Gary Stoner

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc Protection against esophageal cancer in rodents with lyophilized berries: potential mechanisms
    Gary D Stoner
    Division of Hematology and Oncology, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, Columbus 43210, USA
    Nutr Cancer 54:33-46. 2006
  2. pmc Perspectives in cancer chemoprevention
    G D Stoner
    Arthur James Cancer Hospital and Research Institute, Ohio State University, Columbus 43210, USA
    Environ Health Perspect 105:945-54. 1997
  3. ncbi request reprint Introduction to mouse lung tumorigenesis
    G D Stoner
    Division of Environmental Health Sciences, Ohio State University College of Medicine and Public Health, Columbus, USA
    Exp Lung Res 24:375-83. 1998
  4. ncbi request reprint Inhibition of N'-nitrosonornicotine-induced esophageal tumorigenesis by 3-phenylpropyl isothiocyanate
    G D Stoner
    Division of Environmental Health Sciences, The Ohio State University School of Public Health and The Ohio State University Comprehensive Cancer Center, Ohio State University, CHRI, Columbus 43210, USA
    Carcinogenesis 19:2139-43. 1998
  5. ncbi request reprint Isothiocyanates and freeze-dried strawberries as inhibitors of esophageal cancer
    G D Stoner
    Division of Environmental Health Sciences, The Ohio State University School of Public Health, and The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus 43210, USA
    Toxicol Sci 52:95-100. 1999
  6. ncbi request reprint Etiology and chemoprevention of esophageal squamous cell carcinoma
    G D Stoner
    Division of Environmental Health Sciences, The Ohio State University School of Public Health, Columbus, OH 43210, USA
    Carcinogenesis 22:1737-46. 2001
  7. ncbi request reprint Development of a multi-organ rat model for evaluating chemopreventive agents: efficacy of indole-3-carbinol
    Gary Stoner
    Division of Environmental Health Sciences, School of Public Health, College of Medicine and Public Health, The Ohio State University, Columbus, OH, USA
    Carcinogenesis 23:265-72. 2002
  8. ncbi request reprint The effects of L-748706, a selective cyclooxygenase-2 inhibitor, on N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis
    Gary D Stoner
    Cancer Chemoprevention and Support Program, Division of Hematology and Oncology, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
    Carcinogenesis 26:1590-5. 2005
  9. pmc Anthocyanins in black raspberries prevent esophageal tumors in rats
    Li Shu Wang
    Ohio State University Comprehensive Cancer Center, 2001 Polaris Parkway, Columbus, OH 43240, USA
    Cancer Prev Res (Phila) 2:84-93. 2009
  10. ncbi request reprint Piroxicam is an ineffective inhibitor of N-nitrosomethylbenzylamine-induced tumorigenesis in the rat esophagus
    Peter S Carlton
    Division of Environmental Health Sciences, School of Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 62:4376-82. 2002

Collaborators

Detail Information

Publications60

  1. pmc Protection against esophageal cancer in rodents with lyophilized berries: potential mechanisms
    Gary D Stoner
    Division of Hematology and Oncology, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, Columbus 43210, USA
    Nutr Cancer 54:33-46. 2006
    ..Based upon the preclinical data on rodents, we have initiated prevention trials in humans to determine if berries might exhibit chemopreventive effects in the esophagus...
  2. pmc Perspectives in cancer chemoprevention
    G D Stoner
    Arthur James Cancer Hospital and Research Institute, Ohio State University, Columbus 43210, USA
    Environ Health Perspect 105:945-54. 1997
    ..At the conclusion is a brief discussion of future prospects in cancer chemoprevention and obstacles to overcome...
  3. ncbi request reprint Introduction to mouse lung tumorigenesis
    G D Stoner
    Division of Environmental Health Sciences, Ohio State University College of Medicine and Public Health, Columbus, USA
    Exp Lung Res 24:375-83. 1998
    ..It has been very exciting and rewarding to observe the progress made by many dedicated scientists in the field of mouse lung tumorigenesis during the past several years, and I hope that the next few years will be even more exciting...
  4. ncbi request reprint Inhibition of N'-nitrosonornicotine-induced esophageal tumorigenesis by 3-phenylpropyl isothiocyanate
    G D Stoner
    Division of Environmental Health Sciences, The Ohio State University School of Public Health and The Ohio State University Comprehensive Cancer Center, Ohio State University, CHRI, Columbus 43210, USA
    Carcinogenesis 19:2139-43. 1998
    ..These results demonstrate the remarkable chemopreventive efficacy of PPITC in the NNN-induced esophageal tumor model...
  5. ncbi request reprint Isothiocyanates and freeze-dried strawberries as inhibitors of esophageal cancer
    G D Stoner
    Division of Environmental Health Sciences, The Ohio State University School of Public Health, and The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus 43210, USA
    Toxicol Sci 52:95-100. 1999
    ..It proved to be an effective inhibitor, although not as potent as either PEITC or PPITC. The inhibitory effect of the berries could not be attributed solely to the content of the chemopreventive agent, ellagic acid, in the berries...
  6. ncbi request reprint Etiology and chemoprevention of esophageal squamous cell carcinoma
    G D Stoner
    Division of Environmental Health Sciences, The Ohio State University School of Public Health, Columbus, OH 43210, USA
    Carcinogenesis 22:1737-46. 2001
    ....
  7. ncbi request reprint Development of a multi-organ rat model for evaluating chemopreventive agents: efficacy of indole-3-carbinol
    Gary Stoner
    Division of Environmental Health Sciences, School of Public Health, College of Medicine and Public Health, The Ohio State University, Columbus, OH, USA
    Carcinogenesis 23:265-72. 2002
    ..The results of this study clearly demonstrate that I-3-C is not an appropriate chemoprotective agent for human use, in spite of its effects in the breast and colon in this rat animal model...
  8. ncbi request reprint The effects of L-748706, a selective cyclooxygenase-2 inhibitor, on N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis
    Gary D Stoner
    Cancer Chemoprevention and Support Program, Division of Hematology and Oncology, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
    Carcinogenesis 26:1590-5. 2005
    ....
  9. pmc Anthocyanins in black raspberries prevent esophageal tumors in rats
    Li Shu Wang
    Ohio State University Comprehensive Cancer Center, 2001 Polaris Parkway, Columbus, OH 43240, USA
    Cancer Prev Res (Phila) 2:84-93. 2009
    ....
  10. ncbi request reprint Piroxicam is an ineffective inhibitor of N-nitrosomethylbenzylamine-induced tumorigenesis in the rat esophagus
    Peter S Carlton
    Division of Environmental Health Sciences, School of Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 62:4376-82. 2002
    ..The reasons for the lack of effect are largely unknown but may be related to the inability of piroxicam to modulate other biochemical pathways involved in NMBA-induced tumorigenesis...
  11. ncbi request reprint Black raspberries inhibit N-nitrosomethylbenzylamine (NMBA)-induced angiogenesis in rat esophagus parallel to the suppression of COX-2 and iNOS
    Tong Chen
    Cancer Chemoprevention and Support Program, Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine and Public Health, The Ohio State University Columbus, OH 43210, USA
    Carcinogenesis 27:2301-7. 2006
    ..86, P < 0.001) and iNOS (r2 = 0.81, P < 0.005). As high vascularity is a risk factor for metastasis and tumor recurrence, BRB may have cancer therapeutic effects in human esophageal cancer...
  12. pmc Chemopreventive properties of black raspberries in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis: down-regulation of cyclooxygenase-2, inducible nitric oxide synthase, and c-Jun
    Tong Chen
    Cancer Chemoprevention Program, Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 66:2853-9. 2006
    ..Prostaglandin E(2) and total nitrite levels were also decreased by BRB in papillomas. These results suggest a novel tumor suppressive role of BRB through inhibition of COX-2, iNOS, and c-Jun...
  13. pmc Distribution of anthocyanins delivered from a bioadhesive black raspberry gel following topical intraoral application in normal healthy volunteers
    Carlos M Ugalde
    Division of Oral Maxillofacial Surgery, Pathology and Anesthesiology, College of Dentistry, The Ohio State University, Columbus, Ohio, USA
    Pharm Res 26:977-86. 2009
    ..Accordingly, this study assessed the distribution of anthocyanins from the 10% (w/w) FBR gel in saliva, oral tissues and plasma...
  14. pmc Black raspberry components inhibit proliferation, induce apoptosis, and modulate gene expression in rat esophageal epithelial cells
    Nancy N Zikri
    The Ohio State University, Columbus, Ohio 43240, USA
    Nutr Cancer 61:816-26. 2009
    ....
  15. ncbi request reprint Perillyl alcohol as a chemopreventive agent in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis
    Beth W Liston
    Department of Pathology, School of Public Health and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 63:2399-403. 2003
    ..These data indicate that POH has a weakly promoting effect early in nitrosamine-induced esophageal tumorigenesis and suggest that POH may not be an effective chemopreventive agent for esophageal cancer in humans...
  16. ncbi request reprint Inhibition of the growth of premalignant and malignant human oral cell lines by extracts and components of black raspberries
    Chunhua Han
    Department of Radiology, The Ohio State University, Columbus 43210, USA
    Nutr Cancer 51:207-17. 2005
    ....
  17. pmc Effects of a topically applied bioadhesive berry gel on loss of heterozygosity indices in premalignant oral lesions
    Brian S Shumway
    Department of Oral and Maxillofacial Surgery, Anesthesiology and Pathology, College of Dentistry, The Ohio State University, Columbus, OH 43210 1241, USA
    Clin Cancer Res 14:2421-30. 2008
    ..Previously, our laboratories have shown that FBRs are well tolerated and possess potent antioxidant, apoptotic, and differentiation-inducing properties...
  18. ncbi request reprint Prevention and therapy of squamous cell carcinoma of the rodent esophagus using freeze-dried black raspberries
    Gary D Stoner
    Division of Hematology and Oncology and Comprehensive Cancer Center, College of Public Health, The Ohio State University, Columbus, OH 43210, USA
    Acta Pharmacol Sin 28:1422-8. 2007
    ....
  19. pmc Multiple berry types prevent N-nitrosomethylbenzylamine-induced esophageal cancer in rats
    Gary D Stoner
    Department of Internal Medicine and Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Pharm Res 27:1138-45. 2010
    ..We also determined if berries influence the levels of inflammatory cytokines in the serum of carcinogen-treated rats...
  20. pmc Modulation of N-nitrosomethylbenzylamine metabolism by black raspberries in the esophagus and liver of Fischer 344 rats
    Rashmeet K Reen
    Division of Hematology and Oncology, Department of Internal Medicine, The Ohio State University, Columbus 43210, USA
    Nutr Cancer 54:47-57. 2006
    ..Dietary BRBs and PEITC induced glutathione S-transferase activity in the liver...
  21. ncbi request reprint Transitioning from preclinical to clinical chemopreventive assessments of lyophilized black raspberries: interim results show berries modulate markers of oxidative stress in Barrett's esophagus patients
    Laura A Kresty
    Division of Hematology and Oncology, Department of Internal Medicine, The Ohio State University College of Medicine and Public Health, Columbus 43210, USA
    Nutr Cancer 54:148-56. 2006
    ....
  22. pmc A rapid and sensitive LC-MS/MS method for quantification of four anthocyanins and its application in a clinical pharmacology study of a bioadhesive black raspberry gel
    Yonghua Ling
    College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:4027-34. 2009
    ..Measurable saliva and tissue levels of the FBR anthocyanins confirmed that gel-delivered anthocyanins are readily distributed to saliva and easily penetrate human oral mucosa...
  23. pmc Formulation and in-vitro and in-vivo evaluation of a mucoadhesive gel containing freeze dried black raspberries: implications for oral cancer chemoprevention
    Susan R Mallery
    Department of Oral Maxillofacial Surgery and Pathology, College of Dentistry, The Ohio State University, Columbus, OH 43210 1241, USA
    Pharm Res 24:728-37. 2007
    ....
  24. ncbi request reprint Chemoprevention of oral cancer by black raspberries
    Bruce C Casto
    Division of Environmental Health Sciences, School of Public Health, Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 22:4005-15. 2002
    ..These experiments support previous studies from our laboratories showing the chemopreventive activity of black raspberries and show, for the first time, that dietary black raspberries will inhibit tumor formation in the oral cavity...
  25. pmc Effects of phenylethyl isothiocyanate on early molecular events in N-nitrosomethylbenzylamine-induced cytotoxicity in rat esophagus
    Rashmeet K Reen
    Department of Internal Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43240, USA
    Cancer Res 67:6484-92. 2007
    ..Samples obtained from animals treated with PEITC alone or cotreated with PEITC + NMBA were more similar to controls than to samples treated with NMBA alone...
  26. doi request reprint Topical treatment with black raspberry extract reduces cutaneous UVB-induced carcinogenesis and inflammation
    F J Duncan
    Department of Pathology, The Ohio State University, 1645 Neil Avenue, 129 Hamilton Hall, Columbus, OH 43210, USA
    Cancer Prev Res (Phila) 2:665-72. 2009
    ..The ability of topical BRE to reduce acute UVB-induced inflammation and to decrease tumor development in a long-term model provides compelling evidence to explore the clinical efficacy of BRE in the prevention of human skin cancers...
  27. ncbi request reprint Chemopreventive effects of a selective nitric oxide synthase inhibitor on carcinogen-induced rat esophageal tumorigenesis
    Tong Chen
    Division of Environmental Health Sciences, School of Public Health and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 64:3714-7. 2004
    ..These observations suggest that iNOS plays a role in tumor development and that its selective inhibitor, PBIT, significantly inhibits esophageal tumor progression presumably through reducing the production of NO...
  28. pmc Topical application of a bioadhesive black raspberry gel modulates gene expression and reduces cyclooxygenase 2 protein in human premalignant oral lesions
    Susan R Mallery
    Department of Oral and Maxillofacial Surgery, College of Dentistry, The Ohio State University Comprehensive Cancer Center and Solove Research Institute, Columbus, Ohio, USA
    Cancer Res 68:4945-57. 2008
    ..In a patient subset, berry gel application also reduced vascular densities in the superficial connective tissues and induced genes associated with keratinocyte terminal differentiation...
  29. pmc Modulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries: a phase I pilot study
    Li Shu Wang
    Department of Internal Medicine, Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, Ohio 43240, USA
    Clin Cancer Res 17:598-610. 2011
    ....
  30. pmc Foodstuffs for preventing cancer: the preclinical and clinical development of berries
    Gary D Stoner
    Department of Internal Medicine, The Ohio State University, Innovation Centre, 2001 Polaris Parkway, Columbus, Ohio 43240, USA
    Cancer Prev Res (Phila) 2:187-94. 2009
    ..The relative merits of berry powders, extracts, or individual constituents (anthocyanins) for cancer prevention are also discussed...
  31. ncbi request reprint Urinary excretion of black raspberry (Rubus occidentalis) anthocyanins and their metabolites
    Qingguo Tian
    Department of Food Science and Technology, The Ohio State University, 2015 Fyffe Road, Columbus, Ohio 43210, USA
    J Agric Food Chem 54:1467-72. 2006
    ..As compared to the anthocyanin distribution in black raspberries, urinary cyanidin 3-xylosylrutinoside was detected at a higher concentration than that of cyanidin-3-rutinoside...
  32. pmc Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both black raspberries and phenylethyl isothiocyanate
    Gary D Stoner
    Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, Ohio 43240, USA
    Cancer Res 68:6460-7. 2008
    ..Because both PEITC and BRB maintain near-normal levels of expression of these 53 genes, their dysregulation during the early phase of NMBA-induced esophageal cancer may be especially important in the genesis of the disease...
  33. ncbi request reprint Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 days
    Gary D Stoner
    Division of Hematology Oncology, Department of Internal Medicine, College of Medicine, The Ohio State University, 1148 James CHRI, 300 W 10th Avenue, Columbus, OH 43210, USA
    J Clin Pharmacol 45:1153-64. 2005
    ..None of the pharmacokinetic parameters changed significantly between days 1 and 7. In conclusion, 45 g of freeze-dried BRB daily are well tolerated and result in quantifiable anthocyanins and ellagic acid in plasma and urine...
  34. pmc Berry ellagitannins may not be sufficient for prevention of tumors in the rodent esophagus
    Li Shu Wang
    The Ohio State University Comprehensive Cancer Center, Columbus, Ohio 43240, USA
    J Agric Food Chem 58:3992-5. 2010
    ..01-0.62 g/kg of diet). These results suggest that the ellagitannins may not be responsible for the chemopreventive effects of the alcohol/water-insoluble fraction of berries...
  35. pmc Anthocyanins and their role in cancer prevention
    Li Shu Wang
    Department of Internal Medicine and Comprehensive Cancer Center, Ohio State University College of Medicine, Columbus, OH 43210, USA
    Cancer Lett 269:281-90. 2008
    ..Future studies aimed at enhancing the absorption of anthocyanins and/or their metabolites are likely to be necessary for their ultimate use for chemoprevention of human cancer...
  36. pmc Cancer prevention with freeze-dried berries and berry components
    Gary D Stoner
    Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine, The Ohio State University, Innovation Centre, 2001 Polaris Parkway, Columbus, OH 43240, USA
    Semin Cancer Biol 17:403-10. 2007
    ..e., Barrett's esophagus, esophageal dysplasia and colonic polyps, to determine if berries will modulate various histological and molecular biomarkers of development of these diseases...
  37. ncbi request reprint Inducible nitric oxide synthase expression in N-nitrosomethylbenzylamine (NMBA)-induced rat esophageal tumorigenesis
    Tong Chen
    Division of Environmental Health Sciences, School of Public Health and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    Mol Carcinog 40:232-40. 2004
    ..Our data suggest, therefore, that the production of iNOS by the epithelium of the esophagus is associated with the development of NMBA-induced esophageal tumorigenesis in rats...
  38. pmc Drinking water with red beetroot food color antagonizes esophageal carcinogenesis in N-nitrosomethylbenzylamine-treated rats
    John F Lechner
    Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43240, USA
    J Med Food 13:733-9. 2010
    ..However, the sum of constituents of E162 has not been determined, and other components with other mechanisms may also be involved in antagonizing cancer development...
  39. ncbi request reprint Photochemoprevention of UVB-induced skin carcinogenesis in SKH-1 mice by brown algae polyphenols
    Hyejeong Hwang
    Chemoprevention and Support Program, Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Int J Cancer 119:2742-9. 2006
    ..These observations show that brown algae polyphenols have an antiphotocarcinogenic effect which may be associated with the prevention of UVB-induced oxidative stress, inflammation, and cell proliferation in the skin...
  40. pmc Chemoprevention of esophageal squamous cell carcinoma
    Gary D Stoner
    Division of Hematology and Oncology, Department of Internal Medicine, Ohio State University College of Medicine and Comprehensive Cancer Center, Columbus, OH 43210, USA
    Toxicol Appl Pharmacol 224:337-49. 2007
    ..These observations have led to a clinical trial in China to evaluate the ability of freeze-dried strawberries to influence the progression of esophageal dysplasia to SCC...
  41. doi request reprint Effects of a black raspberry diet on gene expression in the rat esophagus
    John F Lechner
    Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Nutr Cancer 60:61-9. 2008
    ..In conclusion, histological and molecular studies indicate that a 5% BRB diet produces only modest effects on the esophagus, the target tissue for NMBA carcinogenesis in the rat...
  42. ncbi request reprint Screening for anthocyanins using high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry with precursor-ion analysis, product-ion analysis, common-neutral-loss analysis, and selected reaction monitoring
    Qingguo Tian
    Department of Food Science and Technology, The Ohio State University, 2015 Fyffe Road, Columbus, Ohio 43210, USA
    J Chromatogr A 1091:72-82. 2005
    ....
  43. ncbi request reprint Functional role of cytochrome p-450 2a3 in N-nitrosomethylbenzylamine metabolism in rat esophagus
    Rajaram Gopalakrishnan
    Department of Periodontics, Prevention, and Geriatrics, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA
    J Toxicol Environ Health A 65:1077-91. 2002
    ..Data suggest that CYP2A3 levels in the rat esophagus can be a determinant of its ability to metabolize this carcinogen in vivo...
  44. ncbi request reprint Inhibition of benzo(a)pyrene diol-epoxide-induced transactivation of activated protein 1 and nuclear factor kappaB by black raspberry extracts
    Chuanshu Huang
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    Cancer Res 62:6857-63. 2002
    ..The RU-ME fraction appears to be the major fraction responsible for the inhibitory activity of black raspberries...
  45. pmc Identification of cyanidin glycosides as constituents of freeze-dried black raspberries which inhibit anti-benzo[a]pyrene-7,8-diol-9,10-epoxide induced NFkappaB and AP-1 activity
    Stephen S Hecht
    The Cancer Center, University of Minnesota Minneapolis, MN 55455, USA
    Carcinogenesis 27:1617-26. 2006
    ..The results of this study demonstrate that cyanidin glycosides of freeze-dried black raspberries are bioactive compounds which could account for at least some of the chemopreventive activity observed in animal models...
  46. pmc Differential effects of black raspberry and strawberry extracts on BaPDE-induced activation of transcription factors and their target genes
    Jingxia Li
    Nelson Institute of Environmental Medicine, New York University School of Medicine, New York, New York 10987, USA
    Mol Carcinog 47:286-94. 2008
    ..These results suggest that black raspberry and strawberry components may target different signaling pathways in exerting their anti-carcinogenic effects...
  47. ncbi request reprint Black raspberry extracts inhibit benzo(a)pyrene diol-epoxide-induced activator protein 1 activation and VEGF transcription by targeting the phosphotidylinositol 3-kinase/Akt pathway
    Chuanshu Huang
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    Cancer Res 66:581-7. 2006
    ..In view of the important roles of AP-1 and VEGF in tumor development, one mechanism for the chemopreventive activity of black raspberries may be inhibition of the PI-3K/Akt/AP-1/VEGF pathway...
  48. ncbi request reprint Differential inhibition of UV-induced activation of NF kappa B and AP-1 by extracts from black raspberries, strawberries, and blueberries
    Chuanshu Huang
    Nelson Institute of Environmental Medicine, New York University School of Medicine, New York, NY 10987, USA
    Nutr Cancer 58:205-12. 2007
    ..These results suggest that berries differ in their ability to influence signaling pathways leading to activation of NF kappa B and AP-1 when using UV light as the inducer...
  49. ncbi request reprint Molecular mechanisms involved in chemoprevention of black raspberry extracts: from transcription factors to their target genes
    Haitian Lu
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Nutr Cancer 54:69-78. 2006
    ..The RO-ME fraction appears to be the major fraction responsible for the inhibitory activity of black raspberries...
  50. ncbi request reprint Tissue self-affinity and polarized light scattering in the born approximation: a new model for precancer detection
    Martin Hunter
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Phys Rev Lett 97:138102. 2006
    ..Power law exponents used to fit dysplastic tissue site spectra are significantly smaller than those from normal sites, indicating that changes in tissue self-affinity can serve as a potential biomarker for precancer...
  51. ncbi request reprint Comparison of phenethyl and 6-phenylhexyl isothiocyanate-induced toxicity in rat esophageal cell lines with and without glutathione depletion
    Tamaro S Hudson
    Division of Cancer Prevention, Cancer Prevention Fellowship Program, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
    Toxicol Lett 155:427-36. 2005
    ..While our data demonstrate structure related differences in ITC-mediated cytotoxicities, these differences do not appear to be directly attributable to cellular GSH pools...
  52. pmc Differential expression of critical cellular genes in human lung adenocarcinomas and squamous cell carcinomas in comparison to normal lung tissues
    Amy L McDoniels-Silvers
    Department of Pathology, Medical College of Ohio, Toledo, OH 43614, USA
    Neoplasia 4:141-50. 2002
    ..Regardless, many of these differences may be useful in the diagnosis and/or treatment of this deadly disease...
  53. ncbi request reprint Interactive gene expression pattern in prostate cancer cells exposed to phenolic antioxidants
    Bhagavathi A Narayanan
    Microarray Systems Laboratory, American Health Foundation, Valhalla, NY 10595, USA
    Life Sci 70:1821-39. 2002
    ..This is a first study to look for changes in a large number of human genes in response to dietary compounds...
  54. ncbi request reprint Prospective grading of neoplastic change in rat esophagus epithelium using angle-resolved low-coherence interferometry
    Adam Wax
    Duke University, Department of Biomedical Engineering, Durham, North Carolina 27708, USA
    J Biomed Opt 10:051604. 2005
    ..We demonstrate that a/LCI is highly effective for monitoring neoplastic change and can be applied to assessing the efficacy of chemopreventive agents in the rat esophagus...
  55. ncbi request reprint Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas
    Amy L McDoniels-Silvers
    Department of Pathology, Medical College of Ohio, Toledo, Ohio 43614, USA
    Clin Cancer Res 8:1127-38. 2002
    ....
  56. ncbi request reprint In situ detection of neoplastic transformation and chemopreventive effects in rat esophagus epithelium using angle-resolved low-coherence interferometry
    Adam Wax
    Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
    Cancer Res 63:3556-9. 2003
    ..This technique also may provide a new screening tool for intraepithelial neoplasia...
  57. ncbi request reprint A monoclonal antibody to a carbohydrate epitope expressed on glycolipid and on alpha3beta1 integrin on human esophageal carcinoma
    Roudabeh J Jamasbi
    Department of Public and Allied Health, 504 Life Sciences Building, Bowling Green State University, Bowling Green, OH 34303 0287, USA
    Hybrid Hybridomics 22:367-76. 2003
    ..Thus, expression of the carbohydrate epitope is the basis for the tumor selective reaction of MAb-9 with a subset of esophageal carcinomas...
  58. ncbi request reprint Differential requirement of signal pathways for benzo[a]pyrene (B[a]P)-induced nitric oxide synthase (iNOS) in rat esophageal epithelial cells
    Jingyuan Chen
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Carcinogenesis 26:1035-43. 2005
    ..In view of the potential role of iNOS in the development of esophageal SCC in humans, we speculate that the induction of iNOS by B[a]P may be one mechanism by which B[a]P could produce carcinogenic effects in the human esophagus...
  59. ncbi request reprint Immunohistochemical assessment of Viadent-associated leukoplakia
    K Mark Anderson
    American Cancer Society, Ohio Division, 5555 Frantz Road, Dublin, OH 43017, USA
    Oral Oncol 41:200-7. 2005
    ..45; p>0.05; p53:normal: 2.65+/-1.37, Viadent: 4.64+/-1.52, dysplasia: 8.71+/-1.37; p<0.05 Kruskal Wallace, Tukey/Kramer). Our Viadent profiles, intermediate between normal and dysplasia, support a preneoplastic nature of this process...
  60. ncbi request reprint Bioactive food components and cancer risk reduction
    Silvia D Stan
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    J Cell Biochem 104:339-56. 2008
    ....