Research Topics
Species | Gary David StonerSummaryAffiliation: The Ohio State University Country: USA Publications
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Publications
Protection against esophageal cancer in rodents with lyophilized berries: potential mechanismsGary D Stoner
Division of Hematology and Oncology, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, Columbus 43210, USA
Nutr Cancer 54:33-46. 2006..Based upon the preclinical data on rodents, we have initiated prevention trials in humans to determine if berries might exhibit chemopreventive effects in the esophagus...- Effects of phenylethyl isothiocyanate on early molecular events in N-nitrosomethylbenzylamine-induced cytotoxicity in rat esophagusRashmeet K Reen
Department of Internal Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43240, USA
Cancer Res 67:6484-92. 2007..Samples obtained from animals treated with PEITC alone or cotreated with PEITC + NMBA were more similar to controls than to samples treated with NMBA alone... 
Prevention and therapy of squamous cell carcinoma of the rodent esophagus using freeze-dried black raspberriesGary D Stoner
Division of Hematology and Oncology and Comprehensive Cancer Center, College of Public Health, The Ohio State University, Columbus, OH 43210, USA
Acta Pharmacol Sin 28:1422-8. 2007....
Effects of a black raspberry diet on gene expression in the rat esophagusJohn F Lechner
Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
Nutr Cancer 60:61-9. 2008..In conclusion, histological and molecular studies indicate that a 5% BRB diet produces only modest effects on the esophagus, the target tissue for NMBA carcinogenesis in the rat...- Topical treatment with black raspberry extract reduces cutaneous UVB-induced carcinogenesis and inflammationF J Duncan
Department of Pathology, The Ohio State University, 1645 Neil Avenue, 129 Hamilton Hall, Columbus, OH 43210, USA
Cancer Prev Res (Phila) 2:665-72. 2009..The ability of topical BRE to reduce acute UVB-induced inflammation and to decrease tumor development in a long-term model provides compelling evidence to explore the clinical efficacy of BRE in the prevention of human skin cancers... - Chemoprevention of esophageal squamous cell carcinomaGary D Stoner
Division of Hematology and Oncology, Department of Internal Medicine, Ohio State University College of Medicine and Comprehensive Cancer Center, Columbus, OH 43210, USA
Toxicol Appl Pharmacol 224:337-49. 2007..These observations have led to a clinical trial in China to evaluate the ability of freeze-dried strawberries to influence the progression of esophageal dysplasia to SCC... - Cancer prevention with freeze-dried berries and berry componentsGary D Stoner
Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine, The Ohio State University, Innovation Centre, 2001 Polaris Parkway, Columbus, OH 43240, USA
Semin Cancer Biol 17:403-10. 2007..e., Barrett's esophagus, esophageal dysplasia and colonic polyps, to determine if berries will modulate various histological and molecular biomarkers of development of these diseases... - Laboratory and clinical studies of cancer chemoprevention by antioxidants in berriesGary David Stoner
Department of Internal Medicine, College of Medicine, The Ohio StateUniversity, Columbus, OH 43210, USA
Carcinogenesis 29:1665-74. 2008..This review article summarizes laboratory and human studies, demonstrating the protective effects of berries and berry constituents on oxidative and other cellular processes leading to cancer development... - Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both black raspberries and phenylethyl isothiocyanateGary D Stoner
Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, Ohio 43240, USA
Cancer Res 68:6460-7. 2008..Because both PEITC and BRB maintain near-normal levels of expression of these 53 genes, their dysregulation during the early phase of NMBA-induced esophageal cancer may be especially important in the genesis of the disease... - Foodstuffs for preventing cancer: the preclinical and clinical development of berriesGary D Stoner
Department of Internal Medicine, The Ohio State University, Innovation Centre, 2001 Polaris Parkway, Columbus, Ohio 43240, USA
Cancer Prev Res (Phila) 2:187-94. 2009..The relative merits of berry powders, extracts, or individual constituents (anthocyanins) for cancer prevention are also discussed... - Multiple berry types prevent N-nitrosomethylbenzylamine-induced esophageal cancer in ratsGary D Stoner
Department of Internal Medicine and Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
Pharm Res 27:1138-45. 2010..We also determined if berries influence the levels of inflammatory cytokines in the serum of carcinogen-treated rats... - Chemopreventive properties of black raspberries in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis: down-regulation of cyclooxygenase-2, inducible nitric oxide synthase, and c-JunTong Chen
Cancer Chemoprevention Program, Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
Cancer Res 66:2853-9. 2006..Prostaglandin E(2) and total nitrite levels were also decreased by BRB in papillomas. These results suggest a novel tumor suppressive role of BRB through inhibition of COX-2, iNOS, and c-Jun... - Anthocyanins in black raspberries prevent esophageal tumors in ratsLi Shu Wang
Ohio State University Comprehensive Cancer Center, 2001 Polaris Parkway, Columbus, OH 43240, USA
Cancer Prev Res (Phila) 2:84-93. 2009.... - Black raspberry components inhibit proliferation, induce apoptosis, and modulate gene expression in rat esophageal epithelial cellsNancy N Zikri
The Ohio State University, Columbus, Ohio 43240, USA
Nutr Cancer 61:816-26. 2009.... - Piroxicam is an ineffective inhibitor of N-nitrosomethylbenzylamine-induced tumorigenesis in the rat esophagusPeter S Carlton
Division of Environmental Health Sciences, School of Public Health, The Ohio State University, Columbus, Ohio 43210, USA
Cancer Res 62:4376-82. 2002..The reasons for the lack of effect are largely unknown but may be related to the inability of piroxicam to modulate other biochemical pathways involved in NMBA-induced tumorigenesis... - Transitioning from preclinical to clinical chemopreventive assessments of lyophilized black raspberries: interim results show berries modulate markers of oxidative stress in Barrett's esophagus patientsLaura A Kresty
Division of Hematology and Oncology, Department of Internal Medicine, The Ohio State University College of Medicine and Public Health, Columbus 43210, USA
Nutr Cancer 54:148-56. 2006.... - The effects of L-748706, a selective cyclooxygenase-2 inhibitor, on N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesisGary D Stoner
Cancer Chemoprevention and Support Program, Division of Hematology and Oncology, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
Carcinogenesis 26:1590-5. 2005.... - Chemopreventive effects of a selective nitric oxide synthase inhibitor on carcinogen-induced rat esophageal tumorigenesisTong Chen
Division of Environmental Health Sciences, School of Public Health and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
Cancer Res 64:3714-7. 2004..These observations suggest that iNOS plays a role in tumor development and that its selective inhibitor, PBIT, significantly inhibits esophageal tumor progression presumably through reducing the production of NO... - Photochemoprevention of UVB-induced skin carcinogenesis in SKH-1 mice by brown algae polyphenolsHyejeong Hwang
Chemoprevention and Support Program, Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
Int J Cancer 119:2742-9. 2006..These observations show that brown algae polyphenols have an antiphotocarcinogenic effect which may be associated with the prevention of UVB-induced oxidative stress, inflammation, and cell proliferation in the skin... - Formulation and in-vitro and in-vivo evaluation of a mucoadhesive gel containing freeze dried black raspberries: implications for oral cancer chemopreventionSusan R Mallery
Department of Oral Maxillofacial Surgery and Pathology, College of Dentistry, The Ohio State University, Columbus, OH 43210 1241, USA
Pharm Res 24:728-37. 2007.... - Chemoprevention of oral cancer by black raspberriesBruce C Casto
Division of Environmental Health Sciences, School of Public Health, Ohio State University, Columbus, OH 43210, USA
Anticancer Res 22:4005-15. 2002..These experiments support previous studies from our laboratories showing the chemopreventive activity of black raspberries and show, for the first time, that dietary black raspberries will inhibit tumor formation in the oral cavity... - Perillyl alcohol as a chemopreventive agent in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesisBeth W Liston
Department of Pathology, School of Public Health and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
Cancer Res 63:2399-403. 2003..These data indicate that POH has a weakly promoting effect early in nitrosamine-induced esophageal tumorigenesis and suggest that POH may not be an effective chemopreventive agent for esophageal cancer in humans... - Modulation of N-nitrosomethylbenzylamine metabolism by black raspberries in the esophagus and liver of Fischer 344 ratsRashmeet K Reen
Division of Hematology and Oncology, Department of Internal Medicine, The Ohio State University, Columbus 43210, USA
Nutr Cancer 54:47-57. 2006..Dietary BRBs and PEITC induced glutathione S-transferase activity in the liver... - Black raspberries inhibit N-nitrosomethylbenzylamine (NMBA)-induced angiogenesis in rat esophagus parallel to the suppression of COX-2 and iNOSTong Chen
Cancer Chemoprevention and Support Program, Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine and Public Health, The Ohio State University Columbus, OH 43210, USA
Carcinogenesis 27:2301-7. 2006..86, P < 0.001) and iNOS (r2 = 0.81, P < 0.005). As high vascularity is a risk factor for metastasis and tumor recurrence, BRB may have cancer therapeutic effects in human esophageal cancer... - Inducible nitric oxide synthase expression in N-nitrosomethylbenzylamine (NMBA)-induced rat esophageal tumorigenesisTong Chen
Division of Environmental Health Sciences, School of Public Health and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
Mol Carcinog 40:232-40. 2004..Our data suggest, therefore, that the production of iNOS by the epithelium of the esophagus is associated with the development of NMBA-induced esophageal tumorigenesis in rats... - Distribution of anthocyanins delivered from a bioadhesive black raspberry gel following topical intraoral application in normal healthy volunteersCarlos M Ugalde
Division of Oral Maxillofacial Surgery, Pathology and Anesthesiology, College of Dentistry, The Ohio State University, Columbus, Ohio, USA
Pharm Res 26:977-86. 2009..Accordingly, this study assessed the distribution of anthocyanins from the 10% (w/w) FBR gel in saliva, oral tissues and plasma... - Inhibition of the growth of premalignant and malignant human oral cell lines by extracts and components of black raspberriesChunhua Han
Department of Radiology, The Ohio State University, Columbus 43210, USA
Nutr Cancer 51:207-17. 2005.... - Anthocyanins and their role in cancer preventionLi Shu Wang
Department of Internal Medicine and Comprehensive Cancer Center, Ohio State University College of Medicine, Columbus, OH 43210, USA
Cancer Lett 269:281-90. 2008..Future studies aimed at enhancing the absorption of anthocyanins and/or their metabolites are likely to be necessary for their ultimate use for chemoprevention of human cancer... - Topical application of a bioadhesive black raspberry gel modulates gene expression and reduces cyclooxygenase 2 protein in human premalignant oral lesionsSusan R Mallery
Department of Oral and Maxillofacial Surgery, College of Dentistry, The Ohio State University Comprehensive Cancer Center and Solove Research Institute, Columbus, Ohio, USA
Cancer Res 68:4945-57. 2008..In a patient subset, berry gel application also reduced vascular densities in the superficial connective tissues and induced genes associated with keratinocyte terminal differentiation... - Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 daysGary D Stoner
Division of Hematology/Oncology, Department of Internal Medicine, College of Medicine, The Ohio State University, 1148 James CHRI, 300 W 10th Avenue, Columbus, OH 43210, USA
J Clin Pharmacol 45:1153-64. 2005..None of the pharmacokinetic parameters changed significantly between days 1 and 7. In conclusion, 45 g of freeze-dried BRB daily are well tolerated and result in quantifiable anthocyanins and ellagic acid in plasma and urine... - Urinary excretion of black raspberry (Rubus occidentalis) anthocyanins and their metabolitesQingguo Tian
Department of Food Science and Technology, The Ohio State University, 2015 Fyffe Road, Columbus, Ohio 43210, USA
J Agric Food Chem 54:1467-72. 2006..As compared to the anthocyanin distribution in black raspberries, urinary cyanidin 3-xylosylrutinoside was detected at a higher concentration than that of cyanidin-3-rutinoside... - Drinking water with red beetroot food color antagonizes esophageal carcinogenesis in N-nitrosomethylbenzylamine-treated ratsJohn F Lechner
Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43240, USA
J Med Food 13:733-9. 2010..However, the sum of constituents of E162 has not been determined, and other components with other mechanisms may also be involved in antagonizing cancer development... - Effects of a topically applied bioadhesive berry gel on loss of heterozygosity indices in premalignant oral lesionsBrian S Shumway
Department of Oral and Maxillofacial Surgery, Anesthesiology and Pathology, College of Dentistry, The Ohio State University, Columbus, OH 43210 1241, USA
Clin Cancer Res 14:2421-30. 2008..Previously, our laboratories have shown that FBRs are well tolerated and possess potent antioxidant, apoptotic, and differentiation-inducing properties... - A rapid and sensitive LC-MS/MS method for quantification of four anthocyanins and its application in a clinical pharmacology study of a bioadhesive black raspberry gelYonghua Ling
College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
J Chromatogr B Analyt Technol Biomed Life Sci 877:4027-34. 2009..Measurable saliva and tissue levels of the FBR anthocyanins confirmed that gel-delivered anthocyanins are readily distributed to saliva and easily penetrate human oral mucosa... - Screening for anthocyanins using high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry with precursor-ion analysis, product-ion analysis, common-neutral-loss analysis, and selected reaction monitoringQingguo Tian
Department of Food Science and Technology, The Ohio State University, 2015 Fyffe Road, Columbus, Ohio 43210, USA
J Chromatogr A 1091:72-82. 2005....
Research Grants
- Prevention of Esophageal Cancer with BerriesGary Stoner; Fiscal Year: 2007....
- Chemoprevention of Esophageal Squamous Cell CarcinomaGary Stoner; Fiscal Year: 2004..abstract_text> ..