Nicole F Steinmetz

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint Structure-based engineering of an icosahedral virus for nanomedicine and nanotechnology
    N F Steinmetz
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Top Microbiol Immunol 327:23-58. 2009
  2. pmc Viral nanoparticles as platforms for next-generation therapeutics and imaging devices
    Nicole F Steinmetz
    Department of Molecular Biology and Center of Integrative Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
    Nanomedicine 6:634-41. 2010
  3. pmc Buckyballs meet viral nanoparticles: candidates for biomedicine
    Nicole F Steinmetz
    Department of Cell Biology, Center for Integrative Molecular Biosciences, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 131:17093-5. 2009
  4. doi request reprint Layer-by-layer assembly of viral nanoparticles and polyelectrolytes: the film architecture is different for spheres versus rods
    Nicole F Steinmetz
    Department of Biological Chemistry, John Innes Centre, Colney, Norwich, NR47UH, UK
    Chembiochem 9:1662-70. 2008
  5. doi request reprint Assembly of multilayer arrays of viral nanoparticles via biospecific recognition: a quartz crystal microbalance with dissipation monitoring study
    Nicole F Steinmetz
    Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, United Kingdom
    Biomacromolecules 9:456-62. 2008
  6. ncbi request reprint Chemical introduction of reactive thiols into a viral nanoscaffold: a method that avoids virus aggregation
    Nicole F Steinmetz
    Department of Biological Chemistry, John Innes Centre, Colney, Norwich, Norfolk NR4 7UH, UK
    Chembiochem 8:1131-6. 2007
  7. ncbi request reprint Decoration of cowpea mosaic virus with multiple, redox-active, organometallic complexes
    Nicole F Steinmetz
    Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK
    Small 2:530-3. 2006
  8. pmc Guiding plant virus particles to integrin-displaying cells
    Marisa L Hovlid
    Department of Chemistry, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Nanoscale 4:3698-705. 2012
  9. pmc Potato virus X as a novel platform for potential biomedical applications
    Nicole F Steinmetz
    Department of Cell Biology, Center for Integrative Molecular Biosciences, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nano Lett 10:305-12. 2010
  10. pmc Transferrin-mediated targeting of bacteriophage HK97 nanoparticles into tumor cells
    Rick K Huang
    Department of Molecular Biology and Center for Integrative Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Nanomedicine (Lond) 6:55-68. 2011

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Structure-based engineering of an icosahedral virus for nanomedicine and nanotechnology
    N F Steinmetz
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Top Microbiol Immunol 327:23-58. 2009
    ..Overall, the potential applications of viral nanobuilding blocks are manifold and range from nanoelectronics to biomedical applications...
  2. pmc Viral nanoparticles as platforms for next-generation therapeutics and imaging devices
    Nicole F Steinmetz
    Department of Molecular Biology and Center of Integrative Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
    Nanomedicine 6:634-41. 2010
    ..These can be used as imaging reagents, targeting ligands and therapeutic molecules...
  3. pmc Buckyballs meet viral nanoparticles: candidates for biomedicine
    Nicole F Steinmetz
    Department of Cell Biology, Center for Integrative Molecular Biosciences, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 131:17093-5. 2009
    ..These results open the door for the development of novel therapeutic devices with potential applications in photoactivated tumor therapy...
  4. doi request reprint Layer-by-layer assembly of viral nanoparticles and polyelectrolytes: the film architecture is different for spheres versus rods
    Nicole F Steinmetz
    Department of Biological Chemistry, John Innes Centre, Colney, Norwich, NR47UH, UK
    Chembiochem 9:1662-70. 2008
    ..Incorporation of CPMV in alternating arrays of VNPs and polyelectrolytes is demonstrated; in stark contrast, TMV particles were found to be excluded from the arrays, and floated atop the architecture in an ordered structure...
  5. doi request reprint Assembly of multilayer arrays of viral nanoparticles via biospecific recognition: a quartz crystal microbalance with dissipation monitoring study
    Nicole F Steinmetz
    Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, United Kingdom
    Biomacromolecules 9:456-62. 2008
    ..The degree of intralayer and interlayer cross-linking and hence the mechanical properties and order of the array can be modulated by the grafting density and spacer length of the biotin moieties on the CPMV particles...
  6. ncbi request reprint Chemical introduction of reactive thiols into a viral nanoscaffold: a method that avoids virus aggregation
    Nicole F Steinmetz
    Department of Biological Chemistry, John Innes Centre, Colney, Norwich, Norfolk NR4 7UH, UK
    Chembiochem 8:1131-6. 2007
    ..They therefore provide a useful additional building block in the CPMV toolbox...
  7. ncbi request reprint Decoration of cowpea mosaic virus with multiple, redox-active, organometallic complexes
    Nicole F Steinmetz
    Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK
    Small 2:530-3. 2006
  8. pmc Guiding plant virus particles to integrin-displaying cells
    Marisa L Hovlid
    Department of Chemistry, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Nanoscale 4:3698-705. 2012
    ..Both types of particles showed strong and selective affinity for several different cancer cell lines that express RGD-binding integrin receptors...
  9. pmc Potato virus X as a novel platform for potential biomedical applications
    Nicole F Steinmetz
    Department of Cell Biology, Center for Integrative Molecular Biosciences, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nano Lett 10:305-12. 2010
    ..Applying bioconjugation chemistries to PVX opens the door for chemical functionalization with targeting and therapeutic molecules...
  10. pmc Transferrin-mediated targeting of bacteriophage HK97 nanoparticles into tumor cells
    Rick K Huang
    Department of Molecular Biology and Center for Integrative Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Nanomedicine (Lond) 6:55-68. 2011
    ..Next-generation targeted nanodevices are currently under development for imaging and therapeutic applications. We engineered HK97 viral nanoparticles (VNPs) for tumor cell-specific targeting...
  11. ncbi request reprint Plant viral capsids as nanobuilding blocks: construction of arrays on solid supports
    Nicole F Steinmetz
    Department of Biological Chemistry and Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Colney Lane, Norwich NR4 7UH, United Kingdom
    Langmuir 22:10032-7. 2006
    ..This approach provides novel structured arrays which have the potential for development as functional devices at the nanoscale...
  12. doi request reprint Controlled immobilisation of active enzymes on the cowpea mosaic virus capsid
    Alaa A A Aljabali
    Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK
    Nanoscale 4:5640-5. 2012
    ..Virus-biomacromolecule hybrids have great potential for uses in catalysis, diagnostic assays or biosensors...
  13. pmc Labeling live cells by copper-catalyzed alkyne--azide click chemistry
    Vu Hong
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA
    Bioconjug Chem 21:1912-6. 2010
    ..This procedure extends the application of this fastest of azide-based bioorthogonal reactions to the exterior of living cells...
  14. pmc Cowpea mosaic virus nanoparticles target surface vimentin on cancer cells
    Nicole F Steinmetz
    Department for Cell Biology, Center for Integrative Molecular Biosciences, The Scripps Research Institute, La Jolla, CA, USA
    Nanomedicine (Lond) 6:351-64. 2011
    ..Vimentin is surface-expressed on cells involved in inflammation; the function remains unknown. We investigated the expression of surface vimentin on cancer cells and evaluated targeting nanoparticles to tumors exploiting vimentin...
  15. pmc Development of viral nanoparticles for efficient intracellular delivery
    Zhuojun Wu
    Department of Cell Biology and Chemistry, Center for Integrative Molecular Biosciences, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Nanoscale 4:3567-76. 2012
    ..Our data provide the groundwork for the development of efficient drug delivery formulations based on CPMV-R5...
  16. pmc Intravital imaging of human prostate cancer using viral nanoparticles targeted to gastrin-releasing Peptide receptors
    Nicole F Steinmetz
    Department of Cell Biology, Center of Integrative Molecular Biosciences, The Scripps Research Institute, North Torrey Pines Rd, La Jolla, CA 92037, USA
    Small 7:1664-72. 2011
    ..Further development of this viral nanoparticle platform may open the door to potential clinical noninvasive molecular imaging strategies...
  17. ncbi request reprint Cowpea mosaic virus for material fabrication: addressable carboxylate groups on a programmable nanoscaffold
    Nicole F Steinmetz
    Department of Biological Chemistry, John Innes Centre, Colney, Norwich NR4 7UH, United Kingdom
    Langmuir 22:3488-90. 2006
    ..The display of multiple redox centers on the virus particle surface may lead to the development of novel electron-transfer mediators in redox catalysis, to biosensors, and to nanoelectronic devices such as molecular batteries...
  18. pmc CPMV-DOX delivers
    Alaa A A Aljabali
    Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK
    Mol Pharm 10:3-10. 2013
    ..This study is the first demonstrating the utility of CPMV as a drug delivery vehicle...
  19. pmc PEGylated viral nanoparticles for biomedicine: the impact of PEG chain length on VNP cell interactions in vitro and ex vivo
    Nicole F Steinmetz
    Department of Cell Biology, Center for Integrative Molecular Biosciences, The Scripps Research Institute, La Jolla, California 92037, USA
    Biomacromolecules 10:784-92. 2009
    ..The large CPMV surface area available after PEGylation allows further attachment of imaging and therapeutic molecules to the particle to generate multifunctionality...
  20. pmc The art of engineering viral nanoparticles
    Jonathan K Pokorski
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Pharm 8:29-43. 2011
    ..With all these techniques in hand, the potential applications of VNPs are limited only by the imagination...
  21. ncbi request reprint Utilisation of plant viruses in bionanotechnology
    Nicole F Steinmetz
    Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Colney, Norwich, United Kingdom
    Org Biomol Chem 5:2891-902. 2007
    ....