R M Steinman

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. pmc Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone
    Mikael C I Karlsson
    Laboratory of Molecular Genetics and Immunology, The Rockefeller University, Box 98, 1230 York Avenue, New York, NY 10021, USA
    J Exp Med 198:333-40. 2003
  2. ncbi request reprint Dendritic cells: understanding immunogenicity
    Ralph M Steinman
    The Rockefeller University and Chris Browne Center for Immunology and Immune Disease, New York, NY 10021 6399, USA
    Eur J Immunol 37:S53-60. 2007
  3. pmc Targeting of the non-mutated tumor antigen HER2/neu to mature dendritic cells induces an integrated immune response that protects against breast cancer in mice
    Bei Wang
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center of Immunology and Immune Disease, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA
    Breast Cancer Res 14:R39. 2012
  4. doi request reprint Some scientific and organizational challenges in cancer immunology
    Ralph M Steinman
    The Rockefeller University, New York, NY 10065 6399, USA
    Ann N Y Acad Sci 1174:1-5. 2009
  5. ncbi request reprint Dendritic cells: from the fabric of immunology
    Ralph M Steinman
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021 6399, USA
    Clin Invest Med 27:231-6. 2004
  6. ncbi request reprint Dendritic cells: translating innate to adaptive immunity
    R M Steinman
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021 6399, USA
    Curr Top Microbiol Immunol 311:17-58. 2006
  7. ncbi request reprint Lasker Basic Medical Research Award. Dendritic cells: versatile controllers of the immune system
    Ralph M Steinman
    The Rockefeller University, 1230 York Avenue, New York, New York 10065 6399, USA
    Nat Med 13:1155-9. 2007
  8. pmc Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance
    Laura Bonifaz
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 196:1627-38. 2002
  9. ncbi request reprint Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking
    G J Randolph
    Department of Pathology, Cornell University Medical College, 1300 York Avenue, Room C 420, New York, NY 10021, USA
    Science 282:480-3. 1998
  10. pmc Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo
    D Hawiger
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 194:769-79. 2001

Collaborators

Detail Information

Publications114 found, 100 shown here

  1. pmc Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone
    Mikael C I Karlsson
    Laboratory of Molecular Genetics and Immunology, The Rockefeller University, Box 98, 1230 York Avenue, New York, NY 10021, USA
    J Exp Med 198:333-40. 2003
    ..The marginal zone is therefore a dynamic structure in which retention and trafficking of B cells requires specific macrophage-B cell interactions...
  2. ncbi request reprint Dendritic cells: understanding immunogenicity
    Ralph M Steinman
    The Rockefeller University and Chris Browne Center for Immunology and Immune Disease, New York, NY 10021 6399, USA
    Eur J Immunol 37:S53-60. 2007
    ..These subjects should be studied in vivo with clinically relevant antigens, so that the activities of DC can be better integrated into the prevention and treatment of disease in patients...
  3. pmc Targeting of the non-mutated tumor antigen HER2/neu to mature dendritic cells induces an integrated immune response that protects against breast cancer in mice
    Bei Wang
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center of Immunology and Immune Disease, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA
    Breast Cancer Res 14:R39. 2012
    ..The aim of this study was to determine the immunogenicity of a HER2 protein vaccine that directly targets to DEC+ dendritic cells (DCs) in a mouse breast cancer model...
  4. doi request reprint Some scientific and organizational challenges in cancer immunology
    Ralph M Steinman
    The Rockefeller University, New York, NY 10065 6399, USA
    Ann N Y Acad Sci 1174:1-5. 2009
    ..The subject is the need for a much better supported and organized effort to design optimal studies of immunology in cancer patients so that cancer vaccines can become a major means to prevent and treat this disease...
  5. ncbi request reprint Dendritic cells: from the fabric of immunology
    Ralph M Steinman
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021 6399, USA
    Clin Invest Med 27:231-6. 2004
  6. ncbi request reprint Dendritic cells: translating innate to adaptive immunity
    R M Steinman
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021 6399, USA
    Curr Top Microbiol Immunol 311:17-58. 2006
    ..DC biology should continue to be helpful in understanding pathogenesis and protection in the setting of prevalent clinical problems...
  7. ncbi request reprint Lasker Basic Medical Research Award. Dendritic cells: versatile controllers of the immune system
    Ralph M Steinman
    The Rockefeller University, 1230 York Avenue, New York, New York 10065 6399, USA
    Nat Med 13:1155-9. 2007
  8. pmc Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance
    Laura Bonifaz
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 196:1627-38. 2002
    ..Therefore, DEC-205 provides an efficient receptor-based mechanism for DCs to process proteins for MHC class I presentation in vivo, leading to tolerance in the steady state and immunity after DC maturation...
  9. ncbi request reprint Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking
    G J Randolph
    Department of Pathology, Cornell University Medical College, 1300 York Avenue, Room C 420, New York, NY 10021, USA
    Science 282:480-3. 1998
    ..Monocytes that remained in the subendothelial matrix became macrophages. Therefore, monocytes have two potential fates associated with distinct patterns of migration...
  10. pmc Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo
    D Hawiger
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 194:769-79. 2001
    ..We conclude that in the absence of additional stimuli DCs induce transient antigen-specific T cell activation followed by T cell deletion and unresponsiveness...
  11. ncbi request reprint A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells
    M Guo
    Laboratory of Molecular Immunology, Rockefeller University, New York, New York, USA
    Hum Immunol 61:729-38. 2000
    ..Therefore, the MG38 anti-DEC-205 antibody is useful for identifying DCs and reveals clear differences in sites where MMR and DEC-205 are expressed in lymphoid tissues...
  12. ncbi request reprint Presentation of epstein-barr virus latency antigens to CD8(+), interferon-gamma-secreting, T lymphocytes
    M Subklewe
    Laboratory of Cellular Physiology and Immunology Rockefeller University, New York, NY 10021 6399, USA
    Eur J Immunol 29:3995-4001. 1999
    ..Therefore our data provide more evidence for the efficacy of DC in eliciting rapid responses to EBV latency antigens in circulating CD8(+) T cells...
  13. ncbi request reprint Cutting edge: langerin/CD207 receptor on dendritic cells mediates efficient antigen presentation on MHC I and II products in vivo
    Juliana Idoyaga
    Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    J Immunol 180:3647-50. 2008
    ..Peptide MHC I and II complexes persist for days. Dose response studies indicate only modest differences between Langerin and DEC receptors in these functions. Thus, Langerin effectively mediates Ag presentation...
  14. ncbi request reprint Dendritic cells, infected with vesicular stomatitis virus-pseudotyped HIV-1, present viral antigens to CD4+ and CD8+ T cells from HIV-1-infected individuals
    A Granelli-Piperno
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021 Mount Sinai Medical School, New York, NY 10029, USA
    J Immunol 165:6620-6. 2000
    ..Therefore, nonreplicating vaccines can be targeted to immature DCs, which upon further maturation induce combined and robust CD4(+) and CD8(+) immunity...
  15. pmc The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation
    Shin ichiro Fujii
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 199:1607-18. 2004
    ....
  16. ncbi request reprint The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
    W Jiang
    Laboratory of Molecular Immunology, Rockefeller University, New York, New York 10021, USA
    Nature 375:151-5. 1995
    ..Thus DEC-205 is a novel endocytic receptor that can be used by dendritic cells and thymic epithelial cells to direct captured antigens from the extracellular space to a specialized antigen-processing compartment...
  17. ncbi request reprint Paucity of functional T-cell memory to melanoma antigens in healthy donors and melanoma patients
    M V Dhodapkar
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10021, USA
    Clin Cancer Res 6:4831-8. 2000
    ....
  18. pmc Mature dendritic cells boost functionally superior CD8(+) T-cell in humans without foreign helper epitopes
    M V Dhodapkar
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, New York 10021, USA
    J Clin Invest 105:R9-R14. 2000
    ..These data begin to outline the kinetics of T-cell immunity in response to DCs and demonstrate that booster injections of mature DCs enhance both qualitative and quantitative aspects of CD8(+) T-cell function in humans...
  19. ncbi request reprint Differential antigen processing by dendritic cell subsets in vivo
    Diana Dudziak
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    Science 315:107-11. 2007
    ..This difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing...
  20. pmc A subset of dendritic cells induces CD4+ T cells to produce IFN-gamma by an IL-12-independent but CD70-dependent mechanism in vivo
    Helena Soares
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 204:1095-106. 2007
    ..The results indicate that two DC subsets have innate propensities to differentially affect the Th1/Th2 balance in vivo and by distinct mechanisms...
  21. pmc In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination
    Laura C Bonifaz
    Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 199:815-24. 2004
    ....
  22. pmc Immature dendritic cells selectively replicate macrophagetropic (M-tropic) human immunodeficiency virus type 1, while mature cells efficiently transmit both M- and T-tropic virus to T cells
    A Granelli-Piperno
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, New York 10021, USA
    J Virol 72:2733-7. 1998
    ..Therefore, the developmental stage of DCs can influence the interaction of these cells with HIV-1 and influence the extent to which M-tropic and T-tropic virus can replicate...
  23. pmc A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels
    G J Randolph
    Department of Pathology, Cornell University Medical College, 1300 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 95:6924-9. 1998
    ....
  24. ncbi request reprint The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor
    B R Wong
    Laboratory of Immunology, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 273:28355-9. 1998
    ..Furthermore, transfection experiments with TRANCE-R deletion mutants revealed that multiple regions of the TRANCE-R can mediate NF-kappaB activation...
  25. doi request reprint Enhanced T-cell responses to glioma cells coated with the anti-EGF receptor antibody and targeted to activating FcgammaRs on human dendritic cells
    Devi Banerjee
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Immunother 31:113-20. 2008
    ..These data suggest that immunity to EGFR expressing tumors, including glioma, can be enhanced through the concerted function of antitumor monoclonal antibodies, activating FcgammaR, and DCs...
  26. pmc Innate NKT lymphocytes confer superior adaptive immunity via tumor-capturing dendritic cells
    Kang Liu
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 202:1507-16. 2005
    ..Therefore, the access of dying tumor cells to DCs that are maturing to activated NKT cells efficiently induces long-lived adaptive resistance...
  27. ncbi request reprint Use of the fluorescence activated cell sorter to enrich dendritic cells from mouse spleen
    M T Crowley
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021
    J Immunol Methods 133:55-66. 1990
    ....
  28. pmc Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature
    U O'DOHERTY
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021 6399
    Immunology 82:487-93. 1994
    ....
  29. pmc Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells
    M V Dhodapkar
    Laboratory of Immunology and Cellular Physiology, General Clinical Research Center, and Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York 10021, USA
    J Clin Invest 104:173-80. 1999
    ..These data provide the first controlled evidence of the immunogenicity of DCs in humans, and demonstrate that a single injection of mature DCs rapidly expands T-cell immunity...
  30. pmc Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin/CD209 is abundant on macrophages in the normal human lymph node and is not required for dendritic cell stimulation of the mixed leukocyte reaction
    Angela Granelli-Piperno
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, Rockefeller University, New York, NY 10021, USA
    J Immunol 175:4265-73. 2005
    ..These results indicate that DC-SIGN has the potential to contribute to macrophage function in normal human lymph node, and that DCs do not require DC-SIGN to transmit HIV or to initiate T cell responses...
  31. ncbi request reprint Detection and activation of human Valpha24+ natural killer T cells using alpha-galactosyl ceramide-pulsed dendritic cells
    Shin ichiro Fujii
    Laboratory of Tumor Immunology and Immunotherapy, The Rockefeller University, New York, NY 10021, USA
    J Immunol Methods 272:147-59. 2003
    ..These data help to establish the conditions for loading DCs with alpha-GalCer for immune therapeutic targeting of NKT cells, and provide a new simple assay to monitor NKT function in humans...
  32. pmc Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valves
    Jae Hoon Choi
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 206:497-505. 2009
    ..In addition, after intravenous injection, aortic DCs could capture anti-CD11c antibody and cross-present ovalbumin to T cells. These results indicate that bona fide DCs are a constituent of the normal aorta and cardiac valves...
  33. pmc Broad T cell immunity to the LcrV virulence protein is induced by targeted delivery to DEC-205/CD205-positive mouse dendritic cells
    Yoonkyung Do
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York 10065 6399, USA
    Eur J Immunol 38:20-9. 2008
    ..This study sets the stage for the analysis of functional roles of IFN-gamma-producing T cells in Y. pestis infection...
  34. pmc The human cancer antigen mesothelin is more efficiently presented to the mouse immune system when targeted to the DEC-205/CD205 receptor on dendritic cells
    Bei Wang
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10065, USA
    Ann N Y Acad Sci 1174:6-17. 2009
    ..DEC-205-targeting could be valuable for enhancing immunity to MSLN in cancers where this nonmutated protein is expressed...
  35. ncbi request reprint Antigen capture, processing, and presentation by dendritic cells: recent cell biological studies
    R M Steinman
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021, USA
    Hum Immunol 60:562-7. 1999
    ..This presentation of cellular antigens by DCs likely explains the phenomenon of cross priming in the setting of transplantation and other clinical states...
  36. ncbi request reprint Virus replication begins in dendritic cells during the transmission of HIV-1 from mature dendritic cells to T cells
    A Granelli-Piperno
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York 10021 6399, USA
    Curr Biol 9:21-9. 1999
    ..The initial site for HIV-1 replication remains unknown and it is unclear whether replication can take place in DCs or whether the virus must first be transmitted from DCs to T cells...
  37. pmc Intensified and protective CD4+ T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine
    Christine Trumpfheller
    Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 203:607-17. 2006
    ..We suggest that a DEC-targeted vaccine, in part because of an unusually strong and protective CD4+ T cell response, will improve vaccine efficacy as a stand-alone approach or with other modalities...
  38. ncbi request reprint A dominant complement fixation pathway for pneumococcal polysaccharides initiated by SIGN-R1 interacting with C1q
    Young Sun Kang
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Cell 125:47-58. 2006
    ..The transmembrane lectin SIGN-R1 therefore contributes to innate resistance by an unusual C3 activation pathway...
  39. pmc Activation of natural killer T cells by alpha-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein
    Shin ichiro Fujii
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021 6399, USA
    J Exp Med 198:267-79. 2003
    ..Therefore a single dose of alphaGalCer i.v. rapidly stimulates the full maturation of DCs in situ, and this accounts for the induction of combined Th1 CD4+ and CD8+ T cell immunity to a coadministered protein...
  40. ncbi request reprint CD8+ T cells from most HIV-1-infected patients, even when challenged with mature dendritic cells, lack functional recall memory to HIV gag but not other viruses
    Geraldine Arrode
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    Eur J Immunol 35:159-70. 2005
    ..Therefore, monocyte-derived DC from HIV patients present viral antigens effectively, but there is a selective inability to expand CD8(+) IFN-gamma-producing and IFN-gamma and IL-2 double-producing T cells when challenged with HIV-1 gag...
  41. pmc Influenza virus-induced dendritic cell maturation is associated with the induction of strong T cell immunity to a coadministered, normally nonimmunogenic protein
    Marie K Brimnes
    Department of Microbiology, Mount Sinai School of Medicine, New York, 10029 NY, USA
    J Exp Med 198:133-44. 2003
    ..Therefore respiratory infection can induce DC maturation and simultaneously B and T cell immunity to an innocuous antigen inhaled concurrently...
  42. pmc Effective expansion of alloantigen-specific Foxp3+ CD25+ CD4+ regulatory T cells by dendritic cells during the mixed leukocyte reaction
    Sayuri Yamazaki
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center of Immunology and Immune Disease, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:2758-63. 2006
    ..Therefore, alloantigen-selected Tregs are more effective suppressors of responses to major transplantation antigens, and these Tregs can be expanded from a polyclonal repertoire by DCs...
  43. pmc siRNA knockdown of PD-L1 and PD-L2 in monocyte-derived dendritic cells only modestly improves proliferative responses to Gag by CD8(+) T cells from HIV-1-infected individuals
    Gaelle Breton
    Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    J Clin Immunol 29:637-45. 2009
    ....
  44. pmc Antibody to Langerin/CD207 localizes large numbers of CD8alpha+ dendritic cells to the marginal zone of mouse spleen
    Juliana Idoyaga
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:1524-9. 2009
    ..Therefore, anti-Langerin antibodies localize a majority of CD8(+) DCs to non-T cell regions of mouse spleen, where they are distinct from adjacent macrophages...
  45. pmc Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti-human DEC205 monoclonal antibody
    Cheolho Cheong
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    Blood 116:3828-38. 2010
    ....
  46. pmc HIV gag protein is efficiently cross-presented when targeted with an antibody towards the DEC-205 receptor in Flt3 ligand-mobilized murine DC
    Leonia Bozzacco
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center, The Rockefeller University, New York, NY 10065 6399, USA
    Eur J Immunol 40:36-46. 2010
    ..These findings support future experiments to use Flt3L to enhance presentation of DC-targeted vaccines...
  47. pmc Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses
    Cagan Gurer
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    Blood 112:1231-9. 2008
    ....
  48. pmc Dendritic cells cross-present latency gene products from Epstein-Barr virus-transformed B cells and expand tumor-reactive CD8(+) killer T cells
    M Subklewe
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10021, USA
    J Exp Med 193:405-11. 2001
    ..Therefore, the capacity of DCs to cross-present antigens from dead cells extends to the expansion of high affinity T cells specific for viral latency antigens involved in cell transformation...
  49. pmc Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells
    M V Dhodapkar
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10021, USA
    J Exp Med 193:233-8. 2001
    ..These data demonstrate the feasibility of antigen-specific inhibition of effector T cell function in vivo in humans and urge caution with the use of immature DCs when trying to enhance tumor or microbial immunity...
  50. ncbi request reprint Induction of Epstein-Barr virus-specific cytotoxic T-lymphocyte responses using dendritic cells pulsed with EBNA-3A peptides or UV-inactivated, recombinant EBNA-3A vaccinia virus
    M Subklewe
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY, USA
    Blood 94:1372-81. 1999
    ..Therefore, mature DCs are powerful stimulators of EBV-specific CTLs and their major histocompatibility complex class I products can even be charged with UV-inactivated recombinant vaccinia...
  51. ncbi request reprint The interaction of immunodeficiency viruses with dendritic cells
    R M Steinman
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Curr Top Microbiol Immunol 276:1-30. 2003
    ..The interaction of HIV-1 and SIV with DCs is therefore intricate but pertinent to understanding how these viruses disrupt immune function and elicit immune responses...
  52. pmc CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes
    Kristin V Tarbell
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Exp Med 199:1467-77. 2004
    ..This might be harnessed as a new avenue for immunotherapy, especially because CD25+ CD4+ regulatory cells responsive to a single autoantigen can inhibit diabetes mediated by reactivity to multiple antigens...
  53. pmc Sustained expansion of NKT cells and antigen-specific T cells after injection of alpha-galactosyl-ceramide loaded mature dendritic cells in cancer patients
    David H Chang
    Laboratory of Tumor Immunology and Immunotherapy, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 201:1503-17. 2005
    ..These data demonstrate the feasibility of sustained expansion of NKT cells in vivo in humans, including patients who have advanced cancer, and suggest that NKT activation might help to boost adaptive T cell immunity in vivo...
  54. ncbi request reprint Cell type-dependent retention and transmission of HIV-1 by DC-SIGN
    Christine Trumpfheller
    Laboratory of Cellular Physiology and Immunology, and Chris Browne Center for Immunology and Immune Diseases, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Int Immunol 15:289-98. 2003
    ....
  55. ncbi request reprint Invariant natural killer T cells are preserved in patients with glioma and exhibit antitumor lytic activity following dendritic cell-mediated expansion
    Kavita M Dhodapkar
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Human Disease, Rockefeller University, New York, NY 10021, USA
    Int J Cancer 109:893-9. 2004
    ..These data suggest that targeting NKT cells may provide a novel strategy for immunotherapy of glioma...
  56. pmc Expansion of FOXP3high regulatory T cells by human dendritic cells (DCs) in vitro and after injection of cytokine-matured DCs in myeloma patients
    Devi K Banerjee
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, 1230 York Avenue no 176, New York, NY 10021, USA
    Blood 108:2655-61. 2006
    ..A single injection of cytokine-matured DCs led to rapid enhancement of FOXP3(+) Treg's in vivo in 3 of 3 myeloma patients. These data reveal a role for DCs in increasing the number of functional FOXP3(high) Treg's in humans...
  57. ncbi request reprint SIGN-R1, a novel C-type lectin expressed by marginal zone macrophages in spleen, mediates uptake of the polysaccharide dextran
    Young Sun Kang
    Laboratory of Cellular Physiology and Immunology, and Chris Browne Center for Immunology and Immune Diseases, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Int Immunol 15:177-86. 2003
    ..Therefore, SIGN-R1 mediates the uptake of dextran polysaccharides, and it is predominantly expressed in the macrophages of the splenic marginal zone and lymph node medulla...
  58. ncbi request reprint Endogenously expressed nef uncouples cytokine and chemokine production from membrane phenotypic maturation in dendritic cells
    Davorka Messmer
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021, USA
    J Immunol 169:4172-82. 2002
    ....
  59. pmc Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells
    Sayuri Yamazaki
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 198:235-47. 2003
    ..The capacity to expand CD25+ CD4+ T cells provides DCs with an additional mechanism to regulate autoimmunity and other immune responses...
  60. ncbi request reprint Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN
    C G Park
    Laboratory of Cellular Physiology and Immunology, Box 176, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Int Immunol 13:1283-90. 2001
    ..This family of mouse C-type lectins is therefore complex, but only one of the new genes, DC-SIGN, is juxtaposed to CD23 and is expressed at high levels in DC...
  61. pmc TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor
    B R Wong
    Laboratory of Immunology, The Rockefeller University, New York 10021, USA
    J Exp Med 186:2075-80. 1997
    ..Therefore, TRANCE is a new DC-restricted survival factor that mediates T cell-DC communication and may provide a tool to selectively enhance DC activity...
  62. pmc Distinct features of dendritic cells and anti-Ig activated B cells as stimulators of the primary mixed leukocyte reaction
    J P Metlay
    Rockefeller University, New York, New York
    J Exp Med 169:239-54. 1989
    ..Thus, anti-Ig B lymphoblasts and dendritic cells, two cell types which differ markedly in phenotype, also differ in efficiency and mechanism for initiating responses in allogeneic T cells...
  63. pmc Mature dendritic cells infected with canarypox virus elicit strong anti-human immunodeficiency virus CD8+ and CD4+ T-cell responses from chronically infected individuals
    J Engelmayer
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Virol 75:2142-53. 2001
    ..Therefore, these results suggest that targeting canarypox virus vectors to mature DCs could potentially elicit both anti-HIV CD8+ and CD4+ helper responses in vivo...
  64. pmc Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant
    M Paula Longhi
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 206:1589-602. 2009
    ..Therefore, the adjuvant action of poly IC requires a widespread innate type I IFN response that directly links antigen presentation by DCs to adaptive immunity...
  65. pmc Normal human dermis contains distinct populations of CD11c+BDCA-1+ dendritic cells and CD163+FXIIIA+ macrophages
    Lisa C Zaba
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York 10021, USA
    J Clin Invest 117:2517-25. 2007
    ..In summary, the normal dermis contains typical immunostimulatory myeloid DCs identified by CD11c and BDCA-1, as well as an additional population of poorly stimulatory macrophages marked by CD163 and FXIIIA...
  66. pmc Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)
    Michelle A Lowes
    Laboratory for Investigative Dermatology and Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:19057-62. 2005
    ....
  67. ncbi request reprint The innate functions of dendritic cells in peripheral lymphoid tissues
    Ralph M Steinman
    Laboratories of Cellular Physiology and Immunology, The Rockefeller University, 1230 York Ave, New York, NY 10021 6399, USA
    Adv Exp Med Biol 560:83-97. 2005
  68. pmc An IFN-gamma-IL-18 signaling loop accelerates memory CD8+ T cell proliferation
    Yoshiko Iwai
    Laboratory of Cellular Immunology and Physiology, The Rockefeller University, New York, New York, United States of America
    PLoS ONE 3:e2404. 2008
    ..These results indicate that a positive regulatory loop involving IFN-gamma and IL-18 signaling contributes to the accelerated memory CD8(+) T cell proliferation during a recall response to antigen presented by DCs...
  69. pmc Influenza virus-infected dendritic cells stimulate strong proliferative and cytolytic responses from human CD8+ T cells
    N Bhardwaj
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021
    J Clin Invest 94:797-807. 1994
    ....
  70. ncbi request reprint The control of immunity and tolerance by dendritic cell
    R M Steinman
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021 6399, USA
    Pathol Biol (Paris) 51:59-60. 2003
    ....
  71. ncbi request reprint The immunodeficiency virus coreceptor, Bonzo/STRL33/TYMSTR, is expressed by macaque and human skin- and blood-derived dendritic cells
    R Ignatius
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, New York 10021, USA
    AIDS Res Hum Retroviruses 16:1055-9. 2000
    ..Therefore, Bonzo/STRL33/TYMSTR is expressed in DCs and T cells that can play a role in the transmission of immunodeficiency viruses...
  72. ncbi request reprint Dendritic cells in the T-cell areas of lymphoid organs
    R M Steinman
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021, USA
    Immunol Rev 156:25-37. 1997
    ....
  73. ncbi request reprint Myeloid dendritic cells
    R M Steinman
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021 6399, USA
    J Leukoc Biol 66:205-8. 1999
    ..These features of dendritic cell biology provide targets to manipulate the immune response in vivo...
  74. ncbi request reprint Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo
    G J Randolph
    Department of Pathology, Weill Medical College of Cornell University, New York, USA
    Immunity 11:753-61. 1999
    ..Thus, a substantial minority of inflammatory monocytes carry phagocytosed particles to lymph nodes and differentiate into DCs...
  75. pmc DEC-205/CD205+ dendritic cells are abundant in the white pulp of the human spleen, including the border region between the red and white pulp
    Maggi Pack
    The Rockefeller University, New York, NY 10021, USA
    Immunology 123:438-46. 2008
    ..Therefore, anti-DEC-205/CD205 antibodies are useful for identifying DCs in human splenic white pulp and its border region with the red pulp...
  76. doi request reprint CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain
    Karen Bulloch
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10065, USA
    J Comp Neurol 508:687-710. 2008
    ..Collectively, these findings suggest a new member of the dendritic cell family residing among the heterogeneous microglia population...
  77. ncbi request reprint Tolerogenic dendritic cells
    Ralph M Steinman
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10021 6399, USA
    Annu Rev Immunol 21:685-711. 2003
    ..We suggest that several clinical situations, including autoimmunity and certain infectious diseases, can be influenced by the antigen-specific tolerogenic role of DCs...
  78. ncbi request reprint Taking dendritic cells into medicine
    Ralph M Steinman
    The Rockefeller University, New York 10065, USA
    Nature 449:419-26. 2007
    ..Here we present some medical implications of DC biology that account for illness and provide opportunities for prevention and therapy...
  79. pmc Immune tolerance after delivery of dying cells to dendritic cells in situ
    Kang Liu
    Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 196:1091-7. 2002
    ..The specific tolerance that develops when dendritic cells process self tissues in the steady state should prevent or reduce the development of autoimmunity when dying cells are subsequently processed during infection...
  80. ncbi request reprint Antigen-bearing immature dendritic cells induce peptide-specific CD8(+) regulatory T cells in vivo in humans
    Madhav V Dhodapkar
    Laboratory of Tumor Immunology and Immunotherapy Rockefeller University New York, NY 10021, USA
    Blood 100:174-7. 2002
    ..These data show the capacity of immature DCs to induce antigen-specific regulatory CD8(+) T cells in humans...
  81. ncbi request reprint Dendritic cell function in vivo during the steady state: a role in peripheral tolerance
    Ralph M Steinman
    The Rockefeller University, Laboratories of Cellular Physiology and Immunology, Molecular Immunology, Molecular Genetics and Immunology, and Human Immunology and Immune Therapy, New York, New York 10021 6399, USA
    Ann N Y Acad Sci 987:15-25. 2003
    ..It is proposed that dendritic cells play a major role in defining immunologic self, not only centrally in the thymus but also in the periphery...
  82. pmc Dendritic cells as controllers of antigen-specific Foxp3+ regulatory T cells
    Sayuri Yamazaki
    Laboratory of Cellular Physiology and Immunology, and Chris Browne Center of Immunology and Immune Disease, The Rockefeller University, New York, NY 10065, USA
    J Dermatol Sci 54:69-75. 2009
    ..These findings need to be pursued to develop novel immune suppressive therapies using antigen-specific Treg educated by DCs...
  83. pmc New monoclonal anti-mouse DC-SIGN antibodies reactive with acetone-fixed cells
    Cheolho Cheong
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    J Immunol Methods 360:66-75. 2010
    ..DC-SIGN expressed on the cell surface was sensitive to collagenase treatment, as monitored by polyclonal and MAb. These new reagents should be helpful to probe the biology of DC-SIGN in vivo...
  84. doi request reprint Some active areas of DC research and their medical potential
    Ralph M Steinman
    Rockefeller University, New York, NY, USA
    Eur J Immunol 40:2085-8. 2010
    ..In this Preface, I will introduce the Viewpoints and consider some future challenges as well as the medical relevance of DC research...
  85. pmc Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas
    Cheolho Cheong
    Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    Cell 143:416-29. 2010
    ..Thus the blood monocyte reservoir becomes the dominant presenting cell in response to select microbes, yielding DC-SIGN(+) cells with critical functions of DCs...
  86. pmc Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors
    Sayuri Yamazaki
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center of Immunology and Immune Disease, Rockefeller University, New York, NY 10021 6399, USA
    Blood 110:4293-302. 2007
    ..These results indicate that DCs are specialized to differentiate functional peripheral Foxp3(+)T regs and help set the stage to use DCs to actively suppress the immune response in an antigen-specific manner...
  87. pmc Selective blockade of the inhibitory Fcgamma receptor (FcgammaRIIB) in human dendritic cells and monocytes induces a type I interferon response program
    Kavita M Dhodapkar
    Lab of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 204:1359-69. 2007
    ..Manipulation of FcgammaR balance on DCs and monocytes may provide a novel approach to regulating IFN-mediated pathways in autoimmunity and human cancer...
  88. pmc Dendritic cell maturation by innate lymphocytes: coordinated stimulation of innate and adaptive immunity
    CHRISTIAN MUNZ
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 202:203-7. 2005
    ..Here, we comment on the evidence that these pathways are TLR independent and have the potential to respond to infection, malignancy, and immunotherapy...
  89. ncbi request reprint Harnessing the immune system against human glioma
    Kavita M Dhodapkar
    The Rockefeller University, Laboratory of Cellular Physiology and Immunology, 1230 York Ave, New York, NY 10021, USA
    Ann N Y Acad Sci 1062:13-21. 2005
    ..Our hypothesis is that optimal vaccination approaches against cancer will need to recruit both innate and adaptive defense mechanisms...
  90. ncbi request reprint The interactions of dendritic cells with antigen-specific, regulatory T cells that suppress autoimmunity
    Kristin V Tarbell
    Laboratory of Cellular Physiology and Immunology and the Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, 1230 York Avenue, Box 176, New York, NY 10021 6399, USA
    Semin Immunol 18:93-102. 2006
    ..Distinct states of DC differentiation or maturation are likely to be important for the emerging roles of DCs in the biology of Tregs, particularly the control of autoimmunity in an antigen-dependent manner...
  91. pmc Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses
    Silvia B Boscardin
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 203:599-606. 2006
    ..We conclude that antigen targeting to DCs combined with a maturation stimulus produces broad-based and long-lived T cell help for humoral immune responses...
  92. pmc Selective blockade of inhibitory Fcgamma receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells
    Kavita M Dhodapkar
    Laboratory of Tumor Immunology and Immunotherapy, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:2910-5. 2005
    ..These data suggest an approach for modifying this balance to enhance immunity to immune complexes and antibody-coated tumor cells and to silence DC activation by immune complexes in autoimmune states...
  93. ncbi request reprint Immunotherapy: bewitched, bothered, and bewildered no more
    Ralph M Steinman
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021 6399, USA
    Science 305:197-200. 2004
    ..We suggest steps to be taken to reinvigorate basic research in human subjects as part of the mainstream of science...
  94. ncbi request reprint Some interfaces of dendritic cell biology
    Ralph M Steinman
    Laboratory of Cellular Physiology and Immunology and the Chris Browne Center for Immunology and Immune Disease, The Rockefeller University, New York 10021 6399, USA
    APMIS 111:675-97. 2003
    ..Nonetheless, DCs are providing new opportunities to study patients and the many clinical conditions that involve the immune system...
  95. pmc Bone marrow-derived chimerism in non-irradiated, cyclosporin-treated rats receiving microvascularized limb transplants: evidence for donor-derived dendritic cells in recipient lymphoid tissues
    M Talmor
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, USA
    Immunology 86:448-55. 1995
    ..The combination of cyclosporin and vascularized bone provides a means for inducing chimerism in lymphoid tissues of non-irradiated recipients...
  96. ncbi request reprint DEC-205, a 205-kDa protein abundant on mouse dendritic cells and thymic epithelium that is detected by the monoclonal antibody NLDC-145: purification, characterization, and N-terminal amino acid sequence
    W J Swiggard
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021 6399, USA
    Cell Immunol 165:302-11. 1995
    ..We refer to the protein as DEC-205, in view of its abundant expression by dendritic and thymic epithelial cells, and the revised molecular mass...
  97. ncbi request reprint Dendritic cells and the control of immunity: enhancing the efficiency of antigen presentation
    R M Steinman
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, 1230 York Ave, New York, NY 10021-6399, USA
    Mt Sinai J Med 68:160-6. 2001
    ..The harnessing of these and other features of DCs provides opportunities for improving immune-based therapies and vaccine design...
  98. pmc Clustering with dendritic cells precedes and is essential for T-cell proliferation in a mitogenesis model
    J M Austyn
    Rockefeller University, New York, New York
    Immunology 63:691-6. 1988
    ..However, non-clusters will respond when supplemented with additional DC. We conclude that clustering with DC precedes and seems essential for T-cell mitogenesis in the periodate model...
  99. pmc Dendritic cell-targeted protein vaccines: a novel approach to induce T-cell immunity
    C Trumpfheller
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    J Intern Med 271:183-92. 2012
    ....
  100. ncbi request reprint Identification of macrophages and dendritic cells in the osteopetrotic (op/op) mouse
    M D Witmer-Pack
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021
    J Cell Sci 104:1021-9. 1993
    ..With respect to dendritic cells, the data are consistent with prior in vitro work where it was noted that GM-CSF but not M-CSF supported dendritic cell viability, function and growth...
  101. ncbi request reprint Interleukin 6 is the principal cytolytic T lymphocyte differentiation factor for thymocytes in human leukocyte conditioned medium
    J E Ming
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021
    J Mol Cell Immunol 4:203-11; discussion 211-2. 1989
    ..These results indicate that IL-6 is the principal CTL differentiation factor produced by stimulated human leukocytes...