Gary David Stoner

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc Protection against esophageal cancer in rodents with lyophilized berries: potential mechanisms
    Gary D Stoner
    Division of Hematology and Oncology, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, Columbus 43210, USA
    Nutr Cancer 54:33-46. 2006
  2. pmc Effects of phenylethyl isothiocyanate on early molecular events in N-nitrosomethylbenzylamine-induced cytotoxicity in rat esophagus
    Rashmeet K Reen
    Department of Internal Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43240, USA
    Cancer Res 67:6484-92. 2007
  3. ncbi request reprint Prevention and therapy of squamous cell carcinoma of the rodent esophagus using freeze-dried black raspberries
    Gary D Stoner
    Division of Hematology and Oncology and Comprehensive Cancer Center, College of Public Health, The Ohio State University, Columbus, OH 43210, USA
    Acta Pharmacol Sin 28:1422-8. 2007
  4. doi request reprint Effects of a black raspberry diet on gene expression in the rat esophagus
    John F Lechner
    Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Nutr Cancer 60:61-9. 2008
  5. doi request reprint Topical treatment with black raspberry extract reduces cutaneous UVB-induced carcinogenesis and inflammation
    F J Duncan
    Department of Pathology, The Ohio State University, 1645 Neil Avenue, 129 Hamilton Hall, Columbus, OH 43210, USA
    Cancer Prev Res (Phila) 2:665-72. 2009
  6. pmc Chemoprevention of esophageal squamous cell carcinoma
    Gary D Stoner
    Division of Hematology and Oncology, Department of Internal Medicine, Ohio State University College of Medicine and Comprehensive Cancer Center, Columbus, OH 43210, USA
    Toxicol Appl Pharmacol 224:337-49. 2007
  7. pmc Cancer prevention with freeze-dried berries and berry components
    Gary D Stoner
    Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine, The Ohio State University, Innovation Centre, 2001 Polaris Parkway, Columbus, OH 43240, USA
    Semin Cancer Biol 17:403-10. 2007
  8. pmc Laboratory and clinical studies of cancer chemoprevention by antioxidants in berries
    Gary David Stoner
    Department of Internal Medicine, College of Medicine, The Ohio StateUniversity, Columbus, OH 43210, USA
    Carcinogenesis 29:1665-74. 2008
  9. pmc Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both black raspberries and phenylethyl isothiocyanate
    Gary D Stoner
    Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, Ohio 43240, USA
    Cancer Res 68:6460-7. 2008
  10. pmc Foodstuffs for preventing cancer: the preclinical and clinical development of berries
    Gary D Stoner
    Department of Internal Medicine, The Ohio State University, Innovation Centre, 2001 Polaris Parkway, Columbus, Ohio 43240, USA
    Cancer Prev Res (Phila) 2:187-94. 2009

Research Grants

Collaborators

  • Tong Chen
  • Laura A Kresty
  • Haiming Ding
  • SUSAN REGINA MALLERY
  • Li Shu Wang
  • Stephen Hecht
  • Rashmeet K Reen
  • Meng Tong
  • ALAN DOUGLAS KINGHORN
  • C Huang
  • John F Lechner
  • Steven J Schwartz
  • Qingguo Tian
  • Carlos M Ugalde
  • Kenneth M Riedl
  • Yonghua Ling
  • Chen Ren
  • Zhongfa Liu
  • Kenneth K Chan
  • F J Duncan
  • Nancy N Zikri
  • Beth W Liston
  • Henry W Fields
  • Peter E Larsen
  • Peter S Carlton
  • Russell J Mumper
  • Brian S Shumway
  • Hyejeong Hwang
  • M Monica Giusti
  • Chunhua Han
  • Ashok Gupta
  • Bruce C Casto
  • Cassandra Henry
  • Colleen M McIntyre
  • Claudio M Rocha
  • Bethany Larue
  • Brian C Wulff
  • Kapila A Rodrigo
  • Ping Pei
  • Anne M Van Buskirk
  • Tatiana M Oberyszyn
  • Guillermo E Chacon
  • Donna F Kusewitt
  • Kathleen L Tober
  • U V R Vijaya Saradhi
  • Yhonghua Ling
  • Jason R Martin
  • John Lechner
  • Daniela Cukovic
  • Jared C Zwick
  • Sridevi Salagrama
  • Bo Lu
  • Alan A Dombkowski
  • Hyeon Cheol Shin
  • Ronald G Nines
  • Steven M D'Ambrosio
  • Bruce Casto
  • Wendy Frankel
  • Ronald Nines
  • Robeena Aziz
  • Herman A Schut
  • Suzy Habib
  • Dennis K Pearl
  • Rajaram Gopalakrishnan
  • Mark A Morse
  • Thomas J Knobloch
  • Carrie L Kraly
  • Christopher M Weghorst

Detail Information

Publications35

  1. pmc Protection against esophageal cancer in rodents with lyophilized berries: potential mechanisms
    Gary D Stoner
    Division of Hematology and Oncology, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, Columbus 43210, USA
    Nutr Cancer 54:33-46. 2006
    ..Based upon the preclinical data on rodents, we have initiated prevention trials in humans to determine if berries might exhibit chemopreventive effects in the esophagus...
  2. pmc Effects of phenylethyl isothiocyanate on early molecular events in N-nitrosomethylbenzylamine-induced cytotoxicity in rat esophagus
    Rashmeet K Reen
    Department of Internal Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43240, USA
    Cancer Res 67:6484-92. 2007
    ..Samples obtained from animals treated with PEITC alone or cotreated with PEITC + NMBA were more similar to controls than to samples treated with NMBA alone...
  3. ncbi request reprint Prevention and therapy of squamous cell carcinoma of the rodent esophagus using freeze-dried black raspberries
    Gary D Stoner
    Division of Hematology and Oncology and Comprehensive Cancer Center, College of Public Health, The Ohio State University, Columbus, OH 43210, USA
    Acta Pharmacol Sin 28:1422-8. 2007
    ....
  4. doi request reprint Effects of a black raspberry diet on gene expression in the rat esophagus
    John F Lechner
    Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Nutr Cancer 60:61-9. 2008
    ..In conclusion, histological and molecular studies indicate that a 5% BRB diet produces only modest effects on the esophagus, the target tissue for NMBA carcinogenesis in the rat...
  5. doi request reprint Topical treatment with black raspberry extract reduces cutaneous UVB-induced carcinogenesis and inflammation
    F J Duncan
    Department of Pathology, The Ohio State University, 1645 Neil Avenue, 129 Hamilton Hall, Columbus, OH 43210, USA
    Cancer Prev Res (Phila) 2:665-72. 2009
    ..The ability of topical BRE to reduce acute UVB-induced inflammation and to decrease tumor development in a long-term model provides compelling evidence to explore the clinical efficacy of BRE in the prevention of human skin cancers...
  6. pmc Chemoprevention of esophageal squamous cell carcinoma
    Gary D Stoner
    Division of Hematology and Oncology, Department of Internal Medicine, Ohio State University College of Medicine and Comprehensive Cancer Center, Columbus, OH 43210, USA
    Toxicol Appl Pharmacol 224:337-49. 2007
    ..These observations have led to a clinical trial in China to evaluate the ability of freeze-dried strawberries to influence the progression of esophageal dysplasia to SCC...
  7. pmc Cancer prevention with freeze-dried berries and berry components
    Gary D Stoner
    Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine, The Ohio State University, Innovation Centre, 2001 Polaris Parkway, Columbus, OH 43240, USA
    Semin Cancer Biol 17:403-10. 2007
    ..e., Barrett's esophagus, esophageal dysplasia and colonic polyps, to determine if berries will modulate various histological and molecular biomarkers of development of these diseases...
  8. pmc Laboratory and clinical studies of cancer chemoprevention by antioxidants in berries
    Gary David Stoner
    Department of Internal Medicine, College of Medicine, The Ohio StateUniversity, Columbus, OH 43210, USA
    Carcinogenesis 29:1665-74. 2008
    ..This review article summarizes laboratory and human studies, demonstrating the protective effects of berries and berry constituents on oxidative and other cellular processes leading to cancer development...
  9. pmc Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both black raspberries and phenylethyl isothiocyanate
    Gary D Stoner
    Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, Ohio 43240, USA
    Cancer Res 68:6460-7. 2008
    ..Because both PEITC and BRB maintain near-normal levels of expression of these 53 genes, their dysregulation during the early phase of NMBA-induced esophageal cancer may be especially important in the genesis of the disease...
  10. pmc Foodstuffs for preventing cancer: the preclinical and clinical development of berries
    Gary D Stoner
    Department of Internal Medicine, The Ohio State University, Innovation Centre, 2001 Polaris Parkway, Columbus, Ohio 43240, USA
    Cancer Prev Res (Phila) 2:187-94. 2009
    ..The relative merits of berry powders, extracts, or individual constituents (anthocyanins) for cancer prevention are also discussed...
  11. pmc Multiple berry types prevent N-nitrosomethylbenzylamine-induced esophageal cancer in rats
    Gary D Stoner
    Department of Internal Medicine and Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Pharm Res 27:1138-45. 2010
    ..We also determined if berries influence the levels of inflammatory cytokines in the serum of carcinogen-treated rats...
  12. pmc Chemopreventive properties of black raspberries in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis: down-regulation of cyclooxygenase-2, inducible nitric oxide synthase, and c-Jun
    Tong Chen
    Cancer Chemoprevention Program, Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 66:2853-9. 2006
    ..Prostaglandin E(2) and total nitrite levels were also decreased by BRB in papillomas. These results suggest a novel tumor suppressive role of BRB through inhibition of COX-2, iNOS, and c-Jun...
  13. pmc Anthocyanins in black raspberries prevent esophageal tumors in rats
    Li Shu Wang
    Ohio State University Comprehensive Cancer Center, 2001 Polaris Parkway, Columbus, OH 43240, USA
    Cancer Prev Res (Phila) 2:84-93. 2009
    ....
  14. pmc Black raspberry components inhibit proliferation, induce apoptosis, and modulate gene expression in rat esophageal epithelial cells
    Nancy N Zikri
    The Ohio State University, Columbus, Ohio 43240, USA
    Nutr Cancer 61:816-26. 2009
    ....
  15. ncbi request reprint Piroxicam is an ineffective inhibitor of N-nitrosomethylbenzylamine-induced tumorigenesis in the rat esophagus
    Peter S Carlton
    Division of Environmental Health Sciences, School of Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 62:4376-82. 2002
    ..The reasons for the lack of effect are largely unknown but may be related to the inability of piroxicam to modulate other biochemical pathways involved in NMBA-induced tumorigenesis...
  16. ncbi request reprint Transitioning from preclinical to clinical chemopreventive assessments of lyophilized black raspberries: interim results show berries modulate markers of oxidative stress in Barrett's esophagus patients
    Laura A Kresty
    Division of Hematology and Oncology, Department of Internal Medicine, The Ohio State University College of Medicine and Public Health, Columbus 43210, USA
    Nutr Cancer 54:148-56. 2006
    ....
  17. ncbi request reprint The effects of L-748706, a selective cyclooxygenase-2 inhibitor, on N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis
    Gary D Stoner
    Cancer Chemoprevention and Support Program, Division of Hematology and Oncology, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
    Carcinogenesis 26:1590-5. 2005
    ....
  18. ncbi request reprint Chemopreventive effects of a selective nitric oxide synthase inhibitor on carcinogen-induced rat esophageal tumorigenesis
    Tong Chen
    Division of Environmental Health Sciences, School of Public Health and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 64:3714-7. 2004
    ..These observations suggest that iNOS plays a role in tumor development and that its selective inhibitor, PBIT, significantly inhibits esophageal tumor progression presumably through reducing the production of NO...
  19. ncbi request reprint Photochemoprevention of UVB-induced skin carcinogenesis in SKH-1 mice by brown algae polyphenols
    Hyejeong Hwang
    Chemoprevention and Support Program, Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Int J Cancer 119:2742-9. 2006
    ..These observations show that brown algae polyphenols have an antiphotocarcinogenic effect which may be associated with the prevention of UVB-induced oxidative stress, inflammation, and cell proliferation in the skin...
  20. pmc Formulation and in-vitro and in-vivo evaluation of a mucoadhesive gel containing freeze dried black raspberries: implications for oral cancer chemoprevention
    Susan R Mallery
    Department of Oral Maxillofacial Surgery and Pathology, College of Dentistry, The Ohio State University, Columbus, OH 43210 1241, USA
    Pharm Res 24:728-37. 2007
    ....
  21. ncbi request reprint Chemoprevention of oral cancer by black raspberries
    Bruce C Casto
    Division of Environmental Health Sciences, School of Public Health, Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 22:4005-15. 2002
    ..These experiments support previous studies from our laboratories showing the chemopreventive activity of black raspberries and show, for the first time, that dietary black raspberries will inhibit tumor formation in the oral cavity...
  22. ncbi request reprint Perillyl alcohol as a chemopreventive agent in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis
    Beth W Liston
    Department of Pathology, School of Public Health and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 63:2399-403. 2003
    ..These data indicate that POH has a weakly promoting effect early in nitrosamine-induced esophageal tumorigenesis and suggest that POH may not be an effective chemopreventive agent for esophageal cancer in humans...
  23. pmc Modulation of N-nitrosomethylbenzylamine metabolism by black raspberries in the esophagus and liver of Fischer 344 rats
    Rashmeet K Reen
    Division of Hematology and Oncology, Department of Internal Medicine, The Ohio State University, Columbus 43210, USA
    Nutr Cancer 54:47-57. 2006
    ..Dietary BRBs and PEITC induced glutathione S-transferase activity in the liver...
  24. ncbi request reprint Black raspberries inhibit N-nitrosomethylbenzylamine (NMBA)-induced angiogenesis in rat esophagus parallel to the suppression of COX-2 and iNOS
    Tong Chen
    Cancer Chemoprevention and Support Program, Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine and Public Health, The Ohio State University Columbus, OH 43210, USA
    Carcinogenesis 27:2301-7. 2006
    ..86, P < 0.001) and iNOS (r2 = 0.81, P < 0.005). As high vascularity is a risk factor for metastasis and tumor recurrence, BRB may have cancer therapeutic effects in human esophageal cancer...
  25. ncbi request reprint Inducible nitric oxide synthase expression in N-nitrosomethylbenzylamine (NMBA)-induced rat esophageal tumorigenesis
    Tong Chen
    Division of Environmental Health Sciences, School of Public Health and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    Mol Carcinog 40:232-40. 2004
    ..Our data suggest, therefore, that the production of iNOS by the epithelium of the esophagus is associated with the development of NMBA-induced esophageal tumorigenesis in rats...
  26. pmc Distribution of anthocyanins delivered from a bioadhesive black raspberry gel following topical intraoral application in normal healthy volunteers
    Carlos M Ugalde
    Division of Oral Maxillofacial Surgery, Pathology and Anesthesiology, College of Dentistry, The Ohio State University, Columbus, Ohio, USA
    Pharm Res 26:977-86. 2009
    ..Accordingly, this study assessed the distribution of anthocyanins from the 10% (w/w) FBR gel in saliva, oral tissues and plasma...
  27. ncbi request reprint Inhibition of the growth of premalignant and malignant human oral cell lines by extracts and components of black raspberries
    Chunhua Han
    Department of Radiology, The Ohio State University, Columbus 43210, USA
    Nutr Cancer 51:207-17. 2005
    ....
  28. pmc Anthocyanins and their role in cancer prevention
    Li Shu Wang
    Department of Internal Medicine and Comprehensive Cancer Center, Ohio State University College of Medicine, Columbus, OH 43210, USA
    Cancer Lett 269:281-90. 2008
    ..Future studies aimed at enhancing the absorption of anthocyanins and/or their metabolites are likely to be necessary for their ultimate use for chemoprevention of human cancer...
  29. pmc Topical application of a bioadhesive black raspberry gel modulates gene expression and reduces cyclooxygenase 2 protein in human premalignant oral lesions
    Susan R Mallery
    Department of Oral and Maxillofacial Surgery, College of Dentistry, The Ohio State University Comprehensive Cancer Center and Solove Research Institute, Columbus, Ohio, USA
    Cancer Res 68:4945-57. 2008
    ..In a patient subset, berry gel application also reduced vascular densities in the superficial connective tissues and induced genes associated with keratinocyte terminal differentiation...
  30. ncbi request reprint Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 days
    Gary D Stoner
    Division of Hematology Oncology, Department of Internal Medicine, College of Medicine, The Ohio State University, 1148 James CHRI, 300 W 10th Avenue, Columbus, OH 43210, USA
    J Clin Pharmacol 45:1153-64. 2005
    ..None of the pharmacokinetic parameters changed significantly between days 1 and 7. In conclusion, 45 g of freeze-dried BRB daily are well tolerated and result in quantifiable anthocyanins and ellagic acid in plasma and urine...
  31. ncbi request reprint Urinary excretion of black raspberry (Rubus occidentalis) anthocyanins and their metabolites
    Qingguo Tian
    Department of Food Science and Technology, The Ohio State University, 2015 Fyffe Road, Columbus, Ohio 43210, USA
    J Agric Food Chem 54:1467-72. 2006
    ..As compared to the anthocyanin distribution in black raspberries, urinary cyanidin 3-xylosylrutinoside was detected at a higher concentration than that of cyanidin-3-rutinoside...
  32. pmc Drinking water with red beetroot food color antagonizes esophageal carcinogenesis in N-nitrosomethylbenzylamine-treated rats
    John F Lechner
    Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43240, USA
    J Med Food 13:733-9. 2010
    ..However, the sum of constituents of E162 has not been determined, and other components with other mechanisms may also be involved in antagonizing cancer development...
  33. pmc Effects of a topically applied bioadhesive berry gel on loss of heterozygosity indices in premalignant oral lesions
    Brian S Shumway
    Department of Oral and Maxillofacial Surgery, Anesthesiology and Pathology, College of Dentistry, The Ohio State University, Columbus, OH 43210 1241, USA
    Clin Cancer Res 14:2421-30. 2008
    ..Previously, our laboratories have shown that FBRs are well tolerated and possess potent antioxidant, apoptotic, and differentiation-inducing properties...
  34. pmc A rapid and sensitive LC-MS/MS method for quantification of four anthocyanins and its application in a clinical pharmacology study of a bioadhesive black raspberry gel
    Yonghua Ling
    College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:4027-34. 2009
    ..Measurable saliva and tissue levels of the FBR anthocyanins confirmed that gel-delivered anthocyanins are readily distributed to saliva and easily penetrate human oral mucosa...
  35. ncbi request reprint Screening for anthocyanins using high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry with precursor-ion analysis, product-ion analysis, common-neutral-loss analysis, and selected reaction monitoring
    Qingguo Tian
    Department of Food Science and Technology, The Ohio State University, 2015 Fyffe Road, Columbus, Ohio 43210, USA
    J Chromatogr A 1091:72-82. 2005
    ....

Research Grants11

  1. Prevention of Esophageal Cancer with Berries
    Gary Stoner; Fiscal Year: 2007
    ....
  2. Chemoprevention of Esophageal Squamous Cell Carcinoma
    Gary Stoner; Fiscal Year: 2004
    ..abstract_text> ..