Erich M Sturgis

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi A pilot study of Helicobacter pylori infection and risk of laryngopharyngeal cancer
    Zhannat Z Nurgalieva
    Department of Gastroenterology--Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Head Neck 27:22-7. 2005
  2. ncbi The role of human papillomavirus in squamous carcinoma of the head and neck
    Guojun Li
    Department of Head and Neck Surgery, Unit 441, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Curr Oncol Rep 8:130-9. 2006
  3. ncbi Glutathione S-transferase polymorphisms and risk of differentiated thyroid carcinomas: a case-control analysis
    Tang Ho
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Tex 77030 4009, USA
    Arch Otolaryngol Head Neck Surg 132:756-61. 2006
  4. ncbi Trends in head and neck cancer incidence in relation to smoking prevalence: an emerging epidemic of human papillomavirus-associated cancers?
    Erich M Sturgis
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 110:1429-35. 2007
  5. ncbi Association of XRCC1 polymorphisms and risk of differentiated thyroid carcinoma: a case-control analysis
    Tang Ho
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Thyroid 19:129-35. 2009
  6. ncbi Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck
    Zhongqiu Wang
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer 11:17. 2012
  7. ncbi A review of social and behavioral efforts at oral cancer preventions in India
    Erich M Sturgis
    Department of Head and Neck Surgery, Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 26:937-44. 2004
  8. ncbi Neoadjuvant chemotherapy for squamous cell carcinoma of the oral tongue in young adults: a case series
    Erich M Sturgis
    Department of Head and Neck Surgery, Unit 441, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
    Head Neck 27:748-56. 2005
  9. ncbi Radiation response genotype and risk of differentiated thyroid cancer: a case-control analysis
    Erich M Sturgis
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Laryngoscope 115:938-45. 2005
  10. ncbi DNA repair gene ERCC1 and ERCC2/XPD polymorphisms and risk of squamous cell carcinoma of the head and neck
    Erich M Sturgis
    Department of Head and Neck Surgery, Box 441, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
    Arch Otolaryngol Head Neck Surg 128:1084-8. 2002

Research Grants

  1. Use of Serum HPV16 DNA as a Marker for Oropharyngeal Cancer Recurrence
    Erich Sturgis; Fiscal Year: 2007

Collaborators

Detail Information

Publications101 found, 100 shown here

  1. ncbi A pilot study of Helicobacter pylori infection and risk of laryngopharyngeal cancer
    Zhannat Z Nurgalieva
    Department of Gastroenterology--Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Head Neck 27:22-7. 2005
    ..However, segregation analyses suggested that H. pylori may play a role in laryngeal cancers not associated with HPV-16 infection, and further study in this group is warranted...
  2. ncbi The role of human papillomavirus in squamous carcinoma of the head and neck
    Guojun Li
    Department of Head and Neck Surgery, Unit 441, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Curr Oncol Rep 8:130-9. 2006
    ....
  3. ncbi Glutathione S-transferase polymorphisms and risk of differentiated thyroid carcinomas: a case-control analysis
    Tang Ho
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Tex 77030 4009, USA
    Arch Otolaryngol Head Neck Surg 132:756-61. 2006
    ..To determine the association between glutathione S-transferase (GST) polymorphisms and the risk of differentiated thyroid carcinoma (DTC) and benign thyroid tumors...
  4. ncbi Trends in head and neck cancer incidence in relation to smoking prevalence: an emerging epidemic of human papillomavirus-associated cancers?
    Erich M Sturgis
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 110:1429-35. 2007
    ..To hasten the reduction of HPV-16 prevalence in the population, widespread vaccination of adolescent and young adult males should also be considered...
  5. ncbi Association of XRCC1 polymorphisms and risk of differentiated thyroid carcinoma: a case-control analysis
    Tang Ho
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Thyroid 19:129-35. 2009
    ..These SNPs have been increasingly studied in the epidemiology of various cancer types. In this study we evaluated the risk association between six common SNPs of the XRCC1 gene and differentiated thyroid carcinoma (DTC)...
  6. ncbi Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck
    Zhongqiu Wang
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer 11:17. 2012
    ....
  7. ncbi A review of social and behavioral efforts at oral cancer preventions in India
    Erich M Sturgis
    Department of Head and Neck Surgery, Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 26:937-44. 2004
    ..In most regions of India, it is the most common cancer in men and the third most common cancer in women. Prevention is an effective tool to reduce disease burden on society and may offer particular advantages in developing countries...
  8. ncbi Neoadjuvant chemotherapy for squamous cell carcinoma of the oral tongue in young adults: a case series
    Erich M Sturgis
    Department of Head and Neck Surgery, Unit 441, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
    Head Neck 27:748-56. 2005
    ....
  9. ncbi Radiation response genotype and risk of differentiated thyroid cancer: a case-control analysis
    Erich M Sturgis
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Laryngoscope 115:938-45. 2005
    ..Radiation is the only clear etiologic agent for differentiated thyroid cancer (DTC). Understanding the factors affecting sensitivity to gamma radiation and susceptibility to DTC will be critical to early detection and prevention of DTC...
  10. ncbi DNA repair gene ERCC1 and ERCC2/XPD polymorphisms and risk of squamous cell carcinoma of the head and neck
    Erich M Sturgis
    Department of Head and Neck Surgery, Box 441, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
    Arch Otolaryngol Head Neck Surg 128:1084-8. 2002
    ..To determine the effect of the ERCC1 C8092A polymorphism and the ERCC2/XPD G23591A polymorphism on the risk of squamous cell carcinoma of the head and neck (SCCHN)...
  11. ncbi After the smoke clears: environmental and occupational risks for carcinoma of the upper aerodigestive tract
    Erich M Sturgis
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Cancer J 11:96-103. 2005
    ..However, this is not an all-inclusive review; rather, it is designed to give the reader an understanding of the topic, to allow for appropriate counseling of patients, and perhaps to advance public health initiatives...
  12. ncbi Descriptive epidemiology and risk factors for head and neck cancer
    Erich M Sturgis
    Department of Head and Neck Surgery, 1515 Holcombe Boulevard, Unit 441, Houston, TX 77030 4009, USA
    Semin Oncol 31:726-33. 2004
    ..Newer data suggest a genetic contribution. This group is the focus of primary and secondary preventative efforts...
  13. ncbi The epidemic of HPV-associated oropharyngeal cancer is here: is it time to change our treatment paradigms?
    Erich M Sturgis
    Departments of Head and Neck Surgery, and Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas
    J Natl Compr Canc Netw 9:665-73. 2011
    ..However, data are currently insufficient to change treatment paradigms for HPV-associated oropharyngeal cancer outside of a closely monitored clinical trial...
  14. ncbi Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck
    Chunying Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 110:867-75. 2007
    ....
  15. ncbi Early risk factors for enlargement of the tracheoesophageal puncture after total laryngectomy: nodal metastasis and extent of surgery
    Katherine A Hutcheson
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Arch Otolaryngol Head Neck Surg 138:833-9. 2012
    ..To determine the early risk factors for enlargement of the tracheoesophageal puncture (TEP) after total laryngectomy...
  16. ncbi Association between the V109G polymorphism of the p27 gene and the risk and progression of oral squamous cell carcinoma
    Guojun Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 10:3996-4002. 2004
    ..We hypothesized that this p27 T109G polymorphism is associated with squamous cell carcinoma of the head and neck (SCCHN) risk...
  17. ncbi Potentially functional single nucleotide polymorphisms in the core nucleotide excision repair genes and risk of squamous cell carcinoma of the head and neck
    Jiaze An
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 1365, 1155 Pressler, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:1633-8. 2007
    ..These findings suggest that these potentially functional SNPs may collectively contribute to susceptibility to SCCHN. These findings need to be validated in larger, independent studies...
  18. ncbi In vitro benzo[a]pyrene diol epoxide-induced DNA damage and chromosomal aberrations in primary lymphocytes, smoking, and risk of squamous cell carcinoma of the head and neck
    Ping Xiong
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Cancer 121:2735-40. 2007
    ..Further validation studies are warranted...
  19. ncbi Prospective imaging assessment of mortality risk after head-and-neck radiotherapy
    Benjamin J Moeller
    Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 78:667-74. 2010
    ..Unresolved questions include whether functional or anatomic imaging might improve mortality risk assessment for this disease. We addressed these issues in a prospective institutional trial...
  20. ncbi Multivariable analysis of risk factors for enlargement of the tracheoesophageal puncture after total laryngectomy
    Katherine A Hutcheson
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Head Neck 34:557-67. 2012
    ..Prevention of this complication requires identification of high-risk individuals, and surgical and prosthetic correlates of TEP enlargement...
  21. ncbi Fas single nucleotide polymorphisms and risk of thyroid and salivary gland carcinomas: a case-control analysis
    Tang Ho
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Head Neck 30:297-305. 2008
    ..The purpose of this study was to examine the association between 4 Fas single nucleotide polymorphisms (SNPs) and risk of differentiated thyroid carcinoma (DTC) and salivary gland carcinoma (SGC)...
  22. ncbi Polymorphisms of vitamin D receptor gene protect against the risk of head and neck cancer
    Zhensheng Liu
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Pharmacogenet Genomics 15:159-65. 2005
    ..001). These data suggest that the VDR f and t alleles and their genotypes may protect against SCCHN. However, further studies are warranted to confirm these findings...
  23. ncbi p53 codon 72 polymorphism associated with risk of human papillomavirus-associated squamous cell carcinoma of the oropharynx in never-smokers
    Xuemei Ji
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 29:875-9. 2008
    ..5; 95% CI, 4.8-106.2). These findings suggest that p53 codon 72 variant genotypes modify the risk of HPV16-associated SCCOP and may be markers of genetic susceptibility to HPV16-associated SCCOP, especially among never-smokers...
  24. ncbi Differences in history of sexual behavior between patients with oropharyngeal squamous cell carcinoma and patients with squamous cell carcinoma at other head and neck sites
    Kristina R Dahlstrom
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Head Neck 33:847-55. 2011
    ....
  25. ncbi Genetic polymorphisms of p21 are associated with risk of squamous cell carcinoma of the head and neck
    Guojun Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 26:1596-602. 2005
    ..001). Our results suggest that the presence of these two p21 polymorphisms may be a marker of genetic susceptibility to SCCHN...
  26. ncbi FAS and FASLG genetic variants and risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck
    Dapeng Lei
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 19:1484-91. 2010
    ..We therefore investigated the association between the FAS and FASLG polymorphisms and risk for second primary malignancy (SPM) after index squamous cell carcinoma of the head and neck (SCCHN)...
  27. ncbi Outcomes of patients with tonsillar carcinoma treated with post-tonsillectomy radiation therapy
    Gokcen Yildirim
    The University of Texas M D Anderson Cancer Center, Department of Radiation Oncology, Unit 97, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Head Neck 32:473-80. 2010
    ..Our aim was to evaluate the therapeutic outcomes of patients with squamous cell carcinoma of the tonsil that underwent tonsillectomies followed by radiotherapy...
  28. ncbi Genotypes and haplotypes of ERCC1 and ERCC2/XPD genes predict levels of benzo[a]pyrene diol epoxide-induced DNA adducts in cultured primary lymphocytes from healthy individuals: a genotype-phenotype correlation analysis
    Hui Zhao
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 29:1560-6. 2008
    ..Our findings suggest that the genotypes and haplotypes of ERCC1 and ERCC2/XPD may have an effect on in vitro BPDE-induced DNA adduct levels...
  29. ncbi p73 G4C14-to-A4T14 polymorphism and risk of second primary malignancy after index squamous cell carcinoma of head and neck
    Fanglin Li
    Department of Head and Neck Surgery, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 125:2660-5. 2009
    ..g., older patients, men, minorities, ever smokers, and ever drinkers). Our results support that this p73 polymorphism may be a marker for risk of SPM among patients with an incident SCCHN...
  30. ncbi A novel functional variant (-842G>C) in the PIN1 promoter contributes to decreased risk of squamous cell carcinoma of the head and neck by diminishing the promoter activity
    Jiachun Lu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 30:1717-21. 2009
    ..Large prospective studies of diverse ethnic groups and diverse cancer sites are warranted to validate our findings...
  31. ncbi Single-nucleotide polymorphisms at the TP53-binding or responsive promoter regions of BAX and BCL2 genes and risk of squamous cell carcinoma of the head and neck
    Kexin Chen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 28:2008-12. 2007
    ..Our data suggest that the risk of SCCHN may be associated with these two SNPs of BAX and BCL2 promoter regions, particularly among TP53 heterozygotes. Larger studies are needed to validate these findings...
  32. ncbi Polymorphisms of the DNA repair gene MGMT and risk and progression of head and neck cancer
    Zhengdong Zhang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    DNA Repair (Amst) 9:558-66. 2010
    ....
  33. ncbi A variant of the DNA repair gene XRCC3 and risk of squamous cell carcinoma of the head and neck: a case-control analysis
    Hongbing Shen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 99:869-72. 2002
    ..26; 95% CI, 1.02-4.99). These findings suggest that the variant XRCC3 18067TT genotype may not play a major role in the etiology of SCCHN but may contribute to a subset of SCCHN. Larger studies are needed to verify these findings...
  34. ncbi Polymorphisms of FAS and FAS ligand genes involved in the death pathway and risk and progression of squamous cell carcinoma of the head and neck
    Zhengdong Zhang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 12:5596-602. 2006
    ....
  35. ncbi 172G>T variant in the 5' untranslated region of DNA repair gene RAD51 reduces risk of squamous cell carcinoma of the head and neck and interacts with a P53 codon 72 variant
    Jiachun Lu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 28:988-94. 2007
    ..The finding that the functional RAD51 172G>T SNP, particularly in the presence of the P53 Arg72Arg genotype, may be a marker of susceptibility to SCCHN needs to be validated by larger studies of different ethnic populations...
  36. ncbi p73 G4C14-to-A4T14 polymorphism and risk of human papillomavirus-associated squamous cell carcinoma of the oropharynx in never smokers and never drinkers
    Xingming Chen
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 113:3307-14. 2008
    ....
  37. ncbi Association of a p73 exon 2 G4C14-to-A4T14 polymorphism with risk of squamous cell carcinoma of the head and neck
    Guojun Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 25:1911-6. 2004
    ..70; 95% CI, 1.19-2.43), women (1.61; 1.09-2.37), current smokers (1.77; 1.25-2.51) and patients with oral cancer (1.54; 1.15-2.07). Our results suggest that this p73 polymorphism may be a risk marker for genetic susceptibility to SCCHN...
  38. ncbi Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: a case-control analysis
    Ana S Neumann
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 115:131-6. 2005
    ..Future studies should incorporate detailed data on alcohol consumption, dietary folate intake and related serologic measurements...
  39. ncbi Human papillomavirus & WHO type I nasopharyngeal carcinoma
    Emily J Lo
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Laryngoscope 120:S185. 2010
    ..Given the rise in oropharyngeal tumors positive for high risk human papillomavirus (HPV) and the unique biology of WHO type INPC, we chose to examine the relationship between HPV and WHO type I NPC...
  40. ncbi Polymorphisms of methionine synthase and methionine synthase reductase and risk of squamous cell carcinoma of the head and neck: a case-control analysis
    Zhengdong Zhang
    Department of Epidemiology, Unit 189, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 14:1188-93. 2005
    ..In conclusion, our data provide evidence that support the association between the MTR A2756G and MTRR G66A polymorphisms and SCCHN risk and that these two polymorphisms may have a joint effect on risk of SCCHN...
  41. ncbi Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck
    Zhensheng Liu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 31:1977-81. 2010
    ..Although we added additional evidence for the association of the two SNPs with cancer risk as reported in GWAS, additional studies are needed to replicate our findings...
  42. ncbi Combined effects of the p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms on the risk of HPV16-associated oral cancer in never-smokers
    Xingming Chen
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 29:2120-5. 2008
    ..22-106.0) than did HPV16-seronegative never-smokers in the low-risk group. These findings suggest that the combined variants of p53 and p73 significantly increase the risk of HPV16-associated oral cancer, especially among never-smokers...
  43. ncbi Outcomes and adverse events of enlarged tracheoesophageal puncture after total laryngectomy
    Katherine A Hutcheson
    Department of Head and Neck Surgery, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Laryngoscope 121:1455-61. 2011
    ..The primary objective was to summarize control of leakage around the VP after conservative management of enlarged TEP...
  44. ncbi Polymorphisms of XPG/ERCC5 and risk of squamous cell carcinoma of the head and neck
    Hongxia Ma
    Department of Epidemiology, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Pharmacogenet Genomics 22:50-7. 2012
    ..We investigated the association between XPG/ERCC5 polymorphisms and risk of SCCHN...
  45. ncbi Association of p53 codon 72 polymorphism with risk of second primary malignancy in patients with squamous cell carcinoma of the head and neck
    Fanglin Li
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 116:2350-9. 2010
    ..The authors hypothesized that p53 codon 72 polymorphism may be associated with risk of SPMs and SPM-free survival among patients with squamous cell carcinoma of the head and neck (SCCHN)...
  46. ncbi Reduced DNA repair capacity for removing tobacco carcinogen-induced DNA adducts contributes to risk of head and neck cancer but not tumor characteristics
    Li E Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 16:764-74. 2010
    ..In this study, we investigated the associations between genetically determined DNA repair capacity (DRC) for removing tobacco-induced DNA adducts and risk of SCCHN and tumor characteristics...
  47. ncbi The six-nucleotide deletion/insertion variant in the CASP8 promoter region is inversely associated with risk of squamous cell carcinoma of the head and neck
    Chunying Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Cancer Prev Res (Phila) 3:246-53. 2010
    ..Further validation by population-based case-control studies and rigorous mechanistic studies is warranted...
  48. ncbi XPD/ERCC2 EXON 8 Polymorphisms: rarity and lack of significance in risk of squamous cell carcinoma of the head and neck
    Erich M Sturgis
    Department of Head and Neck Surgery, Box 441, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston 77030 4009, USA
    Oral Oncol 38:475-7. 2002
    ..The objective was to assess whether two polymorphisms in the nucleotide excision repair gene XPD (ERCC2) are markers of SCCHN risk...
  49. ncbi Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck
    Zhensheng Liu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 116:4753-60. 2010
    ..The authors hypothesized that common polymorphisms in pre-miRNAs are associated individually and (more likely) collectively with the risk of squamous cell carcinoma of the head and neck (SCCHN)...
  50. ncbi Combined p53-related genetic variants together with HPV infection increase oral cancer risk
    Zhongqiu Wang
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 131:E251-8. 2012
    ..Larger studies are needed to validate our findings...
  51. ncbi Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck
    Hongxia Ma
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    BMC Cancer 11:258. 2011
    ..Therefore, we investigated the association between potentially functional SNPs in PLCE1 and susceptibility to SCCHN...
  52. ncbi A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck
    Sheng Wei
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cancer 116:2984-92. 2010
    ....
  53. ncbi A functional variant at the miR-184 binding site in TNFAIP2 and risk of squamous cell carcinoma of the head and neck
    Zhensheng Liu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 32:1668-74. 2011
    ..Larger replication studies are needed to confirm our findings...
  54. ncbi Squamous cell carcinoma of the head and neck in never smoker-never drinkers: a descriptive epidemiologic study
    Kristina R Dahlstrom
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 30:75-84. 2008
    ..This study reports the demographic and potential risk factors of a large series of never smoker-never drinker (NSND) patients...
  55. ncbi Genetic polymorphisms of p21 and risk of second primary malignancy in patients with index squamous cell carcinoma of the head and neck
    Dapeng Lei
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 31:222-7. 2010
    ..00, 95% CI = 1.26-3.00), and the risk was particularly pronounced in several subgroups. Our results support an increased risk of SPM after index SCCHN with both p21 polymorphisms individually and in combination...
  56. ncbi Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx
    Xiadong Zhai
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:4345-52. 2008
    ..To date, only one reported study has investigated the association between NEIL1 and NEIL2 polymorphisms and cancer risk...
  57. ncbi Association of combined p73 and p53 genetic variants with tumor HPV16-positive oropharyngeal cancer
    Zhongqiu Wang
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 7:e35522. 2012
    ..Identification of such susceptible biomarkers would greatly influence on individualized treatment for an improved prognosis...
  58. ncbi Thymidylate synthase 5'- and 3'-untranslated region polymorphisms associated with risk and progression of squamous cell carcinoma of the head and neck
    Zhengdong Zhang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 10:7903-10. 2004
    ..We hypothesized that polymorphisms of the thymidylate synthase (TYMS) gene, which regulates a key enzyme in folate metabolism required for DNA synthesis and repair, are associated with SCCHN risk...
  59. ncbi Effects of MDM2 promoter polymorphisms and p53 codon 72 polymorphism on risk and age at onset of squamous cell carcinoma of the head and neck
    Hongping Yu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Mol Carcinog 50:697-706. 2011
    ..Further studies with large sample sizes are warranted to validate these results...
  60. ncbi No Association between hOGG1 Ser326Cys polymorphism and risk of squamous cell carcinoma of the head and neck
    Zhengdong Zhang
    Department of Epidemiology, University of Texas M.D. Anderson Cancer Center, Houston, 77030, USA
    Cancer Epidemiol Biomarkers Prev 13:1081-3. 2004
  61. ncbi Gamma radiation sensitivity and risk of malignant and benign salivary gland tumors: a pilot case-control analysis
    Rong Zheng
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030-4009, USA
    Cancer 100:561-7. 2004
    ..However, larger studies are needed to verify these findings...
  62. ncbi Gastrostomy in oropharyngeal cancer patients with ERCC4 (XPF) germline variants
    David G Kornguth
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Int J Radiat Oncol Biol Phys 62:665-71. 2005
    ..We hypothesized that two ERCC4 single-nucleotide polymorphisms are associated with normal-tissue toxicity in patients treated with radiotherapy for oropharyngeal squamous cell carcinoma (OPSCC)...
  63. ncbi Expression of nucleotide excision repair genes and the risk for squamous cell carcinoma of the head and neck
    Lie Cheng
    Department of Epidemiology, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA
    Cancer 94:393-7. 2002
    ..42 [2.63-15.69], 2.86 [1.39-5.90], 3.69 [1.73-7.90], and 2.46 [1.19-5.09], respectively). CONCLUSIONS: Reduced expression of ERCC1, XPB/ERCC3, XPG/ERCC5, and CSB/ERCC6 is associated with a more than two-fold increased risk of SCCHN...
  64. ncbi A pilot case-control study of gamma-radiation sensitivity and risk of papillary thyroid cancer
    Ping Xiong
    Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030-4009, USA
    Thyroid 15:94-9. 2005
    ..High levels of chromatid breaks induced by gamma-radiation may constitute an independent risk factor for PTC, but further study is needed...
  65. ncbi Matched-pair analysis of survival of never smokers and ever smokers with squamous cell carcinoma of the head and neck
    Kristen B Pytynia
    The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030-4009, USA
    J Clin Oncol 22:3981-8. 2004
    ....
  66. ncbi Expression of nucleotide excision repair proteins in lymphocytes as a marker of susceptibility to squamous cell carcinomas of the head and neck
    Qingyi Wei
    Department of Epidemiology, Unit 189, and Li Mao, Department of Thoracic and Head and Neck Medical Oncology, Unit 432, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 14:1961-6. 2005
    ..5; 95% CI, 2.32-56.6). These results suggest that XPF may be a crucial rate-limiting factor in DNA repair and that the reverse-protein microarray assay may be a useful tool for measuring protein markers of susceptibility to cancer...
  67. ncbi Glutathione S-transferase polymorphisms and risk of second primary malignancy after index squamous cell carcinoma of the head and neck
    Mark E Zafereo
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Cancer Prev Res (Phila) 2:432-9. 2009
    ..2-2.5). This large prospective cohort study supports a modestly increased risk of SPM after index SCCHN with GSTP1 Ile(105)Val polymorphism and an even greater risk of SPM with multiple combined GST risk genotypes...
  68. ncbi Association of p73 G4C14-to-A4T14 polymorphism with human papillomavirus type 16 status in squamous cell carcinoma of the head and neck in non-Hispanic whites
    Xuemei Ji
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 115:1660-8. 2009
    ....
  69. ncbi Polymorphisms of MDM4 and risk of squamous cell carcinoma of the head and neck
    Hongping Yu
    Departments of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Pharmacogenet Genomics 21:388-96. 2011
    ..We investigated the association between MDM4 polymorphisms and the risk of squamous cell carcinoma of the head and neck (SCCHN)...
  70. ncbi Human papillomavirus seropositivity synergizes with MDM2 variants to increase the risk of oral squamous cell carcinoma
    Xingming Chen
    Departments of Head and Neck Surgery and Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 70:7199-208. 2010
    ..Taken together, our results indicate that the risk of OSCC associated with HPV16 L1 seropositivity is modified by MDM2 promoter polymorphisms...
  71. ncbi Neoadjuvant chemotherapy-specific and overall treatment outcomes in patients with cutaneous angiosarcoma of the face with periorbital involvement
    Sheri L Demartelaere
    Section of Ophthalmology, Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 30:639-46. 2008
    ..The goal of this report was to investigate the overall treatment outcomes and the neoadjuvant chemotherapy-specific outcomes in patients with cutaneous angiosarcoma of the face with periorbital involvement...
  72. ncbi Nucleotide excision repair as a marker for susceptibility to tobacco-related cancers: a review of molecular epidemiological studies
    Ana S Neumann
    Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mol Carcinog 42:65-92. 2005
    ....
  73. ncbi In vitro benzo[a]pyrene diol epoxide-induced DNA adducts and risk of squamous cell carcinoma of head and neck
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 67:5628-34. 2007
    ..In conclusion, we confirmed the previously reported association between in vitro BPDE-induced DNA adduct levels and SCCHN risk, and the assay may help identify individuals at high risk of developing smoking-related cancers...
  74. ncbi Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients
    Nadezhda V Koshkina
    Department of Pediatrics, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Pediatr Hematol Oncol 29:815-21. 2007
    ..This study suggests an association between the Fas exon 3 A>G polymorphism and osteosarcoma risk; however, further study is needed with pediatric controls and a larger sample size...
  75. ncbi Primary tracheal malignant neoplasms: the University of Texas MD Anderson Cancer Center experience
    Benjamin D Webb
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Am Coll Surg 202:237-46. 2006
    ..Although squamous cell carcinoma was the most common pathology in smokers, adenoid cystic carcinoma was more prevalent among nonsmokers. Operation with adjuvant postoperative radiotherapy is recommended for most patients...
  76. ncbi Melanoma metastatic to cervical lymph nodes: Can radiotherapy replace formal dissection after local excision of nodal disease?
    Matthew T Ballo
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Head Neck 27:718-21. 2005
    ..Completion cervical lymphadenectomy is usually performed after excisional biopsy of nodal metastases from melanoma. Radiation (XRT) might be effective for some patients in lieu of formal lymph node dissection...
  77. ncbi Outcomes after definitive treatment for cutaneous angiosarcoma of the face and scalp
    B Ashleigh Guadagnolo
    Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Head Neck 33:661-7. 2011
    ..The aim of the present analysis was to retrospectively evaluate outcomes in patients with cutaneous angiosarcoma of the face/scalp treated curatively with surgery, radiation therapy (RT), or a combination of surgery and RT...
  78. ncbi Squamous cell carcinoma of the temporal bone
    Paul W Gidley
    Department of Head and Neck Surgery, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Laryngoscope 120:1144-51. 2010
    ..To study the survival outcomes of patients with squamous cell carcinoma (SCC) of the temporal bone. A secondary purpose was to evaluate the University of Pittsburgh staging system as a predictor of survival...
  79. ncbi Haplotypes of two variants in p16 (CDKN2/MTS-1/INK4a) exon 3 and risk of squamous cell carcinoma of the head and neck: a case-control study
    Yuxin Zheng
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 11:640-5. 2002
    ..We conclude that these polymorphic p16 genotypes or haplotypes may not play a major role in the etiology of SCCHN, if any. However, our limited sample size and power call for larger studies for additional verification of our findings...
  80. ncbi Association of TGF-beta1 genetic variants with HPV16-positive oropharyngeal cancer
    Xiaoxiang Guan
    Departments of Epidemiology, and Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 16:1416-22. 2010
    ....
  81. ncbi P53 codon 72 polymorphism and risk of squamous cell carcinoma of the head and neck: a case-control study
    Hongbing Shen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Lett 183:123-30. 2002
    ..Arg/Arg; P=0.066 for Pro/Pro and Arg/Pro combined vs. Arg/Arg). While the results suggest that the P53 codon 72 polymorphism may contribute to oral cancer susceptibility, larger studies are needed to confirm these findings...
  82. ncbi Nucleotide excision repair core gene polymorphisms and risk of second primary malignancy in patients with index squamous cell carcinoma of the head and neck
    Mark E Zafereo
    Department of Head and Neck Surgery, University of Texas M D Anderson Cancer Center, Houston, 77030 4009, USA
    Carcinogenesis 30:997-1002. 2009
    ..These findings need to be validated in future studies with larger sample sizes and longer follow-up time...
  83. ncbi Osteosarcoma of the jaw/craniofacial region: outcomes after multimodality treatment
    B Ashleigh Guadagnolo
    Division of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cancer 115:3262-70. 2009
    ..The current study was performed to evaluate outcomes in patients with osteosarcoma of the head and neck (OHN) who were treated with surgery with or without radiotherapy (RT)...
  84. ncbi Polymorphisms of the DNMT3B gene and risk of squamous cell carcinoma of the head and neck: a case-control study
    Zhensheng Liu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Box 189, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Lett 268:158-65. 2008
    ..Further mechanistic studies are needed to unravel the underlying molecular mechanisms...
  85. ncbi Sarcomas of the head and neck region
    Erich M Sturgis
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 441, Houston, TX 77030 4009, USA
    Curr Opin Oncol 15:239-52. 2003
    ..This review discusses the classification, etiology, diagnosis, evaluation, treatment, and prognosis of sarcoma of the head and neck region...
  86. ncbi Postirradiation osteosarcoma of the mandible with heterologous differentiation
    Raja R Seethala
    Department of Pathology, M. D. Anderson Cancer Center, Houston, TX 77030, USA
    Arch Pathol Lab Med 130:385-8. 2006
    ..To our knowledge, this is the first report of osteosarcoma of the mandible with heterologous differentiation...
  87. ncbi Genetic polymorphisms in the PTPN13 gene and risk of squamous cell carcinoma of head and neck
    Jiangong Niu
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 30:2053-8. 2009
    ..6241 Y2081D GG genotype was borderline in patients with laryngeal cancer. In conclusion, polymorphisms in the PTPN13 coding region may be biomarkers for susceptibility to SCCHN in USA populations...
  88. ncbi Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck
    Kexin Chen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:4300-5. 2007
    ....
  89. ncbi CYP2E1 G1532C, NQO1 Pro187Ser, and CYP1B1 Val432Leu polymorphisms are not associated with risk of squamous cell carcinoma of the head and neck
    Guojun Li
    Department of Epidemiology, Unit 189, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 14:1034-6. 2005
  90. ncbi Serum cotinine concentration and wound complications in head and neck reconstruction
    Vincent P Marin
    University of Texas Southwestern at Dallas, USA
    Plast Reconstr Surg 121:451-7. 2008
    ..The authors examined whether the preoperative serum concentrations of cotinine accurately predict the risk of complications in patients undergoing flap reconstruction of head and neck cancer defects...
  91. ncbi Chromosome instability and risk of squamous cell carcinomas of head and neck
    Li E Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 68:4479-85. 2008
    ....
  92. ncbi Genetic susceptibility--molecular epidemiology of head and neck cancer
    Erich M Sturgis
    Department of Head and Neck Surgery and Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Curr Opin Oncol 14:310-7. 2002
    ..The ability to identify such high-risk individuals will have major influences on the practice of cancer prevention in the future...
  93. ncbi Gamma radiation-induced apoptosis, G2 delay, and the risk of salivary and thyroid carcinomas--a preliminary report
    Rong Zheng
    The Department of Head and Neck Surgery, Unit 441, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
    Head Neck 26:612-8. 2004
    ..90-17.08). CONCLUSIONS: Our data suggests that gamma radiation-induced apoptosis may serve as a biomarker of genetic susceptibility to salivary and thyroid carcinoma, and further confirmatory studies with larger sample size are warranted...
  94. ncbi Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review
    Paul Brennan
    International Agency for Research on Cancer, Lyon, France
    Am J Epidemiol 159:1-16. 2004
    ..These considerations suggest the potential for the organization of a consortium of investigators conducting studies in this field...
  95. ncbi Heterotopic parathyroid inclusion in a cervical lymph node
    Emanuela Veras
    Department of Pathology and Laboratory Medicine, The University of Texas Medical School at Houston, Texas, USA
    Head Neck 29:1160-3. 2007
    ..During the pathologic examination of neck dissection specimens, unexpected findings within the lymph nodes may be discovered. Such findings may include benign epithelial inclusions, a second primary tumor, or chronic inflammatory diseases...
  96. ncbi Molecular and clinicopathologic comparisons of head and neck squamous carcinoma variants: common and distinctive features of biological significance
    Hong Ran Choi
    Department of Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Am J Surg Pathol 28:1299-310. 2004
    ....
  97. ncbi Polymorphisms and haplotypes of serine hydroxymethyltransferase and risk of squamous cell carcinoma of the head and neck: a case-control analysis
    Zhengdong Zhang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Pharmacogenet Genomics 15:557-64. 2005
    ..In conclusion, these three SHMT1 polymorphisms may play a joint role in the etiology of SCCHN in a non-Hispanic white population...
  98. ncbi X-ray repair cross-complementing group 1 (XRCC1) single-nucleotide polymorphisms and the risk of salivary gland carcinomas
    Tang Ho
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 110:318-25. 2007
    ..X-ray repair cross complementing group 1 (XRCC1) is important in the repair of single-strand DNA breaks caused by endogenous oxidative species and exogenous carcinogens...
  99. ncbi Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
    Mia Hashibe
    Gene Environment Epidemiology Group, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008 Lyon, France
    J Natl Cancer Inst 99:777-89. 2007
    ....
  100. ncbi Epidemiology of carcinogen metabolism genes and risk of squamous cell carcinoma of the head and neck
    Tang Ho
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 29:682-99. 2007
    ....
  101. ncbi RET polymorphisms and haplotypes and risk of differentiated thyroid cancer
    Tang Ho
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 1402, USA
    Laryngoscope 115:1035-41. 2005
    ..To determine whether common (allele frequencies > 5%) single nucleotide polymorphisms located in exons 2, 7, 11, 13, 14, and 15 of the RET proto-oncogene are associated with risk of differentiated thyroid carcinoma (DTC)...

Research Grants2

  1. Use of Serum HPV16 DNA as a Marker for Oropharyngeal Cancer Recurrence
    Erich Sturgis; Fiscal Year: 2007
    ..Secondly, in follow-up such a marker may have utility in earlier detection of recurrent disease, which at present has an extremely poor prognosis. ..