LISA T STOWERS

..Recent discoveries of potential pheromones reveal that they may be more structurally and functionally diverse than previously defined...

..Instead, LUSH undergoes a conformational change upon pheromone binding that is sufficient for neuronal activation...

..This review focuses on these non-VNO receptors and neurons, and evaluates their potential for mediating stereotyped olfactory behavior in mammals...

..However, first progress has been made in identifying components of sexually dimorphic olfactory circuits in both Drosophila and the mouse...

..But direct visualization of second order neurons in Drosophila now suggests that dendritic targeting occurs independently of interactions with incoming sensory neurons...

..Our results substantiate the idea of MUP proteins as pheromone ligands that mediate male-male aggression through the accessory olfactory neural pathway...

..This co-option of existing sensory mechanisms provides a molecular solution to the difficult problem of evolving a variety of species-specific molecular detectors...

..3) Define the function of liver specific MUPs in regulating social behavior. These aims will be tested using genomic and molecular genetic strategies to elucidate the extent to which MUPs function in pheromone signaling. ..

..This important first step will allow us to predictably activate social responses in mice, and therefore define at the cellular and molecular level, the underlying mechanisms of neural function and dysfunction. ..

..This important first step will allow us to predictably activate social responses in mice, and therefore define at the cellular and molecular level, the underlying mechanisms of neural function and dysfunction. ..

..This important first step will allow us to predictably activate social responses in mice, and therefore define at the cellular and molecular level, the underlying mechanisms of neural function and dysfunction. ..