. ncbi request reprint Controlling the fate of NIK: a central stage in noncanonical NF-kappaB signaling
    Shao Cong Sun
    Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, BOX 902, Houston, TX 77030, USA
    Sci Signal 3:pe18. 2010
    ..Thus, controlling the fate of NIK is emerging as a central mechanism in noncanonical NF-kappaB signaling...
  11. pmc Non-canonical NF-κB signaling pathway
    Shao Cong Sun
    Department of Immunology, The University of Texas MD Anderson Cancer Center, The University of Texas Graduate School of Biomedical Sciences at Houston, 7455 Fannin Street, BOX 902, Houston, TX 77030, USA
    Cell Res 21:71-85. 2011
    ..Tight control of the fate of NIK is important, since deregulated NIK accumulation is associated with lymphoid malignancies...
  12. doi request reprint CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes
    S C Sun
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cell Death Differ 17:25-34. 2010
    ..Interestingly, CYLD itself is subject to different mechanisms of regulation...
  13. doi request reprint Deubiquitylation and regulation of the immune response
    Shao Cong Sun
    Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, BOX 902, Houston, Texas 77030, USA
    Nat Rev Immunol 8:501-11. 2008
    ..As described in this Review, recent studies of several DUBs, in particular CYLD and A20, show that deubiquitylation has an important role in the regulation of both innate and adaptive immune responses...
  14. pmc Mutual regulation between deubiquitinase CYLD and retroviral oncoprotein Tax
    Xuefeng Wu
    Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, BOX 902, Houston TX 77030, USA
    Cell Biosci 1:27. 2011
    ..abstract:..
  15. ncbi request reprint Augmentation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by the synthetic retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) through up-regulation of TRAIL receptors in human lung ca
    S Y Sun
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 60:7149-55. 2000
    ..These findings suggest a novel strategy for the prevention and treatment of human lung cancer with the CD437 and TRAIL combination...
  16. ncbi request reprint How much do we know about retinoid-regulated genes?
    Shi Yong Sun
    Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Biol Ther 1:28-30. 2002
  17. ncbi request reprint The synthetic retinoid CD437 selectively induces apoptosis in human lung cancer cells while sparing normal human lung epithelial cells
    Shi Yong Sun
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 62:2430-6. 2002
    ..These results predict a differential effect of CD437 on tumor and normal cells in vivo and strongly suggest that CD437 may be a useful agent for chemoprevention and/or treatment of human cancer, especially lung cancer...
  18. pmc NF-κB as a target for oncogenic viruses
    Shao Cong Sun
    Department of Immunology, The University of Texas MD Anderson Cancer Center, USA
    Curr Top Microbiol Immunol 349:197-244. 2011
    ..This chapter will discuss the molecular mechanisms by which NF-κB is activated by the viral oncoproteins...
  19. ncbi request reprint Identification of retinamides that are more potent than N-(4-hydroxyphenyl)retinamide in inhibiting growth and inducing apoptosis of human head and neck and lung cancer cells
    S Y Sun
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 10:595-601. 2001
    ..Our results suggest that 2CPR acts via retinoic acid receptors and may be a good candidate for prevention and treatment of some head and neck and lung cancers...
  20. doi request reprint New insights into NF-kappaB regulation and function
    Shao Cong Sun
    Department of Immunology, MD Anderson Cancer Center, University of Texas, Houston, TX 77030, USA
    Trends Immunol 29:469-78. 2008
    ..New research has also identified several novel regulatory proteins that control the transcriptional activity of nuclear NF-kappaB...
  21. ncbi request reprint Identification of a novel synthetic triterpenoid, methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate, that potently induces caspase-mediated apoptosis in human lung cancer cells
    Kevin B Kim
    Department of Thoracic Head and Neck Medical Oncology, Box 432, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 1:177-84. 2002
    ..Our results demonstrate that CDDO-Me may be a good candidate for additional evaluation as a potential therapeutic agent for human lung cancers and possibly other types of cancer...
  22. ncbi request reprint Enhanced growth inhibition and apoptosis induction in NSCLC cell lines by combination of celecoxib and 4HPR at clinically relevant concentrations
    Shi Yong Sun
    Department of Thoracic, Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Biol Ther 4:407-13. 2005
    ..It suggests further investigations of this combination for lung cancer treatment...
  23. ncbi request reprint Evidence that the human death receptor 4 is regulated by activator protein 1
    Baoxiang Guan
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 21:3121-9. 2002
    ..Therefore, our findings may increase the understanding of the mechanisms underlying AP-1-mediated apoptosis as well as drug-induced apoptosis...
  24. ncbi request reprint Hypermethylation of the death-associated protein kinase promoter attenuates the sensitivity to TRAIL-induced apoptosis in human non-small cell lung cancer cells
    Ximing Tang
    Molecular Biology Laboratory, Department of Thoracic Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Unit 432, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Res 2:685-91. 2004
    ..These results suggest that DAP kinase is involved in TRAIL-mediated cell apoptosis and that a demethylating agent may have a role in enhancing TRAIL-mediated apoptosis in some NSCLC cells by reactivation of DAP kinase...
  25. ncbi request reprint Apoptosis as a novel target for cancer chemoprevention
    Shi Yong Sun
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX77030 4095, USA
    J Natl Cancer Inst 96:662-72. 2004
    ..In this review, we construct a paradigm supporting apoptosis as a novel target for cancer chemoprevention by highlighting recent studies of several chemopreventive agents that engage apoptosis pathways...
  26. ncbi request reprint Retinoids and their receptors in cancer development and chemoprevention
    Shi Yong Sun
    Department of Thoracic Head and Neck Medical Oncology, Box 432, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Crit Rev Oncol Hematol 41:41-55. 2002
    ....
  27. ncbi request reprint Regulation of T cell development by the deubiquitinating enzyme CYLD
    William W Reiley
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Nat Immunol 7:411-7. 2006
    ..Because of a cell-autonomous defect in T cell development, CYLD-deficient mice had substantially fewer mature CD4(+) and CD8(+) single-positive thymocytes and peripheral T cells...
  28. pmc Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation
    William Reiley
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA 17033, USA
    Mol Cell Biol 25:3886-95. 2005
    ..These findings suggest that CYLD serves as a novel target of IKK and that the site-specific phosphorylation of CYLD regulates its signaling function...
  29. ncbi request reprint Negative regulation of JNK signaling by the tumor suppressor CYLD
    William Reiley
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Biol Chem 279:55161-7. 2004
    ..These findings identify the JNK signaling pathway as a major downstream target of CYLD and suggest a receptor-dependent role of CYLD in regulating the IkappaB kinase pathway...
  30. ncbi request reprint Activation of NF-kappa B by the human T cell leukemia virus type I Tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinase
    Nicole S Harhaj
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 282:4185-92. 2007
    ..Together, these results demonstrate that Tax induces relocalization of the IKK complex in a ubiquitin-dependent manner, and dynamic changes in the subcellular localization of the IKK complex may be critical for Tax function...
  31. pmc Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses
    William W Reiley
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Exp Med 204:1475-85. 2007
    ..These results emphasize a critical role for CYLD in preventing spontaneous activation of the Tak1 axis of T cell signaling and, thereby, maintaining normal T cell function...
  32. ncbi request reprint Deregulation of NF-kappaB and its upstream kinases in cancer
    Shao Cong Sun
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Cancer Metastasis Rev 22:405-22. 2003
    ..In this review, we discuss our current knowledge of NF-kappaB activation, with a focus on the NF-kappaB-activating kinases and their roles in cancer formation...
  33. ncbi request reprint Regulation of NF-kappaB2/p100 processing by its nuclear shuttling
    Gongxian Liao
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA 17033, USA
    Oncogene 22:4868-74. 2003
    ..These results suggest that nuclear shuttling is a mechanism regulating the processing of NF-kappaB2/p100...
  34. ncbi request reprint Study of T-cell signaling by somatic cell mutagenesis and complementation cloning
    Mary Ellen Cvijic
    Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    J Immunol Methods 278:293-304. 2003
    ..Clearly, creation of a somatic cell genetic system can yield exciting new advances in deciphering signal transduction events by discovery of novel pathway participants...
  35. ncbi request reprint S9, a 19 S proteasome subunit interacting with ubiquitinated NF-kappaB2/p100
    Abraham Fong
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    J Biol Chem 277:40697-702. 2002
    ..Finally, we provide genetic evidence for the essential role of S9 in the inducible processing of p100...
  36. pmc Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice
    Wei Jin
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Invest 118:1858-66. 2008
    ..These findings establish CYLD as a crucial negative regulator of osteoclastogenesis and suggest its involvement in the p62/TRAF6 signaling axis...
  37. ncbi request reprint Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation
    Gutian Xiao
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 279:30099-105. 2004
    ..These data also provide the first evidence for explaining why overexpression of IKKalpha or its activation by many other stimuli such as tumor necrosis factor and mitogens fails to induce p100 processing...
  38. pmc Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD
    Minying Zhang
    Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 283:18621-6. 2008
    ..These findings establish CYLD as a key negative regulator of IKKepsilon/TBK1 and suggest a role for CYLD in the control of RIG-I ubiquitination...
  39. ncbi request reprint Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway
    Edward W Harhaj
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami School of Medicine, Miami, FL 33136, USA
    Virology 333:145-58. 2005
    ..Collectively, these results indicate that CD40 is a novel Tax-regulated gene, and the regulation of CD40 by Tax may play a role in cellular activation and HTLV-I-induced disease pathogenesis...
  40. ncbi request reprint Activation of NF-kappaB by HTLV-I and implications for cell transformation
    Shao Cong Sun
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA 17033, USA
    Oncogene 24:5952-64. 2005
    ..Clarifying the precise nature and consequences of the constitutive NF-kappaB activation in ATL cells is important for developing rational therapeutic strategies for this T-cell malignancy...
  41. ncbi request reprint Deregulated activation of oncoprotein kinase Tpl2/Cot in HTLV-I-transformed T cells
    Geetha Babu
    Department of Microbiology and Immunology, Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 281:14041-7. 2006
    ..Finally, Tpl2/Cot participates in the activation of NF-kappaB by Tax. These findings indicate that deregulated activation of Tpl2/Cot may occur in human cancer cells...
  42. ncbi request reprint Deubiquitinating enzyme CYLD regulates the peripheral development and naive phenotype maintenance of B cells
    Wei Jin
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 282:15884-93. 2007
    ..These findings demonstrate a critical role for CYLD in regulating the basal activity of NF-kappaB and maintaining the naive phenotype and proper activation of B cells...

Research Grants40

  1. ACTIVATION OF IKB KINASE BY HTLV-I TAX
    Shao Cong Sun; Fiscal Year: 2002
    ..abstract_text> ..
  2. Signaling Functions of the Tumor Suppressor CYLD
    Shao Cong Sun; Fiscal Year: 2006
    ..2) Examine how CYLD negatively regulates peripheral T-cell activation and whether the CYLD deficiency causes autoimmunity. (3) Investigate the biochemical mechanism and functional significance of CYLD phosphorylation. ..
  3. Molecular Mechanisms Mediating NF-kB2/p100 Processing
    Shao Cong Sun; Fiscal Year: 2003
    ..abstract_text> ..
  4. DEREGULATION OF NFKB/REL BY TAX & ADULT T CELL LEUKEMIA
    Shao Cong Sun; Fiscal Year: 1999
    ..Finally, the precise mechanism of Tax-induced transcriptional induction of c-rel gene will be explored by isolation and functional analyses of the human c-rel gene promoter. ..
  5. Molecular Mechanisms Mediating NF-kB2/p100 Processing
    Shao Cong Sun; Fiscal Year: 2007
    ..abstract_text> ..
  6. Signaling Functions of the Tumor Suppressor CYLD
    Shao Cong Sun; Fiscal Year: 2009
    ..2) Examine how CYLD negatively regulates peripheral T-cell activation and whether the CYLD deficiency causes autoimmunity. (3) Investigate the biochemical mechanism and functional significance of CYLD phosphorylation. ..
  7. Molecular Mechanisms Regulating Noncanonical NF-kB Signaling
    Shao Cong Sun; Fiscal Year: 2010
    ..The studies proposed in this application address the molecular mechanisms of noncanonical NF-?B signaling and will be important for the development of new and effective immune therapies. ..
  8. ACTIVATION OF IKB KINASE BY HTLV-I TAX
    Shao Cong Sun; Fiscal Year: 2003
    ..abstract_text> ..
  9. TpI2 Kinase in Macrophage Activation by Microbes
    Shao Cong Sun; Fiscal Year: 2004
    ..We also expect to have isolated novel signaling molecules participating in this important innate immune response. ..
  10. Molecular Mechanisms Mediating NF-kB2/p100 Processing
    Shao Cong Sun; Fiscal Year: 2006
    ..abstract_text> ..
  11. TpI2 Kinase in Macrophage Activation by Microbes
    Shao Cong Sun; Fiscal Year: 2006
    ..We also expect to have isolated novel signaling molecules participating in this important innate immune response. ..
  12. Molecular Mechanisms Regulating Noncanonical NF-kB Signaling
    Shao Cong Sun; Fiscal Year: 2009
    ..The goal of this revision project is to understand the molecular mechanism by which a protein kinase, NIK, regulates inflammatory T-cell production and EAE pathogenesis. ..
  13. The IKK/Tpl2 axis of TLR signaling
    Shao Cong Sun; Fiscal Year: 2010
    ....
  14. NIK KINASE AND T CELL COSTIMULATION
    Shao Cong Sun; Fiscal Year: 2003
    ..It is also expected that novel signaling molecules will have been isolated which function in the T cell co-stimulatory pathway. ..
  15. NIK KINASE AND T CELL COSTIMULATION
    Shao Cong Sun; Fiscal Year: 2001
    ..It is also expected that novel signaling molecules will have been isolated which function in the T cell co-stimulatory pathway. ..
  16. ACTIVATION OF IKB KINASE BY HTLV-I TAX
    Shao Cong Sun; Fiscal Year: 2001
    ..abstract_text> ..
  17. NIK KINASE AND T CELL COSTIMULATION
    Shao Cong Sun; Fiscal Year: 1999
    ..It is also expected that novel signaling molecules will have been isolated which function in the T cell co-stimulatory pathway. ..
  18. ACTIVATION OF IKB KINASE BY HTLV-I TAX
    Shao Cong Sun; Fiscal Year: 2001
    ..abstract_text> ..
  19. Molecular Mechanisms Regulating Noncanonical NF-kB Signaling
    Shao Cong Sun; Fiscal Year: 2009
    ..The studies proposed in this application address the molecular mechanisms of noncanonical NF-?B signaling and will be important for the development of new and effective immune therapies. ..
  20. NIK KINASE AND T CELL COSTIMULATION
    Shao Cong Sun; Fiscal Year: 2002
    ..It is also expected that novel signaling molecules will have been isolated which function in the T cell co-stimulatory pathway. ..
  21. Regulation of T-cell function and autoimmune inflammation by deubiquitinase CYLD
    Shao Cong Sun; Fiscal Year: 2010
    ..This knowledge is important for rational design of effective immunological therapies. ..
  22. TpI2 Kinase in Macrophage Activation by Microbes
    Shao Cong Sun; Fiscal Year: 2007
    ..We also expect to have isolated novel signaling molecules participating in this important innate immune response. ..
  23. DEREGULATION OF NF-KB/REL BY TAX & ADULT T-CELL LEUKEMIA
    Shao Cong Sun; Fiscal Year: 1999
    ..Finally, the precise mechanism of Tax-induced transcriptional induction of c-rel gene will be explored by isolation and functional analyses of the human c-rel gene promoter. ..
  24. NIK KINASE AND T CELL COSTIMULATION
    Shao Cong Sun; Fiscal Year: 2000
    ..It is also expected that novel signaling molecules will have been isolated which function in the T cell co-stimulatory pathway. ..
  25. Signaling Functions of the Tumor Suppressor CYLD
    Shao Cong Sun; Fiscal Year: 2007
    ..2) Examine how CYLD negatively regulates peripheral T-cell activation and whether the CYLD deficiency causes autoimmunity. (3) Investigate the biochemical mechanism and functional significance of CYLD phosphorylation. ..
  26. ACTIVATION OF IKB KINASE BY HTLV-I TAX
    Shao Cong Sun; Fiscal Year: 2000
    ..abstract_text> ..
  27. TpI2 Kinase in Macrophage Activation by Microbes
    Shao Cong Sun; Fiscal Year: 2005
    ..We also expect to have isolated novel signaling molecules participating in this important innate immune response. ..
  28. ACTIVATION OF IKB KINASE BY HTLV-I TAX
    Shao Cong Sun; Fiscal Year: 2001
    ..abstract_text> ..
  29. The IKK/Tpl2 axis of TLR signaling
    Shao Cong Sun; Fiscal Year: 2011
    ....