Erich M Sturgis

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint The role of human papillomavirus in squamous carcinoma of the head and neck
    Guojun Li
    Department of Head and Neck Surgery, Unit 441, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Curr Oncol Rep 8:130-9. 2006
  2. ncbi request reprint Glutathione S-transferase polymorphisms and risk of differentiated thyroid carcinomas: a case-control analysis
    Tang Ho
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Tex 77030 4009, USA
    Arch Otolaryngol Head Neck Surg 132:756-61. 2006
  3. ncbi request reprint Trends in head and neck cancer incidence in relation to smoking prevalence: an emerging epidemic of human papillomavirus-associated cancers?
    Erich M Sturgis
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 110:1429-35. 2007
  4. doi request reprint Association of XRCC1 polymorphisms and risk of differentiated thyroid carcinoma: a case-control analysis
    Tang Ho
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Thyroid 19:129-35. 2009
  5. pmc Outcomes and patterns of care of patients with locally advanced oropharyngeal carcinoma treated in the early 21st century
    Adam S Garden
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Radiat Oncol 8:21. 2013
  6. pmc Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma
    Lei Jin
    Department of Stomatology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China
    Mol Cancer 12:80. 2013
  7. pmc Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck
    Ziyuan Zhou
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    BMC Cancer 12:159. 2012
  8. pmc Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck
    Zhongqiu Wang
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer 11:17. 2012
  9. ncbi request reprint Descriptive epidemiology and risk factors for head and neck cancer
    Erich M Sturgis
    Department of Head and Neck Surgery, 1515 Holcombe Boulevard, Unit 441, Houston, TX 77030 4009, USA
    Semin Oncol 31:726-33. 2004
  10. ncbi request reprint Radiation response genotype and risk of differentiated thyroid cancer: a case-control analysis
    Erich M Sturgis
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Laryngoscope 115:938-45. 2005

Research Grants

Collaborators

Detail Information

Publications110 found, 100 shown here

  1. ncbi request reprint The role of human papillomavirus in squamous carcinoma of the head and neck
    Guojun Li
    Department of Head and Neck Surgery, Unit 441, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Curr Oncol Rep 8:130-9. 2006
    ....
  2. ncbi request reprint Glutathione S-transferase polymorphisms and risk of differentiated thyroid carcinomas: a case-control analysis
    Tang Ho
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Tex 77030 4009, USA
    Arch Otolaryngol Head Neck Surg 132:756-61. 2006
    ..To determine the association between glutathione S-transferase (GST) polymorphisms and the risk of differentiated thyroid carcinoma (DTC) and benign thyroid tumors...
  3. ncbi request reprint Trends in head and neck cancer incidence in relation to smoking prevalence: an emerging epidemic of human papillomavirus-associated cancers?
    Erich M Sturgis
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 110:1429-35. 2007
    ..To hasten the reduction of HPV-16 prevalence in the population, widespread vaccination of adolescent and young adult males should also be considered...
  4. doi request reprint Association of XRCC1 polymorphisms and risk of differentiated thyroid carcinoma: a case-control analysis
    Tang Ho
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Thyroid 19:129-35. 2009
    ..These SNPs have been increasingly studied in the epidemiology of various cancer types. In this study we evaluated the risk association between six common SNPs of the XRCC1 gene and differentiated thyroid carcinoma (DTC)...
  5. pmc Outcomes and patterns of care of patients with locally advanced oropharyngeal carcinoma treated in the early 21st century
    Adam S Garden
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Radiat Oncol 8:21. 2013
    ..We performed this study to assess outcomes of patients with oropharyngeal cancer treated with modern therapy approaches...
  6. pmc Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma
    Lei Jin
    Department of Stomatology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China
    Mol Cancer 12:80. 2013
    ..Thus, genetic variants may modulate individual susceptibility to HPV-associated oral squamous cell carcinoma (OSCC)...
  7. pmc Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck
    Ziyuan Zhou
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    BMC Cancer 12:159. 2012
    ..Therefore, genetic variants of NOXA and MCL1 may modify the SCCHN risk associated with HPV16 seropositivity...
  8. pmc Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck
    Zhongqiu Wang
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer 11:17. 2012
    ....
  9. ncbi request reprint Descriptive epidemiology and risk factors for head and neck cancer
    Erich M Sturgis
    Department of Head and Neck Surgery, 1515 Holcombe Boulevard, Unit 441, Houston, TX 77030 4009, USA
    Semin Oncol 31:726-33. 2004
    ..Newer data suggest a genetic contribution. This group is the focus of primary and secondary preventative efforts...
  10. ncbi request reprint Radiation response genotype and risk of differentiated thyroid cancer: a case-control analysis
    Erich M Sturgis
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Laryngoscope 115:938-45. 2005
    ..Radiation is the only clear etiologic agent for differentiated thyroid cancer (DTC). Understanding the factors affecting sensitivity to gamma radiation and susceptibility to DTC will be critical to early detection and prevention of DTC...
  11. ncbi request reprint A review of social and behavioral efforts at oral cancer preventions in India
    Erich M Sturgis
    Department of Head and Neck Surgery, Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 26:937-44. 2004
    ..In most regions of India, it is the most common cancer in men and the third most common cancer in women. Prevention is an effective tool to reduce disease burden on society and may offer particular advantages in developing countries...
  12. ncbi request reprint Neoadjuvant chemotherapy for squamous cell carcinoma of the oral tongue in young adults: a case series
    Erich M Sturgis
    Department of Head and Neck Surgery, Unit 441, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
    Head Neck 27:748-56. 2005
    ....
  13. ncbi request reprint The epidemic of HPV-associated oropharyngeal cancer is here: is it time to change our treatment paradigms?
    Erich M Sturgis
    Departments of Head and Neck Surgery, and Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas
    J Natl Compr Canc Netw 9:665-73. 2011
    ..However, data are currently insufficient to change treatment paradigms for HPV-associated oropharyngeal cancer outside of a closely monitored clinical trial...
  14. ncbi request reprint After the smoke clears: environmental and occupational risks for carcinoma of the upper aerodigestive tract
    Erich M Sturgis
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Cancer J 11:96-103. 2005
    ..However, this is not an all-inclusive review; rather, it is designed to give the reader an understanding of the topic, to allow for appropriate counseling of patients, and perhaps to advance public health initiatives...
  15. ncbi request reprint DNA repair gene ERCC1 and ERCC2/XPD polymorphisms and risk of squamous cell carcinoma of the head and neck
    Erich M Sturgis
    Department of Head and Neck Surgery, Box 441, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
    Arch Otolaryngol Head Neck Surg 128:1084-8. 2002
    ..To determine the effect of the ERCC1 C8092A polymorphism and the ERCC2/XPD G23591A polymorphism on the risk of squamous cell carcinoma of the head and neck (SCCHN)...
  16. ncbi request reprint Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck
    Chunying Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 110:867-75. 2007
    ....
  17. ncbi request reprint Early risk factors for enlargement of the tracheoesophageal puncture after total laryngectomy: nodal metastasis and extent of surgery
    Katherine A Hutcheson
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Arch Otolaryngol Head Neck Surg 138:833-9. 2012
    ..To determine the early risk factors for enlargement of the tracheoesophageal puncture (TEP) after total laryngectomy...
  18. ncbi request reprint Association between the V109G polymorphism of the p27 gene and the risk and progression of oral squamous cell carcinoma
    Guojun Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 10:3996-4002. 2004
    ..We hypothesized that this p27 T109G polymorphism is associated with squamous cell carcinoma of the head and neck (SCCHN) risk...
  19. ncbi request reprint Potentially functional single nucleotide polymorphisms in the core nucleotide excision repair genes and risk of squamous cell carcinoma of the head and neck
    Jiaze An
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 1365, 1155 Pressler, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:1633-8. 2007
    ..These findings suggest that these potentially functional SNPs may collectively contribute to susceptibility to SCCHN. These findings need to be validated in larger, independent studies...
  20. pmc Prospective imaging assessment of mortality risk after head-and-neck radiotherapy
    Benjamin J Moeller
    Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 78:667-74. 2010
    ..Unresolved questions include whether functional or anatomic imaging might improve mortality risk assessment for this disease. We addressed these issues in a prospective institutional trial...
  21. ncbi request reprint In vitro benzo[a]pyrene diol epoxide-induced DNA damage and chromosomal aberrations in primary lymphocytes, smoking, and risk of squamous cell carcinoma of the head and neck
    Ping Xiong
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Cancer 121:2735-40. 2007
    ..Further validation studies are warranted...
  22. pmc Multivariable analysis of risk factors for enlargement of the tracheoesophageal puncture after total laryngectomy
    Katherine A Hutcheson
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Head Neck 34:557-67. 2012
    ..Prevention of this complication requires identification of high-risk individuals, and surgical and prosthetic correlates of TEP enlargement...
  23. ncbi request reprint Fas single nucleotide polymorphisms and risk of thyroid and salivary gland carcinomas: a case-control analysis
    Tang Ho
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Head Neck 30:297-305. 2008
    ..The purpose of this study was to examine the association between 4 Fas single nucleotide polymorphisms (SNPs) and risk of differentiated thyroid carcinoma (DTC) and salivary gland carcinoma (SGC)...
  24. ncbi request reprint Polymorphisms of vitamin D receptor gene protect against the risk of head and neck cancer
    Zhensheng Liu
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Pharmacogenet Genomics 15:159-65. 2005
    ..001). These data suggest that the VDR f and t alleles and their genotypes may protect against SCCHN. However, further studies are warranted to confirm these findings...
  25. pmc Differences in history of sexual behavior between patients with oropharyngeal squamous cell carcinoma and patients with squamous cell carcinoma at other head and neck sites
    Kristina R Dahlstrom
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Head Neck 33:847-55. 2011
    ....
  26. doi request reprint p53 codon 72 polymorphism associated with risk of human papillomavirus-associated squamous cell carcinoma of the oropharynx in never-smokers
    Xuemei Ji
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 29:875-9. 2008
    ..5; 95% CI, 4.8-106.2). These findings suggest that p53 codon 72 variant genotypes modify the risk of HPV16-associated SCCOP and may be markers of genetic susceptibility to HPV16-associated SCCOP, especially among never-smokers...
  27. ncbi request reprint Genetic polymorphisms of p21 are associated with risk of squamous cell carcinoma of the head and neck
    Guojun Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 26:1596-602. 2005
    ..001). Our results suggest that the presence of these two p21 polymorphisms may be a marker of genetic susceptibility to SCCHN...
  28. pmc Incidence and pattern of second primary malignancies in patients with index oropharyngeal cancers versus index nonoropharyngeal head and neck cancers
    Samuel J Gan
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 119:2593-601. 2013
    ....
  29. pmc Genetic variants in p53-related genes confer susceptibility to second primary malignancy in patients with index squamous cell carcinoma of head and neck
    Lei Jin
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 34:1551-7. 2013
    ..However, larger studies are needed to validate our findings. ..
  30. doi request reprint Outcomes of patients with tonsillar carcinoma treated with post-tonsillectomy radiation therapy
    Gokcen Yildirim
    The University of Texas M D Anderson Cancer Center, Department of Radiation Oncology, Unit 97, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Head Neck 32:473-80. 2010
    ..Our aim was to evaluate the therapeutic outcomes of patients with squamous cell carcinoma of the tonsil that underwent tonsillectomies followed by radiotherapy...
  31. pmc FAS and FASLG genetic variants and risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck
    Dapeng Lei
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 19:1484-91. 2010
    ..We therefore investigated the association between the FAS and FASLG polymorphisms and risk for second primary malignancy (SPM) after index squamous cell carcinoma of the head and neck (SCCHN)...
  32. pmc The impact of radiographic retropharyngeal adenopathy in oropharyngeal cancer
    G Brandon Gunn
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
    Cancer 119:3162-9. 2013
    ..We performed this study to define the incidence of radiographic retropharyngeal lymph node (RPLN) involvement in oropharyngeal cancer (OPC) and its impact on clinical outcomes, neither of which has been well established to date...
  33. pmc A novel functional variant (-842G>C) in the PIN1 promoter contributes to decreased risk of squamous cell carcinoma of the head and neck by diminishing the promoter activity
    Jiachun Lu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 30:1717-21. 2009
    ..Large prospective studies of diverse ethnic groups and diverse cancer sites are warranted to validate our findings...
  34. pmc p73 G4C14-to-A4T14 polymorphism and risk of second primary malignancy after index squamous cell carcinoma of head and neck
    Fanglin Li
    Department of Head and Neck Surgery, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 125:2660-5. 2009
    ..g., older patients, men, minorities, ever smokers, and ever drinkers). Our results support that this p73 polymorphism may be a marker for risk of SPM among patients with an incident SCCHN...
  35. ncbi request reprint Single-nucleotide polymorphisms at the TP53-binding or responsive promoter regions of BAX and BCL2 genes and risk of squamous cell carcinoma of the head and neck
    Kexin Chen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 28:2008-12. 2007
    ..Our data suggest that the risk of SCCHN may be associated with these two SNPs of BAX and BCL2 promoter regions, particularly among TP53 heterozygotes. Larger studies are needed to validate these findings...
  36. pmc Genotypes and haplotypes of ERCC1 and ERCC2/XPD genes predict levels of benzo[a]pyrene diol epoxide-induced DNA adducts in cultured primary lymphocytes from healthy individuals: a genotype-phenotype correlation analysis
    Hui Zhao
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 29:1560-6. 2008
    ..Our findings suggest that the genotypes and haplotypes of ERCC1 and ERCC2/XPD may have an effect on in vitro BPDE-induced DNA adduct levels...
  37. pmc p73 G4C14-to-A4T14 polymorphism and risk of human papillomavirus-associated squamous cell carcinoma of the oropharynx in never smokers and never drinkers
    Xingming Chen
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 113:3307-14. 2008
    ....
  38. pmc Polymorphisms of the DNA repair gene MGMT and risk and progression of head and neck cancer
    Zhengdong Zhang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    DNA Repair (Amst) 9:558-66. 2010
    ....
  39. ncbi request reprint A variant of the DNA repair gene XRCC3 and risk of squamous cell carcinoma of the head and neck: a case-control analysis
    Hongbing Shen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 99:869-72. 2002
    ..26; 95% CI, 1.02-4.99). These findings suggest that the variant XRCC3 18067TT genotype may not play a major role in the etiology of SCCHN but may contribute to a subset of SCCHN. Larger studies are needed to verify these findings...
  40. pmc Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck
    Zhensheng Liu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 31:1977-81. 2010
    ..Although we added additional evidence for the association of the two SNPs with cancer risk as reported in GWAS, additional studies are needed to replicate our findings...
  41. ncbi request reprint Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: a case-control analysis
    Ana S Neumann
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 115:131-6. 2005
    ..Future studies should incorporate detailed data on alcohol consumption, dietary folate intake and related serologic measurements...
  42. pmc Combined effects of the p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms on the risk of HPV16-associated oral cancer in never-smokers
    Xingming Chen
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 29:2120-5. 2008
    ..22-106.0) than did HPV16-seronegative never-smokers in the low-risk group. These findings suggest that the combined variants of p53 and p73 significantly increase the risk of HPV16-associated oral cancer, especially among never-smokers...
  43. pmc Outcomes and adverse events of enlarged tracheoesophageal puncture after total laryngectomy
    Katherine A Hutcheson
    Department of Head and Neck Surgery, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Laryngoscope 121:1455-61. 2011
    ..The primary objective was to summarize control of leakage around the VP after conservative management of enlarged TEP...
  44. ncbi request reprint Polymorphisms of methionine synthase and methionine synthase reductase and risk of squamous cell carcinoma of the head and neck: a case-control analysis
    Zhengdong Zhang
    Department of Epidemiology, Unit 189, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 14:1188-93. 2005
    ..In conclusion, our data provide evidence that support the association between the MTR A2756G and MTRR G66A polymorphisms and SCCHN risk and that these two polymorphisms may have a joint effect on risk of SCCHN...
  45. doi request reprint Human papillomavirus & WHO type I nasopharyngeal carcinoma
    Emily J Lo
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Laryngoscope 120:S185. 2010
    ..Given the rise in oropharyngeal tumors positive for high risk human papillomavirus (HPV) and the unique biology of WHO type INPC, we chose to examine the relationship between HPV and WHO type I NPC...
  46. ncbi request reprint 172G>T variant in the 5' untranslated region of DNA repair gene RAD51 reduces risk of squamous cell carcinoma of the head and neck and interacts with a P53 codon 72 variant
    Jiachun Lu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 28:988-94. 2007
    ..The finding that the functional RAD51 172G>T SNP, particularly in the presence of the P53 Arg72Arg genotype, may be a marker of susceptibility to SCCHN needs to be validated by larger studies of different ethnic populations...
  47. ncbi request reprint Polymorphisms of FAS and FAS ligand genes involved in the death pathway and risk and progression of squamous cell carcinoma of the head and neck
    Zhengdong Zhang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 12:5596-602. 2006
    ....
  48. ncbi request reprint Association of a p73 exon 2 G4C14-to-A4T14 polymorphism with risk of squamous cell carcinoma of the head and neck
    Guojun Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 25:1911-6. 2004
    ..70; 95% CI, 1.19-2.43), women (1.61; 1.09-2.37), current smokers (1.77; 1.25-2.51) and patients with oral cancer (1.54; 1.15-2.07). Our results suggest that this p73 polymorphism may be a risk marker for genetic susceptibility to SCCHN...
  49. pmc Genetic variation in MDM2 and p14ARF and susceptibility to salivary gland carcinoma
    Lei Jin
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 7:e49361. 2012
    ..The aim of this study was to determine whether genetic variants in MDM2 and p14(ARF) are associated with risk of salivary gland carcinoma (SGC)...
  50. pmc Variants in nucleotide excision repair core genes and susceptibility to recurrence of squamous cell carcinoma of the oropharynx
    Xicheng Song
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Int J Cancer 133:695-704. 2013
    ..However, validation of these results is warranted...
  51. pmc Polymorphisms of XPG/ERCC5 and risk of squamous cell carcinoma of the head and neck
    Hongxia Ma
    Department of Epidemiology, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Pharmacogenet Genomics 22:50-7. 2012
    ..We investigated the association between XPG/ERCC5 polymorphisms and risk of SCCHN...
  52. ncbi request reprint XPD/ERCC2 EXON 8 Polymorphisms: rarity and lack of significance in risk of squamous cell carcinoma of the head and neck
    Erich M Sturgis
    Department of Head and Neck Surgery, Box 441, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston 77030 4009, USA
    Oral Oncol 38:475-7. 2002
    ..The objective was to assess whether two polymorphisms in the nucleotide excision repair gene XPD (ERCC2) are markers of SCCHN risk...
  53. pmc The six-nucleotide deletion/insertion variant in the CASP8 promoter region is inversely associated with risk of squamous cell carcinoma of the head and neck
    Chunying Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Cancer Prev Res (Phila) 3:246-53. 2010
    ..Further validation by population-based case-control studies and rigorous mechanistic studies is warranted...
  54. pmc Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck
    Zhensheng Liu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 116:4753-60. 2010
    ..The authors hypothesized that common polymorphisms in pre-miRNAs are associated individually and (more likely) collectively with the risk of squamous cell carcinoma of the head and neck (SCCHN)...
  55. pmc Reduced DNA repair capacity for removing tobacco carcinogen-induced DNA adducts contributes to risk of head and neck cancer but not tumor characteristics
    Li E Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 16:764-74. 2010
    ..In this study, we investigated the associations between genetically determined DNA repair capacity (DRC) for removing tobacco-induced DNA adducts and risk of SCCHN and tumor characteristics...
  56. pmc Association of p53 codon 72 polymorphism with risk of second primary malignancy in patients with squamous cell carcinoma of the head and neck
    Fanglin Li
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 116:2350-9. 2010
    ..The authors hypothesized that p53 codon 72 polymorphism may be associated with risk of SPMs and SPM-free survival among patients with squamous cell carcinoma of the head and neck (SCCHN)...
  57. pmc Significance of MDM2 and P14 ARF polymorphisms in susceptibility to differentiated thyroid carcinoma
    Fenghua Zhang
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Surgery 153:711-7. 2013
    ..We hypothesized that functional polymorphisms in the promoters of MDM2 and p14(ARF) contribute to the interindividual difference in predisposition to DTC...
  58. pmc Combined p53-related genetic variants together with HPV infection increase oral cancer risk
    Zhongqiu Wang
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 131:E251-8. 2012
    ..Larger studies are needed to validate our findings...
  59. pmc Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck
    Hongxia Ma
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    BMC Cancer 11:258. 2011
    ..Therefore, we investigated the association between potentially functional SNPs in PLCE1 and susceptibility to SCCHN...
  60. pmc A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck
    Sheng Wei
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cancer 116:2984-92. 2010
    ....
  61. pmc Genetic polymorphisms of p21 and risk of second primary malignancy in patients with index squamous cell carcinoma of the head and neck
    Dapeng Lei
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 31:222-7. 2010
    ..00, 95% CI = 1.26-3.00), and the risk was particularly pronounced in several subgroups. Our results support an increased risk of SPM after index SCCHN with both p21 polymorphisms individually and in combination...
  62. ncbi request reprint Squamous cell carcinoma of the head and neck in never smoker-never drinkers: a descriptive epidemiologic study
    Kristina R Dahlstrom
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 30:75-84. 2008
    ..This study reports the demographic and potential risk factors of a large series of never smoker-never drinker (NSND) patients...
  63. pmc Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx
    Xiadong Zhai
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:4345-52. 2008
    ..To date, only one reported study has investigated the association between NEIL1 and NEIL2 polymorphisms and cancer risk...
  64. pmc A functional variant at the miR-184 binding site in TNFAIP2 and risk of squamous cell carcinoma of the head and neck
    Zhensheng Liu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 32:1668-74. 2011
    ..Larger replication studies are needed to confirm our findings...
  65. pmc Association of combined p73 and p53 genetic variants with tumor HPV16-positive oropharyngeal cancer
    Zhongqiu Wang
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 7:e35522. 2012
    ..Identification of such susceptible biomarkers would greatly influence on individualized treatment for an improved prognosis...
  66. pmc Effects of MDM2 promoter polymorphisms and p53 codon 72 polymorphism on risk and age at onset of squamous cell carcinoma of the head and neck
    Hongping Yu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Mol Carcinog 50:697-706. 2011
    ..Further studies with large sample sizes are warranted to validate these results...
  67. ncbi request reprint Thymidylate synthase 5'- and 3'-untranslated region polymorphisms associated with risk and progression of squamous cell carcinoma of the head and neck
    Zhengdong Zhang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 10:7903-10. 2004
    ..We hypothesized that polymorphisms of the thymidylate synthase (TYMS) gene, which regulates a key enzyme in folate metabolism required for DNA synthesis and repair, are associated with SCCHN risk...
  68. ncbi request reprint Gastrostomy in oropharyngeal cancer patients with ERCC4 (XPF) germline variants
    David G Kornguth
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Int J Radiat Oncol Biol Phys 62:665-71. 2005
    ..We hypothesized that two ERCC4 single-nucleotide polymorphisms are associated with normal-tissue toxicity in patients treated with radiotherapy for oropharyngeal squamous cell carcinoma (OPSCC)...
  69. ncbi request reprint No Association between hOGG1 Ser326Cys polymorphism and risk of squamous cell carcinoma of the head and neck
    Zhengdong Zhang
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Cancer Epidemiol Biomarkers Prev 13:1081-3. 2004
  70. ncbi request reprint Gamma radiation sensitivity and risk of malignant and benign salivary gland tumors: a pilot case-control analysis
    Rong Zheng
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cancer 100:561-7. 2004
    ..The objectives of the current study were to determine whether gamma radiation-induced chromatid breaks increase the risk of MSTs and BSTs and whether there is any difference in risk between these two diseases...
  71. ncbi request reprint A pilot case-control study of gamma-radiation sensitivity and risk of papillary thyroid cancer
    Ping Xiong
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Thyroid 15:94-9. 2005
    ..High levels of chromatid breaks induced by gamma-radiation may constitute an independent risk factor for PTC, but further study is needed...
  72. ncbi request reprint Expression of nucleotide excision repair genes and the risk for squamous cell carcinoma of the head and neck
    Lie Cheng
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer 94:393-7. 2002
    ..The objective of this study was to assess the variation in baseline expression of five nucleotide excision repair genes between individuals with SCCHN and cancer free controls...
  73. pmc Polymorphisms of MDM4 and risk of squamous cell carcinoma of the head and neck
    Hongping Yu
    Departments of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Pharmacogenet Genomics 21:388-96. 2011
    ..We investigated the association between MDM4 polymorphisms and the risk of squamous cell carcinoma of the head and neck (SCCHN)...
  74. ncbi request reprint Expression of nucleotide excision repair proteins in lymphocytes as a marker of susceptibility to squamous cell carcinomas of the head and neck
    Qingyi Wei
    Department of Epidemiology, Unit 189, and Li Mao, Department of Thoracic and Head and Neck Medical Oncology, Unit 432, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 14:1961-6. 2005
    ..5; 95% CI, 2.32-56.6). These results suggest that XPF may be a crucial rate-limiting factor in DNA repair and that the reverse-protein microarray assay may be a useful tool for measuring protein markers of susceptibility to cancer...
  75. ncbi request reprint Matched-pair analysis of survival of never smokers and ever smokers with squamous cell carcinoma of the head and neck
    Kristen B Pytynia
    The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
    J Clin Oncol 22:3981-8. 2004
    ..To compare survival rates between patients with squamous cell carcinoma of the head and neck (SCCHN) without a history of smoking (never smokers) and those with a current or previous history of smoking (ever smokers)...
  76. pmc Association of p73 G4C14-to-A4T14 polymorphism with human papillomavirus type 16 status in squamous cell carcinoma of the head and neck in non-Hispanic whites
    Xuemei Ji
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 115:1660-8. 2009
    ....
  77. pmc Glutathione S-transferase polymorphisms and risk of second primary malignancy after index squamous cell carcinoma of the head and neck
    Mark E Zafereo
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Cancer Prev Res (Phila) 2:432-9. 2009
    ..2-2.5). This large prospective cohort study supports a modestly increased risk of SPM after index SCCHN with GSTP1 Ile(105)Val polymorphism and an even greater risk of SPM with multiple combined GST risk genotypes...
  78. pmc Human papillomavirus seropositivity synergizes with MDM2 variants to increase the risk of oral squamous cell carcinoma
    Xingming Chen
    Departments of Head and Neck Surgery and Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 70:7199-208. 2010
    ..Taken together, our results indicate that the risk of OSCC associated with HPV16 L1 seropositivity is modified by MDM2 promoter polymorphisms...
  79. doi request reprint Neoadjuvant chemotherapy-specific and overall treatment outcomes in patients with cutaneous angiosarcoma of the face with periorbital involvement
    Sheri L Demartelaere
    Section of Ophthalmology, Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 30:639-46. 2008
    ..The goal of this report was to investigate the overall treatment outcomes and the neoadjuvant chemotherapy-specific outcomes in patients with cutaneous angiosarcoma of the face with periorbital involvement...
  80. ncbi request reprint Primary tracheal malignant neoplasms: the University of Texas MD Anderson Cancer Center experience
    Benjamin D Webb
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Am Coll Surg 202:237-46. 2006
    ..This study was conducted to review the presentation, management, and outcomes of primary tracheal cancers at our institution, a large multidisciplinary cancer center...
  81. ncbi request reprint In vitro benzo[a]pyrene diol epoxide-induced DNA adducts and risk of squamous cell carcinoma of head and neck
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 67:5628-34. 2007
    ..In conclusion, we confirmed the previously reported association between in vitro BPDE-induced DNA adduct levels and SCCHN risk, and the assay may help identify individuals at high risk of developing smoking-related cancers...
  82. ncbi request reprint Nucleotide excision repair as a marker for susceptibility to tobacco-related cancers: a review of molecular epidemiological studies
    Ana S Neumann
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mol Carcinog 42:65-92. 2005
    ....
  83. ncbi request reprint Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients
    Nadezhda V Koshkina
    Department of Pediatrics, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Pediatr Hematol Oncol 29:815-21. 2007
    ..This study suggests an association between the Fas exon 3 A>G polymorphism and osteosarcoma risk; however, further study is needed with pediatric controls and a larger sample size...
  84. ncbi request reprint Melanoma metastatic to cervical lymph nodes: Can radiotherapy replace formal dissection after local excision of nodal disease?
    Matthew T Ballo
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Head Neck 27:718-21. 2005
    ..Completion cervical lymphadenectomy is usually performed after excisional biopsy of nodal metastases from melanoma. Radiation (XRT) might be effective for some patients in lieu of formal lymph node dissection...
  85. ncbi request reprint Squamous cell carcinoma of the temporal bone
    Paul W Gidley
    Department of Head and Neck Surgery, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Laryngoscope 120:1144-51. 2010
    ..To study the survival outcomes of patients with squamous cell carcinoma (SCC) of the temporal bone. A secondary purpose was to evaluate the University of Pittsburgh staging system as a predictor of survival...
  86. ncbi request reprint Sarcomas of the head and neck region
    Erich M Sturgis
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 441, Houston, TX 77030 4009, USA
    Curr Opin Oncol 15:239-52. 2003
    ..This review discusses the classification, etiology, diagnosis, evaluation, treatment, and prognosis of sarcoma of the head and neck region...
  87. ncbi request reprint Haplotypes of two variants in p16 (CDKN2/MTS-1/INK4a) exon 3 and risk of squamous cell carcinoma of the head and neck: a case-control study
    Yuxin Zheng
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 11:640-5. 2002
    ..We conclude that these polymorphic p16 genotypes or haplotypes may not play a major role in the etiology of SCCHN, if any. However, our limited sample size and power call for larger studies for additional verification of our findings...
  88. ncbi request reprint P53 codon 72 polymorphism and risk of squamous cell carcinoma of the head and neck: a case-control study
    Hongbing Shen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Lett 183:123-30. 2002
    ..Arg/Arg; P=0.066 for Pro/Pro and Arg/Pro combined vs. Arg/Arg). While the results suggest that the P53 codon 72 polymorphism may contribute to oral cancer susceptibility, larger studies are needed to confirm these findings...
  89. pmc Outcomes after definitive treatment for cutaneous angiosarcoma of the face and scalp
    B Ashleigh Guadagnolo
    Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Head Neck 33:661-7. 2011
    ..The aim of the present analysis was to retrospectively evaluate outcomes in patients with cutaneous angiosarcoma of the face/scalp treated curatively with surgery, radiation therapy (RT), or a combination of surgery and RT...
  90. ncbi request reprint Postirradiation osteosarcoma of the mandible with heterologous differentiation
    Raja R Seethala
    Department of Pathology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Arch Pathol Lab Med 130:385-8. 2006
    ..To our knowledge, this is the first report of osteosarcoma of the mandible with heterologous differentiation...
  91. pmc Polymorphisms of the DNMT3B gene and risk of squamous cell carcinoma of the head and neck: a case-control study
    Zhensheng Liu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Box 189, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Lett 268:158-65. 2008
    ..Further mechanistic studies are needed to unravel the underlying molecular mechanisms...
  92. pmc Nucleotide excision repair core gene polymorphisms and risk of second primary malignancy in patients with index squamous cell carcinoma of the head and neck
    Mark E Zafereo
    Department of Head and Neck Surgery, University of Texas M D Anderson Cancer Center, Houston, 77030 4009, USA
    Carcinogenesis 30:997-1002. 2009
    ..These findings need to be validated in future studies with larger sample sizes and longer follow-up time...
  93. doi request reprint Osteosarcoma of the jaw/craniofacial region: outcomes after multimodality treatment
    B Ashleigh Guadagnolo
    Division of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cancer 115:3262-70. 2009
    ..The current study was performed to evaluate outcomes in patients with osteosarcoma of the head and neck (OHN) who were treated with surgery with or without radiotherapy (RT)...
  94. pmc Association of TGF-beta1 genetic variants with HPV16-positive oropharyngeal cancer
    Xiaoxiang Guan
    Departments of Epidemiology, and Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 16:1416-22. 2010
    ....
  95. pmc Genetic polymorphisms in the PTPN13 gene and risk of squamous cell carcinoma of head and neck
    Jiangong Niu
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 30:2053-8. 2009
    ..6241 Y2081D GG genotype was borderline in patients with laryngeal cancer. In conclusion, polymorphisms in the PTPN13 coding region may be biomarkers for susceptibility to SCCHN in USA populations...
  96. ncbi request reprint Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck
    Kexin Chen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:4300-5. 2007
    ....
  97. ncbi request reprint CYP2E1 G1532C, NQO1 Pro187Ser, and CYP1B1 Val432Leu polymorphisms are not associated with risk of squamous cell carcinoma of the head and neck
    Guojun Li
    Department of Epidemiology, Unit 189, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 14:1034-6. 2005
  98. ncbi request reprint Polymorphisms and haplotypes of serine hydroxymethyltransferase and risk of squamous cell carcinoma of the head and neck: a case-control analysis
    Zhengdong Zhang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Pharmacogenet Genomics 15:557-64. 2005
    ..In conclusion, these three SHMT1 polymorphisms may play a joint role in the etiology of SCCHN in a non-Hispanic white population...
  99. ncbi request reprint Epidemiology of carcinogen metabolism genes and risk of squamous cell carcinoma of the head and neck
    Tang Ho
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 29:682-99. 2007
    ....
  100. ncbi request reprint X-ray repair cross-complementing group 1 (XRCC1) single-nucleotide polymorphisms and the risk of salivary gland carcinomas
    Tang Ho
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 110:318-25. 2007
    ..X-ray repair cross complementing group 1 (XRCC1) is important in the repair of single-strand DNA breaks caused by endogenous oxidative species and exogenous carcinogens...
  101. ncbi request reprint Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review
    Paul Brennan
    International Agency for Research on Cancer, Lyon, France
    Am J Epidemiol 159:1-16. 2004
    ..These considerations suggest the potential for the organization of a consortium of investigators conducting studies in this field...

Research Grants2

  1. Use of Serum HPV16 DNA as a Marker for Oropharyngeal Cancer Recurrence
    Erich Sturgis; Fiscal Year: 2007
    ..Secondly, in follow-up such a marker may have utility in earlier detection of recurrent disease, which at present has an extremely poor prognosis. ..