Research Topics
Species | Shi Yong SunSummaryAffiliation: The University of Texas Country: USA Publications
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Publications
The noncanonical NF-κB pathwayShao Cong Sun
Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Immunol Rev 246:125-40. 2012..This review discusses both the historical perspectives and the recent progress in the regulation and biological function of the noncanonical NF-κB pathway...- Mutual regulation between deubiquitinase CYLD and retroviral oncoprotein TaxXuefeng Wu
Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, BOX 902, Houston TX 77030, USA
Cell Biosci 1:27. 2011..abstract:.. - Non-canonical NF-κB signaling pathwayShao Cong Sun
Department of Immunology, The University of Texas MD Anderson Cancer Center, The University of Texas Graduate School of Biomedical Sciences at Houston, 7455 Fannin Street, BOX 902, Houston, TX 77030, USA
Cell Res 21:71-85. 2011..Tight control of the fate of NIK is important, since deregulated NIK accumulation is associated with lymphoid malignancies... 
NF-κB as a target for oncogenic virusesShao Cong Sun
Department of Immunology, The University of Texas MD Anderson Cancer Center, USA
Curr Top Microbiol Immunol 349:197-244. 2011..This chapter will discuss the molecular mechanisms by which NF-κB is activated by the viral oncoproteins...- Controlling the fate of NIK: a central stage in noncanonical NF-kappaB signalingShao Cong Sun
Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, BOX 902, Houston, TX 77030, USA
Sci Signal 3:pe18. 2010..Thus, controlling the fate of NIK is emerging as a central mechanism in noncanonical NF-kappaB signaling... - CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processesS C Sun
Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Cell Death Differ 17:25-34. 2010..Interestingly, CYLD itself is subject to different mechanisms of regulation... - New insights into NF-kappaB regulation and functionShao Cong Sun
Department of Immunology, MD Anderson Cancer Center, University of Texas, Houston, TX 77030, USA
Trends Immunol 29:469-78. 2008..New research has also identified several novel regulatory proteins that control the transcriptional activity of nuclear NF-kappaB... - Deubiquitylation and regulation of the immune responseShao Cong Sun
Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, BOX 902, Houston, Texas 77030, USA
Nat Rev Immunol 8:501-11. 2008..As described in this Review, recent studies of several DUBs, in particular CYLD and A20, show that deubiquitylation has an important role in the regulation of both innate and adaptive immune responses... 
Augmentation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by the synthetic retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) through up-regulation of TRAIL receptors in human lung caS Y Sun
Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 60:7149-55. 2000..These findings suggest a novel strategy for the prevention and treatment of human lung cancer with the CD437 and TRAIL combination...- Identification of retinamides that are more potent than N-(4-hydroxyphenyl)retinamide in inhibiting growth and inducing apoptosis of human head and neck and lung cancer cellsS Y Sun
Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Epidemiol Biomarkers Prev 10:595-601. 2001..Our results suggest that 2CPR acts via retinoic acid receptors and may be a good candidate for prevention and treatment of some head and neck and lung cancers... - How much do we know about retinoid-regulated genes?Shi Yong Sun
Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
Cancer Biol Ther 1:28-30. 2002 - The synthetic retinoid CD437 selectively induces apoptosis in human lung cancer cells while sparing normal human lung epithelial cellsShi Yong Sun
Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Cancer Res 62:2430-6. 2002..These results predict a differential effect of CD437 on tumor and normal cells in vivo and strongly suggest that CD437 may be a useful agent for chemoprevention and/or treatment of human cancer, especially lung cancer... - Evidence that the human death receptor 4 is regulated by activator protein 1Baoxiang Guan
Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Oncogene 21:3121-9. 2002..Therefore, our findings may increase the understanding of the mechanisms underlying AP-1-mediated apoptosis as well as drug-induced apoptosis... - Hypermethylation of the death-associated protein kinase promoter attenuates the sensitivity to TRAIL-induced apoptosis in human non-small cell lung cancer cellsXiming Tang
Molecular Biology Laboratory, Department of Thoracic Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Unit 432, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Mol Cancer Res 2:685-91. 2004..These results suggest that DAP kinase is involved in TRAIL-mediated cell apoptosis and that a demethylating agent may have a role in enhancing TRAIL-mediated apoptosis in some NSCLC cells by reactivation of DAP kinase... - Retinoids and their receptors in cancer development and chemopreventionShi Yong Sun
Department of Thoracic Head and Neck Medical Oncology, Box 432, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Crit Rev Oncol Hematol 41:41-55. 2002.... - Identification of a novel synthetic triterpenoid, methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate, that potently induces caspase-mediated apoptosis in human lung cancer cellsKevin B Kim
Department of Thoracic/Head and Neck Medical Oncology, Box 432, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Mol Cancer Ther 1:177-84. 2002..Our results demonstrate that CDDO-Me may be a good candidate for additional evaluation as a potential therapeutic agent for human lung cancers and possibly other types of cancer... - Enhanced growth inhibition and apoptosis induction in NSCLC cell lines by combination of celecoxib and 4HPR at clinically relevant concentrationsShi-Yong Sun
Department of Thoracic, Head and Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Biol Ther 4:407-13. 2005..It suggests further investigations of this combination for lung cancer treatment... - Apoptosis as a novel target for cancer chemopreventionShi-Yong Sun
Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX77030-4095, USA
J Natl Cancer Inst 96:662-72. 2004..In this review, we construct a paradigm supporting apoptosis as a novel target for cancer chemoprevention by highlighting recent studies of several chemopreventive agents that engage apoptosis pathways... - Regulation of T cell development by the deubiquitinating enzyme CYLDWilliam W Reiley
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Nat Immunol 7:411-7. 2006..Because of a cell-autonomous defect in T cell development, CYLD-deficient mice had substantially fewer mature CD4(+) and CD8(+) single-positive thymocytes and peripheral T cells... - Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylationWilliam Reiley
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA 17033, USA
Mol Cell Biol 25:3886-95. 2005..These findings suggest that CYLD serves as a novel target of IKK and that the site-specific phosphorylation of CYLD regulates its signaling function... - Negative regulation of JNK signaling by the tumor suppressor CYLDWilliam Reiley
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
J Biol Chem 279:55161-7. 2004..These findings identify the JNK signaling pathway as a major downstream target of CYLD and suggest a receptor-dependent role of CYLD in regulating the IkappaB kinase pathway... - S9, a 19 S proteasome subunit interacting with ubiquitinated NF-kappaB2/p100Abraham Fong
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
J Biol Chem 277:40697-702. 2002..Finally, we provide genetic evidence for the essential role of S9 in the inducible processing of p100... - Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLDMinying Zhang
Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 283:18621-6. 2008..These findings establish CYLD as a key negative regulator of IKKepsilon/TBK1 and suggest a role for CYLD in the control of RIG-I ubiquitination... - Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in miceWei Jin
Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
J Clin Invest 118:1858-66. 2008..These findings establish CYLD as a crucial negative regulator of osteoclastogenesis and suggest its involvement in the p62/TRAF6 signaling axis... - Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responsesWilliam W Reiley
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
J Exp Med 204:1475-85. 2007..These results emphasize a critical role for CYLD in preventing spontaneous activation of the Tak1 axis of T cell signaling and, thereby, maintaining normal T cell function... - Study of T-cell signaling by somatic cell mutagenesis and complementation cloningMary Ellen Cvijic
Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
J Immunol Methods 278:293-304. 2003..Clearly, creation of a somatic cell genetic system can yield exciting new advances in deciphering signal transduction events by discovery of novel pathway participants... - Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylationGutian Xiao
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
J Biol Chem 279:30099-105. 2004..These data also provide the first evidence for explaining why overexpression of IKKalpha or its activation by many other stimuli such as tumor necrosis factor and mitogens fails to induce p100 processing... - Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathwayEdward W Harhaj
Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami School of Medicine, Miami, FL 33136, USA
Virology 333:145-58. 2005..Collectively, these results indicate that CD40 is a novel Tax-regulated gene, and the regulation of CD40 by Tax may play a role in cellular activation and HTLV-I-induced disease pathogenesis... - Deregulation of NF-kappaB and its upstream kinases in cancerShao Cong Sun
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Cancer Metastasis Rev 22:405-22. 2003..In this review, we discuss our current knowledge of NF-kappaB activation, with a focus on the NF-kappaB-activating kinases and their roles in cancer formation... - Activation of NF-kappaB by HTLV-I and implications for cell transformationShao Cong Sun
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA 17033, USA
Oncogene 24:5952-64. 2005..Clarifying the precise nature and consequences of the constitutive NF-kappaB activation in ATL cells is important for developing rational therapeutic strategies for this T-cell malignancy... - Deregulated activation of oncoprotein kinase Tpl2/Cot in HTLV-I-transformed T cellsGeetha Babu
Department of Microbiology and Immunology, Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
J Biol Chem 281:14041-7. 2006..Finally, Tpl2/Cot participates in the activation of NF-kappaB by Tax. These findings indicate that deregulated activation of Tpl2/Cot may occur in human cancer cells... - Activation of NF-kappa B by the human T cell leukemia virus type I Tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinaseNicole S Harhaj
Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
J Biol Chem 282:4185-92. 2007..Together, these results demonstrate that Tax induces relocalization of the IKK complex in a ubiquitin-dependent manner, and dynamic changes in the subcellular localization of the IKK complex may be critical for Tax function... - Deubiquitinating enzyme CYLD regulates the peripheral development and naive phenotype maintenance of B cellsWei Jin
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
J Biol Chem 282:15884-93. 2007..These findings demonstrate a critical role for CYLD in regulating the basal activity of NF-kappaB and maintaining the naive phenotype and proper activation of B cells... - Regulation of NF-kappaB2/p100 processing by its nuclear shuttlingGongxian Liao
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA 17033, USA
Oncogene 22:4868-74. 2003..These results suggest that nuclear shuttling is a mechanism regulating the processing of NF-kappaB2/p100...
Research Grants
- Signaling Functions of the Tumor Suppressor CYLDShao Cong Sun; Fiscal Year: 2007..2) Examine how CYLD negatively regulates peripheral T-cell activation and whether the CYLD deficiency causes autoimmunity. (3) Investigate the biochemical mechanism and functional significance of CYLD phosphorylation. ..
- Molecular Mechanisms Mediating NF-kB2/p100 ProcessingShao Cong Sun; Fiscal Year: 2006..abstract_text> ..
- Molecular Mechanisms Regulating Noncanonical NF-kB SignalingShao Cong Sun; Fiscal Year: 2010..The studies proposed in this application address the molecular mechanisms of noncanonical NF-?B signaling and will be important for the development of new and effective immune therapies. ..
- Regulation of T-cell function and autoimmune inflammation by deubiquitinase CYLDShao Cong Sun; Fiscal Year: 2010..This knowledge is important for rational design of effective immunological therapies. ..
- Molecular Mechanisms Regulating Noncanonical NF-kB SignalingShao Cong Sun; Fiscal Year: 2009..The goal of this revision project is to understand the molecular mechanism by which a protein kinase, NIK, regulates inflammatory T-cell production and EAE pathogenesis. ..
- The IKK/Tpl2 axis of TLR signalingShao Cong Sun; Fiscal Year: 2010....
- Signaling Functions of the Tumor Suppressor CYLDShao Cong Sun; Fiscal Year: 2009..2) Examine how CYLD negatively regulates peripheral T-cell activation and whether the CYLD deficiency causes autoimmunity. (3) Investigate the biochemical mechanism and functional significance of CYLD phosphorylation. ..
- Molecular Mechanisms Mediating NF-kB2/p100 ProcessingShao Cong Sun; Fiscal Year: 2007..abstract_text> ..
- TpI2 Kinase in Macrophage Activation by MicrobesShao Cong Sun; Fiscal Year: 2007..We also expect to have isolated novel signaling molecules participating in this important innate immune response. ..
- ACTIVATION OF IKB KINASE BY HTLV-I TAXShao Cong Sun; Fiscal Year: 2003..abstract_text> ..
- DEREGULATION OF NFKB/REL BY TAX & ADULT T CELL LEUKEMIAShao Cong Sun; Fiscal Year: 1999..Finally, the precise mechanism of Tax-induced transcriptional induction of c-rel gene will be explored by isolation and functional analyses of the human c-rel gene promoter. ..
- NIK KINASE AND T CELL COSTIMULATIONShao Cong Sun; Fiscal Year: 2003..It is also expected that novel signaling molecules will have been isolated which function in the T cell co-stimulatory pathway. ..
- Molecular Mechanisms Mediating NF-kB2/p100 ProcessingShao Cong Sun; Fiscal Year: 2003..abstract_text> ..
- The IKK/Tpl2 axis of TLR signalingShao Cong Sun; Fiscal Year: 2011....